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E380 – TRIAMMONIUM CITRATE

E380 Triammonium citrate is an ammonium salt of citric acid used globally as a food additive, acidity regulator, emulsifier, and buffering agent. 
E380 Triammonium citrate maintains the pH of processed foods, acts as a stabilizer, and is widely found in dairy products, jams, and soft drinks. 
E380 Triammonium citrate is a chemical compound whose molecular formula is C6H17N3O7.[1]

CAS:    3458-72-8
MF:    C6H8O7.3H3N
MW:    243.21
EINECS:    222-394-5

Synonyms
2,3-propanetricarboxylicacid,2-hydroxy-triammoniumsalt;Ammonium Cltrate tribasic;CITRIC ACID, DIAMMONIUM;CITRIC ACID, DIAMMONIUM, DIBASIC;CITRIC ACID DIAMMONIUM SALT;CITRIC ACID, AMMONIUM SALT, DIBASIC;Ammonium citrate tribasic, 98.5%;Ammonium citrate tribasic, AR,98.5%

E380 Triammonium citrate is a citrate salt in which all three carboxy groups are deprotonated and associated with ammonium ions as counter-cations. 
E380 Triammonium citrate has a role as a buffer and a food emulsifier. 
E380 Triammonium citrate is an ammonium salt and a citrate salt.
E380 Triammonium citrate is the tribasic ammonium salt of citric acid produced by neutralizing citric acid with ammonia. 
E380 Triammonium citrate is typically supplied as a white crystalline powder that dissolves readily in water.
In food and beverage applications, E380 Triammonium citrate functions primarily as an acidity regulator and buffering agent. 
E380 Triammonium citrate helps maintain stable pH levels in formulations and supports processing stability in certain food systems.
In addition to its use in food applications, E380 Triammonium citrate is also used in fermentation processes as a nitrogen source for microbial growth. 
E380 Triammonium citrate's buffering properties make it suitable for systems where controlled acidity is required.

E380 Triammonium citrate, with the CAS number 3458-72-8, is a chemical compound formed from citric acid and ammonia. 
E380 Triammonium citrate is characterized by its white crystalline appearance and is highly soluble in water, making it useful in various applications. 
E380 Triammonium citrate acts as a buffering agent, helping to maintain pH levels in solutions, which is particularly valuable in biochemical and pharmaceutical contexts. 
E380 Triammonium citrate is often utilized in food and beverage industries as a flavoring agent and preservative due to its ability to enhance taste and stability. 
Additionally, E380 Triammonium citrate can serve as a nitrogen source in fertilizers, promoting plant growth. 
E380 Triammonium citrate is generally regarded as safe for consumption, although its use should be regulated according to specific guidelines. 
E380 Triammonium citrate's properties, such as hygroscopicity and stability under various conditions, make it a versatile ingredient in both industrial and laboratory settings. 
Overall, E380 Triammonium citrate is an important compound with diverse applications across multiple fields.

E380 Triammonium citrate Chemical Properties
Melting point: 185 °C (dec.) (lit.)
Boiling point: 100 °C (lit.)
density: 1 g/mL at 25 °C (lit.)
vapor density: 1.8 (vs air)
vapor pressure: 0Pa at 25℃
storage temp.: Inert atmosphere,Room Temperature
solubility: H2O: 1 M at 20 °C, clear, colorless
form: Crystals
color: White to off-white
PH: 7.5(1 mM solution);7.4(10 mM solution);7.32(100 mM solution);8.18(1000 mM solution)
Water Solubility: Soluble in water. Slightly soluble in alcohol.
BRN: 3779194
Stability: Stable. Incompatible with strong oxidizing agents.
Major Application: diagnostic assay manufacturing
InChI: 1S/C6H8O7.3H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);3*1H3
InChIKey: YWYZEGXAUVWDED-UHFFFAOYSA-N
LogP: -1.43 at 25℃
CAS DataBase Reference: 3458-72-8(CAS DataBase Reference)
EPA Substance Registry System: E380 Triammonium citrate (3458-72-8)

E380 Triammonium citrate is a white powdery material with a slight ammonia-like odor.

Uses    
E380 Triammonium citrate is mainly used for chemical analysis, in industry for water treatment, in food industry for buffering agent and emulsifier, for metal surface cleaning (in particular petroleum pipeline cleaning), as a ceramic dispersant,as auxiliary infiltration agent, as detergent material and as soil improvement agent component.
E380 Triammonium citrate is applied in electroplating industry for non cyanide plating complexing agent, used mostly for preparing anti rust agent in machinery industry and as buffering agent. 
E380 Triammonium citrate serves as a chemical reagent in analytical chemistry to determine the efficient phosphate levels in phosphate salts and fertilizer.
E380 Triammonium citrateis widely utilized as a buffering agent and emulsifier in food industry. 
E380 Triammonium citrate acts as a complexing agent in electroplating industry and is also used for metal surface cleaning. 
E380 Triammonium citrate is employed in chemical analysis and in water treatment. 
E380 Triammonium citrate serves as a chemical reagent in analytical chemistry to determine the efficient phosphate levels in phosphate salts and fertilizer. 
E380 Triammonium citrate is used in industries for water treatment, as a ceramic dispersant, a detergent material and a component for soil improvement. 
E380 Triammonium citrate is used in medical and electronics industries as an auxiliary infiltration agent.
E380 Triammonium citrate is widely used across multiple industries for its buffering performance and role in fermentation systems.

Beverages
Used as a buffering agent in certain beverage formulations to help maintain stable pH and support consistent product quality during processing and storage.

Dairy Processing
Applied in dairy systems to regulate acidity and improve process control, contributing to stable texture and product consistency.

Fermentation
Widely used in fermentation media as a nitrogen source and buffering agent, supporting microbial growth and stable fermentation conditions.

Biotechnology and Microbiological Media
Incorporated into culture media formulations to provide nutrients and maintain optimal pH for microbial cultivation and enzyme production.

Industrial Applications
Utilized in selected industrial processes where pH control, solubility, and nitrogen supply are required for efficient system performance.

Agricultural Uses    
E380 Triammonium citrate is a white, granular, water-soluble salt of ammonia and citric acid. 
E380 Triammonium citrate is used in a neutral solution for determining the phosphorus content of phosphate fertilizers (such as calcium hydrogen phosphate (CaHPO4)), that are insoluble in water but dissolve in complexing citrate solutions.
The fertilizer residue, after extraction of watersoluble phosphorus, is re-extracted with a neutral or strongly alkaline solution of 1 normal (1N) ammonium citrate for a prescribed period, and the slurry filtered. 
Citrate-soluble phosphorus is the phosphorus content in the filtrate and is expressed as a percentage by weight of the fertilizer.
The extraction of phosphate with 1N ammonium citrate is carried out routinely for 30 minutes, first at room temperature and then at 4O℃ For neutral ammonium citrate solution, a temperature of 65℃ is preferred.
Some European countries use an alkaline ammonium citrate solution, which extracts smaller amounts of phosphorus. 
Some experts consider E380 Triammonium citrate to be better correlated with phosphorus uptake and plant growth. 
However, most countries use a neutral normal E380 Triammonium citrate solution for extracting citrate soluble phosphorus.

Industrial uses    
E380 Triammonium citrate can serve as an effective leaching agent for extracting lead from lead oxide ore. 
E380 Triammonium citrate has been reported that, under conditions of 800 r/min and 40°C, leaching with a 1.25 mol/L solution of E380 Triammonium citrate for 21 minutes can extract approximately 95% of the lead content from samples with a particle size range of +75 to 96 μm.

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