PRODUCTS

E466 CARBOXY METHYL CELLULOSE (CMC)

E466 Carboxy Methyl Cellulose (CMC) is used as thickeners in the manufacture of ice cream, mayonnaise, cheese products; as thickener toothpaste like consistency regulator in desserts, jellies, creams and pastes; in the shells of fish, meat, confectionery, cosmetics.
E466 Carboxy Methyl Cellulose (CMC) is used as a stabilizer of consistency thickener agent for encapsulation.
In laundry detergents, E466 Carboxy Methyl Cellulose (CMC) is used as a soil suspension polymer designed to deposit onto cotton and other cellulosic fabrics, creating a negatively charged barrier to soils in the wash solution.

CAS Number: 9004-32-4
EC number: 618-378-6
MDL number: MFCD00081472
E number: E466 (thickeners, ...)
Molecular Formula: C₆H₇O₂(OR₁)(OR₂)(OR₃), where R₁, R₂, and R₃ can be H, CH₂COONa, or CH₂COOH
[C₆H₇O₂(OH)ₓ(OCH₂COONa)ᵧ]n, where n ≥ 4, x = 1.50-2.80, y = 0.20–1.50, and x + y = 3.0.
Molecular Weight: approximately 17,000 g/mol, with the degree of polymerization being approximately 100 or higher
Commercial grades can have molecular weights ranging from 50,000 to 800,000 g/mol

SYNONYMS:
CMC, Sodium carboxymethyl cellulose, Cellulose gum, Carboxymethyl cellulose sodium salt, Sodium cellulose glycolate, Cellulose methyl ether, Tylose C, Blanose, Cellulose gum, CMC, Sodium CMC, Sodium salt of a carboxymethyl ether of cellulose, NaCMC, Carboxymethylcellulose, carmellose, E466, Carboxymethyl cellulose, CMC-Na, cellulose gum, carmellose sodium, b10, carbo, Carboxyl Methyl Cellulose sodium, cmc2, Color Speckles, Cellex, Carboxymethylcellulose, carmellose, E466, Carboxymethylcellulose sodium, CMC gum, NaCMC, Sodium CMC, CMC, NaCMC, Sodium CMC

E466 Carboxy Methyl Cellulose (CMC) Main feature - the ability to form very viscous colloidal solution, which does not lose its properties for a long time.
E466 Carboxy Methyl Cellulose (CMC) is the thickening agent and a desiccant to stabilize the foam and emulsion is a crystallization inhibitor forms complexes with proteins increasing their viscosity without changing shear, rheological properties of the system.

E466 Carboxy Methyl Cellulose (CMC) is an anionic polysaccharide due to a negatively charged group forms complexes with proteins of milk.
E466 Carboxy Methyl Cellulose (CMC) is a cellulose derivative with carboxymethyl groups (-CH2-COOH) bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone.

E466 Carboxy Methyl Cellulose (CMC) is a multi-functional ingredient that can be used as a thickener, binder, emulsifier and stabilizer in food with the European food additive number E466.
Together with xanthan gum, they’re the most used and common thickener among others in food applications.

Commonly we call E466 Carboxy Methyl Cellulose (CMC) (used in food) is its salt, sodium carboxymethyl cellulose or sodium CMC instead of carboxymethyl cellulose itself.
Due to the poor water solubility of E466 Carboxy Methyl Cellulose (CMC), it is usually made into its sodium salt in order to be better use it.

Sodium E466 Carboxy Methyl Cellulose (CMC) is a water-soluble cellulose ether obtained by chemical modification from natural cellulose such as cotton linter or wood pulp.
E466 Carboxy Methyl Cellulose (CMC) can also replace some other thickeners, like guar gum, gelatin, agar, sodium alginate and pectin in some food applications.

The application of E466 Carboxy Methyl Cellulose (CMC) is various according to varieties of viscosities and mesh sizes.
E466 Carboxy Methyl Cellulose (CMC) is the partial sodium salt of a carboxymethyl ether of cellulose, the cellulose being obtained directly from strains of fibrous plant material.

E466 Carboxy Methyl Cellulose (CMC) is white fibrous or granular powder, odorless and tasteless.
E466 Carboxy Methyl Cellulose (CMC) is hygroscopic and easily dispersed in water to form a transparent colloidal solution.
E466 Carboxy Methyl Cellulose (CMC) is white powder color.

E466 Carboxy Methyl Cellulose (CMC) has a fibrous appearance.
The purpose of use of E466 Carboxy Methyl Cellulose (CMC) in foods is to increase consistency.
Low viscosity products are sold in the market at cheap prices.

When you buy cheap products, you add more product to your formula and E466 Carboxy Methyl Cellulose (CMC) costs you more.
E466 Carboxy Methyl Cellulose (CMC) is soluble in hot and cold water.
While the natural pH of E466 Carboxy Methyl Cellulose (CMC) is 8.25, it is commercially produced at pH 6-7.5 for better solubility.

As the pH of E466 Carboxy Methyl Cellulose (CMC) is lowered, its solubility also decreases and it becomes insoluble in water at pH 4 and below 4.
E466 Carboxy Methyl Cellulose (CMC) is actually the sodium salt of carboxymethyl cellulose.
E466 Carboxy Methyl Cellulose (CMC) is derived from cellulose, which is made water-soluble by a chemical reaction.

The water-solubility is achieved by introducing carboxymethyl groups along the cellulose chain, which makes hydration of the molecule possible.
E466 Carboxy Methyl Cellulose (CMC) is known for its excellent water retaining capacity
This synthetically made polymer, E466 Carboxy Methyl Cellulose (CMC), is derived from cellulose, which is made water-soluble by undergoing a chemical reaction.

E466 Carboxy Methyl Cellulose (CMC) is of astronomical value in the pharmaceutical and cosmetic industry due to the multifarious benefits it provides when added to various preparations.
E466 Carboxy Methyl Cellulose (CMC) is synthesized by the alkali-catalyzed reaction of cellulose with chloroacetic acid.

The polar (organic acid) carboxyl groups render the cellulose soluble and chemically reactive.
E466 Carboxy Methyl Cellulose (CMC) is used in food under the E number E466 or E469 (when it is enzymatically hydrolyzed) as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream.

E466 Carboxy Methyl Cellulose (CMC) is also a constituent of many non-food products, such as toothpaste, laxatives, diet pills, water-based paints, detergents, textile sizing, reusable heat packs, various paper products, and also in leather crafting to help burnish the edges.
E466 Carboxy Methyl Cellulose (CMC) is a hydrocolloid derived from cellulose.

In the complex world of food additives, E466 Carboxy Methyl Cellulose (CMC) has earned its place as a versatile and widely used ingredient.
E466 Carboxy Methyl Cellulose (CMC) derivative finds itself in a myriad of food products, contributing to texture, stability, and more.

E466 Carboxy Methyl Cellulose (CMC) is obtained through a chemical modification process that involves adding carboxymethyl groups to cellulose, a natural polymer found in plant cell walls.
This modification enhances E466 Carboxy Methyl Cellulose (CMC)'s water-binding properties, solubility, and stability, making it valuable for a wide range of applications.

USES and APPLICATIONS of E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) is used in food Industry as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream.
E466 Carboxy Methyl Cellulose (CMC) is used in ice packs to form a eutectic mixture resulting in a lower freezing point, and therefore more cooling capacity than ice.

E466 Carboxy Methyl Cellulose (CMC) is used to achieve tartrate or cold stability in wine.
This innovation may save megawatts of electricity used to chill wine in warm climates.
E466 Carboxy Methyl Cellulose (CMC) has thickening, emulsifying, shaping, puffing and fresh keeping properties and can be used in place of food gum like gelatin, agar and sodium alginate.

The addition of E466 Carboxy Methyl Cellulose (CMC) in food can reduce the food production cost, increase the food grade, improve the food taste, and extend the shelf life, so it is an ideal food additive in the food industry and can be widely used in the production of various kinds of solid and liquid beverages, canned food, candy, cakes, instant noodles, ready-to-serve food, soymilk and fruit juice.

In laundry detergents, E466 Carboxy Methyl Cellulose (CMC) is used as a soil suspension polymer designed to deposit onto cotton and other cellulosic fabrics, creating a negatively charged barrier to soils in the wash solution.
E466 Carboxy Methyl Cellulose (CMC) is also used as a thickening agent, for example, in the oil-drilling industry as an ingredient of drilling mud, where it acts as a viscosity modifier and water retention agent.

E466 Carboxy Methyl Cellulose (CMC) is sometimes used as an electrode binder in advanced battery applications (i.e. lithium ion batteries), especially with graphite anodes.
E466 Carboxy Methyl Cellulose (CMC)'s water solubility allows for less toxic and costly processing than with non-water-soluble binders, like the traditional polyvinylidene fluoride (PVDF), which requires toxic n-methylpyrrolidone (NMP) for processing.

E466 Carboxy Methyl Cellulose (CMC) is often used in conjunction with styrene-butadiene rubber (SBR) for electrodes requiring extra flexibility, e.g. for use with silicon-containing anodes.
E466 Carboxy Methyl Cellulose (CMC) is also used in ice packs to form a eutectic mixture resulting in a lower freezing point, and therefore more cooling capacity than ice.

Aqueous solutions of E466 Carboxy Methyl Cellulose (CMC) have also been used to disperse carbon nanotubes, where the long CMC molecules are thought to wrap around the nanotubes, allowing them to be dispersed in water.
In conservation-restoration, E466 Carboxy Methyl Cellulose (CMC) is used as an adhesive or fixative.

E466 Carboxy Methyl Cellulose (CMC) is used for a viscosity modifier or thickener and to stabilize emulsions in various products, including ice cream, mayonnaise, and beverages.
E466 Carboxy Methyl Cellulose (CMC) is also used extensively in gluten-free and reduced-fat food products.

E466 Carboxy Methyl Cellulose (CMC)'s variable viscosity (high while cold, and low while hot) makes it useful in the preparation of cold foods and textures in beverages and edible gels.
With a DS around 1.0, E466 Carboxy Methyl Cellulose (CMC) can prevent dehydration and shrinkage of gelatin while also contributing to a more airy structure.

In some foods, E466 Carboxy Methyl Cellulose (CMC) can be used to control oil and moisture content.
E466 Carboxy Methyl Cellulose (CMC) is used to achieve tartrate or cold stability in wine, which can prevent excess energy usage while chilling wine in warm climates.

E466 Carboxy Methyl Cellulose (CMC) is more stable than metatartaric acid and is very effective in inhibiting tartrate precipitation.
It is reported that KHT crystals, in the presence of E466 Carboxy Methyl Cellulose (CMC), grow slower and change their morphology.
Their shape becomes flatter because they lose 2 of the 7 faces, changing their dimensions.

E466 Carboxy Methyl Cellulose (CMC) molecules, negatively charged at wine pH, interact with the electropositive surface of the crystals, where potassium ions are accumulated.
The slower growth of the crystals and the modification of their shape are caused by the competition between E466 Carboxy Methyl Cellulose (CMC) molecules and bitartrate ions for binding to the KHT crystals.

Food fraud: Shrimp and prawns: E466 Carboxy Methyl Cellulose (CMC) injections have been used to fraudulently increase the weight and visual appeal of shrimp and prawns so as to short-weight customers.
E466 Carboxy Methyl Cellulose (CMC) is used in applications ranging from food production to medical treatments.

E466 Carboxy Methyl Cellulose (CMC) is commonly used as a viscosity modifier or thickener and to stabilize emulsions in both food and non-food products.
E466 Carboxy Methyl Cellulose (CMC) is used primarily because it has high viscosity, is nontoxic, and is generally considered to be hypoallergenic, as the major source fiber is either softwood pulp or cotton linter.

E466 Carboxy Methyl Cellulose (CMC) is also used in non-food products which include products such as toothpaste, laxatives, diet pills, water-based paints, detergents, textile sizing, reusable heat packs, various paper products, filtration materials, synthetic membranes, wound healing applications, and also in leather crafting to help burnish edges.

E466 Carboxy Methyl Cellulose (CMC) is often used in its sodium salt form, sodium carboxymethyl cellulose.
The food-grade of E466 Carboxy Methyl Cellulose (CMC) is primarily used as a thickener in our daily food.
In the taste, E466 Carboxy Methyl Cellulose (CMC) imparts the food a thickening and creamier characteristics, making it more appealing to consumers compared with that without it.

Generally, E466 Carboxy Methyl Cellulose (CMC) functions as a thickening, suspending, emulsifying, stabilizing and film-forming agent in many foods such as in beverages, bakery, dairy, dessert products and meat products.
E466 Carboxy Methyl Cellulose (CMC) has a certain thickening and emulsifying effect, which can be used to stabilize yogurt drinks and increase the viscosity of yogurt systems.

Due to E466 Carboxy Methyl Cellulose (CMC)'s certain hydrophilicity and rehydration properties, sodium carboxymethyl cellulose can be used to improve the eating quality of pasta such as bread and steamed buns, prolong the shelf life of pasta products, and enhance the taste.
Because E466 Carboxy Methyl Cellulose (CMC) has a certain gelation effect, it is beneficial for food to form a gel better.

Therefore, E466 Carboxy Methyl Cellulose (CMC) can be used to make jelly and jam, etc.
E466 Carboxy Methyl Cellulose (CMC) is often used as thickener for food industry, adhesive for ceramic industry, sizing agent for paper industry, sizing agent for textile printing and dyeing, viscosifier and emulsifier for pharmaceutical industry, etc.

E466 Carboxy Methyl Cellulose (CMC) is used as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream.
E466 Carboxy Methyl Cellulose (CMC) is used primarily because it has high viscosity, is nontoxic, and is generally considered to be hypoallergenic as the major source fiber is either softwood pulp or cotton linter.

E466 Carboxy Methyl Cellulose (CMC) is used extensively in gluten-free and reduced fat food products.
In laundry detergents, E466 Carboxy Methyl Cellulose (CMC) is used as a soil suspension polymer designed to deposit onto cotton and other cellulosic fabrics, creating a negatively charged barrier to soils in the wash solution.

In ophthalmology, E466 Carboxy Methyl Cellulose (CMC) is used as a lubricant in artificial tears to treat dry eyes.
Extensive treatment may be required to treat severe dry eye syndrome or Meibomian gland dysfunction (MGD).
Classified as E466, E466 Carboxy Methyl Cellulose (CMC) serves as an emulsifier in ice cream, yoghurt, salad dressings, beverages, and meat products.

-Enhancing Texture and Consistency:
One of the standout features of E466 Carboxy Methyl Cellulose (CMC) is its ability to enhance the texture and consistency of various food products.

E466 Carboxy Methyl Cellulose (CMC) acts as a thickener, preventing phase separation and maintaining a uniform texture in products like sauces, dressings, and ice creams.
This ensures a smooth and enjoyable sensory experience for consumers.

-Application of E466 Carboxy Methyl Cellulose (CMC) in Soymilk:
E466 Carboxy Methyl Cellulose (CMC) can be used in soymilk to produce suspending, emulsifying and stabilizing effects.

E466 Carboxy Methyl Cellulose (CMC) can organically mix with the sizing mixture together to prevent fat floating or protein subsiding.
In addition, E466 Carboxy Methyl Cellulose (CMC) can also play an active role in whitening in color of soymilk, sweetening in taste, and removing soybean odor.

-Application of E466 Carboxy Methyl Cellulose (CMC) in Instant Paste Food:
In paste food such as instant peanut paste, sesame paste and almond paste, E466 Carboxy Methyl Cellulose (CMC) is used as the thickening agent to provide the instant paste food with the characteristics of dissolving even in cool water and being smooth, fine and fragrant, as well as of improving the taste of artificial sweetener.
As far as the stability is concerned, E466 Carboxy Methyl Cellulose (CMC) has advantages over starch paste.

-Application of E466 Carboxy Methyl Cellulose (CMC) in the Production of Condiment
Specially modified E466 Carboxy Methyl Cellulose (CMC) has favorable resistance to both salts and acids, thickening and stabilizing properties.

E466 Carboxy Methyl Cellulose (CMC) can be used in the condiment like peanut butter, chili sauce, jam and oyster sauce to improve the quality and tissue of these products, make the state of products become thicker and more stable, and improve the color, aroma as well as taste of products.

-Gluten-Free and Vegan Applications of E466 Carboxy Methyl Cellulose (CMC):
As the demand for gluten-free and vegan products continues to rise, E466 Carboxy Methyl Cellulose (CMC) steps in as a vital tool.

In gluten-free baking, E466 Carboxy Methyl Cellulose (CMC) can mimic the structural properties of gluten, leading to better texture and consistency in products like bread and cakes.
For vegan alternatives, E466 Carboxy Methyl Cellulose (CMC) ensures that plant-based foods maintain their desired appearance and mouthfeel.

-Specific culinary uses of E466 Carboxy Methyl Cellulose (CMC):
E466 Carboxy Methyl Cellulose (CMC) powder is widely used in the ice cream industry, to make ice creams without churning or extremely low temperatures, thereby eliminating the need for conventional churners or salt ice mixes.

E466 Carboxy Methyl Cellulose (CMC) is used in baking breads and cakes.
The use of E466 Carboxy Methyl Cellulose (CMC) gives the loaf an improved quality at a reduced cost by reducing the need for fat.

E466 Carboxy Methyl Cellulose (CMC) is also used as an emulsifier in biscuits.
Dispersing fat uniformly in the dough improves the release of the dough from the molds and cutters, achieving well-shaped biscuits without any distorted edges.

E466 Carboxy Methyl Cellulose (CMC) can also help to reduce the amount of egg yolk or fat used in making the biscuits.
The use of E466 Carboxy Methyl Cellulose (CMC) in candy preparation ensures smooth dispersion in flavor oils and improves texture and quality.
E466 Carboxy Methyl Cellulose (CMC) is used in chewing gums, margarine, and peanut butter as an emulsifier.

-Medical applications of E466 Carboxy Methyl Cellulose (CMC):
E466 Carboxy Methyl Cellulose (CMC) is also used in numerous medical applications.
Some examples include:

Device for epistaxis (nose bleeding).
A poly-vinyl chloride (PVC) balloon is covered by E466 Carboxy Methyl Cellulose (CMC) knitted fabric reinforced by nylon.

The device is soaked in water to form a gel, which is inserted into the nose of the patient and inflated.
The combination of the inflated balloon and the therapeutic effect of the E466 Carboxy Methyl Cellulose (CMC) stops the bleeding.

Fabric used as a dressing following ear, nose, and throat surgical procedures.
Water is added to form a gel, and this gel is inserted into the sinus cavity following surgery.

In ophthalmology, E466 Carboxy Methyl Cellulose (CMC) is used as a lubricating agent in artificial tears solutions for the treatment of dry eyes.
In veterinary medicine, E466 Carboxy Methyl Cellulose (CMC) is used in abdominal surgeries in large animals, particularly horses, to prevent the formation of bowel adhesions.

-Research applications of E466 Carboxy Methyl Cellulose (CMC):
Insoluble E466 Carboxy Methyl Cellulose (CMC) (water-insoluble) can be used in the purification of proteins, particularly in the form of charged filtration membranes or as granules in cation-exchange resins for ion-exchange chromatography.

Its low solubility is a result of a lower DS value (the number of carboxymethyl groups per anhydroglucose unit in the cellulose chain) compared to soluble E466 Carboxy Methyl Cellulose (CMC).

Insoluble E466 Carboxy Methyl Cellulose (CMC) offers physical properties similar to insoluble cellulose, while the negatively charged carboxylate groups allow it to bind to positively charged proteins.
Insoluble E466 Carboxy Methyl Cellulose (CMC) can also be chemically cross-linked to enhance the mechanical strength of the material

Moreover, E466 Carboxy Methyl Cellulose (CMC) has been used extensively to characterize enzyme activity from endoglucanases (part of the cellulase complex); it is a highly specific substrate for endo-acting cellulases, as its structure has been engineered to decrystallize cellulose and create amorphous sites that are ideal for endoglucanase action.

E466 Carboxy Methyl Cellulose (CMC) is desirable because the catalysis product (glucose) is easily measured using a reducing sugar assay, such as 3,5-dinitrosalicylic acid.
Using E466 Carboxy Methyl Cellulose (CMC) in enzyme assays is especially important in screening for cellulase enzymes that are needed for more efficient cellulosic ethanol conversion.

E466 Carboxy Methyl Cellulose (CMC) was misused in early work with cellulase enzymes, as many had associated whole cellulase activity with CMC hydrolysis.
As the mechanism of cellulose depolymerization became better understood, E466 Carboxy Methyl Cellulose (CMC) became clear that exo-cellulases are dominant in the degradation of crystalline (e.g. Avicel) and not soluble (e.g. CMC) cellulose

-Detergent uses of E466 Carboxy Methyl Cellulose (CMC):
E466 Carboxy Methyl Cellulose (CMC) is a common ingredient in cleaning products because of its thickening and stabilizing properties and nontoxic composition.

In detergent and cleaning products, E466 Carboxy Methyl Cellulose (CMC) can be used to enhance texture and assist in the suspension of dirt and grime in the cleaning product.
E466 Carboxy Methyl Cellulose (CMC)'s adjustable viscosity can be used to standardize the textures of the products, especially when used along with other chemicals.

E466 Carboxy Methyl Cellulose (CMC) helps with the removal of grease and aids in the creation of small bubbles in the soap.
This, along with E466 Carboxy Methyl Cellulose (CMC)'s ability to suspend dirt in mixtures, can make soaps and other cleaning products more efficient.

-Textile uses of E466 Carboxy Methyl Cellulose (CMC):
E466 Carboxy Methyl Cellulose (CMC) is used in textiles as a thickening agent in textile printing, constituting about 2-3% of printing pastes.
E466 Carboxy Methyl Cellulose (CMC) is also used in fabric finishing to affect the fabric's texture.

Additionally, E466 Carboxy Methyl Cellulose (CMC) serves as a binding agent in non-woven fabrics, contributing to the strength and stability of the material.
In sizing applications, about 1-3% of E466 Carboxy Methyl Cellulose (CMC) is used to protect yarns during weaving to reduce breakages.

E466 Carboxy Methyl Cellulose (CMC) aids in thickening printing pastes, which makes the prints themselves more precise.
E466 Carboxy Methyl Cellulose (CMC) is also used to thicken dyes.
Additionally, E466 Carboxy Methyl Cellulose (CMC) is an alternative to synthetic thickeners.

-Cosmetics uses of E466 Carboxy Methyl Cellulose (CMC):
E466 Carboxy Methyl Cellulose (CMC) is an ingredient used in over 50% of cosmetic products.
As a thickening agent, E466 Carboxy Methyl Cellulose (CMC) is used in formulations where viscosity needs to be precisely controlled.

In hair care, about 25% of shampoos and conditioners utilize E466 Carboxy Methyl Cellulose (CMC) for its conditioning and detangling effects.
E466 Carboxy Methyl Cellulose (CMC) is also used in the makeup and toothpaste industries to control the products' texture.

Due to its ability to retain moisture, E466 Carboxy Methyl Cellulose (CMC) is also used in skincare products.
E466 Carboxy Methyl Cellulose (CMC) serves as a film-forming agent in approximately 10% of sunscreens.

E466 Carboxy Methyl Cellulose (CMC) aids in pigment suspension and dispersion, binding other ingredients for even distribution.
E466 Carboxy Methyl Cellulose (CMC), when combined with Fatty Acid Ethanolamine or 2,2'-Iminodiethanol in a hair product, can form a thin film around the hair.

PROPERTIES OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) is a white or lightly yellow powder with no odor, flavor, or poisonous properties.
E466 Carboxy Methyl Cellulose (CMC) is hygroscopic and dissolves well in hot or cold water, forming a viscous solution.
E466 Carboxy Methyl Cellulose (CMC) is not soluble in organic solvents like methanol, ethanol, acetone, chloroform, and benzene.

The functional properties of E466 Carboxy Methyl Cellulose (CMC) depend on the degree of substitution of the cellulose structure (i.e., how many of the hydroxyl groups have been converted to carboxymethylene groups in the substitution reaction), as well as the chain length of the cellulose backbone structure and the degree of clustering of the carboxymethyl substituents.

E466 Carboxy Methyl Cellulose (CMC) is commonly used as a viscosity modifier or thickener and to stabilize emulsions in various products, both food and non-food-related.
E466 Carboxy Methyl Cellulose (CMC) is mainly used because it has a high viscosity, is nontoxic, and is generally considered to be hypoallergenic, as the major source fiber is either softwood pulp or cotton linter.

ADVANTAGES & CHARACTERISTICS OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC), is a water-soluble polymer obtained by chemical modification of natural cellulose with carboxymethyl groups.
E466 Carboxy Methyl Cellulose (CMC) is widely used as a thickener, stabilizer and emulsifier.
E466 Carboxy Methyl Cellulose (CMC), plays an important role especially in food, pharmaceutical, cosmetic and industrial products.
E466 Carboxy Methyl Cellulose (CMC) is Food Grade: 5000 cps high viscosity.

BENEFITS AND USES OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) is utilised for treating dry and red eyes and is used in making artificial teardrops and lens solutions.
E466 Carboxy Methyl Cellulose (CMC) stops your lotions, creams from separating, and controls the thickness and texture of liquids, creams, and gels.

E466 Carboxy Methyl Cellulose (CMC) helps to stabilize your formulations and increase their shelf life.
You can find it in eye drops, personal care items, and cosmeceuticals for the numerous benefits it provides.

E466 Carboxy Methyl Cellulose (CMC) increases the thickness of your shampoos, conditioners, and hair masks and gives them a creamy texture.
You can add E466 Carboxy Methyl Cellulose (CMC) to your serums to make their consistency less runny and impart more humectant properties to them.

HOW E466 CARBOXY METHYL CELLULOSE (CMC) WORKS:
E466 Carboxy Methyl Cellulose (CMC) works by enhancing the viscosity of the formulations to which it is added.
E466 Carboxy Methyl Cellulose (CMC) acts as a humectant and prevents dryness and irritation when added to pharmaceutical preparations.

CONCENTRATION AND SOLUBILITY OF E466 CARBOXY METHYL CELLULOSE (CMC):
The maximum recommended concentration of use of E466 Carboxy Methyl Cellulose (CMC) is 2% of the formulation.
E466 Carboxy Methyl Cellulose (CMC) is soluble in water but is insoluble in oil and ethanol.

HOW TO USE E466 CARBOXY METHYL CELLULOSE (CMC):
Heat the water phase to 60°C
Add our pure E466 Carboxy Methyl Cellulose (CMC) to it while stirring continuously with a mixer
Add the mixture to the heated oil phase.
Adjust the pH to complete the formulation.

FEATURES OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) is referred to as CMC, which is stable to drugs, light and heat.
In addition, E466 Carboxy Methyl Cellulose (CMC) is not easy to ferment and has a strong emulsifying power for oil and wax, so it can be stored for a long time.

Edible E466 Carboxy Methyl Cellulose (CMC) can emulsify and stabilize beverages containing fat and protein.
Therefore, E466 Carboxy Methyl Cellulose (CMC)-Na is often used as a thickener in the food industry.

EXTENDING SHELF LIFE AND STABILITY OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) also plays a role in extending the shelf life of certain food items.
In baked goods, for instance, E466 Carboxy Methyl Cellulose (CMC) helps retain moisture, preventing staleness and improving overall quality over time.
Additionally, its stabilizing properties make E466 Carboxy Methyl Cellulose (CMC) a valuable ingredient in processed foods that might otherwise undergo undesirable changes during storage.

PREPARATION OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) is synthesized by the alkali-catalyzed reaction of cellulose with chloroacetic acid.
The polar (organic acid) carboxyl groups render the cellulose soluble and chemically reactive.

Fabrics made of cellulose – e.g., cotton or viscose (rayon) – may also be converted into CMC.
Following the initial reaction, the resultant mixture produces approximately 60% CMC and 40% salts (sodium chloride and sodium glycolate).
This product, called technical E466 Carboxy Methyl Cellulose (CMC), is used in detergents.

An additional purification process is used to remove salts to produce pure E466 Carboxy Methyl Cellulose (CMC), which is used for food and pharmaceutical applications.
An intermediate 'semi-purified' grade is also produced, which is typically used in paper applications such as the restoration of archival documents.

STRUCTURE OF E466 CARBOXY METHYL CELLULOSE (CMC):
E466 Carboxy Methyl Cellulose (CMC) is a derivative of the regenerated cellulose [C6H10O5]n with hydroxy-acetic acid (hydroxyethanoic acid) CH2(OH)COOH or sodium monochloroacetate (Na[ClCH2COO]).
The E466 Carboxy Methyl Cellulose (CMC) backbone consists of D-glucose residues linked by -1,4-linkage.

E466 Carboxy Methyl Cellulose (CMC) has carboxymethyl groups (-CH2-COOH) bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone.
E466 Carboxy Methyl Cellulose (CMC) is often used as its sodium salt, sodium carboxymethyl cellulose.

MAIN USES AND FUNCTIONS OF E466 CARBOXY METHYL CELLULOSE (CMC):
Following are its main uses and functions:
*Beverages:
stabilize the particles and improve the mouthfeel.

*Bakery:
improve volume and texture, retain moisture and prolong shelf life.

*Dessert:
retain fluids in hydrocolloid dressings, improve mouthfeel and reduce syneresis.

*Dairy:
control ice crystal growth in ice cream, prevent syneresis and improve texture.

*Meat:
water binding and improve yield.

Cosmetics uses of E466 Carboxy Methyl Cellulose (CMC): Per the “European Commission database for information on cosmetic substances and ingredients”, cellulose gum acts as a binding, emulsion stabilising, film forming, masking and viscosity controlling agent in cosmetic and personal care products.

Toothpaste: E466 Carboxy Methyl Cellulose (CMC)'s role in toothpaste is to enable the liquid and solid raw material mix completely and provide the toothpaste a proper viscosity, brightness and smoothness in molding and flowing.
Other uses of E466 Carboxy Methyl Cellulose (CMC) such as in oil drilling, detergent, paper making, textile, mining, ceramic and so on.

PROPERTIES OF E466 CARBOXY METHYL CELLULOSE (CMC):
*Appearance
E466 Carboxy Methyl Cellulose (CMC) is slightly hygroscopic white or slightly yellowish or greyish odourless and tasteless, granular or fibrous powder.

*Degree of Substitution
Also called DS, it means the average number of hydroxyl groups substituted per glucopyranose unit.
A complete substitution would provide a DS of 3.
According to the EU, food grade cellulose gum DS value is 0.2-1.5 carboxymethyl groups (-CH2COOH) per anhydroglucose unit.

*Solubility
**In water
Yields a viscous colloidal solution with water.
E466 Carboxy Methyl Cellulose (CMC) has good solubility in water and absorbs water easily.
E466 Carboxy Methyl Cellulose (CMC) forms a colloidal solution when dissolved in cold or hot water.

The degree of substitution (DS) and viscosity are two main factors affecting its water solubility.
Generally, the viscosity is between 25 mPa.s and 50,000 mPa.s, E466 Carboxy Methyl Cellulose (CMC) is only soluble in alkali when DS value < 0.3.

E466 Carboxy Methyl Cellulose (CMC) is water-soluble when the DS value more than 0.4 and it is easily be dissolved in water when DS approaches 0.7 and less water-soluble when DS above 1.
With the increasing of DS value, the transparency of its solution will be improved accordingly.

**In organic solvents
E466 Carboxy Methyl Cellulose (CMC) is insoluble in organic solvents such as methanol, ethanol, copper, chloroform and benzene.

*Viscosity
Generally, the viscosity of E466 Carboxy Methyl Cellulose (CMC)'s solution is related to the polymerization degree of cellulose (DP), the solution concentration, pH value, temperature, degree of substitution, and etc.
DP Depends on the origin of the cellulolytic material.

*Concentration
The viscosity increases with the going up of the solution concentration.
PH Generally, the viscosity of the 1% sodium E466 Carboxy Methyl Cellulose (CMC) solution reaches the highest level at pH range from 6.5 to 9.0.

The viscosity does not change much in the PH value from 9.0-11.0. The viscosity drops rapidly and begins to form E466 Carboxy Methyl Cellulose (CMC) when PH<6.
And the process will be complete at pH ≌2.5.
The viscosity will decrease at PH>9, initially the decreasing process is slow with the increasing of PH, but will accelerate when PH>11.5.

*Temperature
The viscosity decreased with temperature increasing but it will rise when cool down.
However, a permanent viscosity reduction will occur when the temperature rises to a certain level.
The higher the degree of substitution, the smaller the viscosity is affected by temperature.

IS E466 CARBOXY METHYL CELLULOSE (CMC) SAFE TO EAT?
Yes, E466 Carboxy Methyl Cellulose (CMC)'s safety used as a food additive has been approved by the U.S. Food and Drug Administration (FDA), European Food Safety Authority (EFSA), Joint FAO/WHO Expert Committee on Food Additives (JECFA), as well as other authorities.

FDA
E466 Carboxy Methyl Cellulose (CMC) is generally recognized as safe (GRAS) when used in accordance with good manufacturing practice in food for human consumption.

E466 Carboxy Methyl Cellulose (CMC) can be used for anticaking agent or free-flow agent, drying agent, emulsifier or emulsifier salt, formulation aid, humectant, stabilizer or thickener and texturizer in Cheeses, Food Dress, Art Sw Jelly & Fruit Jams and Froz Desserts.

EFSA
E466 Carboxy Methyl Cellulose (CMC) is listed in Commission Regulation (EU) No 231/2012 as an authorised food additive and categorized as “additives other than colours and sweeteners”

E466 Carboxy Methyl Cellulose (CMC)'s application is listed in Group I and separately by E 466.
*The following foods may contain with it:
*Desserts, snacks, edible ices, chewing gum
*Vegetable oil, breakfast cereals, food supplements
*Cream, milk products, dried fruit and vegetables
*Nut butters and nut spreads, cocoa and Chocolate products
*Bread and rolls, fine bakery wares, unripened and processed cheese
*Sauces, soups and broths, meat products
*Beverage

E466 Carboxy Methyl Cellulose (CMC) is a water-soluble stabilizer and thickener for different food related applications.
When E466 Carboxy Methyl Cellulose (CMC) is Food or Beverages, the question is how the cellulose gum can improve the final product properties and this is mostly related to the viscosity of the product in use.

The grades and functionality of the E466 Carboxy Methyl Cellulose (CMC) can be tailored for specific uses such as for battery, pharmaceutical, food and personal care applications.

WHAT IS E466 CARBOXY METHYL CELLULOSE (CMC) USED FOR?
E466 Carboxy Methyl Cellulose (CMC) is often used in foods and beverages to make foods thick and creamy to attract the appetite of customers.
E466 Carboxy Methyl Cellulose (CMC) thickens and stabilizes a lot of foods by retaining moisture, keeping oil and water phased ingredients don’t separate and produces a consistent texture and so on.

IS E466 CARBOXY METHYL CELLULOSE (CMC) VEGAN?
Generally, E466 Carboxy Methyl Cellulose (CMC) is vegan as it produced from cellulose, the plant-based fiber commonly from wood chips and the manufacturing process without the use of animal matter or products derived from animal origin.
So E466 Carboxy Methyl Cellulose (CMC) is considered vegan.

IS E466 CARBOXY METHYL CELLULOSE (CMC) GLUTEN FREE?
Yes, E466 Carboxy Methyl Cellulose (CMC) is typically gluten-free and people with celiacs can eat it.
E466 Carboxy Methyl Cellulose (CMC) is an ingredient commonly found in both gluten-free and gluten-containing food labels.
E466 Carboxy Methyl Cellulose (CMC) is produced from cellulose complying with the FDA’s definition of gluten free, that it does not contain wheat, rye, barley, or crossbreeds of these grains.

WHAT IS E466 CARBOXY METHYL CELLULOSE (CMC) MADE OF?
E466 Carboxy Methyl Cellulose (CMC) is composed of anhydroglucose unit with average 0.2-1.5 carboxymethyl groups (-CH2COOH) on it.

HOW IS E466 CARBOXY METHYL CELLULOSE (CMC) MADE?
Generally, there are two steps in manufacturing process of sodium E466 Carboxy Methyl Cellulose (CMC), alkalinization and etherification.

Step 1: Alkalinization
Disperse the raw material cellulose pulp in alkali solution (generally sodium hydroxide, 5–50%) to obtain alkali cellulose.
Cell-OH+NaOH →Cell·O-Na+ +H2O

Step 2: Etherification
Etherification of alkali cellulose with sodium monochloroacetate (up to 30%) in an alcohol-water medium.
The mixture of alkali cellulose and reagent is heated (50–75°C) and stirred during the process.

ClCH2COOH+NaOH→ClCH2COONa+H2O
Cell·O-Na+ +ClCH2COO- →Cell-OCH2COO-Na
The DS of the sodium CMC can be controlled by the reaction conditions and use of organic solvents (such as isopropanol).

PHYSICAL and CHEMICAL PROPERTIES of E466 CARBOXY METHYL CELLULOSE (CMC):
CAS No. 9004-32-4
Formula C5h7o4coona
EINECS 618-415-6
Certification BRC, ISO, FDA, HACCP
Packaging Material Laminated Material
Storage Method Normal
Shelf Life >12 Months
Main Active Ingredient Agar
Boiling Point: 525-528°C

Melting Point: 274°C (dec.)
pH: 6.0-8.0
Solubility: Soluble in water
Viscosity: High
Melting point: 274 °C (dec.)
Density: 1.6 g/cm³
FEMA: 2239 | CARBOXYMETHYLCELLULOSE
Storage temp.: Room temp
Solubility: H2O: 20 mg/mL, soluble

Form: Low viscosity
pKa: 4.30 (at 25℃)
Color: White to light yellow
Odor: Odorless
pH Range: 6.5 - 8.5
pH: pH (10g/l, 25℃) 6.0-8.0
Viscosity: 900 to 1400 mPa-s (1%, H2O, 25 ℃)
Water Solubility: Soluble
Merck: 14,1829

Stability: Stable.
Incompatible with strong oxidizing agents.
Substances Added to Food (formerly EAFUS): CARBOXYMETHYL CELLULOSE, SODIUM SALT
SCOGS (Select Committee on GRAS Substances): Sodium Carboxymethyl cellulose
Chemical formula: Variable
Molar mass: Variable
Physical state: Solid
Color: Light yellow

Odor: Odorless
Melting point/freezing point: Melting point: > 300.05 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: > 250 °C

pH: At 10 g/l at 20 °C
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: Soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available

Relative density: 1.59
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available
CAS Number: 9004-32-4

Chemical formula: The polymers contain substituted anhydroglucose units with the following general formula:
C6H7O2(OR1)(OR2)(OR3), where R1, R2, R3 each may be one of the following:
— H
— CH2COONa
— CH2COOH
OR can be written as: [C6H7O2 (OH)x (OCH2COONa)y]n n≥4
x = 1.50-2.80; y = 0.20–1.50; x + y = 3.0

Molecular Weight: Higher than approximately 17 000 (degree of polymerisation approximately 100)
Chemical Name: Carboxymethyl Cellulose
INCI Name: Cellulose Gum
Pearl Name: Cellulose Gum
General Trade Name: CMC, Cellulose Gum, Tylose
CAS Number: 9004-32-4

EC Number: 618-378-6
IUPAC Number: Sodium carboxymethylcellulose
E Food Code: E466
CAS Number: 9004-32-4
EC number: 618-378-6
MDL number: MFCD00081472
E number: E466 (thickeners, ...)

Molecular Formula: C₆H₇O₂(OR₁)(OR₂)(OR₃), where R₁, R₂, and R₃ can be H, CH₂COONa, or CH₂COOH
[C₆H₇O₂(OH)ₓ(OCH₂COONa)ᵧ]n, where n ≥ 4, x = 1.50-2.80, y = 0.20–1.50, and x + y = 3.0.
Molecular Weight: approximately 17,000 g/mol, with the degree of polymerization being approximately 100 or higher
Commercial grades can have molecular weights ranging from 50,000 to 800,000 g/mol
Appearance: CMC is typically a white or cream-colored powder, which can be granular or fibrous.
It may also appear slightly yellowish or greyish.
Odor: It is generally odorless.
Taste: CMC is considered tasteless.

Solubility:
A key property is its high solubility in water, where it forms viscous solutions or gels. It is practically insoluble or very slightly soluble in anhydrous ethanol and other organic solvents like ether and chloroform. It is soluble in alkaline solutions, which increases its viscosity.
Melting Point:
CMC does not have a distinct melting point; it typically decomposes, with some sources indicating decomposition around 274°C.
Density: The bulk density of CMC powder is typically in the range of 0.5 to 0.7 g/cm³.
The density of the solid material is around 1.05 g/cm³ to 1.601 g/cm³ depending on temperature and specific form.
pH: A 1% aqueous solution of CMC usually has a pH value between 5.0 and 8.5.

FIRST AID MEASURES of E466 CARBOXY METHYL CELLULOSE (CMC):
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of E466 CARBOXY METHYL CELLULOSE (CMC):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of E466 CARBOXY METHYL CELLULOSE (CMC):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system

EXPOSURE CONTROLS/PERSONAL PROTECTION of E466 CARBOXY METHYL CELLULOSE (CMC):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of E466 CARBOXY METHYL CELLULOSE (CMC):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of E466 CARBOXY METHYL CELLULOSE (CMC):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available