Synonyms: Ethylene diamine; CAS NO:107-15-3; EC NO:203-468-6; etilendiamin; ethane-1,2-diamine
Ethylene diamine is the organic compound with the formula C2H4(NH2)2. This colorless liquid with an ammonia-like odor is a strongly basic amine. Ethylene diamine is used in large quantities for production of many industrial chemicals.
Synonyms:
Ethylene diamine; CAS NO:107-15-3; EC NO:203-468-6; SYNONYMS:Ethylendiamin; etilendiamin; ethane-1,2-diamine; ETİLENDİAMİN; etilendiamin; ETİLEN DİAMİN; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilene diamin; etilendiamin; etılendıamıne; etilen diamine; etilen; 1,2-diaminoethane; 1,2-ethanediamine; edamine; ethane-1,2-diamine; ethyl diamine; Ethylene diamine; Ethylene diamine (1:1) sulfate; Ethylene diamine (1:1) sulfite; Ethylene diamine conjugate acid; Ethylene diamine dihydrobromide; Ethylene diamine dihydrochloride; Ethylene diamine dihydrogen iodide; Ethylene diamine dihydroiodide; Ethylene diamine dinitrate; Ethylene diamine hydrochloride; Ethylene diamine monohydrochloride; Ethylene diamine phosphate, Ethylene diamine sulfate; Ethylene diamine, 3H-labeled cpd; Ethylene diamine;Ethane-1,2-diamine; 1,2-Ethanediamine; 1,2-Diaminoethane; 107-15-3; Ethylene diamine; Ethylendiamine; DimEthylene diamine; edamine, 1,2-Ethylene diamine; Aethaldiamin, Aethylenediamin; Ethyleendiamine; Ethylene-diamine; beta-Aminoethylamine; 1,2-Diaminoaethan; Algicode 106L; Amerstat 274; etilendiamin; 1,2-Diamino-ethaan; 1,2-Diamino-ethano; Ethylendiamin; ethane-1,2-diamine; etilendiamin; etilendiamin; ETİLEN DİAMİN; etilendiamin; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilene diamin; Aethaldiamin [German]; Ethylendiamin;ethane-1,2-diamine;etilendiamin; ETİLEN DİAMİN; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilene diamin;Caswell No. 437; Ethyleendiamine [Dutch]; Aethylenediamin [German]; Ethylene-diamine [French]; 1,2-Diaminoaethan [German]; 1,2-Diamino-ethaan [Dutch]; 1,2-Diamino-ethano [Italian]; CHEBI:30347; EINECS 203-468-6; EPA Pesticide Chemical Code 004205; Ethylendiamin;ethane-1,2-diamine;etilendiamin; ETİLEN DİAMİN; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilene diamin; etilendiamin; etılendıamıne; etilen diamine; etilen; 1,2-diaminoethane; 1,2-ethanediamine; edamine; ethane-1,2-diamine; ethyl diamine; Ethylene diamine; Ethylene diamine (1:1) sulfate; Ethylene diamine (1:1) sulfite; Ethylene diamine conjugate acid; ETİLENDİAMİN; Ethylene diamine dihydrobromide; Ethylene diamine dihydrochloride; Ethylene diamine dihydrogen iodide; Ethylene diamine dihydroiodide; Ethylene diamine dinitrate; Ethylene diamine hydrochloride; Ethylene diamine monohydrochloride; Ethylene diamine phosphate, Ethylene diamine sulfate; Ethylene diamine, 3H-labeled cpd; Ethylene diamine;Ethane-1,2-diamine; 1,2-Ethanediamine; 1,2-Diaminoethane; 107-15-3; Ethylene diamine; Ethylendiamine; DimEthylene diamine; edamine, 1,2-Ethylene diamine; Aethaldiamin, Aethylenediamin; Ethyleendiamine; Ethylene-diamine; beta-Aminoethylamine; 1,2-Diaminoaethan; Algicode 106L; Amerstat 274, 1,2-Diamino-ethaan; 1,2-Diamino-ethano; Ethylendiamin; ethane-1,2-diamine; etilendiamin; ETİLEN DİAMİN; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilene diamin; Aethaldiamin [German]; Ethylendiamin;ethane-1,2-diamine;etilendiamin; ETİLEN DİAMİN; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilendiamin; etilene diamin;Caswell No. 437; ETİLENDİAMİN; etilendiamin; etilendiamin; ETİLENDİAMİN; Ethyleendiamine [Dutch]; ETİLENDİAMİN; Aethylenediamin [German]; ETİLENDİAMİN; Ethylene-diamine [French]; 1,2-Diaminoaethan [German]; 1,2-Diamino-ethaan [Dutch]; 1,2-Diamino-ethano [Italian]; CHEBI:30347; EINECS 203-468-6; EPA Pesticide Chemical Code 004205; BRN 0605263; Ethylendiamin; AI3-24231; PIICEJLVQHRZGT-UHFFFAOYSA-N; Ethylene diamine, ReagentPlus(R), >=99%; Ethylene diamine [JAN]; ethylenediarnine; 1,2-Ethanediamine, homopolymer; 2-aminoethylamine; ethylene di amine; 1,4-diazabutane; 1,2-diaminoethan; Ethylene diamine, piperazine polymer; ethylene - diamine; EDN; 1,2-diamino-ethane; ethane 1,2-diamine; Ethylene diamine; Ethylendiamin;ethane-1,2-diamine;etilendiamin; ETİLEN DİAMİN; ETİLEN DİAMİNE; ETHYLENE DİAMİNE; Ethylene diamine; etilen diamin; etilendiamin; etilene diamin;ATHYLENE DIAMIN; ETHYLENE DİAMİNE; ETHYLENE DİAMİN; ETİLEN DİAMİN; ETHLEN DİAMİN; ETILEN DIAMIN; ETILEN DIAMINE; EDILEN DIAMIN; etilen diamin; etilendiamin; etilendiamin; etılendıamın; etilendıamin; etilendiamin; EPI-DA; ETHANE,1,2-DIAMINO; ETİLENDİAMİN; etilendiamin; 1,2-DIAMINOETHANE; 1,2-ETHANEDIAMINE;1,2 Ethylene diamine; ETİLENDİAMİN; Ethylene diamine; EDA; ETHANE-1,2-DIAMINE; 1,2-Diaminoaethan; 1,2-Diamino-ethaan; etilen diamin; ethilen diamin; etilen diamine; Ethylene diamine; Ethylene diamine
Ethylene diamine
Ethylene diamine
Ethylene diamine
Skeletal formula of Ethylene diamine
Ball and stick model of Ethylene diamine
Space-filling model of Ethylene diamine
Names
Preferred IUPAC name
Ethane-1,2-diamine
Systematic IUPAC name
Ethane-1,2-diamine[2]
Other names
Edamine[1] 1,2-Diaminoethane, 'en' when a ligand
Identifiers
CAS Number
107-15-3 check
3D model (JSmol)
Interactive image
Abbreviations en
Beilstein Reference 605263
ChEBI
CHEBI:30347 check
ChEMBL
ChEMBL816 check
ChemSpider
13835550 check
ECHA InfoCard 100.003.154 Edit this at Wikidata
EC Number
203-468-6
Gmelin Reference 1098
KEGG
D01114 check
MeSH Ethylene diamine
PubChem CID
3301
RTECS number
KH8575000
UNII
60V9STC53F check
UN number 1604
CompTox Dashboard (EPA)
DTXSID5021881 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula C2H8N2
Molar mass 60.100 g·mol−1
Appearance Colorless liquid[3]
Odor Ammoniacal[3]
Density 0.90 g/cm3[3]
Melting point 8 °C (46 °F; 281 K)[3]
Boiling point 116 °C (241 °F; 389 K)[3]
Solubility in water miscible
log P −2.057
Vapor pressure 1.3 kPa (at 20 °C)
Henry's law
constant (kH) 5.8 mol Pa−1 kg−1
Magnetic susceptibility (χ)
-46.26·10−6 cm3/mol
-76.2·10−6 cm3/mol (HCl salt)
Refractive index (nD) 1.4565
Thermochemistry
Heat capacity (C) 172.59 J K−1 mol−1
Std molar
entropy (So298) 202.42 J K−1 mol−1
Std enthalpy of
formation (ΔfH⦵298) −63.55–−62.47 kJ mol−1
Std enthalpy of
combustion (ΔcH⦵298) −1.8678–−1.8668 MJ mol−1
Hazards
GHS pictograms GHS02: Flammable GHS05: Corrosive GHS07: Harmful GHS08: Health hazard
GHS Signal word Danger
GHS hazard statements H226, H302, H312, H314, H317, H334
GHS precautionary statements P261, P280, P305+351+338, P310
NFPA 704 (fire diamond)
NFPA 704 four-colored diamond
330
Flash point 34 °C (93 °F; 307 K)[3]
Autoignition
temperature 385 °C (725 °F; 658 K)[3]
Explosive limits 2.7–16%
Lethal dose or concentration (LD, LC):
LD50 (median dose) 500 mg/kg (oral, rat)
470 mg/kg (oral, guinea pig)
1160 mg/kg (oral, rat)[5]
NIOSH (US health exposure limits):
PEL (Permissible) TWA 10 ppm (25 mg/m3)[4]
REL (Recommended) TWA 10 ppm (25 mg/m3)[4]
IDLH (Immediate danger) 1000 ppm[4]
Related compounds
Related alkanamines 1,2-Diaminopropane, 1,3-Diaminopropane
Related compounds Ethylamine, Ethylenedinitramine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Ethylene diamine (abbreviated as en when a ligand) is the organic compound with the formula C2H4(NH2)2. This colorless liquid with an ammonia-like odor is a strongly basic amine. It is a widely used building block in chemical synthesis, with approximately 500,000 tonnes produced in 1998.[6] Ethylene diamine readily reacts with moisture in humid air to produce a corrosive, toxic and irritating mist, to which even short exposures can cause serious damage to health (see safety). Ethylene diamine is the first member of the so-called polyethylene amines.
Synthesis
Ethylene diamine is produced industrially by treating 1,2-dichloroethane with ammonia under pressure at 180 °C in an aqueous medium:[6][7]
Ethylendiamin
In this reaction hydrogen chloride is generated, which forms a salt with the amine. The amine is liberated by addition of sodium hydroxide and can then be recovered by rectification [de]. Diethylenetriamine (DETA) and triethylenetetramine (TETA) are formed as by-products.
Another industrial route to Ethylene diamine involves the reaction of ethanolamine and ammonia:[8]
EDA synthesis
This process involves passing the gaseous reactants over a bed of nickel heterogeneous catalysts.
Ethylene diamine can be purified by treatment with sodium hydroxide to remove water followed by distillation.[9]
Applications
Ethylene diamine is used in large quantities for production of many industrial chemicals. It forms derivatives with carboxylic acids (including fatty acids), nitriles, alcohols (at elevated temperatures), alkylating agents, carbon disulfide, and aldehydes and ketones. Because of its bifunctional nature, having two amines, it readily forms heterocycles such as imidazolidines.
Precursor to chelation agents, drugs, and agrochemicals
A most prominent derivative of Ethylene diamine is the chelating agent EDTA, which is derived from Ethylene diamine via a Strecker synthesis involving cyanide and formaldehyde. HydroxyethylEthylene diamine is another commercially significant chelating agent.[6] Numerous bio-active compounds and drugs contain the N-CH2-CH2-N linkage, including some antihistamines.[10] Salts of ethylenebisdithiocarbamate are commercially significant fungicides under the brand names Maneb, Mancozeb, Zineb, and Metiram. Some imidazoline-containing fungicides are derived from Ethylene diamine.[6]
Pharmaceutical ingredientEthylene diamine is an ingredient in the common bronchodilator drug aminophylline, where it serves to solubilize the active ingredient theophylline. Ethylene diamine has also been used in dermatologic preparations, but has been removed from some because of causing contact dermatitis.[11] When used as a pharmaceutical excipient, after oral administration its bioavailability is about 0.34, due to a substantial first-pass effect. Less than 20% is eliminated by renal excretion.[12]
Ethylene diamine-derived antihistamines are the oldest of the five classes of first-generation antihistamines, beginning with piperoxan aka benodain, discovered in 1933 at the Pasteur Institute in France, and also including mepyramine, tripelennamine, and antazoline. The other classes are derivatives of ethanolamine, alkylamine, piperazine, and others (primarily tricyclic and tetracyclic compounds related to phenothiazines, tricyclic antidepressants, as well as the cyproheptadine-phenindamine family)
Role in polymersEthylene diamine, because it contains two amine groups, is a widely used precursor to various polymers. Condensates derived from formaldehyde are plasticizers. It is widely used in the production of polyurethane fibers. The PAMAM class of dendrimers are derived from Ethylene diamine.[6]
TetraacetylEthylene diamine
The bleaching activator tetraacetylEthylene diamine is generated from Ethylene diamine. The derivative N,N-ethylenebis(stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline and motor oil.
Other applications
as a solvent, it is miscible with polar solvents and is used to solubilize proteins such as albumins and casein. It is also used in certain electroplating baths.
as a corrosion inhibitor in paints and coolants.Ethylene diamine dihydroiodide (EDDI) is added to animal feeds as a source of iodide.
chemicals for color photography developing, binders, adhesives, fabric softeners, curing agents for epoxies, and dyes.
as a compound to sensitize nitromethane into an explosive. This mixture was used at Picatinny Arsenal during WWII, giving the nitromethane and Ethylene diamine mixture the nickname PLX, or Picatinny Liquid Explosive.
Coordination chemistryEthylene diamine is a well-known bidentate chelating ligand for coordination compounds, with the two nitrogen atoms donating their lone pairs of electrons when Ethylene diamine acts as a ligand. It is often abbreviated "en" in inorganic chemistry. The complex [Co(Ethylene diamine)3]3+ is an archetypical chiral tris-chelate complex. The salen ligands, some of which are used in catalysis, are derived from the condensation of salicylaldehydes and Ethylene diamine.
Related ligands
Related derivatives of Ethylene diamine include Ethylene diaminetetraacetic acid (EDTA), tetramethylEthylene diamine (TMEDA), and tetraethylEthylene diamine (TEEDA). Chiral analogs of Ethylene diamine include 1,2-diaminopropane and trans-diaminocyclohexane.
SafetyEthylene diamine, like ammonia and other low-molecular weight amines, is a skin and respiratory irritant. Unless tightly contained, liquid Ethylene diamine will release toxic and irritating vapors into its surroundings, especially on heating. The vapors react with moisture in humid air to form a characteristic white mist, which is extremely irritating to skin, eyes, lungs and mucus membranes.
Ethylene diamine appears as a clear colorless liquid with an ammonia-like odor. Flash point of 91°F and a melting point of 47°F. Corrosive to tissue. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Density 7.5 lb / gal. Used to make other chemicals and as a fungicide.
CAMEO Chemicals
Ethylene diamine is an alkane-alpha,omega-diamine in which the alkane is ethane. It has a role as a GABA agonist. It derives from a hydride of an ethane.
ChEBI
Ethylene diamine is an organic compound that is used as a building block for the production of many other chemical products. It is also used as an excipient in many pharmacological preparations such as creams. Notably, Ethylene diamine is a contact sensitizer capable of producing local and generalized reactions. Sensitivity to Ethylene diamine may be identified with a clinical patch test.
Molecular Weight of Ethylene diamine 60.1 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
XLogP3 -2 Computed by XLogP3 3.0 (PubChem release 2019.06.18)
Hydrogen Bond Donor Count of Ethylene diamine 2 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Hydrogen Bond Acceptor Count of Ethylene diamine 2 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Rotatable Bond Count of Ethylene diamine 1 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact Mass of Ethylene diamine 60.068748 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic Mass of Ethylene diamine 60.068748 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
Topological Polar Surface Area of Ethylene diamine 52 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Heavy Atom Count of Ethylene diamine 4 Computed by PubChem
Formal Charge of Ethylene diamine 0 Computed by PubChem
Complexity of Ethylene diamine 6 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Isotope Atom Count of Ethylene diamine 0 Computed by PubChem
Defined Atom Stereocenter Count of Ethylene diamine0 Computed by PubChem
Undefined Atom Stereocenter Count of Ethylene diamine 0 Computed by PubChem
Defined Bond Stereocenter Count of Ethylene diamine 0 Computed by PubChem
Undefined Bond Stereocenter Count of Ethylene diamine 0 Computed by PubChem
Covalently-Bonded Unit Count of Ethylene diamine 1 Computed by PubChem
Compound Is of Ethylene diamine Canonicalized Yes
Applications
Ethylene diamine is used in large quantities for production of many industrial chemicals. It forms derivatives with carboxylic acids (including fatty acids), nitriles, alcohols (at elevated temperatures), alkylating agents, carbon disulfide, and aldehydes and ketones. Because of its bifunctional nature, having two amines, it readily forms heterocycles such as imidazolidines.
Precursor to chelating agents
The most prominent derivative of Ethylene diamine is EDTA, which is derived from Ethylene diamine via a Strecker synthesis involving cyanide and formaldehyde. Hydroxyethylethyelenediamine is another commercially significant chelating agent. The salen ligands, derived from the condensation of salicald
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History
Saved
Communityehydes and Ethylene diamine, are popular chelating agents in the research laboratory although not commercially significant. [1]
Precursor to pharmaceuticals and agrichemicals
Numerous bio-active compounds contain the N-CH2-CH2-N linkage, including aminophylline and some antihistamines. [2] Salts of ethylenebisdithiocarbamate are commercially significant fungicides under the brandnames Maneb, Mancozeb, Zineb, and Metiram. Some imidazoline-containing fungicides are derived from Ethylene diamine. [1]
Role in polymers
Ethylene diamine, by virtue of its bifunctionality (i.e. it contains two reactive amines) is widely used in diverse polyester formulations. Condensates derived from formaldehyde are plasticizers. It is widely used in the production of polyurethane fibers. The PAMAM class of dendrimers are derived from Ethylene diamine. [1]
Tetraacetylethylenediam to
The bleaching activator tetraacetylEthylene diamine is generated from Ethylene diamine. The derivative N, N-ethylenebis (stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline and motor oil.
Specialized applications
as a solvent, it is miscible with polar solvents and is used to solubilize proteins such as albumins and casein. It is also used in certain electroplating baths
as a corrosion inhibitor in paints and coolants.
Ethylene diamine dihydroiodide (EDDI) is added to animal feeds as a source of iodide.
chemicals for color photography developing, binders, adhesives, fabric softeners, curing agents for epoxys, and dyes.
Coordination chemistry
Ethylene diamine is the prototypical chelating ligand for coordination compounds, such as [Co (Ethylene diamine) 3] 3+.
Ethylene diamine (most abbreviated containing a ligand) is an organic compound with the formula 2 C2H4 (NH2). This colorless liquid with an ammonia-like fragrance is a strong base amine. It is a building block widely used in chemical synthesis, under approximately 500,000 tons in 1998. Ethylene diamine is a corrosive, toxic and irritating mist by reacting; security can cause short damage (see Security).
Ethylene diamine (CAS # 000107-15-3, 1,2-diaminoethane) is the lowest molecular weight Ethylene diamine. It is a one-component product containing two primary nitrogen. It has an ammonia-like odor and is clear and colorless.
Applications
Ethylene diamine is used in large quantities for the production of most industrial chemicals. It consists of carboxylic acids (including fatty acids), nitriles, alcohols (at high temperatures), alkylating agents, carbon disulfide and aldehydes and derivatives with ketones. Due to their binary details, two amines are available, they have heterocycles such as imidazolidines.
Pioneer of chelation agents, medicines and agrochemicals
The most prominent derivative of Ethylene diamine is EDTA, which is derived from Ethylene diamine by Strecker synthesis containing cyanide and formaldehyde. HydroxyethylEthylene diamine is an important commercial chelating agent. Contains N-CH2-CH2-N bond. Salts of ethylenebisdithiocarbamate, commercial activity under the brands Maneb, Mancozeb, Zineb and Metiram are important fungicides. Some imidazoline-containing fungicides are non-specific from Ethylene diamine.
Pharmaceutical substance
Ethylene diamine is a substance that dissolves the active ingredient theophylline in aminophylline, the common sweating bronchodilator drug. Ethylene diamine is also necessary in dermatological preparations, but has been removed from some as it causes contact dermatitis. Using it as a pharmaceutical excipient, its bioavailability is about 0.34, some of the major first-pass effects. With the urinal excretion we expect less than 20% to be eliminated.
Participate in polymers
Ethylene diamine is a commonly used precursor for various polymers because it contains two amine groups. Capacitors derived from formaldehyde are plasticizers. It is widely applied from polyurethane fiber. Dendrimers are our species from PAMAM grade Ethylene diamine.
tetraacetylEthylene diaminedtpmp
The bleach activator tetraacetylEthylene diamine is produced from Ethylene diamine. Its derivative is N, N-ethylenebis (stearamide) (EBS), an important commercial release agent and a surfactant containing gasoline and engine oil.
Other applications
It can be mixed with polar solvents as a solvent and used to dissolve proteins such as albumin and caseins. It is also used in electroplating baths.
They are used as corrosion inhibitors in paints and coolants.
Ethylene diamine dihydroiodide (EDDI) is added to animal feed as a source of iodide.
Chemicals, binders, adhesives, fabric softeners, curing agents and dyes for epoxies.
APPLICATIONS
• Bleach activators
• Chelating agents
• Corrosion inhibitors
• Elastomeric fibers
• Fungicides
• Lubricating oils and fuel
• Mineral Processing Aids
• Medicine
• Plastic lubricants
• Polyamide Resins
• Tire Processing Products
• Textile Materials
• Urethane chemicals
Product Categories: Alpha, Omega-Alkanediamines; alpha-omega-Alkaned
iam days; alpha, omega-two function alkanes; Biochemistry; monofunctional and alpha, omega-two function alkanes; Reagents for Oligosaccharide Synthesis; Chemistry; organic amine; Bioactive Small Molecules; Building blocks; Cell Biology; Chemical Synthesis; E: Nitrogen Compounds; Organic Building Blocks; polyamines
Ethylene diamine (abbreviated as en when a ligand) is the organic compound with the formula C2H4 (NH2) 2. This colorless liquid with an ammonia-like odor is a strongly basic amine. It is a widely used building block in chemical synthesis, with approximately 500,000 tonnes produced in 1998. Ethylene diamine readily reacts with moisture in humid air to produce a corrosive, toxic and irritating mist, to which even short exposures can cause serious damage to health (see safety).
Ethylene diamine (CAS # 000107-15-3, 1,2- diaminoethane) is the lowest molecular weight Ethylene diamine. It is a single-component product with two primary nitrogens. It has an ammonia-like odor and is clear and colorless.
Applications
Ethylene diamine is used in large quantities for production of many industrial chemicals. It forms derivatives with carboxylic acids (including fatty acids), nitriles, alcohols (at elevated temperatures), alkylating agents, carbon disulfide, and aldehydes and ketones. Because of its bifunctional nature, having two amines, it readily forms heterocycles such as imidazolidines.
Precursor to chelation agents, drugs, and agrochemicals
A most prominent derivative of Ethylene diamine is the chelating agent EDTA, which is derived from Ethylene diamine via a Strecker synthesis involving cyanide and formaldehyde. HydroxyethylEthylene diamine is another commercially significant chelating agent. Numerous bio-active compounds and drugs contain the N-CH2-CH2-N linkage, including some antihistamines. Salts of ethylenebisdithiocarbamate are commercially significant fungicides under the brand names Maneb, Mancozeb, Zineb, and Metiram. Some imidazoline-containing fungicides are derived from Ethylene diamine.
Pharmaceutical ingredient
Ethylene diamine is an ingredient in the common bronchodilator drug aminophylline, where it serves to solubilize the active ingredient theophylline. Ethylene diamine has also been used in dermatologic preparations, but has been removed from some because of causing contact dermatitis. When used as a pharmaceutical excipient, after oral administration its bioavailability is about 0.34, due to a substantial first-pass effect. Less than 20% is eliminated by urinal excretion.
Role in polymers
Ethylene diamine, because it contains two amine groups, is a widely used precursor to various polymers. Condensates derived from formaldehyde are plasticizers. It is widely used in the production of polyurethane fibers. The PAMAM class of dendrimers are derived from Ethylene diamine.
Tetraacetylethylenediam to
The bleaching activator tetraacetylEthylene diamine is generated from Ethylene diamine. The derivative N, N-ethylenebis (stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline and motor oil.
Other applications
as a solvent, it is miscible with polar solvents and is used to solubilize proteins such as albumins and casein. It is also used in certain electroplating baths.
as a corrosion inhibitor in paints and coolants.
Ethylene diamine dihydroiodide (EDDI) is added to animal feeds as a source of iodide.
chemicals for color photography developing, binders, adhesives, fabric softeners, curing agents for epoxys, and dyes.
APPLICATIONS
• Bleach activators
• Chelating agents
• Corrosion inhibitors
• Elastomeric fibers
• Fungicides
• Lube oil and fuel additives
• Mineral processing aids
• Pharmaceuticals
• Plastic lubricants
• Polyamide resins
• Rubber processing additives
• Textile additives
• Urethane chemicals
Product Categories: Pharmaceutical Intermediates; alpha, omega-Alkanediamines; alpha, omega-Bifunctional Alkanes; Biochemistry; Monofunctional & alpha, omega-Bifunctional Alkanes; Reagents for Oligosaccharide Synthesis; Chemistry; organic amine; Bioactive Small Molecules; Building Blocks; Cell Biology; Chemical Synthesis; E; Nitrogen Compounds; Organic Building Blocks; Polyamines
SUMMARY
(EDTA) is an effective chelating agent and lubricant. EDTA is thought to chemically soften the root canal dentin, remove the smear layer and increase dentin permeability. It binds to the calcium ion in EDTA dentin to form water-soluble calcium chelates. It is recommended to use EDTA and NaOCl together in order to effectively remove the inorganic and organic components of the smear layer. This article discusses the use and effectiveness of EDA in endodontic treatment. The purpose of this review is to examine studies with EDA in endodontics