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E281 (Sodium propionate)

E281 (Sodium propionate)

CAS NO.: 137-40-6
EC/LIST NO.:  205-290-4

E281 (Sodium propionate) is the sodium salt of propionic acid which has the chemical formula Na(C2H5COO). 
This white crystalline solid is deliquescent in moist air.

E281 (Sodium propionate) is the sodium salt of propionic acid that exists as colorless, transparent crystals or a granular crystalline powder. 
E281 (Sodium propionate) is considered generally recognized as safe (GRAS) food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and flavoring agent. 
E281 (Sodium propionate) use as a food additive is also approved in Europe. 
E281 (Sodium propionate) is is prepared by neutralizing propionic acid with sodium hydroxide. 
E281 (Sodium propionate) was previously approved in Canada as an active ingredient in Amino-Cerv (used to treat inflammation or injury of the cervix).


E281 (Sodium propionate) and various direct sodium or calcium salt formulations of the acid are currently most commonly approved and indicated by organizations like the FDA and EMA for use as an antibacterial food additive preservative in animal feed and food for human consumption 5,6.

Similarly, although the use of propanoic acid or any of its direct sodium or calcium salt formulations as excipient ingredients in pharmaceuticals is not necessarily a major role for the compound today, E281 (Sodium propionate) was used in some vaginal cream preparations indicated for cervicitis, cervical tears, and/or postcauterization, postcryosurgery, and postconization of the cervix . 
In such products, the E281 (Sodium propionate) was primarily used to elicit a preservative, bacteriostatic 4,11 effect while other active ingredients combined in the formulation like urea, benzalkonium chloride, inositol, and methionine and cystine amino acids facilitated debridement, enhanced medication spread, epithelialization promotion, and wound healing, respectively 4,1.

Nevertheless, a great variety of propionic acid derivatives exist as separate pharmaceuticals, each with their own unique therapeutic categories, pharmacodynamics, and pharmacokinetics.

E281 (Sodium propionate) is a short chain fatty acid, which is a major part of the luminal contents of the colon. 
E281 (Sodium propionate) is associated with anti-inflammatory properties.

E281 (Sodium propionate) or E281 (Sodium propionate), the sodium salt of propanoic acid that can be used as a preservative in food with the European food additive number E281. 
The common use for this ingredient is as a mold inhibitor in baked goods as they’re easily contaminated with the moisture in the air during cooling, slicing and packaging after the baking process. 

E281 (Sodium propionate), also known as natriumpropionat or E281, belongs to the class of organic compounds known as carboxylic acid salts. 
These are ionic derivatives of carboxylic acid. Based on a literature review a significant number of articles have been published on E281 (Sodium propionate).

E281 (Sodium propionate) is the sodium salt form of propionic acid, a short chain fatty acid (SCFA) and food additive, with potential gastrointestinal (GI) protective activity. 
Upon oral administration of E281 (Sodium propionate), it converts to propionic acid which may protect the GI tract and reduce incidence and severity of GI toxicity from radiation therapy.

E281 (Sodium propionate) is an organic sodium salt comprising equal numbers of sodium and propionate ions. 
E281 (Sodium propionate) has a role as an antifungal drug and a food preservative. It contains a propionate.

E281 (Sodium propionate) (C3H5NaO2) is the sodium salt of propionic acid and is available as a white, free-flowing powder. 
In the food industry it is used safely as a food preservative and prevents the growth of mold and some bacteria. 
In pharmacy, E281 (Sodium propionate) is used in the treatment of skin fungal infections, usually in combination with calcium propionate.

E281 (Sodium propionate) is used as a food preservative, as a mold inhibitor in bakery products and in insect cell culture. 
E281 (Sodium propionate) is also used in pharmaceuticals, cosmetics, agriculture and animal feed as preservative. 
E281 (Sodium propionate) acts as a food additive. Further, it inhibits the growth of lactic acid bacteria.

E281 (Sodium propionate) is a salt of propionic acid, well known for its anti-mold activity. 
E281 (Sodium propionate) is categorized as GRAS by the U.S. FDA, and is used for various applications, globally. 
The ease of availability and economic price point, coupled with the efficacy of E281 (Sodium propionate), has popularized its use in multiple segments.

On the basis of application, the E281 (Sodium propionate) market is segmented as bakery products, meat and meat products, cheese & cheese products, pharmaceuticals, personal care and agrochemicals, and others.

In terms of volume, the bakery products segment constitutes a much larger share in the E281 (Sodium propionate) market than any other segment. 
The increased per capita expenditure on food, owing to the rise in disposable income in multiple developing countries, is surging the demand for E281 (Sodium propionate).

Customer demand is focused on the quality and longevity of the products that they buy. 
Therefore, artificial GRAS preservatives have become an integral part of the bakery industry. 
E281 (Sodium propionate), being recognized as GRAS by the FDA, and being an economically feasible and safe option for all manufacturers, has become the go-to preservative for bakery products. 
Furthermore, the demand for bakery products has been on a constant rise from matured markets such as North America and Europe as well. 
E281 (Sodium propionate) is an integral component of modern bakery products.

The growing demand for E281 (Sodium propionate) in the agricultural and animal feed segment is fueled by the growing awareness amongst the agricultural community for sustainable grain collection and preservation methods.

The growth in the demand for E281 (Sodium propionate) in agrochemicals is also highly attributed to the growing demand for high quality animal and meat products. 
Public awareness towards the ethical production of animal products has surged the demand for high quality animal feed and feed additives such as E281 (Sodium propionate).

Sodium Propanoate or E281 (Sodium propionate) is the sodium salt of propionic acid which has the chemical formula Na(C2H5COO). 
This white crystalline solid is deliquescent in moist air. 
E281 (Sodium propionate) is used as a food preservative and is represented by the food labeling E number E281 in Europe; it is used primarily as a mold inhibitor in bakery products

E281 (Sodium propionate) is the salt form of propionic acid, which is an organic acid that is produced during the chemical degradation of sugar. 
E281 (Sodium propionate) is a compound that is produced naturally in the body when certain fatty acids and amino acids are metabolized. 
Propionic acid is metabolized by a series of enzymatic reactions that are dependent on the presence of vitamin B-12, according to a 1996 article in the "International Journal of Vitamin and Nutrition Research." 
E281 (Sodium propionate) is also chemically manufactured for a variety of industrial uses.
E281 (Sodium propionate) is a common food additive that is industrially manufactured but also occurs in nature. 
Since it is toxic to mold and some species of bacteria, it is an especially effective additive in baked goods or other products that are susceptible to spoilage.
E281 (Sodium propionate) is an effective inhibitor of the growth of certain molds and some bacteria in bakery goods. 
E281 (Sodium propionate) is usually preferred in non-yeast leavened bakery products because the calcium ions’ of calcium propionate interfere with the chemical leavening agents. 
In those bakery products, such as cakes, tortillas, pie fillings etc., chemically leaved agents are used (e.g. baking powder). 
E281 (Sodium propionate)  is easy to handle and easy to incorporate into flour.
E281 (Sodium propionate) is a safe compound when encountered at the low levels found in food.

E281 (Sodium propionate) is the sodium salt of propionic acid that is produced during the chemical degradation of sugar. 
E281 (Sodium propionate) is a safe compound that is toxic to mould and some bacteria, prolonging shelf life. 
E281 (Sodium propionate) is a food additive and has a food label of E281. Widely used in bakery products as its concentrations are commonly low enough that you can’t taste it in products.

Sodium propanoate E281 or E281 (Sodium propionate) is the sodium salt of propionic acid which has the chemical formula Na(C2H5COO). 
E281 (Sodium propionate) is used as a food preservative and is represented by the food labeling E number E281 in Europe; it is used primarily as a mold inhibitor in bakery products. 
E281 (Sodium propionate) is approved for use as a food additive in the EU.

E281 (Sodium propionate) is produced by the reaction of propionic acid and sodium carbonate or sodium hydroxide.

E281 (Sodium propionate) can be produced by the reaction of propionic acid (E280) with sodium hydroxide in hydrogen peroxide and water

Effective inhibitor of the growth of certain moulds and some bacteria.
Integrates well with flours.
Easy to handle.

Molecular Formula : C3H5NaO2
Molecular Weight : 96.06
Part A
Storage : Room Temperature
Shelf Life : 60 Months
HSN Code : 29155000
IMDG Identification :Not Regulated for Transport (Non-Haz)

Appearance (Colour)    White
Appearance (Form)    Fine powder
Solubility (Turbidity) 10% aq. solution    Clear
Solubility (Colour) 10% aq. solution    Colourless
Assay    min. 99%
Melting Point    287 - 289°C

E281 (Sodium propionate) is used as a food preservative and is represented by the food labeling E number E281 in Europe; it is used primarily as a mold inhibitor in bakery products. 
E281 (Sodium propionate) is approved for use as a food additive in the EU,[2] USA[3] and Australia and New Zealand[4] (where it is listed by its INS number 281).

E281 (Sodium propionate) has been used as a supplement in transgalacto-oligosaccharides (TOS) medium for the isolation of bifidobacteria. 
E281 (Sodium propionate) has been used as a supplement in SCFA (short-chain fatty acid) diet prepared for mice.
E281 (Sodium propionate) is used as a food preservative, as a mold inhibitor in bakery products and in insect cell culture. 
E281 (Sodium propionate) is also used in pharmaceuticals, cosmetics, agriculture and animal feed as preservative. 
E281 (Sodium propionate) acts as a food additive. Further, it inhibits the growth of lactic acid bacteria.

Primary uses: Antifungal agent, antiseptic agent (topical), disinfectant, food additive, ophthalmic agent.
E281 (Sodium propionate) is used primarily as a mold inhibitor in bakery products. 
E281 (Sodium propionate) is approved for use as a food additive in the EU, USA and Australia and New Zealand (where it is listed by its INS number 281). 
Chemically synthesized E281 (Sodium propionate) is most commonly used as a preservative in the food industry. 
E281 (Sodium propionate) prevents the growth of mold and some bacteria, thereby prolonging the shelf life of packaged baked goods. 
According to the Code of Federal Regulations, E281 (Sodium propionate) is generally recognized as safe when used as a food additive. 
E281 (Sodium propionate) is also used to prevent mold growth in packaged and processed cheese products. 
In addition, ammonium propionate is used as an additive in animal feed to prevent overgrowth of unwanted bacteria in the stomachs of livestock.
E281 (Sodium propionate) can be used as preservatives; used for anti-mould for cakes, waxberry and other mildew
E281 (Sodium propionate) can be used as germicide and antiseptic.
E281 (Sodium propionate) wet acid preservative has its antibacterial effect be affected by the environmental PH. 
The minimum inhibitory concentration was 0.01% at pH 5.0 and 0.5% at pH 6.5. 
In acidic medium, it has a strong inhibitory effect against various types of mold, aerobic bacillus or Gram-negative bacteria. 
E281 (Sodium propionate) has special effect in prevention the production of aflatoxin while having no effect on the yeast. 
In addition, it is also used as a food preservative.
In the leather, it can be used as masking agent in order to improve the alkali resistance of leather and tanning uniformity.
In the food industry, it can be used for pastry preservation with the usage amount of 2.5g/kg (based on propionic acid, the same as below); in 3% to 5% aqueous solution, the maximal amount for soaking waxberry is 50g/kg. 
E281 (Sodium propionate) can also be used as feed antiseptic.
Germicide, antiseptic. 
Used for determination of transaminase; The general dosage is 0.1-0.3%.

E281 (Sodium propionate) is an antimicrobial agent that is the sodium salt of propionic acid. 
E281 (Sodium propionate) occurs as colorless, transparent crystals or a gran- ular crystalline powder. 
E281 (Sodium propionate) is odorless or has a faint acetic–butyric acid odor, and is deliquescent. 
E281 (Sodium propionate) is prepared by neutralizing propionic acid with sodium hydroxide. 
E281 (Sodium propionate) is used in baked goods; nonalcoholic beverages; cheeses; confections and frostings; gelatins, puddings, and fillings; jams and jellies; meat products; and soft candy.

Widely employed in bread to prevent mould and extend the normal shelf life of a product.
Used in combination with flours as E281 (Sodium propionate) is are easy to incorporate it with them.


IUPAC NAME:

PROPANOIC ACID SODIUM (+1)
 
Propanoic acid, sodium salt
 
Sodium propanoate
   
sodium propanoate
   
E281 (Sodium propionate)

SYNONYMS:

E281 (Sodium propionate)   
137-40-6  
205-290-4  
Natriumpropionat  
Propanoic Acid, Sodium Salt
Propanoic acid, sodium salt   
Propionate de sodium  
Propionic acid sodium salt
sodium propanoate

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