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E219 Sodium methyl p-hydroxybenzoate is a compound with formula Na(CH3(C6H4COO)O).
E219 Sodium methyl p-hydroxybenzoate is the sodium salt of methylparaben.
E219 Sodium methyl p-hydroxybenzoate is a food additive with the E number E219 which is used as a preservative.
CAS: 5026-62-0
MF: C8H9NaO3
MW: 176.15
EINECS: 225-714-1
Synonyms
4-hydroxybenzoic acid methyl ester sodium salt;methyl p-hydroxybenzoate sodium salt;METHYLPARABEN, SODIUM SALT;METHYL 4-HYDROXYBENZOATE SODIUM;METHYL 4-HYDROXYBENZOATE SODIUM SALT;(p-carboxyphenoxy)-sodiumethylester;benzoicacid,4-hydroxy-,methylester,sodiumsalt;Benzoicacid,p-hydroxy-,methylester,sodiumderiv.
E219 Sodium methyl p-hydroxybenzoate, known chemically as Sodium Methyl p-Hydroxybenzoate (or Sodium Methylparaben), is a synthetic preservative.
E219 Sodium methyl p-hydroxybenzoate belongs to the paraben family and is highly prized in the food, cosmetic, and pharmaceutical industries for its ability to extend shelf life by inhibiting the growth of yeasts and molds.
E219 Sodium methyl p-hydroxybenzoate, also known as E219, is a chemical compound in the paraben group.
E219 Sodium methyl p-hydroxybenzoate is the sodium salt of p-hydroxybenzoic acid and methanol.
Parabens are widely used as preservatives in many consumer products, including foods, cosmetics and pharmaceuticals, due to their ability to inhibit the growth of microorganisms.
E219 Sodium methyl p-hydroxybenzoate is particularly valued in the food industry for its antibacterial and antifungal properties, which helps extend the shelf life of products by preventing spoilage.
E219 Sodium methyl p-hydroxybenzoate is the common name for E 219, i.e., the sodium salt of methyl p-hydroxybenzoate (a paraben) used as a preservative.
In the food sector E219 Sodium methyl p-hydroxybenzoate is classified as additive E 219 and may also be described as “sodium salt of methyl p-hydroxybenzoate” or “sodium methyl p-hydroxybenzoate”.
In the cosmetics sector, the label name follows INCI and is SODIUM METHYLPARABEN (the same in Italian and English).
In the pharmaceutical sector, technical synonyms are commonly used, such as “sodium methyl 4-hydroxybenzoate” or “sodium methyl parahydroxybenzoate”.
Functionally, E219 Sodium methyl p-hydroxybenzoate acts as an antimicrobial mainly against yeasts and molds, supporting microbiological stability and shelf life of formulations.
E219 Sodium methyl p-hydroxybenzoate's use remains subject to sector- and concentration-specific regulatory limits, and formulators also consider compatibility, ph, and overall tolerability.
E219 Sodium methyl p-hydroxybenzoate is the sodium salt of methyl p-hydroxybenzoate.
E219 Sodium methyl p-hydroxybenzoate's chemical structure includes a benzene ring, a hydroxyl group, and an ester group.
The sodium form increases its water solubility, making it ideal for use in liquid products or aqueous formulations.
E219 Sodium methyl p-hydroxybenzoate works by inhibiting microbial growth through the destabilization of microbial cell membranes.
E219 Sodium methyl p-hydroxybenzoate is a preservative that belongs to the group of antimicrobial agents.
E219 Sodium methyl p-hydroxybenzoate is used as a preservative in pharmaceuticals and personal care products.
E219 Sodium methyl p-hydroxybenzoate has been shown to have significant cytotoxicity at concentrations above 0.1%.
The concentration-time curve for E219 Sodium methyl p-hydroxybenzoate shows that it has a rapid effect on bacteria, with an increase in the number of dead cells after 24 hours.
E219 Sodium methyl p-hydroxybenzoate also showed significant cytotoxicity against human lung cells at concentrations below 1%.
E219 Sodium methyl p-hydroxybenzoate has been shown to be effective against gram-positive and gram-negative bacteria, but not yeast or moulds.
E219 Sodium methyl p-hydroxybenzoate is soluble in water and glycol ethers, but insoluble in oil.
The solubility of E219 Sodium methyl p-hydroxybenzoate means that it can be used in various formulations such as nanoparticulate compositions and postharvest treatments for fruit and vegetables.
E219 Sodium methyl p-hydroxybenzoate Chemical Properties
Melting point: >125°C
density: 1.42 g/cm3 (20 °C)
storage temp.: Store at +15°C to +25°C.
solubility: Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form: Powder
pka: 8.4[at 20 ℃]
color: White
PH: 9.7-10.3 (1g/l, H2O)
Water Solubility: 418g/L at 20℃
BRN: 4165000
Major Application: pharmaceutical
Cosmetics Ingredients Functions: PRESERVATIVE
InChI: InChI=1S/C8H8O3.Na.H/c1-11-8(10)6-2-4-7(9)5-3-6;;/h2-5,9H,1H3;;
InChIKey: PESXGULMKCKJCC-UHFFFAOYSA-M
LogP: -0.63 at 20℃
CAS DataBase Reference: 5026-62-0(CAS DataBase Reference)
EPA Substance Registry System: E219 Sodium methyl p-hydroxybenzoate (5026-62-0)
E219 Sodium methyl p-hydroxybenzoate is a colorless, crystalline substance that dissolves well in water.
Thanks to its chemical and thermal stability, E219 Sodium methyl p-hydroxybenzoate can be used over a wide range of temperatures, making it an ideal preservative for use in a variety of food products.
In addition, E219 Sodium methyl p-hydroxybenzoate's low toxicological profile makes it safe to use, as long as it is used in accordance with regulations regarding permitted dosages.
Uses
E219 Sodium methyl p-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics.
E219 Sodium methyl p-hydroxybenzoate can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate.
The sodium salt provides improved solubility in water compared to standard methyl 4-hydroxybenzoate.
E219 Sodium methyl p-hydroxybenzoate is mainly used as a preservative in the food industry.
E219 Sodium methyl p-hydroxybenzoate is added to products such as soft drinks, dairy products, fruit products, candy and some types of baked goods to prevent them from spoiling by bacteria, yeast and mold.
In addition, due to its preservative properties, E219 Sodium methyl p-hydroxybenzoate can also be used in some cosmetics and pharmaceutical products.
Contact allergens
E219 Sodium methyl p-hydroxybenzoate is one of the parabens family.
Parabens are esters formed by p-hydroxybenzoic acid and an alcohol.
They are largely used as biocides in cosmetics and toiletries, medicaments, or food.
They have synergistic power with other biocides.
Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.
