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E301 sodium ascorbate is sodium salt of ascorbic acid (commonly known as vitamin C), which is approved for use as a food additive in many countries.
E301 sodium ascorbate is consisted of a combination of sodium and vitamin C, which commonly serve as an antioxidant and an acidity regulator in pharmaceutical manufacturing and in the food industry.
E301 sodium ascorbate contains a L-ascorbate.
CAS Number: 134-03-2
Molecular Formula: C6H7NaO6
Molecular Weight: 198.11
EINECS Number: 205-126-1
Synonyms: E301 sodium ascorbate, 134-03-2, L-Ascorbic acid sodium salt, Sodium L-ascorbate, Vitamin C sodium, Monosodium L-ascorbate, Ascorbicin, Ascorbic acid sodium salt, Natrii ascorbas, Iskia-C, Natri-C, Ascorbate de sodium, Sodascorbate, (+)-Sodium L-ascorbate, L-Ascorbic acid, monosodium salt, Vitamin C Sodium Salt, Vitamin C, sodium salt, ascorbate, Ascorbin, Cevalin, MFCD00082340, 3-Oxo-L-gulofuranolactone sodium, INS NO.301, L(+)-Ascorbic acid sodium salt, INS-301, S033EH8359, L-Ascorbic acid (sodium salt), DTXSID0020105, E-301, CHEBI:113451, l-Ascorbate, sodium, Sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, Cebitate, Aminofenitrooxon, sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate, sodium (L)-ascorbate, sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, E301 sodium ascorbate (II), E301 sodium ascorbate [II], E301 sodium ascorbate (MART.), E301 sodium ascorbate [MART.], sodiumascorbate, E301 sodium ascorbate (USP-RS), E301 sodium ascorbate [USP-RS], Ascorbato sodico, Ascorbato sodico [DCIT], sodium;(2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate, E301 sodium ascorbate (EP MONOGRAPH), E301 sodium ascorbate [EP MONOGRAPH], E301 sodium ascorbate (USP MONOGRAPH), E301 sodium ascorbate [USP MONOGRAPH], MonoE301 sodium ascorbate, Natrii ascorbas [INN-Latin], Ascorbic acid sodium derivative, CCRIS 3291, HSDB 694, HBL 508, L-Ascorbic acid sodium, Ascorbate de sodium [INN-French], EINECS 205-126-1, E301 sodium ascorbate [USP:INN], UNII-S033EH8359, Sodium derivative of 3-oxo-L-gulofuranolactone, Ascorbate, Sodium, sodium (2R)-2-((1S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, E301 sodium ascorbate; Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, (+)-Sodium L-ascorbate;Vitamin C sodium salt;Sodium L-ascorbate, E301, sodium L-ascorbate salt, VITA-JEC C, EC 205-126-1, SCHEMBL3745, ASK-P 10KR, DTXCID60105, L(+)Ascorbic acid sodium salt, E301 sodium ascorbate [FCC], E301 sodium ascorbate [INN], CHEMBL591665, HY-B0166AR, E301 sodium ascorbate [HSDB], E301 sodium ascorbate [VANDF], HY-B0166A, E301 sodium ascorbate [WHO-DD], L-Ascorbic Acid Sodium Salt,(S), Tox21_300556, AKOS015895058, L-Ascorbic acid, sodium salt (1:1), E301 sodium ascorbate [ORANGE BOOK], ASCORBIC ACID SODIUM SALT [MI], CS-6063, DB14482, 3-Keto-L-gulofuranlactone sodium enolate, NCGC00254355-01, BP-30077, CAS-134-03-2, DA-77918, L-Ascorbic acid (sodium salt) (Standard), A0539, E80761, EN300-221566, A806721, Q424551, J-006471, 2,3-Didehydro-L-theo-hexono-1,4-lactone sodium enolate, Z1255486556, sodium (2R)-2-[(1S)-1,2-bis(oxidanyl)ethyl]-4-oxidanyl-5-oxidanylidene-2H-furan-3-olate, Sodium(R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, ASCORBIC ACID SODIUM SALT;L(+)-ASCORBIC ACID SODIUM SALT;L-ASCORBIC ACID SODIUM SALT;L-ASCORBIC ACID NA SALT, SODIUMASCORBATE, GRANULAR,FCC, SODIUMASCORBATE,GRANULAR,USP, SODIUMASCORBATE,POWDER,USP, E301 sodium ascorbate (VC-NA) AND ITS DIRECTLY-COMPRESSION GRANULE.
E301 sodium ascorbate salt of ascorbic acid (Vitamin C), it possesses the same health benefits as Vitamin C, but in a more stable and less acidic form.
This makes it a preferred choice in both medical and commercial applications, particularly when the goal is to provide a milder alternative to pure ascorbic acid.
In addition to its use in supplements and food, E301 sodium ascorbate has various applications in the pharmaceutical and cosmetic industries, where it is used for its antioxidant properties.
E301 sodium ascorbate helps stabilize formulations and prevent oxidation in products like skincare treatments.
E301 sodium ascorbate is also used in the treatment of scurvy, a disease caused by Vitamin C deficiency, and in various laboratory and research settings where it acts as a reducing agent.
E301 sodium ascorbate is the sodium salt of ascorbic acid, commonly known as Vitamin C.
E301 sodium ascorbate is a water-soluble compound that offers the same antioxidant benefits as pure Vitamin C, helping to neutralize harmful free radicals in the body.
E301 sodium ascorbate is often used in food preservation and as a dietary supplement, particularly in cases where individuals may have difficulty tolerating the acidity of pure ascorbic acid.
E301 sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C).
The molecular formula of this chemical compound is C6H7NaO6.
As the sodium salt of ascorbic acid, it is known as a mineral ascorbate.
E301 sodium ascorbate has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.
E301 sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of E301 sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).
As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator.
E301 sodium ascorbate is approved for use as a food additive in the EU, USA, Australia, and New Zealand.
In vitro studies, E301 sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.
E301 sodium ascorbate is produced by dissolving ascorbic acid in water and adding an equivalent amount of sodium hydroxide or sodium bicarbonate in water.
After cessation of effervescence, the E301 sodium ascorbate is precipitated by the addition of isopropanol.
E301 sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C).
The molecular formula of this chemical compound is C6H7NaO6.
As the sodium salt of ascorbic acid, it is known as a mineral ascorbate.
E301 sodium ascorbate has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.
E301 sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of E301 sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).
As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator.
E301 sodium ascorbate is approved for use as a food additive in the EU, USA, Australia, and New Zealand.
In vitro studies, E301 sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.
E301 sodium ascorbate is a versatile and widely used compound, primarily known for its role as an antioxidant and a stabilizing agent.
As a salt of ascorbic acid, it combines the benefits of Vitamin C with the additional advantage of being less acidic than its parent compound, making it easier for people to tolerate, especially those with sensitive stomachs.
This property makes it a preferred choice in both food and pharmaceutical products, where a gentler, less acidic form of Vitamin C is desired.
In this mixture, E301 sodium ascorbate acts as a buffer, creating a less acidic supplement than those made entirely from vitamin C.
E301 sodium ascorbate can be easier to tolerate if the digestive system is sensitive to acid.
As a vitamin C supplement, it provides both sodium and vitamin C for human body, which is effective to prevent or treat vitamin C deficiency.
Besides, studies have shown that taking E301 sodium ascorbate is helpful with cancer prevention and treatment.
E301 sodium ascorbate occurs as a white or slightly yellow-colored, practically odorless, crystalline powder with a pleasant saline taste.
E301 sodium ascorbate is an organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion.
E301 sodium ascorbate has a role as a food antioxidant, a flour treatment agent, a coenzyme, a plant metabolite, a human metabolite, a Daphnia magna metabolite and a reducing agent.
E301 sodium ascorbate is an organic sodium salt and a vitamin C.
E301 sodium ascorbate is preferred by some people for its less acidic nature, making it gentler on the stomach.
E301 sodium ascorbate is a compound with a wide array of uses, primarily due to its potent antioxidant properties.
E301 sodium ascorbate plays an important role in supporting immune function.
E301 sodium ascorbate enhances the body’s ability to fight infections by boosting the production of white blood cells, which are crucial in defending against pathogens.
In addition to its immune-boosting properties, E301 sodium ascorbate is involved in the synthesis of collagen, an essential protein for the skin, cartilage, tendons, and bones.
This function makes it vital for wound healing and tissue repair.
Regular intake of E301 sodium ascorbate is associated with improved skin health, stronger bones, and enhanced muscle function.
Beyond its immune system support, E301 sodium ascorbate is also known for its role in managing oxidative stress.
E301 sodium ascorbate neutralizes free radicals, which are unstable molecules that can damage cells, proteins, and DNA, leading to premature aging, chronic diseases, and even cancer.
By reducing oxidative damage, E301 sodium ascorbate may help mitigate the risk of various health issues related to aging, such as cardiovascular disease, arthritis, and neurodegenerative disorders like Alzheimer’s disease.
Melting point: 220 °C (dec.)(lit.)
alpha: 104 º (c=1, H2O 25 ºC)
Boiling point: 235 °C
Density: 1.66
vapor pressure: 0Pa at 25℃
refractive index: 105.5 ° (C=10, H2O)
storage temp.: 2-8°C
solubility: H2O: 50 mg/mL
form: powder
color: white to slightly yellow
Odor: odorless
PH: 7.48(1 mM solution);7.71(10 mM solution);7.64(100 mM solution);7.62(1000 mM solution)
optical activity: [α]20/D +105±2°, c = 5% in H2O
Water Solubility: 620 g/L (20 ºC)
Merck: 14,830
BRN: 3767246
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -4.2 at 21.9℃
E301 sodium ascorbate is frequently used in intravenous (IV) treatments, particularly for high-dose Vitamin C therapies.
This form of administration allows for a higher concentration of Vitamin C to be delivered directly into the bloodstream, offering potential benefits in cancer treatment, where it may help enhance the effectiveness of certain chemotherapy drugs and reduce side effects.
E301 sodium ascorbate has also been explored as a treatment for viral infections, inflammation, and chronic fatigue syndrome.
E301 sodium ascorbate’s role in food preservation is another significant application.
As a preservative, it extends the shelf life of perishable goods by preventing oxidation, which can cause spoilage and loss of nutrients.
Its ability to prevent browning in fruits and vegetables is especially important in the food industry, where maintaining both the aesthetic and nutritional quality of products is essential.
In meats, E301 sodium ascorbate helps to inhibit the formation of harmful compounds like nitrosamines, which can form during the curing process.
E301 sodium ascorbate is also used to preserve the quality of beverages, such as fruit juices, where it helps retain both flavor and color.
In addition to these well-known uses, E301 sodium ascorbate is a crucial reagent in various scientific research fields.
In biochemistry, it serves as a reducing agent, assisting in redox reactions in both organic and inorganic chemistry.
Researchers use E301 sodium ascorbate to stabilize compounds and prevent oxidation in sensitive reactions.
E301 sodium ascorbate also plays a role in laboratory tests, such as those used to measure the concentration of metal ions or other substances in a sample.
Furthermore, E301 sodium ascorbate’s potential benefits in environmental science are gaining attention.
Due to its reducing properties, it has been proposed as an eco-friendly option for environmental cleanup.
Researchers are exploring its use in the remediation of heavy metal contamination in water and soil, as it could help reduce harmful metal ions into less toxic forms, facilitating environmental restoration.
In summary, E301 sodium ascorbate is much more than just a supplement or food preservative.
Its ability to combat oxidative stress, support immune function, promote skin health, and even contribute to environmental sustainability underscores its significance across a variety of fields.
E301 sodium ascorbate continues to be a valuable tool in medicine, science, industry, and health.
An equivalent amount of sodium bicarbonate is added to a solution of ascorbic acid in water.
Following the cessation of effervescence, the addition of propan-2-ol precipitates E301 sodium ascorbate.
Materials in this group are generally soluble in water.
The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids.
These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines.
They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Incompatible with oxidizing agents, heavy metal ions, especially copper and iron, methenamine, sodium nitrite, sodium salicylate, and theobromine salicylate.
The aqueous solution is reported to be incompatible with stainless steel filters.
In the food industry, E301 sodium ascorbate is commonly used as a preservative to prevent oxidation and extend shelf life.
E301 sodium ascorbate is effective in preventing the browning of fruits and vegetables, preserving the color and nutritional content of the food.
Additionally, it is utilized in processed meats to maintain freshness and prevent spoilage.
Its antioxidant activity also contributes to the prevention of rancidity in oils and fats.
E301 sodium ascorbate is widely used in the field of medicine and health supplements.
E301 sodium ascorbate is an essential ingredient in many Vitamin C supplements, where it is often marketed as a less acidic alternative to pure ascorbic acid.
This makes it a popular choice for people who need to boost their Vitamin C intake but wish to avoid the discomfort that can sometimes accompany high doses of ascorbic acid.
In therapeutic doses, E301 sodium ascorbate can help with the prevention and treatment of scurvy, support the immune system, and promote skin health by aiding in collagen formation.
In addition to its health benefits, E301 sodium ascorbate has various applications in the cosmetic industry.
Its antioxidant properties help in the formulation of skin-care products, as it can neutralize free radicals and protect the skin from oxidative stress.
This makes it valuable in products that aim to prevent premature aging, reduce the appearance of wrinkles, and improve the overall appearance of the skin.
Furthermore, E301 sodium ascorbate plays a critical role in scientific research and laboratory settings.
E301 sodium ascorbate is used as a reducing agent in various chemical reactions and experiments.
Researchers rely on its ability to reduce metal ions and other compounds, facilitating the completion of reactions in both biochemical and synthetic applications.
This makes E301 sodium ascorbate indispensable in numerous research disciplines, including biotechnology, medicine, and chemistry.
Overall, E301 sodium ascorbate is a widely applicable compound with numerous uses in health, food preservation, cosmetics, and scientific research.
Uses:
E301 sodium ascorbate has anti-inflammatory properties and can be used in medical treatments to reduce inflammation and support tissue repair.
Due to its essential role in collagen synthesis, E301 sodium ascorbate is used in treatments that aid in wound healing and tissue repair, as well as in improving skin and joint health.
E301 sodium ascorbate is used as a reducing agent in laboratory research, particularly in biochemistry and organic chemistry.
E301 sodium ascorbate helps in the reduction of metal ions and is used in various redox reactions.
In biochemical studies, E301 sodium ascorbate is often employed to stabilize reactive compounds and prevent oxidation in sensitive experimental setups.
E301 sodium ascorbate is used in synthetic chemistry, especially in the production of pharmaceutical compounds, by acting as a reducing agent in the creation of complex molecules.
E301 sodium ascorbate has potential applications in environmental science, particularly in the remediation of heavy metal contamination.
Its reducing properties can help detoxify polluted environments by transforming harmful metal ions into less toxic forms.
In industries where oxidation could compromise product quality (such as in plastics, rubbers, or oils), E301 sodium ascorbate is sometimes used to stabilize materials and prolong their shelf life.
E301 sodium ascorbate is sometimes added to animal feed to ensure that animals receive an adequate intake of Vitamin C, especially for species that do not produce it naturally.
It helps support immune health and overall well-being in livestock.
E301 sodium ascorbate is an antioxidant that is the sodium form of ascorbic acid.
E301 sodium ascorbate is soluble in water and provides a nonacidic taste.
E301 sodium ascorbate readily reacts with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant.
E301 sodium ascorbate is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress.
E301 sodium ascorbate is used as an antioxidant in pharmaceutical formulations, and also in food products where it increases the effectiveness of sodium nitrite against growth of Listeria monocytogenes in cooked meats.
It improves gel cohesiveness and sensory firmness of fiberized products regardless of vacuum treatment.
E301 sodium ascorbate is also used therapeutically as a source of vitamin C in tablets and parenteral preparations.
E301 sodium ascorbate is used to prevent or treat low levels of vitamin C in people who do not get enough of the vitamin from their diets.
Most people who eat a normal diet do not need extra ascorbic acid. Low levels of vitamin C can result in a condition called scurvy.
Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.
E301 sodium ascorbate is also used to protect your body's cells from damage.
E301 sodium ascorbate is known as an antioxidant.
E301 sodium ascorbate is commonly used as a supplement to provide Vitamin C in a more stomach-friendly form compared to pure ascorbic acid.
It helps in the prevention and treatment of scurvy, supports the immune system, and promotes overall health by enhancing collagen formation for skin, cartilage, tendons, and bones.
E301 sodium ascorbate plays a crucial role in boosting immune function by stimulating white blood cell production and enhancing the body's defense against infections.
As an antioxidant, E301 sodium ascorbate neutralizes free radicals in the body, which helps reduce oxidative stress and may lower the risk of chronic diseases, including cardiovascular diseases and certain types of cancer.
E301 sodium ascorbate is used as a preservative in food products to prevent oxidation, spoilage, and discoloration.
E301 sodium ascorbate helps maintain the freshness and nutritional content of foods, particularly in fruits, vegetables, and processed meats.
It prevents the browning of fruits and vegetables, such as in apples, potatoes, and avocados, by inhibiting enzymatic browning, thus improving the appearance and shelf life of fresh produce.
E301 sodium ascorbate is added to processed meats (like sausages and hot dogs) to prevent rancidity and the formation of harmful compounds like nitrosamines during the curing process.
E301 sodium ascorbate helps preserve the flavor, color, and nutrient content of beverages like fruit juices and soft drinks, protecting them from oxidation.
E301 sodium ascorbate is incorporated into many skincare formulations due to its ability to neutralize free radicals that contribute to skin aging.
It helps reduce the appearance of wrinkles and fine lines by stimulating collagen production and promoting skin elasticity.
E301 sodium ascorbate is often used in skin care products aimed at brightening the complexion and reducing hyperpigmentation, such as dark spots or age spots, due to its ability to inhibit melanin production.
As an antioxidant, E301 sodium ascorbate helps protect the skin from oxidative damage caused by UV radiation, making it a valuable ingredient in sunscreen and sun care products.
E301 sodium ascorbate is used in high-dose intravenous (IV) Vitamin C treatments, which are sometimes used in the treatment of cancer, chronic infections, and other conditions.
IV administration allows higher concentrations of Vitamin C to be delivered directly into the bloodstream, which may enhance the effectiveness of chemotherapy or other treatments.
Safety Profile:
Human mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.
The parenteral administration of 0.25-1.00 g of E301 sodium ascorbate, given daily in divided doses, is recommended in the treatment of vitamin C deficiencies.
Various adverse reactions have been reported following the administration of 1 g or more of E301 sodium ascorbate, although ascorbic acid and E301 sodium ascorbate are usually well tolerated; see Ascorbic acid.
There have been no reports of adverse effects associated with the much lower concentrations of E301 sodium ascorbate and ascorbic acid, which are employed as antioxidants.
Excessive intake of E301 sodium ascorbate can lead to gastrointestinal problems such as nausea, diarrhea, and stomach cramps.
Although it is generally less acidic than pure ascorbic acid, consuming large amounts may still irritate the digestive system, particularly for those with sensitive stomachs.
High doses of Vitamin C (in the form of E301 sodium ascorbate or other derivatives) have been associated with an increased risk of developing kidney stones, especially in individuals who are predisposed to oxalate kidney stones.
This is because excessive Vitamin C may be metabolized into oxalate, which can form stones in the kidneys.
In rare cases, excessive intake of E301 sodium ascorbate can cause a buildup of potassium in the blood (hyperkalemia), which may result in symptoms such as fatigue, weakness, and irregular heart rhythms.
This risk is higher for individuals with kidney problems or those on certain medications.
