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Glycerol tripalmitate, also known as Palmitin or 1,2,3-Tripalmitoyl glycerol, comes from the fatty acid palmitic acid and is a triacylglycerol that contains palmitic acid at the sn-1, sn-2, and sn-3 positions and has been found in palm oil.
Glycerol tripalmitate inhibits glucose-stimulated insulin secretion and reduces viability of INS1 cells in a concentration-dependent manner.
Glycerol tripalmitate of 1,2,3-tripalmitoyl glycerol are elevated by greater than 5-fold in a rat model of diabetes induced by streptozotocin .
CAS Number: 555-44-2
Molecular Formula: C51H98O6
Molecular Weight: 807.32
EINECS Number: 209-098-1
Synonyms:Tripalmitin, Glycerol tripalmitate, Glyceryl tripalmitate, Tripalmitoylglycerol, Palmitic triglyceride, Tripalmitate, Triglyceryl palmitate, Glyceryl trihexadecanoate, Hexadecanoic acid, 1,2,3-propanetriyl ester, Palmitic acid triglycerin ester, tripalmitina, tripalmitine, 1,2,3-trihexadecanoyl-sn-glycerol, 2,3-di(hexadecanoyloxy)propyl hexadecanoate, 1,2,3-Propanetriol trihexadecanoate, Hexadecanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester, TG(16:0/16:0/16:0), 1,2,3-propanetriyl trihexadecanoate, Tripalmitoyl glycerol, tripalmitinum, tripalmitylglycerol, glycero-tripalmitate, Palmitic acid triglyceride, Propane-1,2,3-triyl tripalmitate, Tripalmitin [INN], Glycerin tripalmitate, Palmitin, tri-, 1,2,3-trihexadecanoyl-glycerol, propane-1,2,3-triyl trihexadecanoate, 1,3-bis(hexadecanoyloxy)propan-2-yl hexadecanoate, 1,2,3-trihexadecanoylglycerol, Triglyceride PPP, Glyceryltripalmitate, trihexadecanoylglycerol, PALMITIN;TRIPALMITIN(RG);Glyceryl tripalmitate,Glycerol tripalmitate, Tripalmitin;Tripalmitin 100mg [555-44-2];TRIHEXADECANOIN;TRIPALMITIN;1,2,3-propanetriyltri(hexadecanoate);1,2,3-tris-hexadecanoyloxy-propane
Glycerol tripalmitate has been used to form the lipid matrices of etoposide-incorporated nanoparticles.
Formulations containing Glycerol tripalmitate have been used in cosmetic products as thickening and skin-conditioning agents.
Glycerol tripalmitate is a triglyceride (triester of glycerol and palmitic acid) widely found in fats and oils and used in food, pharmaceutical, and cosmetic applications.
Glycerol tripalmitates chemical formula is C₅₁H₉₈O₆.
It belongs to the class of neutral lipids.
Chemically, glycerol tripalmitate consists of a glycerol backbone esterified with three molecules of palmitic acid (C16:0).
Glycerol tripalmitate contains long saturated hydrocarbon chains.
This structure gives it hydrophobic and lipid-like properties.
Glycerol tripalmitate appears as a white, waxy solid at room temperature.
Glycerol tripalmitate is insoluble in water but soluble in organic solvents and oils.
It has a neutral odor and taste.
Glycerol tripalmitate exhibits typical lipid behavior, forming solid fat structures due to its saturated fatty acid chains.
Glycerol tripalmitate has a relatively high melting point.
This contributes to its use in solid fat systems.
The compound is chemically stable under normal conditions, especially compared to unsaturated fats.
Glycerol tripalmitate is less prone to oxidation.
This improves shelf life.
It functions as an energy storage molecule in biological systems, similar to other triglycerides.
Glycerol tripalmitate can be metabolized to release energy.
This is important in nutrition.
Glycerol tripalmitate is used in food, cosmetics, and pharmaceuticals as a structuring and emollient agent.
Glycerol tripalmitate helps provide texture and stability.
This enhances product performance.
Glycerol tripalmitate is best described as a saturated triglyceride with waxy properties used for energy storage and as a structuring agent, especially in food and formulation systems.
Glycerol tripalmitate exhibits strong intermolecular van der Waals interactions due to its long saturated hydrocarbon chains.
These interactions promote tight molecular packing.
This contributes to its solid and crystalline nature.
The compound shows poor solubility in polar solvents but good compatibility with nonpolar systems, such as oils and hydrocarbons.
Glycerol tripalmitate readily mixes with other lipids.
This is important in formulation design.
Glycerol tripalmitate plays a role in fat crystallization and structuring behavior in multi-component lipid systems.
Glycerol tripalmitate can influence hardness and melting profiles.
This is critical in food and cosmetic products.
It contributes to controlled release properties in lipid-based delivery systems.
Active ingredients can be embedded within its matrix.
This supports pharmaceutical and cosmetic applications.
Melting point: 66–68 °C
Boiling point: 310–320°
Density: 0.8752 g/cm³ (70 ºC)
refractive index: nD80 1.43807
storage temp.: -20°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), Hexanes (Very Slightly)
form: Fine Crystalline Powder
color: White to almost white
biological source: synthetic (organic)
Merck: 14,9736
BRN: 1811188
Cosmetics Ingredients Functions: SKIN CONDITIONING; VISCOSITY CONTROLLING
InChIKey: PVNIQBQSYATKKL-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC
LogP: 21.615 (est)
Glycerol tripalmitate is a triglyceride derived from the fatty acid palmitic acid.
Glycerol tripalmitate has low reactivity under normal conditions, making it suitable for stable formulations.
It does not readily undergo chemical changes.
Glycerol tripalmitate can affect sensory properties, such as texture and mouthfeel in food products.
Glycerol tripalmitate provides firmness and body.
This enhances product quality.
Glycerol tripalmitate is often used in combination with other triglycerides to tailor melting behavior and consistency.
Blending allows adjustment of physical properties.
This supports formulation flexibility.
Because of its defined structure, it is useful in thermal and phase transition studies of lipids.
Glycerol tripalmitate provides predictable behavior under heating and cooling.
This aids research and development.
Glycerol tripalmitate is a highly stable, hydrophobic lipid with strong structuring, crystallization, and compatibility properties, making it valuable in food science, cosmetics, and pharmaceutical systems.
Glycerol tripalmitate is a fully saturated triglyceride, meaning all three fatty acid chains contain no double bonds.
This saturation leads to a more ordered molecular packing.
Glycerol tripalmitate contributes to its solid, crystalline nature.
The compound exhibits a relatively high melting point (~65–66 °C).
This makes it solid at room temperature.
Glycerol tripalmitate is commonly used in solid fat systems.
Glycerol tripalmitate can form different polymorphic crystal structures (α, β′, β forms).
These forms affect texture and stability.
Glycerol tripalmitate shows low susceptibility to oxidative rancidity due to the absence of unsaturation.
This enhances shelf life and stability.
Glycerol tripalmitate is more stable than unsaturated triglycerides.
Glycerol tripalmitate is hydrophobic and nonpolar, with no affinity for water.
It forms lipid phases rather than aqueous solutions.
This is typical for triglycerides.
Glycerol tripalmitate can undergo hydrolysis (lipolysis) to produce glycerol and palmitic acid.
This occurs enzymatically or under acidic/basic conditions.
It is important in digestion and processing.
Glycerol tripalmitate contributes to texture, hardness, and consistency in fat-containing systems.
It helps form solid or semi-solid structures.
This is important in food and cosmetic formulations.
Tripalmitin is often used as a model compound in lipid research.
It helps study crystallization, melting behavior, and fat polymorphism.
Glycerol tripalmitate is a stable, saturated triglyceride with defined melting and crystallization behavior, widely used in lipid science and formulation systems requiring solid fat structure.
Uses:
Glycerol tripalmitate is a triglyceride derived from Palmitic Acid (P144500), a common fatty acid found in plants and animals.
Glycerol tripalmitate is used in the preparation of solid lipid particles for oral delivery of drugs.
Glycerol tripalmitate is widely used in food products as a structuring fat.
Glycerol tripalmitate contributes to hardness, texture, and mouthfeel in products like chocolate and confectionery.
This improves product consistency and stability.
In chocolate and fat-based confectionery, it plays a role in fat crystallization and polymorphism control.
Glycerol tripalmitate helps achieve desired texture and snap.
This enhances product quality.
Glycerol tripalmitate is used in cosmetics and personal-care products as an emollient and structuring agent.
Glycerol tripalmitate improves skin feel and product texture.
This enhances formulation performance.
In pharmaceutical formulations, it is used in lipid-based delivery systems.
Glycerol tripalmitate helps encapsulate and control release of active ingredients.
This supports drug delivery applications.
Glycerol tripalmitate is applied in ointment and cream bases to provide consistency and stability.
It forms semi-solid structures.
This improves application properties.
In lipid research and food science, it is used as a model compound.
Glycerol tripalmitate helps study fat crystallization and phase behavior.
This supports scientific development.
Glycerol tripalmitate is used in nutritional products as a source of energy-rich lipids.
It provides fatty acids and caloric value.
This supports dietary formulations.
In processed foods, it helps stabilize fat blends and prevent phase separation.
Glycerol tripalmitate contributes to uniform texture.
This improves shelf life.
Glycerol tripalmitate is also used in wax-like formulations and specialty materials where solid lipid structure is required.
It provides firmness and stability.
Glycerol tripalmitate is used wherever solid fat structure, stability, texture control, and lipid-based delivery are required across food, cosmetic, pharmaceutical, and research applications.
Glycerol tripalmitate (tripalmitin) is used in bakery and processed food products to improve texture and structural integrity.
It contributes to firmness and stability in fat-containing formulations.
This enhances product quality.
In infant formula and specialized nutrition products, it can be included as a lipid component.
It provides a source of saturated fatty acids.
This supports controlled nutritional profiles.
Glycerol tripalmitate is applied in lipsticks and solid cosmetic sticks as a structuring agent.
It helps maintain shape and firmness.
This improves product stability and application.
In controlled-release pharmaceutical systems, it is used as a lipid matrix material.
Glycerol tripalmitate helps regulate the release of active ingredients over time.
This enhances therapeutic effectiveness.
Glycerol tripalmitate is used in suppositories and solid dosage forms.
Glycerol tripalmitate provides a stable lipid base.
This supports drug delivery.
In microencapsulation technologies, it serves as a carrier for active compounds.
Glycerol tripalmitate protects sensitive ingredients.
This improves stability and shelf life.
Glycerol tripalmitate is applied in fat blends and margarine-type products to adjust melting behavior.
It helps tailor hardness and spreadability.
This supports product formulation.
In coatings for food and pharmaceuticals, it can act as a barrier material.
Glycerol tripalmitate reduces moisture transfer and oxidation.
This improves product stability.
Glycerol tripalmitate is also used in laboratory and analytical studies for investigating lipid phase transitions and crystallization.
It provides a well-defined system.
Glycerol tripalmitate is used wherever solid lipid structure, controlled release, texture enhancement, and stability are required across food, cosmetic, pharmaceutical, and scientific applications.
Safety Profile:
Glycerol tripalmitate is generally considered to have low hazard potential, as it is a common lipid found in food and biological systems.
Glycerol tripalmitate is widely regarded as safe under normal use conditions.
However, standard handling precautions are still recommended in industrial settings.
Skin contact is typically non-irritating, but prolonged exposure to melted or processed material may cause mild irritation in sensitive individuals.
Glycerol tripalmitate is generally well tolerated.
Basic protective measures are sufficient.
Eye contact may cause mild mechanical irritation, especially if particles or melted material enter the eye.
Symptoms can include redness and discomfort.
Eyes should be rinsed with water if exposure occurs.
Inhalation risk is generally low, but dust from powdered forms may cause mild respiratory irritation.
Symptoms can include coughing or throat irritation.
Adequate ventilation and dust control are recommended.
Ingestion is considered safe at typical dietary levels, as it is a triglyceride similar to dietary fats.
Excessive intake may contribute to caloric overload.
Glycerol tripalmitate is not toxic under normal conditions.
Glycerol tripalmitateis not highly flammable, but like other fats, it can burn at elevated temperatures.
