ETHYL LAUROYL ARGINATE

Ethyl Lauroyl Arginate is a cationic surfactant-based food preservative and antimicrobial agent derived from L-arginine, lauric acid, and ethanol. 
Ethyl Lauroyl Arginate acts as a broad-spectrum antimicrobial, effectively reducing bacteria, yeasts, and fungi in foods such as meat products and sauces. 
Ethyl Lauroyl Arginate is safe, biodegradable, and approved by the FDA and EFSA. 

CAS Number: 60372-77-2
Molecular Formula: C20H41ClN4O3
Molecular Weight: 421.01754
EINECS Number: 434-630-6

Synonyms:N(alpha)-Lauroylarginine ethyl ester, 48076-74-0, ethyl lauroyl arginate, lauroyl arginine ethyl ester, ethyl N(alpha)-lauroyl-L-arginate, ethyl N(alpha)-lauroylarginate, ethyl dodecanoyl-L-argininate, ethyl n2-dodecanoyl-l-argininate, N(alpha)-lauroyl-L-arginine ethyl ester, N(alpha)-lauroylarginine ethyl ester, N(alpha)-lauroyl-arginine ethyl ester, N alpha-Lauroyl-L-arginine ethyl ester, N.ALPHA.-LAUROYL-L-ARGININE ETHYL ESTER, N(.ALPHA.)-LAUROYLARGININE ETHYL ESTER, N-(.ALPHA.)-LAE, N-(.ALPHA.)-CAE, N(alpha)-Lae, N(alpha)-Cae, Nacaee, N(alpha)-Cocylarginine ethyl ester, N(alpha)-Cocoylarginine ethyl ester, N(alpha)-Cocoyl-L-arginine ethyl ester, N(.ALPHA.)-COCOYL-L-ARGININE ETHYL ESTER, N(.ALPHA.)-COCYLARGININE ETHYL ESTER, N(alpha)-Cocyl-L-arginine ethyl ester, N(alpha)-Cocoyl-L-arginine ethyl ester, L-EthylLauroylArginate, Lauramide arginine ethyl ester free base, L-Arginine N2-(1-oxododecyl)- ethyl ester, ethyl (2S)-2-(dodecanoylamino)-5-guanidino-pentanoate, ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate, Ethyl N5-(diaminomethylidene)-N2-dodecanoyl-L-ornithinate, Ethyl N~5~-(diaminomethylidene)-N~2~-dodecanoyl-L-ornithinate, L-ornithine N5-(diaminomethylidene)-N2-(1-oxododecyl)- ethyl ester, C20H40N4O3, UNII-E0K8J7A41B, E0K8J7A41B, RefChem:596248, DTXSID60893076, SCHEMBL2409308, SCHEMBL29574713, Q27276710, F88029, ETHYL LAUROYL ARGINATE HCL;N-ALPHA-LAUROYL-L-ARGININEETHYLESTERMONOHYDROCHLORIDE;ETHYL-N-ALPHA-LAUROYL-L-ARGINATEHYDROCHLORIDE;ETHYLLAUROYLARGINATEHYDROCHLORIDE;Aminat G;CytoGuard LA;Ethyl N-lauroyl-L-arginate hydrochloride;Mirenat CF

Ethyl Lauroyl Arginate is a food preservative, antimicrobial compound, and drug more commonly known as E243.
Ethyl Lauroyl Arginate is used to treat dermatological disorders[2] and is often provided in the form of its hydrochloride salt. 
Ethyl Lauroyl Arginate is an amino acid-based surfactant with broad-spectrum antimicrobial activity, high biodegradability and low toxicity. 

Due to these features, LAE is a preservative used in food and cosmetic formulations.
Ethyl Lauroyl Arginate is a synthetic cationic surfactant and antimicrobial agent, widely used as a food preservative and disinfectant.
Its chemical formula is approximately C₂₀H₄₁N₄O₃·HCl.

Ethyl Lauroyl Arginate belongs to the class of amino acid–derived surfactants.
Ethyl Lauroyl Arginate is derived from lauric acid, L-arginine, and ethanol, forming an esterified arginine derivative.
It contains both hydrophobic (fatty chain) and hydrophilic (charged guanidinium group) regions.

This gives it amphiphilic and antimicrobial properties.
Ethyl Lauroyl Arginate appears as a white to off-white powder or granular solid.
It is soluble in water and forms clear solutions.

Ethyl Lauroyl Arginate has a mild characteristic odor.
Ethyl Lauroyl Arginate exhibits strong antimicrobial activity, especially against Gram-positive bacteria, as well as some Gram-negative bacteria and fungi.
It disrupts microbial cell membranes.

This prevents growth and contamination.
Ethyl Lauroyl Arginate functions as a cationic surfactant, interacting with negatively charged microbial membranes.
This leads to membrane destabilization.

This is key to its mechanism of action.
Ethyl lauroyl arginate is rapidly hydrolyzed and degraded in the body into natural components such as arginine and fatty acids.
This contributes to its safety profile.

Ethyl Lauroyl Arginate does not accumulate significantly.
It is chemically stable under normal conditions, but may degrade under extreme pH or temperature.

Proper storage ensures effectiveness.
Ethyl Lauroyl Arginate should be kept in dry conditions.
Ethyl Lauroyl Arginate is best described as a biodegradable, amino acid–based antimicrobial surfactant used for preservation and hygiene, especially in food and industrial applications.

Density: 1.11 [at 20℃]
vapor pressure: 0.001 Pa at 25℃
storage temp.: Inert atmosphere, Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White
Water Solubility: 247 g/L at 20℃
Major Application: pharmaceutical (small molecule)
Cosmetics Ingredients Functions: PRESERVATIVE; ANTI-SEBORRHEIC; HAIR CONDITIONING; SKIN CONDITIONING - MISCELLANEOUS; SKIN CONDITIONING
InChI: InChI=1/C20H40N4O3.ClH/c1-3-5-6-7-8-9-10-11-12-15-18(25)24-17(19(26)27-4-2)14-13-16-23-20(21)22;/h17H,3-16H2,1-2H3,(H,24,25)(H4,21,22,23);1H/t17-;/s3
InChIKey: CUBZMGWLVMQKNE-VOPAOICTNA-N
SMILES: C@@H
(CCCNC(N)=N)NC(=O)CCCCCCCCCCC.Cl |&1:0,r|
LogP: 1.43 at 20℃

Ethyl lauroyl arginate is a white solid, soluble in deionized water up to 247 g/kg at 20 °C with a melting point from 57 °C to 58 °C. 
Ethyl lauroyl arginates partition coefficient between olive oil and water is 0.07; it allows LAE to be located in the water fraction, which is more susceptible to microbial contamination.
This property gives LAE an advantage over other preservatives with a different chemical structure intended for the same applications.

Ethyl lauroyl arginate is a synthetic preservative used in cosmetics to prevent bacteria and fungi from developing in water-based beauty products. 
This increases their shelf life, making them safe and effective. 
For years, this ingredient was successfully used in the food industry to keep eatables fresh, before being introduced to the world of cosmetics. 

Ethyl Lauroyl Arginate HCL also has conditioning properties and prevents oiliness. 
Ethyl lauroyl arginate is commonly added to moisturizers, lotions, serums, face masks, serums, shampoos, conditioners, and makeup removers. 
Ethyl lauroyl arginate has natural origins and is safe for use when used according to guidelines.

Ethyl lauroyl arginate exhibits a cationic (positively charged) guanidinium group, which strongly interacts with negatively charged microbial cell membranes.
This electrostatic interaction is critical for its activity.
It enhances antimicrobial efficiency.

The molecule contains a hydrophobic lauryl (C12) chain, which allows insertion into lipid bilayers.
This disrupts membrane integrity.
Ethyl lauroyl arginate leads to leakage of cellular contents.

Ethyl lauroyl arginate shows broad-spectrum antimicrobial activity, including bacteria, yeasts, and some molds.
Ethyl lauroyl arginate is particularly effective against Gram-positive organisms.
This makes it versatile in preservation.

Ethyl lauroyl arginate is effective at very low concentrations (ppm levels).
Small amounts provide strong antimicrobial action.
This improves cost efficiency.

The compound demonstrates rapid biodegradability, breaking down into arginine, ethanol, and lauric acid derivatives.
These are naturally occurring substances.
This contributes to environmental and biological safety.

Ethyl lauroyl arginate shows good compatibility with many food components, though its activity may be influenced by proteins and fats.
Formulation conditions affect performance.
This requires optimization.

Ethyl lauroyl arginate is stable in a moderate pH range, but may degrade under strongly alkaline conditions.
It performs well in slightly acidic environments.
This is typical in food systems.

Ethyl lauroyl arginate may exhibit surface-active properties, contributing to emulsification and wetting in formulations.
This enhances distribution.
Ethyl lauroyl arginate improves effectiveness.

Ethyl lauroyl arginate is a highly effective, biodegradable cationic surfactant with strong membrane-disrupting antimicrobial activity and low-dose efficiency, making it valuable in food safety and hygiene applications.
Ethyl lauroyl arginate shows rapid action against microorganisms, often inactivating cells within a short contact time.

Ethyl lauroyl arginate disrupts membrane integrity quickly.
This provides fast preservation.
Ethyl lauroyl arginate can affect cell membrane permeability, leading to leakage of ions and essential metabolites.

This disrupts cellular homeostasis.
Ethyl lauroyl arginate results in microbial death.
Ethyl lauroyl arginate may exhibit synergistic effects with other preservation methods, such as low pH, refrigeration, or mild heat treatment.

These combinations enhance antimicrobial performance.
This supports multi-hurdle preservation systems.
Ethyl lauroyl arginate demonstrates low tendency for bioaccumulation, as it is readily metabolized and degraded.

Ethyl lauroyl arginate does not persist significantly in biological systems.
This contributes to safety.
Ethyl lauroyl arginate can interact with food matrix components, such as proteins and lipids, which may reduce or modify its antimicrobial activity.

Formulation optimization is important.
This ensures effectiveness.
Ethyl lauroyl arginate exhibits surface activity that improves wetting and spreading, allowing better coverage on food or material surfaces.

This enhances antimicrobial contact.
Ethyl lauroyl arginate improves performance.
Ethyl lauroyl arginate is often used in controlled dosing systems, ensuring effective antimicrobial levels without exceeding regulatory limits.

Precise application is important.
This ensures safety and compliance.
Ethyl lauroyl arginate is typically formulated as salts (e.g., hydrochloride) to improve stability and solubility.

This enhances handling and use.
Ethyl lauroyl arginate supports industrial applications.
Ethyl lauroyl arginate is a fast-acting, surface-active antimicrobial with strong membrane-disrupting ability, good biodegradability, and formulation-dependent performance, making it highly effective in preservation systems.

Uses Of Ethyl lauroyl arginate:
Ethyl lauroyl arginate is used as a food antimicrobial in the sanitation of preserved foods. 
Ethyl lauroyl arginate is also used in cosmetics as a preservative.
Ethyl lauroyl arginate is the isotope labelled analog of Ethyl Lauroyl Arginate Hydrochloride (E921955). 

Ethyl lauroyl arginate is used as a food antimicrobial in the sanitation of preserved foods.
Ethyl lauroyl arginate is widely used in the food industry as a preservative.
It inhibits the growth of bacteria, yeasts, and molds.

This extends shelf life of products.
In meat and poultry products, it is applied to control surface contamination.
It reduces growth of pathogens and spoilage organisms.

Ethyl lauroyl arginate is used in ready-to-eat and processed foods to prevent microbial spoilage.
Ethyl lauroyl arginate helps maintain product quality during storage.
This enhances stability.

Ethyl lauroyl arginate is applied in dairy products and cheeses to inhibit bacterial growth.
Ethyl lauroyl arginate helps prevent contamination.
This supports product safety.

In beverages and liquid foods, it is used as an antimicrobial agent.
Ethyl lauroyl arginate helps maintain microbiological stability.
This reduces spoilage risk.

Ethyl lauroyl arginate is used in food surface treatments and coatings, such as sprays or dips.
It provides localized antimicrobial protection.
This improves hygiene.

In packaging and food-contact materials, it may be incorporated to provide antimicrobial properties.
Ethyl lauroyl arginate helps control microbial growth on surfaces.
This enhances preservation systems.

Ethyl lauroyl arginate is applied in cosmetic and personal-care products as a preservative.
It prevents microbial contamination.
This improves product shelf life.

Ethyl lauroyl arginate is also used in industrial and sanitation applications for disinfection and microbial control.
It helps maintain hygiene in processing environments.
Ethyl lauroyl arginate is used wherever effective, low-dose antimicrobial protection and preservation are required, especially in food, packaging, cosmetics, and hygiene applications.

Ethyl lauroyl arginate (LAE) is used in fresh and minimally processed foods, such as sliced meats and ready salads.
It helps control surface microbial growth.
This extends freshness without heavy processing.

In seafood products, it is applied to inhibit spoilage organisms and pathogens.
Ethyl lauroyl arginate helps maintain quality during storage.
This improves shelf life.

Ethyl lauroyl arginate is used in bakery products, especially those prone to microbial spoilage.
It inhibits growth of molds and bacteria.
This enhances product stability.

Ethyl lauroyl arginate is applied in sauces, dressings, and emulsified foods to control microbial contamination.
It works well in aqueous systems.
This improves preservation.

In clean-label food formulations, it is used as an alternative to traditional preservatives.
It aligns with consumer demand for safer additives.
This enhances market acceptance.

Ethyl lauroyl arginate is used in active packaging systems, where it is incorporated into films or coatings.
It provides continuous antimicrobial protection.
This improves product safety.

Ethyl lauroyl arginate is applied in sanitizing and surface treatment solutions in food processing environments.
It helps reduce microbial load on equipment and surfaces.
This supports hygiene.

In personal-care products such as oral care and skin formulations, it acts as an antimicrobial agent.
Ethyl lauroyl arginate helps prevent microbial contamination.
This improves product safety.

Ethyl lauroyl arginate is also used in veterinary and agricultural applications to control microbial growth in feeds and surfaces.
It supports hygiene and preservation.
Ethyl lauroyl arginate is used wherever fast-acting, surface-active antimicrobial protection and extended shelf life are required across food, packaging, hygiene, and cosmetic applications.

Safety Profile Of Ethyl lauroyl arginate:

Ethyl lauroyl arginate (LAE, E243) presents low to moderate hazard potential, mainly related to its cationic surfactant nature and irritation effects at high concentrations.
It is generally considered safe at regulated use levels.
However, concentrated forms require careful handling.

Skin contact may cause mild to moderate irritation, especially with prolonged exposure to concentrated solutions.
Symptoms can include redness or dryness.
Protective gloves are recommended.

Eye contact can cause moderate to severe irritation.
Symptoms include redness, pain, and watering.
Immediate rinsing with plenty of water is necessary.

Inhalation of dust or aerosols may cause respiratory irritation.
Symptoms can include coughing or throat discomfort.
Adequate ventilation is recommended.

Ingestion is considered safe at approved levels, but high doses may cause gastrointestinal irritation.
It is not intended for excessive intake.
Medical advice should be sought if large amounts are consumed.

Ethyl lauroyl arginate is not highly flammable, but it can decompose under high temperatures.
Thermal decomposition may produce carbon oxides, nitrogen oxides, and irritating fumes.
Standard fire safety precautions should be followed.

The compound is chemically stable under normal conditions, but may degrade under extreme pH (especially alkaline conditions) or high temperatures.
Ethyl lauroyl arginate should be kept in dry conditions.
From an environmental perspective, it is readily biodegradable and generally low in long-term toxicity, but high concentrations may be harmful to aquatic organisms.