CAS NO: 62-33-9 / 6766-87-6 / 23411-34-9
EC NO: 200-529-9 / 607-231-1 / 804-058-5
E385 (Calcium disodium EDTA) is a common food additive and an ingredient in cosmetic and industrial products.
E385 (Calcium disodium EDTA)’s used in food to preserve flavor, color and texture. However, like many food additives, it has become quite controversial.
E385 (Calcium disodium EDTA) is an odorless crystalline powder with a slightly salty flavor.
It’s a popular food additive, used as a preservative and flavoring agent.
E385 (Calcium disodium EDTA) works as a chelating agent.
This means it binds to metals and prevents them from participating in chemical reactions that might cause discoloration or flavor loss.
The FDA has approved E385 (Calcium disodium EDTA) as a safe food additive but has set limitations on the amount of the substance a food can contain .
E385 (Calcium disodium EDTA) is poorly absorbed by your digestive tract and the maximum Acceptable Daily Intake (ADI) is 1.1 mg per pound (2.5 mg per kg) of body weight per day.
E385 (Calcium disodium EDTA) is a crystalline powder with a slightly salty flavor. It’s a popular food additive that prevents spoilage and preserves flavor and color.
What Is E385 (Calcium disodium EDTA) Used For?
E385 (Calcium disodium EDTA) is found in food, cosmetic and industrial productions.
It’s also used for chelation therapy.
E385 (Calcium disodium EDTA) can be used to preserve texture, flavor and color of many food products.
It’s also used to promote stability and increase the shelf life of certain foods.
The following are common foods that contain E385 (Calcium disodium EDTA):
Salad dressings, sauces and spreads
Pickled vegetables, such as cabbage and cucumbers
Canned beans and legumes
Canned carbonated soft drinks
Distilled alcoholic beverages
Canned crab, clam and shrimp
E385 (Calcium disodium EDTA) is widely used in beauty and cosmetic products.
E385 (Calcium disodium EDTA) allows for better cleaning use, as it enables cosmetic products to foam.
What’s more, as it binds with metal ions, it prevents metals from accumulating on the skin, scalp or hair.
Soaps, shampoos, lotions and contact lens solutions are examples of cosmetic and personal care products that may contain E385 (Calcium disodium EDTA).
E385 (Calcium disodium EDTA) is also found in many industrial products, such as paper and textile, due to its ability to prevent discoloration.
In addition, it’s frequently used in products like laundry detergents, industrial germicides and other cleaning products.
Chelation therapy uses E385 (Calcium disodium EDTA) to treat metal toxicity, such as lead or mercury poisoning.
The substance binds to the excessive metal in your blood, which is then excreted through urine.
While E385 (Calcium disodium EDTA) is only FDA-approved to treat metal poisoning, some holistic healthcare providers suggest chelation therapy as an alternative treatment for conditions like autism, heart disease and Alzheimer’s.
However, current research is unsupportive, and further studies are needed before any conclusions on chelation therapy and certain health conditions can be made.
Chelating agent (metal).
E385 (Calcium disodium EDTA) is a sequestrant and chelating agent whose complete name is disodium calcium ethylenediamine tetraacetate.
It is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels.
A 1% solution has a ph of 6.5–7.5.
It is used to control the reaction of trace metals with some organic and inorganic components in food; to prevent deterioration of color, texture, and development of precipitates; and to prevent oxidation.
Its function is comparable to that of disodium dihydrogen edta.
It is also termed E385 (Calcium disodium EDTA).
Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors.
As this form is already chelated with Ca2+, it is selective for divalent cations with greater affinity for EDTA, which it will exchange for Ca2+.
Calcium disodium edetate, also referred to as calcium sodium EDTA, stands for the chemical compound 2,2 ,2 ,2 -(ethane-1,2-diyldinitrilo)tetraacetic acid, which is a synthetic amino acid.
Edetate refers to the calcium disodium salt of the chelating agent with the formula (HO2CCH2)2NCH2CH2N(CH2CO2H)2. In the United States, it is found under the name calcium disodium versenate.
Edetate is mainly used to complex di and trivalent metal ions.
Edetate can bind to metals via the four carboxylate and two amine groups, and it forms specially strong complexes with Co(III), Cu(II), Mn(II) and Fe(III).
Dimercaprol (BAL, British anti-Lewisite), calcium disodium edetate and penicillamine are the three most common chelating agents used in the treatment of heavy-metal poisoning.
E385 (Calcium disodium EDTA) (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning.
Sodium calcium edetate came into medical use in the United States in 1953.
E385 (Calcium disodium EDTA) is in the chelating agent family of medication.
E385 (Calcium disodium EDTA) is a salt of edetate with two sodium and one calcium atoms.
E385 (Calcium disodium EDTA) works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.
Edetate disodium is a different formulation which does not have the same effects.
E385 (Calcium disodium EDTA)'s primary use is to treat lead poisoning, for which it is an alternative to succimer.
E385 (Calcium disodium EDTA) is given by slow injection into a vein or into a muscle.
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.
E385 (Calcium disodium EDTA) may also be used to treat plutonium poisoning.
E385 (Calcium disodium EDTA) does not appear to be useful for poisoning by tetra-ethyl lead.
Used in pharmaceutical formulations as a chelating agent in concentrations between 0.01-0.1% w/v.
Usually edentate calcium disodium is used in pharmaceutical formulations in preference to edentate or sodium edentate to prevent calcium depletion occurring in the body.
E385 (Calcium disodium EDTA) is a preservative, sequestrant, flavoring agent, and color retention agent.
• Agricultural chemicals (non-pesticidal)
• Oxidizing/reducing agents
• Processing aids, not otherwise listed
• Surface active agents
• Agricultural products (non-pesticidal)
• Lawn and garden care products
Household & Commercial/Institutional Products
• Commercial / Institutional
• Inside the Home
General Manufacturing Information
Industry Processing Sectors
• Food, beverage, and tobacco product manufacturing
• Miscellaneous manufacturing
• Pesticide, fertilizer, and other agricultural chemical manufacturing
• Soap, cleaning compound, and toilet preparation manufacturing
• Synthetic dye and pigment manufacturing
• Synthetic rubber manufacturing
E385 (Calcium disodium EDTA) or CaNa2EDTA, a salt of EDTA which can be used as a preservative in food with the European food additive number E385.
And you may have encountered this ingredient in the preservation of mayonnaise, salad dressing, pickled fruits, canned soda and other canned food.
What is E385 (Calcium disodium EDTA)?
The abbreviation of calcium disodium ethylene diamine tetra-acetate, a multifunctional food additive commonly used as a preservative, sequestrant, antioxidant, flavouring agent, and colour retention agent in canned food.
E385 (Calcium disodium EDTA) can combine with free metal ions (such as Zinc, Iron, Copper, Magnesium, Manganese) which are often present in food & beverage and as a result keep the color, flavor and odour of food by preventing these ions reacting with food.
White, odourless crystalline powder or granular with a faint, salty taste.
What are the Uses?
E385 (Calcium disodium EDTA) is commonly used as a chelating agent, preservative and antioxidant (to prevent oxidation by chelation) in canned food.
It stabilizes food by binding with free polyvalent metal cations.
Canned foods are processed through canning, sealing, heating and sterilization which prolongs the shelf life.
Ingredients commonly added in canned foods are mainly preservatives, antioxidants, sweeteners and synthetic colors.
E385 (Calcium disodium EDTA) promotes flavor retention and reduces discoloration and turbidity in soft drinks.
Coca Cola says it functions as a preservative and protects the freshness and taste in its beverages .
In vitamin C fortified beverages, E385 (Calcium disodium EDTA) prevents the reaction from the interference of uncontrolled metal ions, which will deteriorate colors and reduce the shelf life of vitamin beverage.
It can also preserve an antioxidant in vitamin A, B, D & E.
Per the“European Commission database for information on cosmetic substances and ingredients”, it functions as a chelating agent in cosmetic and personal care products .
Commonly can be found in some lotions, creams, and soaps.
It can be used to treat lead poisoning.
It is a chelating agent, meaning that it binds to metals. When the metals are bound (or sequestered), they are prevented from taking part in chemical reactions that would lead to colour or flavour deterioration.
For example, when used in canned foods, such as lima beans, it prevents the beans from darkening because the iron ions and other metals found in the canning water are bound by the additive and cannot participate in other reactions.
E385 (Calcium disodium EDTA) is made from formaldehyde, sodium cyanide, and Ethylenediamine
E385 (Calcium disodium EDTA) is widely used and is becoming one of the most common organic pollutants.
Besides its use as a food additive, it is used in the textile and paper industries.
It is used to improve stability in pharaceutical products, detergents, shampoos, soaps, argricultural chemical sprays, contact lens cleaners and cosmetics.
It is used in medical laboratories and dentist offices.
E385 (Calcium disodium EDTA) has been approved in the U.S. for use in chelation therapy.
Chelation therapy helps to remove heavy metals from the body and is used to treat lead poisoning and radiation exposure.
As a food additive, it helps to prevent colour or flavour deterioration.
In soft drinks containing ascorbic acid and sodium benzoate, EDTA helps to prevent the formation of benzene which is a known carcinogen.
E385 (Calcium disodium EDTA) in Mayonaisse
It inhibits rancidity (disagreeable odor or taste of decomposing oils or fats) in salad dressings, mayonnaise, sauces, and sandwich spreads.
Foods that may contain E385 (Calcium disodium EDTA) include:
Pickled cabbage and cucumbers
Cooked and canned shrimp, clams and crabmeat
EDTA DISODIUM-CALCIUM SALT
EDETATE CALCIUM DISODIUM
EDETATE CALCIUM DISODIUM SALT
DISODIUM CALCIUM ETHYLENEDIAMINETETRAACETATE
DISODIUM CALCIUM SALT TRIHYDRATE
ETHYLENEDIAMINETETRAACETIC ACID CALCIUM DISODIUM SALT
ETHYLENEDIAMINETETRAACETIC ACID DISODIUM CALCIUM
ETHYLENEDIAMINETETRAACETIC ACID DISODIUM CALCIUM SALT
ETHYLENSDIAMINETETRAACETIC ACID DISODIUM CALCIUM SALT
[ETHYLENEDINITRILO]TETRAACETIC ACID DISODIUM-CALCIUM SALT
Calciate(2-), N,N-1,2-ethanediylbisN-(carboxy-.kappa.O)methylglycinato-.kappa.N,.kappa.O(4-)-, disodium, (OC-6-21)-
[[N,N'-1,2-ethanediyl bis[N-(carboxymethyl)glycinato]](4-)-(N,N',O,O',O,N,O,N')-, disodium, (OCCalciate(2-)
ETHYLENEDIAMINETETRAACETIC ACID DISODIUM CALCIUM SALT HYDRATE
Calciate(2-), [[N,N'-1,2-ethanediylbis[ N-(carboxymethyl)glycinato]](4-)-N,N',O,O',O#N,O#N#' ]-, disodium, (OC-6-21)-
Ethylenediamine tetracetic acid,disodium,calcium salt
Calcium disodium salt
(Ethylenedinitrilo)tetraacetic acid calcium disodium salt, Edathamil, EDTA calcium disodium salt
CALCIUM DISODIUM EDETATE
CALCIUM DISODIUM ETHYLENEDIAMINETETRAACETATE
edta calcium disodium
EDTA CALCIUM DISODIUM SALT
Edetate calcium disodium
Ethylenediaminetetraacetic acid calcium disodium salt
EDTA calcium disodium
Ethylenediaminetetraacetic Acid Disodium Calcium Salt
Sodium calcium edetate
Calcium disodium ethylenediaminetetraacetate
EDTA calcium disodium salt
E385 (Calcium disodium EDTA)UNII-8U5D034955
Edetate Calcium Disodium (anhydrous)
(Ethylenedinitrilo)tetraacetic acid calcium disodium salt
Antallin; Calcitetracemate disodiu; Calcium EDTA; Calcium disodium (ethylenedinitrilo)tetraacetate; E385 (Calcium disodium EDTA); Calcium disodium Versenate
Calcium disodium ethylenediamine tetraacetic acid
Calcium sodium edetate hydrate
Edetate calcium disodium anhydrous
Edetate calcium disodium anhydrous (USP)
Ethylensdiaminetetraacetic acid disodium calcium calcium salt
Sodium calcium edetate, European Pharmacopoeia (EP) Reference Standard
calcium disodium 2,2',2'',2'''-(ethane-1,2-diylbis(azanetriyl))tetraacetate
Sodium calcium edetate;EDTA calcium disodium;Ethylenediaminetetraacetic acid calcium disodium salt