HEXAMETHYLENE TETRAMINE

CAS NO:100-97-0  
EC NO:202-905-8  

Synonyms:
HMTA; E239; Carin; Uramin; Urisol; FORMIN; Hexa B; ekagomh; Heterin; Hexamin; 1,3,5,7- Tetraazaadamantane; Ammonioformaldehyde; Aceto HMT; Aminoform; Ammoform; Cystamin; Cystogen; Esametilentetramina (Italian); Formamine; Formin; Hexaform; Hexamethylenamine; Urotropin; Hexamethyleneamine; Hexamethylenetetraamine; Hexamethylentetramin (German); Hexamethylentetramine; Hexilmethylenamine; HMT; Methamin; Methenamine; Resotropin; Uritone; Urotropine; Esametilentetramina (Italian); 1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane; HEKZAMETİLEN TETRAMİN, HEXAMETİLEN TETRAMİN; hekzametilen tetramin; heksametilen tetramin; hexamın; hexamin; hexamine; hexamıne; HEXAMIN; HEXAMİN; HEXAMİNE; HEXAMINE; HMTA; E239; Carin; Uramin; Urisol; FORMIN; Hexa B; ekagomh; Heterin; Hexamin; 1,3,5,7- Tetraazaadamantane; Ammonioformaldehyde; Aceto HMT; Aminoform; Ammoform; Cystamin; Cystogen; Esametilentetramina (Italian); Formamine; Formin; Hexaform; Hexamethylenamine; Urotropin; Hexamethyleneamine; Hexamethylenetetraamine; Hexamethylentetramin (German); Hexamethylentetramine; Hexilmethylenamine; HMT; Methamin; Methenamine; Resotropin; Uritone; Urotropine; Esametilentetramina (Italian); 1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane; HEKZAMETİLEN TETRAMİN, HEXAMETİLEN TETRAMİN; hekzametilen tetramin; heksametilen tetramin; hexamın; hexamin; hexamine; hexamıne; HEXAMIN; HEXAMİN; HEXAMİNE; HEXAMINE; heksametilen, tetramin; hekzametilen, tetramin.; Hexamethylene tetramin; Hexamethylene tetramine; Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine;Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Hexamethylene tetramine; Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine;Hexamethylene tetramine; Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine; ; Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine; HEKZAMETİLEN TETRAMİN ; Hekzametilen Tetramin; heksametilen, tetramin; hekzametilen, tetramin.; Hexamethylene tetramin; Hexamethylene tetramine; Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine;Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Hexamethylene tetramine; Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine;Hexamethylene tetramine; Hexamethylene tetramine;Hexa methylenetetramine ;Hexa methylene tetramine;Hexa methylene tetra amine; Hexamethylenetetramine; methenamine; methen amine; HEKZAMETİLEN TETRAMİN ;Hekza metilen Tetramin ; Hekzametilen Tetra amin; Hekza metilen Tetra amin ;Hekzametilen Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine; ; Tetramine; Hekza metilen Tetramine;  Hekza metilen Tetra amine; méthénamine ; methenamin; methenamine; metenamin; meten amine; HEKZAMETİLEN TETRAMİN ; Hekzametilen Tetramin
 

HEXAMETHYLENE TETRAMİNE

Hexamethylene tetramine

Hexamethylene tetramine
Hexamine.svg
Hexamine-3D-balls.png
Names
IUPAC name
1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane
Other names
Hexamine; Hexamethylene tetramine;
Urotropine; 1,3,5,7- tetraazaadamantane, Formin, Aminoform
Identifiers of Hexamethylene tetramine
CAS Number of Hexamethylene tetramine    
100-97-0 ☑
3D model (JSmol)    
Interactive image
Beilstein Reference    2018
ChEBI    
CHEBI of Hexamethylene tetramine:6824 ☑
ChEMBL    
ChEMBL1201270 ☑
ChemSpider    
3959 ☑
DrugBank    
DB06799
ECHA InfoCard    100.002.642
EC Number of Hexamethylene tetramine    
202-905-8
E number of Hexamethylene tetramine    E239 (preservatives)
Gmelin Reference of Hexamethylene tetramine    26964
KEGG    
D00393 ☑
MeSH of Hexamethylene tetramine    Hexamethylene tetramine
PubChem CID    
4101
UNII    
J50OIX95QV ☑
CompTox Dashboard (EPA)    

InChI[show] of Hexamethylene tetramine
SMILES[show] of Hexamethylene tetramine
Properties of Hexamethylene tetramine
Chemical formula of Hexamethylene tetramine    C6H12N4
Molar mass of Hexamethylene tetramine    140.186 g/mol
Appearance of Hexamethylene tetramine    White crystalline solid
Odor of Hexamethylene tetramine    Fishy, ammonia like
Density of Hexamethylene tetramine    1.33 g/cm3 (at 20 °C)
Melting point of Hexamethylene tetramine    280 °C (536 °F; 553 K) (sublimes)
Solubility of Hexamethylene tetramine in water    85.3 g/100 mL
Solubility    Soluble in chloroform, methanol, ethanol, acetone, benzene, xylene, ether
Solubility of Hexamethylene tetramine in chloroform    13.4 g/100 g (20 °C)
Solubility  of Hexamethylene tetramine in methanol    7.25 g/100 g (20 °C)
Solubility of Hexamethylene tetramine in ethanol    2.89 g/100 g (20 °C)
Solubility  of Hexamethylene tetramine in acetone    0.65 g/100 g (20 °C)
Solubility of Hexamethylene tetramine  in benzene    0.23 g/100 g (20 °C)
Acidity  of Hexamethylene tetramine(pKa)    4.89[1]
Pharmacology of Hexamethylene tetramine
ATC code    J01XX05 (WHO)
Hazards
Main hazards    Highly combustible, harmful
GHS pictograms    GHS02: Flammable GHS07: Harmful
GHS Signal word    Warning
GHS hazard statements    H228, H317
GHS precautionary statements    P210, P240, P241, P261, P272, P280, P302+352, P321, P333+313, P363, P370+378, P501
NFPA 704 (fire diamond)    
NFPA 704 four-colored diamond
321
Flash point    250 °C (482 °F; 523 K)
Autoignition
temperature    410 °C (770 °F; 683 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Hexamethylene tetramine or Hexamethylene tetramine, also known as hexamine or urotropin, is a heterocyclic organic compound with the formula (CH2)6N4. This white crystalline compound is highly soluble in water and polar organic solvents.  Hexamethylene tetramine has a cage-like structure similar to adamantane. It is useful in the synthesis of other chemical compounds, e.g., plastics, pharmaceuticals, rubber additives. It sublimes in vacuum at 280 °C.

Synthesis, structure, reactivity
Hexamethylene tetramine was discovered by Aleksandr Butlerov in 1859.[2][3] It is prepared industrially by combining formaldehyde and ammonia.[4] The reaction can be conducted in gas phase and in solution.

Synthesis Hexamethylene tetramine
The molecule has a symmetric tetrahedral cage-like structure, similar to adamantane, whose four "corners" are nitrogen atoms and "edges" are methylene bridges. Although the molecular shape defines a cage, no void space is available at the interior for binding other atoms or molecules, unlike crown ethers or larger cryptand structures.

The molecule behaves like an amine base, undergoing protonation and N-alkylation (e.g. Quaternium-15).

Applications of Hexamethylene tetramine
The dominant use of Hexamethylene tetramine is in the production of powdery or liquid preparations of phenolic resins and phenolic resin moulding compounds, where it is added as a hardening component. These products are used as binders, e.g. in brake and clutch linings, abrasive products, non-woven textiles, formed parts produced by moulding processes, and fireproof materials.[4]

Hexamethylene tetramine has been proposed that Hexamethylene tetramine could work as a molecular building block for self-assembled molecular crystals.[5][6]

Medical uses of Hexamethylene tetramine
As the mandelic acid salt (generic Hexamethylene tetramine mandelate, USP[7]) it is used for the treatment of urinary tract infection. It decomposes at an acidic pH to form formaldehyde and ammonia, and the formaldehyde is bactericidal; the mandelic acid adds to this effect. Urinary acidity is typically ensured by co-administering vitamin C (ascorbic acid) or ammonium chloride. Its use had temporarily been reduced in the late 1990s, due to adverse effects, particularly chemically-induced hemorrhagic cystitis in overdose,[8] but its use has now been re-approved because of the prevalence of antibiotic resistance to more commonly used drugs. This drug is particularly suitable for long-term prophylactic treatment of urinary tract infection, because bacteria do not develop resistance to formaldehyde. It should not be used in the presence of chronic kidney disease.

Hexamethylene tetramine in the form of cream and spray is successfully used for treatment of excessive sweating and concomitant odor.[medical citation needed]

Histological stains
Hexamethylene tetramine silver stains are used for staining in histology, including the following types:

Grocott's Hexamethylene tetramine silver stain, used widely as a screen for fungal organisms.
Jones' stain, a Hexamethylene tetramine silver-Periodic acid-Schiff that stains for basement membrane, availing to view the "spiked" Glomerular basement membrane associated with membranous glomerulonephritis.
Solid fuel
Together with 1,3,5-trioxane, Hexamethylene tetramine is a component of hexamine fuel tablets used by campers, hobbyists, the military and relief organizations for heating camping food or military rations. It burns smokelessly, has a high energy density of 30.0 megajoules per kilogram (MJ/kg), does not liquify while burning, and leaves no ashes, although its fumes are toxic.

Standardized 0.149 g tablets of Hexamethylene tetramine (hexamine) are used by fire-protection laboratories as a clean and reproducible fire source to test the flammability of carpets and rugs.[9]

Food additive
Hexamethylene tetramine or hexamine is also used as a food additive as a preservative (INS number 239). It is approved for usage for this purpose in the EU,[10] where it is listed under E number E239, however it is not approved in the USA, Russia, Australia, or New Zealand.[11]

Reagent in organic chemistry
Hexamethylene tetramine is a versatile reagent in organic synthesis.[12] It is used in the Duff reaction (formylation of arenes),[13] the Sommelet reaction (converting benzyl halides to aldehydes),[14] and in the Delepine reaction (synthesis of amines from alkyl halides).[15]

Explosives of Hexamethylene tetramine
Hexamethylene tetramine is the base component to produce RDX and, consequently, C-4[4] as well as Octogen, hexamine dinitrate, hexamine diperchlorate and HMTD.

Historical uses of Hexamethylene tetramine
Hexamethylene tetramine was first introduced into the medical setting in 1899 as a urinary antiseptic.[16] However, it was only used in cases of acidic urine, whereas boric acid was used to treat urinary tract infections with alkaline urine.[17] Scientist De Eds found that there was a direct correlation between the acidity of Hexamethylene tetramine's environment and the rate of its decomposition.[16] Therefore, its effectiveness as a drug depended greatly on the acidity of the urine rather than the amount of the drug administered.[17] In an alkaline environment, Hexamethylene tetramine was found to be almost completely inactive.[17]

Hexamethylene tetramine was also used as a method of treatment for soldiers exposed to phosgene in World War I. Subsequent studies have shown that large doses of Hexamethylene tetramine provide some protection if taken before phosgene exposure but none if taken afterwards.[18]

Producers
Since 1990 the number of European producers has been declining. The French SNPE factory closed in 1990; in 1993, the production of Hexamethylene tetramine in Leuna, Germany ceased; in 1996, the Italian facility of Agrolinz closed down; in 2001, the UK producer Borden closed; in 2006, production at Chemko, Slovak Republic, was closed. Remaining producers include INEOS in Germany, Caldic in the Netherlands, and Hexion in Italy. In the US, Eli Lilly and Company stopped producing Hexamethylene tetramine tablets in 2002.[9] In Australia, Hexamine Tablets for fuel are made by Thales Australia Ltd. In México, Hexamine is produced by Abiya.

Properties of Hexamethylene tetramine
Related Categoriesof Hexamethylene tetramine    Building Blocks, Chemical Synthesis, Nitrogen Compounds - Organic Building Blocks, Organic Building Blocks, Polyamines Less...
Quality Levelof Hexamethylene tetramine      200
gradeof Hexamethylene tetramine      ACS reagent
vapor pressure of Hexamethylene tetramine     <0.01 mmHg ( 20 °C)
assayof Hexamethylene tetramine      ≥99.0%
autoignition temp.of Hexamethylene tetramine      770 °F
ign. residueof Hexamethylene tetramine      ≤0.1%
loss of Hexamethylene tetramine     ≤2.0% loss on drying

Description of Hexamethylene tetramine
General description of Hexamethylene tetramine
Hexamethylene tetramine (HMTA) is a water soluble, heterocyclic organic compound with a cage-like structure resembling adamantane.[1]  Hexamethylene tetramine is commonly used in treating urinary tract infection.[2]

Application of Hexamethylene tetramine
Hexamethylene tetramine (HMTA) may be used as:
• Raw material in the synthesis of blue emitting boron carbon oxynitride (BCNO) phosphors[3] and Zinc oxide (ZnO) nanorods.[6]
• Catalyst in the synthesis of 2-amino-4H-pyran derivatives.[1]
• Surfactant in the synthesis of HMTA capped transition metals doped ZnS nanoparticles.[4]
• Precipitant and template in the synthesis of Ni(OH)2.[5

 Reactions of Hexamethylene tetramine
The chemistry of hexamethylene tetramine, or hexamine (70), has been reviewed thoroughly 〈B-61MI22000, p. 688, 59HC(13)1,p.545, 79S161〉. The discussion below summarizes these reviews. Hexamethylene tetramine has a symmetrical adamantane-like structure, and is quite stable. Hexamethylene tetramine is hydrolyzed by hot mineral acid to formaldehyde and the appropriate ammonium salt, but in cold dilute organic or mineral acid it forms salts. Hexamethylene tetramine is reduced to ammonia and formaldehyde in zinc and mineral acid. Quaternary salts (71) are formed by treatment of hexamine with alkyl halides. These salts are valuable synthetic reagents which may be used to prepare amines, imines and aldehydes (Scheme 48) and to effect ring closure.

Computed Properties    HelpNew Window
Property Name    Property Value    Reference
Molecular Weight of Hexamethylene tetramine     140.19 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
XLogP3-AA    0.3    Computed by XLogP3 3.0 (PubChem release 2019.06.18)
Hydrogen Bond Donor Count of Hexamethylene tetramine     0    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Hydrogen Bond Acceptor Count of Hexamethylene tetramine     4    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Rotatable Bond Count of Hexamethylene tetramine     0    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact Mass of Hexamethylene tetramine     140.106196 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic Mass of Hexamethylene tetramine     140.106196 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Topological Polar Surface Area of Hexamethylene tetramine     13 Ų    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Heavy Atom Count of Hexamethylene tetramine     10    Computed by PubChem
Formal Charge of Hexamethylene tetramine     0    Computed by PubChem
Complexity of Hexamethylene tetramine     84.8    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Isotope Atom Count of Hexamethylene tetramine     0    Computed by PubChem
Defined Atom Stereocenter Count of Hexamethylene tetramine     0    Computed by PubChem
Undefined Atom Stereocenter Count of Hexamethylene tetramine     0    Computed by PubChem
Defined Bond Stereocenter Count of Hexamethylene tetramine     0    Computed by PubChem
Undefined Bond Stereocenter Count of Hexamethylene tetramine     0    Computed by PubChem
Covalently-Bonded Unit Count of Hexamethylene tetramine     1    Computed by PubChem
Compound  of Hexamethylene tetramine Is Canonicalized    Yes

Physical Description    
Hexamethylene tetramine appears as odorless white crystalline powder or colorless lustrous crystals. Sublimes in a vacuum at about 505° F with some decomposition. Solutions are strong bases

Product Description
Hexamethylene tetramine

Application Notes of  Hexamethylene tetramine
Hexamethylene tetramine is used for amino acid preparation. Hexamethylene tetramine is also used in synthesis as a formylation agent and is employed in preparing specialized materials. Hexamethylene tetramine is also used as a precipitating agent.Hexamethylenetetramine (HMTA) may be used as:
• Raw material in the synthesis of blue emitting boron carbon oxynitride (BCNO) phosphors and Zinc oxide (ZnO) nanorods.
• Catalyst in the synthesis of 2-amino-4H-pyran derivatives.
• Surfactant in the synthesis of HMTA capped transition metals doped ZnS nanoparticles.
• Precipitant and template in the synthesis of Ni(OH)2.

Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications
Formylation agent | Amino acid preparation

Hexamethylenetetramine or methenamine is a heterocyclic organic compound with the formula (CH2)6N4. This white crystalline compound is highly soluble in water and polar organic solvents. It has a cage-like structure similar to adamantane. It is useful in the synthesis of other chemical compounds, e.g., plastics, pharmaceuticals, rubber additives. It sublimes in vacuum at 280 °C.

Applications
The dominant use of hexamethylenetetramine is in the production of powdery or liquid preparations of phenolic resins and phenolic resin moulding compounds, where it is added as a hardening component. These products are used as binders, e.g. in brake and clutch linings, abrasive products, non-woven textiles, formed parts produced by moulding processes, and fireproof materials.

It has been proposed that hexamethylenetetramine could work as a molecular building block for self-assembled molecular crystals.

Medical uses
As the mandelic acid salt (generic methenamine mandelate, USP) it is used for the treatment of urinary tract infection. It decomposes at an acidic pH to form formaldehyde and ammonia, and the formaldehyde is bactericidal; the mandelic acid adds to this effect. Urinary acidity is typically ensured by co-administering vitamin C (ascorbic acid) or ammonium chloride. Its use had temporarily been reduced in the late 1990s, due to adverse effects, particularly chemically-induced hemorrhagic cystitis in overdose, but its use has now been re-approved because of the prevalence of antibiotic resistance to more commonly used drugs. This drug is particularly suitable for long-term prophylactic treatment of urinary tract infection, because bacteria do not develop resistance to formaldehyde. It should not be used in the presence of renal insufficiency. Methenamine in the form of cream and spray is successfully used for treatment of excessive sweating and concomitant odour.

Histological stains
Methenamine silver stains are used for staining in histology, including the following types:

Grocott's methenamine silver stain, used widely as a screen for fungal organisms.
Jones' stain, a methenamine silver-Periodic acid-Schiff that stains for basement membrane, availing to view the "spiked" Glomerular basement membrane associated with membranous glomerulonephritis.
Solid fuel
Together with 1,3,5-trioxane, hexamethylenetetramine is a component of hexamine fuel tablets used by campers, hobbyists, the military and relief organizations for heating camping food or military rations. It burns smokelessly, has a high energy density of 30.0 megajoules per kilogram (MJ/kg), does not liquify while burning, and leaves no ashes.

Standardized 0.149 g tablets of methenamine (hexamine) are used by fire-protection laboratories as a clean and reproducible fire source to test the flammability of carpets and rugs.

Food additive
Hexamethylene tetramine or hexamine is also used as a food additive as a preservative (INS number 239). It is approved for usage for this purpose in the EU, where it is listed under E number E239, however it is not approved in the USA, Russia, Australia, or New Zealand.

Reagent in organic chemistry
Hexamethylenetetramine is a versatile reagent in organic synthesis. It is used in the Duff reaction (formylation of arenes), the Sommelet reaction (converting benzyl halides to aldehydes), and in the Delepine reaction (synthesis of amines from alkyl halides).

Explosives
Hexamethylenetetramine is the base component to produce RDX and, consequently, C-4as well as Octogen, hexamine dinitrate and HMTD.

Application
Hexamethylenetetramine (HMTA) may be used as:
• Raw material in the synthesis of blue emitting boron carbon oxynitride (BCNO) phosphors and Zinc oxide (ZnO) nanorods.
• Catalyst in the synthesis of 2-amino-4H-pyran derivatives.
• Surfactant in the synthesis of HMTA capped transition metals doped ZnS nanoparticles.
• Precipitant and template in the synthesis of Ni(OH)2

It can be used as the curing agent for resins and plastics, the vulcanization accelerator of rubber (accelerator H) and textiles shrink-proof agent. It can also be used for making antibacterial drug, explosives and so on. As medicine, after oral administration, it can be decomposed when coming across acidic urine to generate formaldehyde and exerts its antibacterial effect used for treating mild urinary tract infection; it can be externally used for treating ringworm, antiperspirants, and treatment of underarm odor. Its being mixed with caustic soda and sodium phenol can be used as the phosgene absorber of gas masks. 
It can be used as a kind of anti-microbial agents. 
It can be used as anti-shrinking textile finishing agent, bleaching agents of sodium chlorite and the buffer of waterproofing agents CR.
Hexamethylenetetramine is mainly used as the curing agent of plastic and resin, the catalyst and foaming agent of aminoplast, rubber vulcanization accelerator (accelerator H), and the shrink-proof agents of textiles. Hexamethylenetetramine is the raw material for organic synthesis and can be used for the production of chloramphenicol in the pharmaceutical industry. Hexamethylenetetramine can be used as the disinfectant of urinary system with itself having no antibacterial effect and being effective in treating gram-negative bacteria. Its 20% solution can be used for the treatment of underarm odor, sweaty feet, tinea and so on. Its being mixed with caustic soda and sodium phenol can be used as the phosgene absorber of gas masks. It can also be used for the manufacture of pesticides. Hexamethylenetetramine can react with fuming nitric acid to obtain highly explosive cyclonite, briefly referred as RDX. Hexamethylenetetramine can be used as the reagent and chromatography reagents for determination of bismuth, indium, manganese, cobalt, thorium, platinum, producing magnesium, lithium, copper, uranium, beryllium, tellurium, bromide, and iodide.
In the liver function tests, it can be used for formulating thymol turbidity, test and measurement of object such as bismuth, iron, manganese, cobalt, thorium, platinum and magnesium as well as the determination and identification of lithium, iron cyanide, iron bromide and iodide. It can also be used for the determination of copper, uranium, beryllium, tellurium etc. Moreover, it can be used as gas chromatography fixed solution (maximum usage temperature of 180 ℃ with the solvent being chloroform).
HEXAMINE is also useful in adhesives, coatings, and sealing compounds. In medicine, it is an antibacterial agent. It is used as a dye fixative and in the preservation of hides. It is used in vulcanizing rubber and as an anti-corrosive agent in steel. It is used in the detection of metals and in the absorption of poisonous gases. It stabilizes lubricating and insulating oils. It is sometimes burned in camping stoves, because it burns without smoke.