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E341 Calcium phosphates, more commonly known as Calcium phosphate, is a calcium salt of phosphoric acid with the chemical formula Ca3(PO4)2.
E341 Calcium phosphates is also known as tribasic calcium phosphate and bone phosphate of lime (BPL).
E341 Calcium phosphates is a white solid of low solubility. Most commercial samples of "tricalcium phosphate" are in fact hydroxyapatite.
CAS Number: 7758-87-4
Molecular Formula: Ca3O8P2
Molecular Weight: 310.18
EINECS Number: 231-840-8
Synonyms: TRICALCIUM PHOSPHATE, 7758-87-4, Synthos, Calcium orthophosphate, Tricalcium diphosphate, Phosphoric acid, calcium salt (2:3), Tricalcium orthophosphate, Calcigenol simple, Tertiary calcium phosphate, Calcium phosphate, tribasic, Bonarka, Calcium tertiary phosphate, Calcium phosphate (3:2), Natural whitlockite, FEMA No. 3081, Calcium phosphate (Ca3(PO4)2), Calcium orthophosphate, tri-(tert), Tricalcium phosphate (Ca3(PO4)2), INS NO.341(III), INS-341(III), DTXSID1049803, Phosphoric acid calcium(2+) salt (2:3), E-341(III), K4C08XP666, BONE POWDER, PURIFIED, calcium phosphate, tricalcium salt, RefChem:6401, Phosphoric acid, calcium salt (2:3); Ca3(PO4)2, DTXCID5029762, 231-840-8, Calcium phosphate tribasic, Calcium phosphate, tricalcium;diphosphate, 10103-46-5, beta-TCP, beta-Tricalcium phosphate, Phosphoric acid, calcium salt, tricalcium bis(phosphate), alpha-Tricalcium phosphate, Calciresorb;TCP, MFCD00015984, Synthograft, Cerasorb, Calciumphosphate, OSferion, Calcium Phosphate Nanoparticles, tri-calcium phosphate, Caswell No. 148, Ceredex, Multifos, Vitoss, TricOs, Calipharm T, Tricafos P, 21063-37-6, CCRIS 3668, HSDB 879, JAX TCP, EINECS 231-840-8, EINECS 233-283-6, Ca3O8P2, UNII-97Z1WI3NDX, EPA Pesticide Chemical Code 076401, Posture (calcium supplement), Tricalcium bis(orthophosphate), UNII-K4C08XP666, Ca3(PO4)2, calcium-phosphate, alpha-TCP, Calcium phosphates, tricalciumphosphate, Posture (TN), CALCIGENOL, beta tricalcium phosphate, AI3-25607, EC-tri-Calcium phosphate, Calcium phosphate (3/2), EC 231-840-8, Tricalcium phosphate hydrate, SCHEMBL2006, Calcium Phosphate Nanopowder, 97Z1WI3NDX, CHEBI:9679, orb2939162, CHEMBL2106566, Calcium phosphate, AR, 96.0%, CALCIUM PHOSPHATE [WHO-DD], TRICALCIUM PHOSPHATE [FHFI], PRECIPITATED CALCIUM PHOSPHATE, TYD-01441, AKOS015833108, Phosphoric acid, calcium salt (1:?), CX-0072, DB11348, FC41082, Calcium phosphate, 98%, EC-phase basis, CALCIUM PHOSPHATE, TRIBASIC [MI], Calcium phosphate, tribasic (ca.37% Ca), CALCIUM PHOSPHATE, TRIBASIC [HSDB], CALCIUM PHOSPHATE, ANHYDROUS [VANDF], DB-230078, C3736, CS-0013475, NS00082557, C08136, D00938, F863026, Q278387, Calcium phosphate, Reagent for transient & stable DNA transfections, Tricalcium phosphate hydrate, nanopowder, <200 nm particle size (BET), alpha-tri-Calcium phosphate, puriss. p.a., >=75% alpha-phase basis (sinterted powder), alpha-tri-Calcium phosphate, Reagent for transient & stable DNA transfections, beta-tri-Calcium phosphate, puriss. p.a., >=95% beta-phase basis (sintered powder), beta-tri-Calcium phosphate, puriss. p.a., >=98% beta-phase basis (sintered Powder), beta-tri-Calcium phosphate, puriss. p.a., >=98% beta-phase basis (unsintered powder), APATITE TTCP, MONOCLINIC;tricalcium phosphate for technical grade, bonarka, calcigenolsimple, calciumorthophosphate, tri-(tert), calciumphosphate(3:2), calciumtertiaryphosphate, naturalwhitlockite
E341 Calcium phosphates are widely used European food additives that act as acidity regulators, leavening agents, and anti-caking agents. Synthesized from phosphoric acid, this family includes monocalcium, dicalcium, and tricalcium phosphate.
They naturally supply calcium/phosphorus and are completely safe for general consumption within recommended limits.
E341 Calcium phosphates are a group of calcium salts of phosphoric acid, mainly including monocalcium phosphate, dicalcium phosphate, and tricalcium phosphate, and they are used as acidity regulators, leavening agents, anti-caking agents, stabilizers, and calcium fortifiers in food and industrial applications because they help control pH, provide structure, prevent clumping, and supply calcium.
They are widely used in baking powders, fortified foods, and powdered products.
E341 Calcium phosphates improves texture, stability, and mineral nutrition.
E341 Calcium phosphates consist of calcium ions (Ca²⁺) combined with phosphate groups (PO₄³⁻) in different ratios depending on the specific form, which gives them different solubility and functional behavior.
Some forms are more reactive (acid salts), while others are more stable and insoluble.
E341 Calcium phosphates improves versatility in food and industrial systems.
E341 Calcium phosphates appear as white, odorless powders or granules, and their solubility varies from highly soluble (monocalcium phosphate) to very slightly soluble (tricalcium phosphate).
This makes them suitable for both fast-acting and long-term functional roles.
E341 Calcium phosphates improves formulation flexibility and processing control.
E341 Calcium phosphates compounds act as pH regulators, leavening acid sources, anti-caking agents, and calcium supplements, depending on the specific type used.
They are especially important in baking systems where controlled gas release is needed.
E341 Calcium phosphates improves baking performance and nutritional enrichment.
E341 Calcium phosphates are best described as multifunctional calcium–phosphate compounds used to regulate acidity, support leavening in baking, prevent clumping, stabilize food systems, and provide dietary calcium in food, pharmaceutical, and industrial applications.
E341 Calcium phosphates is the calcium salt of phosphoric acid with widely used applications.
It occur abundantly in nature in several forms and are the principal minerals for the production of phosphate fertilizers and for a range of phosphorus compounds.
E341 Calcium phosphates, the tribasic variety (precipitated calcium phosphate), Ca3(PO4)2, is the principal inorganic constituent of bone ash.
The acid salt Ca(H2PO4)2, produced by treating mineral phosphates with sulfuric acid, is employed as a plant food and stabilizer for plastics.
E341 Calcium phosphates is a natural constituent of mammals, and it is a component of bone replacement transplants in much higher amounts with no toxicological problems.
E341 Calcium phosphates is a food additive with functions as an acidity regulator, emulsifier, sequestering agent, humectant and stabiliser (water retaining and thickening).
E341 Calcium phosphates are also important in food structure engineering, because calcium ions interact strongly with proteins and polysaccharides, meaning these compounds can influence not only acidity but also texture, firmness, and water retention in complex food systems.
E341 Calcium phosphates makes them more than just simple mineral additives.
This improves texture design and structural control.
E341 Calcium phosphates are selected based on reaction speed: monocalcium phosphate reacts quickly to release CO₂ in baking powders, while dicalcium phosphate reacts more slowly, allowing better control of dough expansion and crumb structure.
This timing control is essential for consistent baked goods.
E341 Calcium phosphates improves leavening precision and baking performance.
E341 Calcium phosphates are used carefully because calcium can easily form insoluble salts, so formulation strategies are needed to keep calcium stable in solution or suspension without causing cloudiness or sediment.
This is a key challenge in milk and juice fortification.
E341 Calcium phosphates improves mineral stability and product clarity.
E341 Calcium phosphates help regulate calcium equilibrium in milk systems, influencing casein micelle stability, which affects texture, viscosity, and heat stability in processed dairy products.
This is especially important in cheese and recombined milk products.
E341 Calcium phosphates improves dairy texture and processing stability.
E341 Calcium phosphates are widely studied because they mimic natural tooth mineral (hydroxyapatite), helping restore enamel structure by supplying calcium and phosphate ions in oral care products.
This makes them valuable in toothpaste and dental creams.
E341 Calcium phosphates improves dental health and enamel repair.
E341 Calcium phosphates are both essential for bone mineralization, ATP function, and cellular signaling, so E341 compounds are considered biologically relevant mineral systems rather than synthetic additives.
This supports their use in fortified nutrition.
E341 Calcium phosphates improves metabolic relevance and nutritional science value.
E341 Calcium phosphates act as excellent excipients because they provide good compressibility, stability, and flow properties, making them widely used as fillers in pharmaceutical manufacturing.
They also help control disintegration rates in oral tablets.
E341 Calcium phosphates improves pharmaceutical manufacturing and dosage performance.
E341 Calcium phosphates can indirectly contribute to stability by influencing pH and mineral availability, which can affect enzyme activity and microbial growth conditions in certain food matrices.
They are not preservatives but support stability systems.
E341 Calcium phosphates improves shelf-life management and formulation stability.
E341 Calcium phosphates are used in ceramics, biomedical materials, and bone graft substitutes because they are chemically similar to natural bone mineral and can integrate well with biological tissues.
This makes them important in medical material science.
E341 Calcium phosphates improves biomaterial compatibility and structural applications.
E341 Calcium phosphates are central to the phosphorus cycle and soil chemistry, where they act as long-term phosphorus reservoirs that influence plant nutrient availability and ecosystem balance.
This is important in agriculture and water systems.
E341 Calcium phosphates improves environmental nutrient management.
E341 Calcium phosphates is tightly controlled because different forms have different solubility and reactivity, meaning correct selection is essential to avoid unwanted precipitation or inconsistent performance in food products.
This is critical in industrial formulation compliance.
E341 Calcium phosphates improves regulatory safety and formulation accuracy.
Melting point: 1670°C
Density: 3.14
refractive index: 1.63
FEMA: 3081 | TRICALCIUM PHOSPHATE
storage temp.: room temp
solubility: Practically insoluble in water. It dissolves in dilute hydrochloric acid and in dilute nitric acid.
form: aqueous suspension
color: White
PH: 6–8 (50 g/L, H2O, 20°C) suspension
Odor: Odorless
Water Solubility: 0.1 g/L (25 ºC)
Merck: 13,1699
Solubility Product Constant (Ksp): pKsp: 28.68
Cosmetics Ingredients Functions: ORAL CARE; ABRASIVE; ANTICAKING; FRAGRANCE; OPACIFYING
Cosmetic Ingredient Review (CIR): Calcium phosphate (7758-87-4)
InChI: 1S/3Ca.2H3O4P/c;;;21-5(2,3)4/h;;;2(H3,1,2,3,4)/q3*+2;;/p-6
InChIKey: QORWJWZARLRLPR-UHFFFAOYSA-H
SMILES: [Ca+2].[Ca+2].[Ca+2].P([O-])([O-])[O-].P([O-])([O-])[O-]
LogP: -2.15
E341 Calcium phosphates are the largest group of artificial bone graft substitutes.
This is mainly due to their close resemblance to the mineral components of bone.
E341 Calcium phosphates can be used as a countermeasure for exposure to strontium and radium radionuclides.
Upon oral uptake, calcium phosphate competes for and blocks the absorption of radium (Ra-226) and strontium (Sr-90) in the gastrointestinal (GI) tract.
E341 Calcium phosphates refers to numerous materials consisting of calcium ions (Ca2+) together with orthophosphates (PO3−4), metaphosphates or pyrophosphates (P2O4−7) and occasionally oxide and hydroxide ions. Especially, the common mineral apatite has formula Ca5(PO4)3X, where X is F, Cl, OH, or a mixture; it is hydroxyapatite if the extra ion is mainly hydroxide.
Much of the "tricalcium phosphate" on the market is actually powdered hydroxyapatite.
E341 Calcium phosphates are widely used in baking technology, especially monocalcium phosphate, which reacts with baking soda to release carbon dioxide gas, helping dough rise and creating a light, porous texture in baked goods like cakes, muffins, and biscuits.
E341 Calcium phosphates controlled reaction is essential for consistent baking results.
This improves leavening performance and texture quality.
In fortified food systems, E341 Calcium phosphates are used to enrich foods with calcium, an essential mineral for bone health, muscle contraction, and nerve function, without significantly altering taste or stability in solid formulations.
Tricalcium phosphate is especially common in fortified powders and cereals.
E341 Calcium phosphates improves nutritional value and mineral intake.
E341 Calcium phosphates are used as anti-caking agents because they absorb surface moisture and reduce particle adhesion, helping products remain free-flowing during storage.
This is important for industrial packaging and long shelf life.
E341 Calcium phosphates improves flowability and storage stability.
E341 Calcium phosphates are used to adjust mineral balance and improve stability, especially in fortified milk products where calcium must remain evenly distributed without precipitation.
They help maintain smooth texture and consistency.
E341 Calcium phosphates improves product stability and mineral uniformity.
E341 Calcium phosphates are widely used as excipients in tablets and capsules, where they act as fillers, binders, and calcium sources, helping control tablet hardness and disintegration time.
They are also used in antacid formulations.
E341 Calcium phosphates improves drug formulation performance and mineral delivery.
E341 Calcium phosphates are used to support enamel remineralization, helping restore calcium and phosphate ions to tooth surfaces and improve dental health.
This is especially relevant in modern oral care formulations.
E341 Calcium phosphates improves dental protection and enamel strengthening.
E341 Calcium phosphates are used as a major source of dietary calcium and phosphorus, both essential for bone development and metabolic processes in livestock and poultry.
This improves animal nutrition and growth performance.
E341 Calcium phosphates help stabilize protein networks and improve texture in processed foods such as cheeses, baked goods, and ready-to-eat meals.
They also influence viscosity and water retention.
E341 Calcium phosphates improves texture control and product consistency.
In industrial and chemical applications, they are used in ceramics, fertilizers, and water treatment systems, where calcium–phosphate chemistry plays a role in structural materials and nutrient supply.
This improves industrial functionality and material performance.
E341 Calcium phosphates are naturally occurring minerals and are part of the global phosphorus cycle, but excessive phosphate release into water systems can contribute to eutrophication, making controlled use important.
This improves environmental management awareness and sustainability control.
E341 Calcium phosphates, also known as tricalcium phosphate, is a white or almost white powder that is insoluble in water.
It reacts with silicon oxide and carbon at electric furnace temperatures to yield phosphorus vapor.
When reacted with sulfuric acid (H₂SO₄), it forms different products depending on the proportions used: phosphoric acid, dicalcium hydrogen phosphate (CaHPO₄, a white insoluble solid), or calcium dihydrogen phosphate (Ca(H₂PO₄)₂·H₂O, a white soluble solid).
E341 Calcium phosphates solubility product constant (Ksp) is 28.70.
E341 Calcium phosphates occurs in nature as minerals, such as oxyapatite, whitlockite, voelicherite, apatite, and phosphorite.
It has many industrial applications, some of which are similar to those of the monobasic and dibasic salts.
E341 Calcium phosphates is used in fertilizers, dental products, ceramics, and polishing powder.
E341 Calcium phosphates is obtained by treating phosphorite or apatite with sulphuric acid, or from calcium monoacid phosphate with CO2 and water vapour at elevated temperature.
Uses:
E341 Calcium phosphates is an anticaking agent and calcium source that is a white powder that is almost insoluble in water.
It is used as an anticaking agent in table salt and dry vinegar.
E341 Calcium phosphates is used as a source of calcium and phosphorus in cereals and desserts.
E341 Calcium phosphates functions as a bleaching agent in flour and in lard, and prevents undesirable coloring and improves stability for frying.
E341 Calcium phosphates is also termed tribasic calcium phosphate, tricalcium orthophosphate, calcium phosphate tribasic, and precipitated calcium phosphate.
E341 Calcium phosphates are mainly used as leavening agents, acidity regulators, anti-caking agents, stabilizers, and calcium sources because they help control pH, support dough rising, prevent clumping, and provide essential minerals.
E341 Calcium phosphates are used as leavening acids to release carbon dioxide.
This improves dough rise and texture.
In powdered foods and spices, they are used as anti-caking agents.
E341 Calcium phosphates improves flowability and storage stability.
In fortified foods and beverages, they are used as calcium sources.
E341 Calcium phosphates improves nutritional value and bone health support.
E341 Calcium phosphates are used as excipients and calcium supplements.
This improves tablet stability and mineral delivery.
In dairy and processed foods, they are used to stabilize texture and mineral balance.
This improves product consistency and quality.
E341 Calcium phosphates are mainly used as leavening agents, anti-caking agents, acidity regulators, stabilizers, and calcium sources because they help control pH, support baking reactions, prevent clumping, and provide essential minerals.
In baking products, they are used as leavening acids for controlled CO₂ release.
E341 Calcium phosphates improves dough rise and texture.
In powdered foods, they are used as anti-caking agents.
E341 Calcium phosphates improves flowability and storage stability.
In fortified foods and beverages, they are used as calcium sources.
E341 Calcium phosphates improves nutritional value and bone health support.
In pharmaceuticals, they are used as excipients and fillers.
E341 Calcium phosphates improves tablet stability and manufacturing performance.
In dairy and processed foods, they are used to stabilize texture and mineral balance.
E341 Calcium phosphates improves product consistency and quality.
E341 Calcium phosphates is an ionic compound that exists in several forms, including monobasic, dibasic, and tribasic calcium phosphate.
Monobasic calcium phosphate, also termed monocalcium phosphate, calcium biphosphate, or acid calcium phosphate, is used as a leavening agent and acidulant.
Dibasic calcium phosphate, also termed dicalcium phosphate dihydrate, is used as a dough conditioner and mineral supplement.
E341 Calcium phosphates, also termed tricalcium phosphate or precipitated calcium phosphate, is used as an anticaking agent, mineral supplement, and conditioning agent.
E341 Calcium phosphates is used in the manufacture of fertilizers, H₃PO₄ (phosphoric acid), and other phosphorus compounds.
E341 Calcium phosphates is also used in the production of milk-glass, polishing powders, dental powders, porcelains, and pottery; in enameling; for clarifying sugar syrups; in animal feeds as a mineral supplement; as an anticaking agent; and in the textile industry.
E341 Calcium phosphates are mainly used as leavening agents, anti-caking agents, acidity regulators, stabilizers, and calcium sources because they help control acidity, support gas release in baking, prevent clumping in powders, and provide essential calcium for nutrition.
In baking products, they are used as leavening acids that react with sodium bicarbonate to release carbon dioxide, helping dough rise and creating a light, porous texture in cakes, biscuits, and baked goods.
This improves baking performance and texture quality.
E341 Calcium phosphates are used as anti-caking agents that absorb moisture and prevent particles from sticking together, ensuring products remain free-flowing during storage and use.
This improves handling and shelf stability.
In fortified foods and beverages, they are used as a calcium source to increase nutritional value without significantly affecting taste in solid or dry formulations like cereals and powdered drinks.
E341 Calcium phosphates improves mineral intake and nutritional enrichment.
In pharmaceutical formulations, they are used as excipients and fillers in tablets and capsules, helping with compressibility, stability, and controlled disintegration of dosage forms.
This improves drug formulation quality and manufacturing efficiency.
E341 Calcium phosphates are used to stabilize texture and mineral balance, helping maintain consistency and improve structural properties in products like cheese and milk-based foods.
E341 Calcium phosphates improves product stability and texture control.
Safety Profile:
E341 Calcium phosphates are generally considered low hazard food additives, because they are based on calcium and phosphate—both naturally present in the human body—but risks can still appear in industrial handling or from excessive intake of phosphate compounds.
The main hazard is mild irritation of the eyes, skin, and respiratory system, mainly from inhaling fine powder during manufacturing or handling.
E341 Calcium phosphates can usually be avoided with proper dust control and protective equipment.
This improves workplace safety.
Skin contact is generally low risk, though prolonged exposure to dry powder may cause slight dryness or irritation.
Washing with water is sufficient.
Eye contact may cause mechanical irritation, especially from airborne particles or direct powder exposure.
Eye protection is recommended in industrial settings.
This improves handling safety.
Inhalation of dust may cause temporary respiratory irritation, especially in poorly ventilated environments where fine particles become airborne.
Dust masks or ventilation systems are recommended.
E341 Calcium phosphates improves occupational safety.
From a toxicological perspective, E341 Calcium phosphates are considered safe within regulated food limits, but excessive phosphate intake over long periods may contribute to mineral imbalance, especially in individuals with kidney disorders, because phosphate regulation is closely linked to kidney function.
E341 Calcium phosphates requires controlled dietary consumption.
This improves nutritional safety awareness.
E341 Calcium phosphates are generally stable and low toxicity, but high phosphate release into water systems can contribute to eutrophication, which may lead to excessive algae growth and ecosystem imbalance.
This is mainly a concern in industrial wastewater management.
E341 Calcium phosphates improves environmental protection awareness.
