Quick Search

PRODUCTS

E966 (Lactitol)


CAS NO:585-86-4
EC NO:209-566-5

E966 (Lactitol) is a sugar alcohol used as a replacement bulk sweetener for low calorie foods with 30–40% of the sweetness of sucrose. 
E966 (Lactitol) is also used medically as a laxative. 

Chemical and physical data:
Formula:    C12H24O11
Molar mass:    344.313 g·mol−1
Melting point:    146 °C (295 °F)

E966 (Lactitol) is used in a variety of low food energy or low fat foods. High stability makes it popular for baking. 
E966 (Lactitol) is used in sugar-free candies, cookies (biscuits), chocolate, and ice cream, with a sweetness of 30–40% that of sucrose.
E966 (Lactitol) also promotes colon health as a prebiotic. Because of poor absorption, E966 (Lactitol) only has 2–2.5 kilocalories (8.4–10.5 kilojoules) per gram, compared to 4 kilocalories (17 kJ) per gram for typical saccharides. Hence, E966 (Lactitol) is about 60% as caloric as typical saccharides.

Medical
E966 (Lactitol) is listed as an excipient in some prescription drugs.

E966 (Lactitol) is a laxative and is used to prevent or treat constipation, e.g., under the trade name Importal.

In February 2020, E966 (Lactitol) was approved for use in the United States as an osmotic laxative for the treatment of chronic idiopathic constipation (CIC) in adults.

E966 (Lactitol) in combination with Ispaghula husk is an approved combination for idiopathic constipation as a laxative and is used to prevent or treat constipation.

E966 (Lactitol) is a glycosyl alditol consisting of beta-D-galactopyranose and D-glucitol joined by a 1->4 glycosidic bond. 
E966 (Lactitol) is used as a laxative, as an excipient, and as replacement bulk sweetener in some low-calorie foods.
E966 (Lactitol) has a role as a laxative, an excipient and a cathartic.

E966 (Lactitol), also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. 
E966 (Lactitol) is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, E966 (Lactitol) has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis. Pizensy, an oral E966 (Lactitol) powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.

E966 (Lactitol) is used as a noncariogenic replacement for sucrose. 
E966 (Lactitol) is also used as a diluent in solid dosage forms. A direct-compression form is available, as is a direct-compression blend of lactose and E966 (Lactitol).

E966 (Lactitol) is used to treat chronic idiopathic (unknown cause) constipation (CIC). E966 (Lactitol) works by increasing peristalsis (contractions) in the colon, leading to an increase in the number of bowel movements.
E966 (Lactitol) is an orally administered osmotic laxative used to treat chronic idiopathic constipation.
E966 (Lactitol) is an odorless, colorless, sweet, nonhygroscopic, and stable sugar alcohol. 

E966 (Lactitol) is used in constipation.
E966 (Lactitol), a sugar alcohol derived from lactose (milk sugar), is a versatile, reduced calorie sweetener. 

E966 (Lactitol) is used to treat chronic idiopathic (unknown cause) constipation (CIC). E966 (Lactitol) works by increasing peristalsis (contractions) in the colon, leading to an increase in the number of bowel movements.

E966 (Lactitol) is used to treat constipation.
E966 (Lactitol) is also used to prevent the loss of brain function due to liver damage by removing certain toxic chemicals from the blood. 

E966 (Lactitol) is a member of the family of bulk sweeteners known as polyols ( sugar alcohols ).

E966 (Lactitol) was first discovered in 1920, but it wasn’t until the 1980’s when it was first used in foods as a reduced-calorie sweetener.

Despite only being 40% as sweet as sucrose, the sugar alcohol is very similar in taste.

Due to its stability, solubility, low calorie value and similar taste to sucrose, E966 (Lactitol) can be used in a range of low-calorie, low-fat and/or sugar-free foods such as:

Chocolate
Ice cream
Baked goods
Hard and soft candies
Chewing gums and
Sugar substitutes

E966 (Lactitol)s mild sweetness also makes it suitable for blending with other low-calorie sweeteners that are several hundred times sweeter than sucrose, but do not provide the necessary volume.

E966 (Lactitol) is produced by reducing the glucose part of the disaccharide lactose. 
E966 (Lactitol) is not hydrolysed or absorbed in the small intestine.

Benefits of E966 (Lactitol)
The benefits of E966 (Lactitol) include:

Mild sweet flavour with no aftertaste
E966 (Lactitol) has a clean sweet, sugar-like taste, which allows it to be mixed with other low-calorie sweeteners.

The relative sweetness of E966 (Lactitol) rises as its concentration in a food is increased and it leaves no aftertaste.

Low in calories
E966 (Lactitol) is metabolised in the large intestine and yields roughly 2 calories per gram compared to a typical carbohydrate (or sugar) which contributes the usual 4 kcal/g.

In Europen, the EU Nutrition Labelling Directive states that all sugar alcohols, including E966 (Lactitol), have a caloric value of 2.4 kcal/g.

E966 (Lactitol), a polyol (sugar alcohol), is currently used as a bulk sweetener in calorie-controlled foods. Discovered in 1920, it was first used in foods in the 1980’s. 
E966 (Lactitol) has a clean sweet taste that closely resembles the taste profile of sucrose. 
E966 (Lactitol) has only 40 percent of sucrose’s sweetening power.

Sweet and clean taste: 
E966 (Lactitol) has a clean sweet, sugar-like taste with no aftertaste. The relative sweetness of E966 (Lactitol) rises as its concentration in a food is increased. 
E966 (Lactitol)s mild sweet taste allows other flavors to be clearly perceived. 
E966 (Lactitol) is a white crystalline powder.

High quality low-calorie foods: 
E966 (Lactitol)’s many attributes as a bulk sweetener with mild sweetness make it a versatile ingredient for high quality low-calorie, low-fat and sugar-free foods. 
E966 (Lactitol) is not hygroscopic, meaning it will not absorb moisture into products, will maintain crispness and extend the shelf life of cookies and chewing gum. 
E966 (Lactitol) also has similar solubility to glucose, is stable in acid and alkaline conditions and remains stable under the high temperatures of food processing. Due to E966 (Lactitol)’s mild sweetness profile, it can be paired with low-calorie sweeteners commonly used in today’s low-calorie, sugar-free foods (e.g. acesulfame K, aspartame, neotame, saccharin and sucralose).

Low in calories: 
E966 (Lactitol) is not metabolized like a typical carbohydrate (or like sugar) and therefore does not contribute the usual 4 calories per gram. 
E966 (Lactitol) is metabolized in the large intestine and yields, according to tests, only 2 calories per gram. This value has been accepted for labeling purposes in the U.S. by the FDA. The EU Nutrition Labeling Directive states that all sugar alcohols, including E966 (Lactitol), have a caloric value of 2.4 calories per gram.

Improving gut health: 
E966 (Lactitol) is fermented in the colon and consequently has beneficial effects on the colonic microflora. A reduction in the pH of the colon, along with an increase in probiotic bacteria and a significant reduction in potential pathogens emphasizes the beneficial effects of E966 (Lactitol). In essence, E966 (Lactitol) functions as a prebiotic.

E966 (Lactitol) is a sugar alcohol or polyol obtained from the catalytic hydrogenation of lactose. Although E966 (Lactitol) is commonly used to deliver sweetness at low caloric value, E966 (Lactitol) is a multipurpose compound having various applications in the field of food, dairy, and pharmaceutical.

E966 (Lactitol) is primarily used for the treatment of constipation and hepatic encephalopathy. 
E966 (Lactitol) is a synthetic disaccharide.

E966 (Lactitol) is a disaccharide binding a beta-D-galactopyranose and D-glucitol to produce the sugar alcohol also known as E966 (Lactitol). 
E966 (Lactitol)’s derived from lactose, a product of disaccharide’s glucose being reduced. 
E966 (Lactitol) has been used as a laxative agent, excipient, and low-calorie artificial sweetener. Other characteristics of E966 (Lactitol) display antibiotic and prebiotic activity.

E966 (Lactitol) is an artificial sugar alcohol currently used as a bulk sweetener in calorie-controlled foods.

E966 (Lactitol) is listed as an excipient in some prescription drugs, such as Adderall. E966 (Lactitol) is a sugar alcohol used as a replacement bulk sweetener for low calorie foods. 
E966 (Lactitol) is also used medically as a laxative.

About E966 (Lactitol)
Helpful information
E966 (Lactitol) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.

E966 (Lactitol) is used by consumers, by professional workers (widespread uses) and in formulation or re-packing.

Consumer Uses
E966 (Lactitol) is used in the following products: cosmetics and personal care products.
Other release to the environment of E966 (Lactitol) is likely to occur from: indoor use as processing aid.
Article service life
ECHA has no public registered data on the routes by which E966 (Lactitol) is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
E966 (Lactitol) is used in the following products: cosmetics and personal care products.
ECHA has no public registered data on the types of manufacture using E966 (Lactitol). Other release to the environment of E966 (Lactitol) is likely to occur from: indoor use as processing aid.
Formulation or re-packing
E966 (Lactitol) is used in the following products: cosmetics and personal care products. Release to the environment of E966 (Lactitol) can occur from industrial use: formulation of mixtures.

Uses at industrial sites
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using E966 (Lactitol). ECHA has no public registered data on the routes by which E966 (Lactitol) is most likely to be released to the environment.

Manufacture
ECHA has no public registered data on the routes by which E966 (Lactitol) is most likely to be released to the environment.

E966 (Lactitol) is primarily used for the treatment of constipation and hepatic encephalopathy. 
E966 (Lactitol) is a synthetic disaccharide. 
E966 (Lactitol) is similar to a lactulose-like glucose molecule that contains galactose and sorbitol.

IUPAC names
(2S,3R,4R,5R)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
4-O-beta-D-galactopyranosyl-D-glucitol
D-Glucitol, 4-O-b-D-galactopyranosyl-

SYNONYMS:
Lactositol
209-566-5 [EINECS]
4-O-b-D-galactopyranosyl-D-glucitol
4-O-β-D-Galactopyranosyl-D-glucitol [ACD/IUPAC Name]
4-O-β-D-Galactopyranosyl-D-glucitol [German] [ACD/IUPAC Name]
4-O-β-D-Galactopyranosyl-D-glucitol [French] [ACD/IUPAC Name]
585-86-4 [RN]
6414
D-glucitol, 4-O-b-D-galactopyranosyl-
D-Glucitol, 4-O-β-D-galactopyranosyl-
D-Glucitol, 4-O-β-D-galactopyranosyl- [ACD/Index Name]
D-E966 (Lactitol)
E 966
Finlac DC
L2B0WJF7ZY
Lactit
Lactit M
Lactite
E966 (Lactitol) [Portuguese]
E966 (Lactitol) [Wiki]
E966 (Lactitol) ANHYDROUS
Lactobiosit
MFCD00079407
Miruhen
no translation
(2S,3R,4R,5R)-4-(((2S,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,5,6-pentaol
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol
(2S,3R,4R,5R)-4-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]hexane-1,2,3,5,6-pentol
[585-86-4]


 

  • Share !
E-NEWSLETTER