PRODUCTS

OCTYL GALLATE

EC / List no.: 213-853-0
CAS no.: 1034-01-1
Mol. formula: C15H22O5

Octyl gallate is the ester of 1-octanol and gallic acid.
As a food additive, it is used under the E number E311 as an antioxidant and preservative.

Properties
Octyl gallate is a white powder with a characteristic odor.
Propyl gallate is very slightly soluble in water and soluble in alcohol.
Its solubility in lard is 1.1%.
Octyl gallate darkens in the presence of iron.

Uses
This antioxidant is used in numerous pharmaceutical, cosmetic, and food products; such as soaps, shampoos, shaving soaps, skin lotions, deodorants, margarine, and peanut butter.

Propyl gallate is a synergistic antioxidant with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA).

Octyl gallate is a gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.
Propyl gallate has a role as a food antioxidant, a plant metabolite and a hypoglycemic agent.

Where is octyl gallate found?
Octyl gallate is a food additive, preservative, and antioxidant.
Propyl gallate is found primarily in the food and cosmetics industry.

General description
Octyl gallate (3,4,5-trihydroxybenzoate) is reported to possess antifungal activity against Saccharomyces cerevisiae and Zygosaccharomyces bailii.
The fungicidal activity associated with octyl gallate is due to its ability to act as a nonionic surface-active agent (surfactant).
Octyl gallate, an alkyl gallate, is reported to exhibit direct antibacterial activity against Staphylococcus aureus BB568.
Propyl gallate is reported to inhibit the activity of soybean lipoxygenase-1 (EC 1.13.11.12, type I) with an IC50 of 1.3μM.
Propyl gallate is also effective in preventing lipid peroxidation.
Application
Octyl gallate was used in a study to investigate the self-assembly in two comb-shaped supramolecules systems consisting of octyl gallate, hydrogen bonded to the pyridine groups of polyisoprene-block-poly(vinylpyridine) diblock copolymers using synchrotron radiation.

What is Octyl gallate and where is it found?
This chemical is used as an antioxidant and can be found in cosmetic and pharmaceutical products as well as in food products such as margarine and peanut butter.
Further research may identify additional product or industrial usages of this chemical.

What else is Octyl gallate called?
This chemical can be identified by different names, including: 3,4,5-Trihydroxybenzoic acid, octyl ester, C6H2(OH)3COOC8H17 E-311, Gallic acid, octyl ester, Octyl 3,4,5-trihydroxybenzoate

1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive.
2. Octyl Gallate has antimetastatic activity.
3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug/mL.
4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.
5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM.
6. Octyl gallate has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells.
7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.

Octyl gallate, also known as octyl gallic acid, belongs to the class of organic compounds known as galloyl esters.
These are organic compounds that contain an ester derivative of 3,4,5-trihydroxybenzoic acid. Octyl gallate is a secondary metabolite.
Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules.
In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites.
Based on a literature review a significant number of articles have been published on Octyl gallate.

Octyl gallate is the ester formed by 1-octanol and gallic acid.
Octyl gallate can be used as an antioxidant and preservative to be supplemented to the food.
Octyl gallate has been demonstrated to be an effective fungicide being capable of inhibiting the growth of S. cerevisiae and Z. bailii as it can inhibit the fluidity of the cell membrane through acting as a nonionic surface-active agent.
Octyl gallate is also capable of killing both DNA and RNA viruses with a relatively moderate cytotoxicity.
For example, it has the potential to treat influenza.
Octyl gallate also has certain bactericidal activity, being capable of treating the infections associated with enterococci.

During the 1940s, propyl gallate and several other alkyl gallates were allowed for use in foods in a number of countries.
Since gallic acid contains three phenolic hydroxyl groups, it is a rather potent antioxidant; however, the propyl ester has a significant degree of water solubility.
As a consequence, propyl gallate tends to partition into any water phase which may be present and to complex with iron salts to give bluish black colors.
Also, its relatively poor resistance to heat degradation makes it ineffective for baking and frying applications.
The higher alkyl gallates (butyl and octyl) are more fat soluble.

Uses:
Octyl gallate Used in treatment of alcohol dependence.
Octyl gallate is an antioxidant that is used as a preservation agent in a wide variety of foods, oils, and cosmetics.
Octyl gallate is an antioxidant for use in cosmetic and pharmaceutical products and in food products, such as margarine and peanut butter.

Octyl gallate is an antioxidant and preservative in food, pharmaceuticals, and cosmetic products, especially those containing oils or fats.

Octyl gallate uses in Foods
Octyl gallate uses in Broths, instant soups and gravies
Octyl gallate uses in Octyl gallate Instant potato products
Octyl gallate uses in Crisp wheat products
Octyl gallate uses in Marzipan mass and marzipan like products
Octyl gallate uses in Chewing gum
Octyl gallate uses in Flavoring agents, e.g. essential oils
Octyl gallate uses in Margarine
Octyl gallate uses in Peanut butter
Octyl gallate uses in Fats
Octyl gallate uses in Soups
Octyl gallate uses in Sauces
Octyl gallate uses in Cakes
Octyl gallate uses in Pastries
Octyl gallate uses in Dairy blends
Octyl gallate uses in Medicines
Octyl gallate uses in Skin Care Products / Cosmetics
Octyl gallate uses in Antiperspirants / Deodorants
Octyl gallate uses in Hair sprays, gels, tonics and lotions
Octyl gallate uses in Make-ups
Octyl gallate uses in Moisturizers
Octyl gallate uses in Shampoos / Conditioners
Octyl gallate uses in Shaving products
Octyl gallate uses in Soaps / Cleansers
Octyl gallate uses in Sunscreens and Self-Tanners

Other names for Octyl Gallate:
Octyl ester of gallic acid
Octyl 3.4,5-trihydroxybenzoate
E311
Gallic acid, octyl ester
n-Octyl gallate

Formula of Octyl gallate : C15H22O5
Formula Weight of Octyl gallate: 282.34
Melting point of Octyl gallate: 96-102°

Octyl gallate is the ester of 1-octanol and gallic acid.
As a food additive, it is used under the E number E311 as an antioxidant and preservative.

Octyl gallate (Progallin O) is widely used as a food additive, with antimicrobial and antioxidant activity.
Octyl gallate (Progallin O) shows selective and sensitive fluorescent property.

Properties
Octyl gallate is a white powder with a characteristic odor.
Octyl gallate is very slightly soluble in water and soluble in alcohol.
Its solubility in lard is 1.1%.
Octyl gallate darkens in the presence of iron.

Uses of Octyl gallate
This antioxidant is used in numerous pharmaceutical, cosmetic, and food products; such as soaps, shampoos, shaving soaps, skin lotions, deodorants, margarine, and peanut butter.

Octyl gallate is a synergistic antioxidant with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA).

Octyl gallate (n-octyl ester of 3,4,5-trihydroxybenzoic acid) is a white to creamy-white coloured, odourless solid, insoluble in water, soluble in ethanol and in fat, with a slightly bitter taste, used as an anti-oxidant in processed foods.

Functions:
1. Antioxidant - Reduces oxidation to prevent the formation of free radicals which may be harmful to health.
2. Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful
Octyl gallate is used under the E number 311 as an antioxidant and preservative.
This antioxidant is used in numerous cosmetics and pharmaceutical, cosmetic, and food products such as soaps, shampoos, shaving soaps, skin lotions, deodorants, oil, margarine, salad dressings and peanut butter.
Octyl gallate is approved to use as food additive in the US.
Octyl gallate is not approved to use as food additive (E311) in EU.

Description
Octyl gallate is an antioxidant used in margarine Octyl gallate has been shown to exhibit anti-viral function.

Compound Type
Ester
Ether
Food Toxin
Metabolite
Organic Compound
Synthetic Compound

Description
belongs to the class of organic compounds known as galloyl esters.
These are organic compounds that contain an ester derivative of 3,4,5-trihydroxybenzoic acid.

IUPAC NAMES
n-Octyl Gallate
Octyl 3,4,5-trihydroxybenzoate
octyl 3,4,5-trihydroxybenzoate

SYNONYMS:
Octyl gallate
1034-01-1
Octyl 3,4,5-trihydroxybenzoate
n-Octyl gallate
Progallin O
Stabilizer GA 8
n-Octylgallate
Gallic acid octyl ester
Gallic acid, octyl ester
Gallic acid n-octyl ester
BENZOIC ACID, 3,4,5-TRIHYDROXY-, OCTYL ESTER
Oktylester kyseliny gallove
GA 8 (VAN)
NSC 97419
n-Octyl ester of 3,4,5-trihydroxybenzoic acid
UNII-079IIA2811
E311
CHEMBL277346
GA 8
CHEBI:83631
079IIA2811
Oktylester kyseliny gallove [Czech]
EINECS 213-853-0
BRN 2132305
Gallic acid octyl
Stabilizer GA-8
Gallic acid-octyl ester
Gallic acid n-octyl-ester
SCHEMBL36234
4-10-00-02005 (Beilstein Handbook Reference)
Octyl 3,4,5-trihydroxybenzoate #
CAS-1034-01-1
3,4,5-Trihydroxy-benzoic acid octyl ester
Benzoic acid,4,5-trihydroxy-, octyl ester
DB-110046
Octyl gallate, analytical reference material
n-Octyl ester of 3,5-trihydroxybenzoic acid
S9338
ST50826828
octyl 3,4,5-trihydroxybenzoate;Octyl gallate
Octyl gallate, antioxidant, >=99.0% (HPLC)
A800728
J-000952
Q2317929
Octyl gallate, European Pharmacopoeia (EP) Reference Standard
65D