PRODUCTS

METHANDICARBOXYLIC ACID (MALONIC ACID)

Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of Methandicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
Methandicarboxylic acid (Malonic Acid), also known as propanedioic acid, is a dicarboxylic acid with structure CH2(COOH)2.

CAS Number: 141-82-2
Molecular Formula: C3H4O4
Molecular Weight: 104.06
EINECS Number: 205-503-0

Methandicarboxylic acid (Malonic Acid), propanedioic acid, 141-82-2, Dicarboxymethane, Carboxyacetic acid, Methanedicarboxylic acid, malonate, Kyselina malonova, USAF EK-695, 1,3-Propanedioic acid, Dicarboxylate, Malonicacid, Dicarboxylic acid, Kyselina malonova [Czech], NSC 8124, UNII-9KX7ZMG0MK, 9KX7ZMG0MK, AI3-15375, H2malo, EINECS 205-503-0, MFCD00002707, BRN 1751370, Methanedicarbonic acid, CHEBI:30794, Thallium malonate, HOOC-CH2-COOH, NSC-8124, Propane-1,3-dioic acid, alpha,omega-Dicarboxylic acid, DTXSID7021659, HSDB 8437, NSC8124, 4-02-00-01874 (Beilstein Handbook Reference), 1,3-Propanoic acid, PROPANEDIOLIC ACID, METAHNEDICARBOXYLIC ACID, 2fah, Methandicarboxylic acid (Malonic Acid), 99%, Methandicarboxylic acid (Malonic Acid) (8CI), 1o4m, MLI, Malonate dicarboxylic acid, Methandicarboxylic acid (Malonic Acid), 99.5%, Propanedioic acid (9CI), SCHEMBL336, WLN: QV1VQ, Methandicarboxylic acid (Malonic Acid) [MI], CH2(COOH)2, CHEMBL7942, Methandicarboxylic acid (Malonic Acid) [INCI], DTXCID401659, SCHEMBL1471092, BDBM14673, Propanedioic acid dithallium salt, Methandicarboxylic acid (Malonic Acid), analytical standard, AMY11201, BCP05571, STR00614, Tox21_200534, AC8295, LMFA01170041, s3029, Methandicarboxylic acid (Malonic Acid), ReagentPlus(R), 99%, AKOS000119034, CS-W019962, DB02175, PROPANEDIOIC ACID Methandicarboxylic acid (Malonic Acid), NCGC00248681-01, NCGC00258088-01, BP-11453, CAS-141-82-2, SY001875, Methandicarboxylic acid (Malonic Acid), SAJ first grade, >=99.0%, FT-0628127, FT-0628128, FT-0690260, FT-0693474, M0028, NS00013842, EN300-18457, Methandicarboxylic acid (Malonic Acid), Vetec(TM) reagent grade, 98%, C00383, C02028, C04025, Q421972, J-521669, Z57965450, F1908-0177, Methandicarboxylic acid (Malonic Acid), certified reference material, TraceCERT(R), 592A9849-68C3-4635-AA3D-CBC44965EA3A, Methandicarboxylic acid (Malonic Acid), sublimed grade, >=99.95% trace metals basis, DICARBOXYLIC ACID C3; PROPANEDIOLIC ACID; METHANEDICARBOXYLIC ACID, InChI=1/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7, Methandicarboxylic acid (Malonic Acid), anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), 99%, LML

Methandicarboxylic acid (Malonic Acid) have three kinds of crystal forms, of which two are triclinic, and one is monoclinic.
That crystallized from ethanol is white triclinic crystals.
Methandicarboxylic acid (Malonic Acid) decomposes to acetic acid and carbon dioxide at 140℃.

Methandicarboxylic acid (Malonic Acid) does not decompose at 1.067×103~1.333×103Pa vacuum, but directly sublimates.
The ionised form of Methandicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methandicarboxylic acid (Malonic Acid)'s ethyl ester.

Methandicarboxylic acid (Malonic Acid) is a white crystalline solid that decomposes at approximately 135°C.
Methandicarboxylic acid (Malonic Acid) has high solubility in water and oxygenated solvents and exhibits greater acidity than acetic acid, which has a pK value of 4.75.
The pKa values for the loss of its first and second protons are 2.83 and 5.69, respectively.

Methandicarboxylic acid (Malonic Acid) is slightly soluble in pyridine.
Methandicarboxylic acid (Malonic Acid) can decompose to formic acid and carbon dioxide in case of potassium permanganate.
Since that Methandicarboxylic acid (Malonic Acid) generates carbon dioxide and water after heated without pollution problems, it can be directly used as aluminum surface treatment agent.

Methandicarboxylic acid (Malonic Acid) is an alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Methandicarboxylic acid (Malonic Acid) has a role as a human metabolite.
Methandicarboxylic acid (Malonic Acid) is a conjugate acid of a malonate(1-).

Methandicarboxylic acid (Malonic Acid) and extensive property data including for condensed phase thermochemistry are available from the National Institute of Standards and Technology.
Methandicarboxylic acid (Malonic Acid) the sodium salt, which is then reacted with sodium cyanide to provide the sodium salt of cyanoacetic acid via a nucleophilic substitution.
The nitrile group can be hydrolyzed with sodium hydroxide to sodium malonate, and acidification affords Methandicarboxylic acid (Malonic Acid).

Industrially, however, Methandicarboxylic acid (Malonic Acid) is produced by hydrolysis of dimethyl malonate or diethyl malonate.
Methandicarboxylic acid (Malonic Acid) has also been produced through fermentation of glucose.
Methandicarboxylic acid (Malonic Acid) appears to be a typographical error.

The correct name for the compound is "Methanedicarboxylic acid," also known as "Methandicarboxylic acid (Malonic Acid)."
Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid with the chemical formula C3H4O4.
Methandicarboxylic acid (Malonic Acid) is a colorless crystalline solid with a sour taste and is soluble in water, ethanol, and ether.

Methandicarboxylic acid (Malonic Acid) is widely used in organic synthesis as a building block for the production of various compounds.
Methandicarboxylic acid (Malonic Acid) contains two carboxylic acid functional groups (-COOH), which makes it a versatile precursor for the synthesis of carboxylic acids, ketones, and other organic molecules.
In addition to its role in organic synthesis, Methandicarboxylic acid (Malonic Acid) has applications in the food industry as an acidity regulator and flavoring agent.

Methandicarboxylic acid (Malonic Acid) is also used in pharmaceuticals, cosmetics, and personal care products.
Methandicarboxylic acid (Malonic Acid) reacts as a typical carboxylic acid: forming amide, ester, anhydride, and chloride derivatives.
Methandicarboxylic acid (Malonic Acid) anhydride can be used as an intermediate to mono-ester or amide derivatives, while malonyl chloride is most useful to obtain diesters or diamides.

In a well-known reaction, Methandicarboxylic acid (Malonic Acid) condenses with urea to form barbituric acid.
Methandicarboxylic acid (Malonic Acid) may also be condensed with acetone to form Meldrum's acid, a versatile intermediate in further transformations.
The esters of Methandicarboxylic acid (Malonic Acid) are also used as a −CH2COOH synthon in the malonic ester synthesis.

Methandicarboxylic acid (Malonic Acid) is the starting substrate of mitochondrial fatty acid synthesis (mtFASII), in which it is converted to malonyl-CoA by malonyl-CoA synthetase (ACSF3).[13][14]
Additionally, the coenzyme A derivative of malonate, malonyl-CoA, is an important precursor in cytosolic fatty acid biosynthesis along with acetyl CoA.
Methandicarboxylic acid (Malonic Acid) is formed there from acetyl CoA by the action of acetyl-CoA carboxylase, and the malonate is transferred to an acyl carrier protein to be added to a fatty acid chain.

Methandicarboxylic acid (Malonic Acid) is a key component in the Briggs–Rauscher reaction, the classic example of an oscillating chemical reaction.
Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid belonging to the family of carboxylic acids.
Methandicarboxylic acid (Malonic Acid) contains two carboxylic acid functional groups.

Usually, a Methandicarboxylic acid (Malonic Acid) exhibits the same chemical behavior as monocarboxylic acids.
This naturally occurs in certain fruits.
Methandicarboxylic acid (Malonic Acid) is a useful organic compound with various benefits.

Methandicarboxylic acid (Malonic Acid) is IUPAC name is propanedioic acid.
Methandicarboxylic acid (Malonic Acid) should not be confused with malic or maleic acid.
Methandicarboxylic acid (Malonic Acid) or propanedioic acid is the second smallest aliphatic dicarboxylic acid with oxalic acid being the smallest.

Methandicarboxylic acid (Malonic Acid) can be confused with maleic or malic acid as both contain two carboxyl groups, but it is different.
Methandicarboxylic acid (Malonic Acid) differs from these two acids in terms of properties, structure, etc.
The name of this acid is derived from the Greek word Malon which means apple.

Methandicarboxylic acid (Malonic Acid) on heating gives acetic acid.
Methandicarboxylic acid (Malonic Acid) is a white crystalline substance that quickly dissolves in water and oxygenated solutions.
Methandicarboxylic acid (Malonic Acid) has a breakdown temperature of 135 °C.

Methandicarboxylic acid (Malonic Acid) is ionized form, esters and salts are known as malonates, such as the diethyl malonate, which is Methandicarboxylic acid (Malonic Acid)’s diethyl ester.
Methandicarboxylic acid (Malonic Acid) is a symmetrical dicarboxylic acid, meaning it contains two carboxylic acid groups (-COOH) attached to the same carbon atom.
This structure gives Methandicarboxylic acid (Malonic Acid) unique reactivity, allowing it to participate in various organic reactions such as esterification, decarboxylation, and condensation.

Synthetic Applications: One of the key uses of Methandicarboxylic acid (Malonic Acid) is as a starting material for the synthesis of various organic compounds.
The malonic ester synthesis and the Methandicarboxylic acid (Malonic Acid) synthesis are two important reactions that utilize Methandicarboxylic acid (Malonic Acid) as a precursor.
These reactions are widely used in organic synthesis to introduce the malonyl functional group (-CH2COOH) into molecules, enabling the formation of more complex structures.

In the food industry, Methandicarboxylic acid (Malonic Acid) is approved for use as an acidity regulator (pH control agent) and flavoring agent.
Methandicarboxylic acid (Malonic Acid) can be added to food and beverage products to adjust acidity levels, enhance tartness, or provide a sour flavor profile. Methandicarboxylic acid (Malonic Acid) is generally recognized as safe (GRAS) for use in food by regulatory agencies such as the FDA.

Cosmetic and Personal Care Products: Methandicarboxylic acid (Malonic Acid) is utilized in cosmetic and personal care formulations for its exfoliating and skin conditioning properties.
Methandicarboxylic acid (Malonic Acid) is often included in skincare products such as facial cleansers, moisturizers, and chemical peels.
Methandicarboxylic acid (Malonic Acid) helps to promote skin renewal by gently exfoliating dead skin cells and stimulating cell turnover, resulting in smoother and brighter-looking skin.

Methandicarboxylic acid (Malonic Acid) and its derivatives have applications in pharmaceuticals, both as active pharmaceutical ingredients (APIs) and as intermediates in the synthesis of drugs.
For example, Methandicarboxylic acid (Malonic Acid) derivatives are used in the synthesis of barbiturates, which are central nervous system depressants.
Additionally, Methandicarboxylic acid (Malonic Acid) derivatives are studied for their potential pharmacological properties, including antimicrobial and antiviral activities.

Methandicarboxylic acid (Malonic Acid) is used as a standard compound in analytical chemistry for calibration purposes and method validation.
Methandicarboxylic acid (Malonic Acid) is well-defined properties and stability make it a suitable reference material for chromatography, spectroscopy, and other analytical techniques.
Methandicarboxylic acid (Malonic Acid) is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.

Methandicarboxylic acid (Malonic Acid) binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the −CH2CH2− group required for dehydrogenation.
This observation was used to deduce the structure of the active site in succinate dehydrogenase.
Inhibition of this enzyme decreases cellular respiration.

Since Methandicarboxylic acid (Malonic Acid) is a natural component of many foods, it is present in mammals including humans.
Methandicarboxylic acid (Malonic Acid) is an organic compound naturally found in some fruits.
Fruits produced in organic farming have greater concentrations of Methandicarboxylic acid (Malonic Acid) than those generated from conventional farming practices.

Methandicarboxylic acid (Malonic Acid) is often found in some citrus fruits and vegetables.
Methandicarboxylic acid (Malonic Acid) is a component of food items, it is present in animals, including humans.
Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structural formula CH2(COOH)2 and chemical formula C3H4O4.

The name Methandicarboxylic acid (Malonic Acid) originated from the word ‘Malon’ which is Greek for ‘apple’.
The IUPAC name of Methandicarboxylic acid (Malonic Acid) is Propanedioic acid.
Methane Dicarboxylic acid is another name for Methandicarboxylic acid (Malonic Acid).

The ester and salts of Methandicarboxylic acid (Malonic Acid) are called malonates.
The dicarboxylic acid has organic reactions similar to the monocarboxylic acid where amide, ester, anhydride, and chloride derivatives are formed.
Lastly, the malonic ester malonate as a coenzyme A derivative malonyl CoA that is as important a precursor as Acetyl CoA in the biosynthesis of fatty acids.

The Methandicarboxylic acid (Malonic Acid) Lewis structure has been found by the X-ray crystallography method.
The Methandicarboxylic acid (Malonic Acid) structure CH2(COOH)2 has two carboxylic acids.
The salts and esters of Methandicarboxylic acid (Malonic Acid) (malonates) have structures similar to Methandicarboxylic acid (Malonic Acid).

Methandicarboxylic acid (Malonic Acid) appears as a crystalline powder that is white or colourless.
At the boiling point above 140oC the compound decomposes. The melting point is 135-137o C.
If heated to decomposition under fire it emits carbon oxide fumes and acrid irritating smoke.

Methandicarboxylic acid (Malonic Acid) is soluble in water. Solubility 763 g/L.
Methandicarboxylic acid (Malonic Acid) has a white crystal or crystalline powder structure.
The compound is naturally occurring and can be found in many vegetables, fruits.

Methandicarboxylic acid (Malonic Acid) compound was first prepared by Victor Dessaignes by the oxidation reaction of malic acid.
Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structure CH2(COOH)2.
The ionized form of Methandicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.

For example, diethyl malonate is Methandicarboxylic acid (Malonic Acid)'s diethyl ester.
The name originates from the Greek word μᾶλον (malon) meaning 'apple'.
Methandicarboxylic acid (Malonic Acid), formally propanedioic acid, is the second-smallest aliphatic dicarboxylic acid. (Oxalic acid is the smallest.)

Methandicarboxylic acid (Malonic Acid) should not be confused with malic or maleic acid, both of which also contain two carboxyls.
Methandicarboxylic acid (Malonic Acid) is a white crystalline solid with a decomposition point of ≈135 °C.
Methandicarboxylic acid (Malonic Acid) is highly soluble in water and oxygenated solvents.

Methandicarboxylic acid (Malonic Acid) is a precursor to specialty polyesters; Methandicarboxylic acid (Malonic Acid) is used in the manufacture of barbiturates, coatings, and biodegradable containers; and Methandicarboxylic acid (Malonic Acid) is even a component of surgical adhesives.
Methandicarboxylic acid (Malonic Acid) (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH₂(COOH)₂.

The ionized form of Methandicarboxylic acid (Malonic Acid), as well as its esters and salts, are known as malonates.
For example, diethyl malonate is Methandicarboxylic acid (Malonic Acid)'s diethyl ester.
The name originates from the Greek word μᾶλον (malon) meaning 'apple'.

Methandicarboxylic acid (Malonic Acid) is also known as Propanedioic Acid or Dicarboxymethane.
The name is derived from a Greek word Malon which means apple.
Malonates are the ionized form of Methandicarboxylic acid (Malonic Acid), along with its esters and salts.

Methandicarboxylic acid (Malonic Acid) appears as a white crystal or crystalline powder.
Methandicarboxylic acid (Malonic Acid) dissolves in alcohol, pyridine, and ether.
Methandicarboxylic acid (Malonic Acid) was first prepared in the year, 1858 by the French chemist Victor Dessaignes by the oxidation of malic acid.

Methandicarboxylic acid (Malonic Acid) is found in some fruit’s viz citrus fruits.
The amount of Methandicarboxylic acid (Malonic Acid) produced from fruits through organic farming is greater than the fruits grown through conventional agriculture.
Methandicarboxylic acid (Malonic Acid) can be produced through the fermentation of glucose.

Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid with the chemical formula C3H4O4 and the structural formula CH2(COOH)2.
The word 'Methandicarboxylic acid (Malonic Acid)' comes from the Greek word ‘malon', which means 'apple.'

Propanedioic acid is the IUPAC designation for Methandicarboxylic acid (Malonic Acid).
Methandicarboxylic acid (Malonic Acid) is also known as Methane Dicarboxylic acid.
Malonates are the ester and salts of Methandicarboxylic acid (Malonic Acid).

Melting point: 132-135 °C (dec.) (lit.)
Boiling point: 140℃（decomposition）
Density: 1.619 g/cm3 at 25 °C
vapor pressure: 0-0.2Pa at 25℃
refractive index: 1.4780
Flash point: 157°C
storage temp.: Sealed in dry,Room Temperature
solubility: 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
pka: 2.83(at 25℃)
form: Liquid
color: White
PH: 3.17(1 mM solution);2.5(10 mM solution);1.94(100 mM solution)
Water Solubility: 1400 g/L (20 ºC)
Merck: 14,5710
BRN: 1751370
Stability: Stable. Incompatible with oxidizing agents, reducing agents, bases.
InChIKey: OFOBLEOULBTSOW-UHFFFAOYSA-N
LogP: -0.81

In a well - known reaction, Methandicarboxylic acid (Malonic Acid) condenses with urea to form barbituric acid.
Methandicarboxylic acid (Malonic Acid) is also frequently used as an enolate in Knoevenagel condensations or condensed with acetone to form Meldrum's acid.
The esters of Methandicarboxylic acid (Malonic Acid) are also used as a - CH2COOH synthon in the malonic ester synthesis.

Methandicarboxylic acid (Malonic Acid) is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the respiratory electron transport chain.
Methandicarboxylic acid (Malonic Acid) binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the ?CH2CH2? group required for dehydrogenation.
This observation was used to deduce the structure of the active site in succinate dehydrogenase.

Methandicarboxylic acid (Malonic Acid) is a carboxylic acid.
Methandicarboxylic acid (Malonic Acid) donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.

Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Methandicarboxylic acid (Malonic Acid) with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water.

Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions.
The pH of solutions of carboxylic acids is therefore less than 7.0.
Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt.

Methandicarboxylic acid (Malonic Acid) in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Methandicarboxylic acid (Malonic Acid) to corrode or dissolve iron, steel, and aluminum parts and containers.
Methandicarboxylic acid (Malonic Acid), like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.

The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.
Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.

Methandicarboxylic acid (Malonic Acid), especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.
Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.
Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents.

These reactions generate heat. A wide variety of products is possible.
Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions Methandicarboxylic acid (Malonic Acid) is incompatible with strong oxidizers.
Methandicarboxylic acid (Malonic Acid) is also incompatible with bases and reducing agents.

The calcium salt of Methandicarboxylic acid (Malonic Acid) occurs in high concentrations in beetroot.
Methandicarboxylic acid (Malonic Acid) exists in its normal state as white crystals.
Methandicarboxylic acid (Malonic Acid) is the classic example of a competitive inhibitor: It acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.

In organic chemistry, a Methandicarboxylic acid (Malonic Acid) is an organic compound containing two carboxyl groups (−COOH).
The general molecular formula for dicarboxylic acids can be written as HO2C−R−CO2H, where R can be aliphatic or aromatic.
In general, Methandicarboxylic acid (Malonic Acid)s show similar chemical behavior and reactivity to monocarboxylic acids.

Methandicarboxylic acid (Malonic Acid)s are used in the preparation of copolymers such as polyamides and polyesters.
The most widely used dicarboxylic acid in the industry is adipic acid, which is a precursor in the production of nylon.
Other examples of Methandicarboxylic acid (Malonic Acid)s include aspartic acid and glutamic acid, two amino acids in the human body. The name can be abbreviated to diacid.

Methandicarboxylic acid (Malonic Acid) is a naturally occurring substance found in many fruits and vegetables.
There is a suggestion that citrus fruits produced in organic farming contain higher levels of Methandicarboxylic acid (Malonic Acid) than fruits produced in conventional agriculture.
Methandicarboxylic acid (Malonic Acid) was first prepared in 1858 by the French chemist Victor Dessaignes via the oxidation of malic acid.

The synthesis of Methandicarboxylic acid (Malonic Acid) usually begins with chloroacetic acid.
Methandicarboxylic acid (Malonic Acid) is also synthesized by cyanoacetic acid or by acid saponification reaction of malonates.
From monochloroacetic acid, Methandicarboxylic acid (Malonic Acid) is produced by sodium or potassium cyanide.

The sodium carbonate primarily breaks down to give sodium salt which reacts with sodium cyanide to give sodium salt of cyanoacetic acid by the process of nucleophilic substitution.
Further, via hydrolyzation, the nitrile group binds with sodium malonate, whose acidification results in the production of Methandicarboxylic acid (Malonic Acid).
In addition, Methandicarboxylic acid (Malonic Acid) and coenzyme A can be biosynthesized from malonyl-CoA through Methandicarboxylic acid (Malonic Acid)s interaction with the enzyme fatty acid synthase.
malonyl/acetyl transferase domain.

An Methandicarboxylic acid (Malonic Acid) in which the two carboxy groups are separated by a single methylene group.
In humans, Methandicarboxylic acid (Malonic Acid) is involved in fatty acid biosynthesis. Outside of the human body, Methandicarboxylic acid (Malonic Acid) has been detected, but not quantified in, several different foods, such as red beetroots, corns, scarlet beans, common beets, and cow milks.
This could make Methandicarboxylic acid (Malonic Acid) a potential biomarker for the consumption of these foods.

Methandicarboxylic acid (Malonic Acid), with regard to humans, has been found to be associated with several diseases such as eosinophilic esophagitis, combined malonic and methylMethandicarboxylic acid (Malonic Acid)uria, and early preeclampsia; Methandicarboxylic acid (Malonic Acid) has also been linked to the inborn metabolic disorder malonyl-coa decarboxylase deficiency.
Methandicarboxylic acid (Malonic Acid) is a dicarboxylic acid with structural formula CH2(COOH)2 and chemical formula C3H4O4.
The name Methandicarboxylic acid (Malonic Acid) originated from the word ‘Malon’ which is Greek for ‘apple’.

Methane Dicarboxylic acid is another name for Methandicarboxylic acid (Malonic Acid).
The ester and salts of Methandicarboxylic acid (Malonic Acid) are called malonates.
The dicarboxylic acid has organic reactions similar to the monocarboxylic acid where amide, ester, anhydride, and chloride derivatives are formed.

Lastly, the malonic ester malonate as a coenzyme A derivative malonyl CoA that is as important a precursor as Acetyl CoA in the biosynthesis of fatty acids.
Methandicarboxylic acid (Malonic Acid) can also be a component in alkyd resins, which are used in a number of coatings applications for protecting against damage caused by UV light, oxidation, and corrosion.
One application of Methandicarboxylic acid (Malonic Acid) is in the coatings industry as a crosslinker for low-temperature cure powder coatings, which are becoming increasingly valuable for heat sensitive substrates and a desire to speed up the coatings process.

The global coatings market for automobiles was estimated to be $18.59 billion in 2014 with projected combined annual growth rate of 5.1% through 2022.
Methandicarboxylic acid (Malonic Acid) is used in a number of manufacturing processes as a high value specialty chemical including the electronics industry, flavors and fragrances industry, specialty solvents, polymer crosslinking, and pharmaceutical industry.
In 2004, annual global production of Methandicarboxylic acid (Malonic Acid) and related diesters was over 20,000 metric tons.

Potential growth of these markets could result from advances in industrial biotechnology that seeks to displace petroleum-based chemicals in industrial applications.
Methandicarboxylic acid (Malonic Acid) was listed as one of the top 30 chemicals to be produced from biomass by the US Department of Energy.
In food and drug applications, Methandicarboxylic acid (Malonic Acid) can be used to control acidity, either as an excipient in pharmaceutical formulation or natural preservative additive for foods.

Methandicarboxylic acid (Malonic Acid) is used as a building block chemical to produce numerous valuable compounds, including the flavor and fragrance compounds gamma-nonalactone, cinnamic acid, and the pharmaceutical compound valproate.
Methandicarboxylic acid (Malonic Acid) (up to 37.5% w/w) has been used to cross-link corn and potato starches to produce a biodegradable thermoplastic; the process is performed in water using non-toxic catalysts.

Preparation Of Methandicarboxylic acid (Malonic Acid):
Methandicarboxylic acid (Malonic Acid) is usually produced from chloroacetic acid.
Reaction: The chloroacetic acid is added to the reaction kettle by adding sodium carbonate aqueous solution to generate sodium chloroacetate aqueous solution, and then 30% sodium cyanide solution is slowly added dropwise, and the reaction is carried out at a predetermined temperature to generate sodium cyanoacetate.
After the cyanation reaction is completed, add sodium hydroxide for heating and hydrolysis to generate sodium malonate solution, concentrate, then dropwise add sulfuric acid for acidification to generate Methandicarboxylic acid (Malonic Acid), filter and dry to obtain the product.

This method often does not produce a pure enough product or the pure product has an extremely low yield.
Industrially, Methandicarboxylic acid (Malonic Acid) is also produced by hydrolyzing dimethyl malonate or diethyl malonate.
This manufacturing method is able to bring about a higher yield and purity, but the organic synthesis of Methandicarboxylic acid (Malonic Acid) through these processes is extremely costly and environmentally hazardous.

Uses Of Methandicarboxylic acid (Malonic Acid):
Methandicarboxylic acid (Malonic Acid) is used as an intermediate in the manufacture of barbiturates and other pharmaceuticals.
Methandicarboxylic acid (Malonic Acid) is a component used as a stabilizer in many high-end cosmetic and pharmaceutical products.
Methandicarboxylic acid (Malonic Acid) is also used as building block in chemical synthesis, specifically to introduce the molecular group -CH2-COOH.

Methandicarboxylic acid (Malonic Acid) is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation.
Methandicarboxylic acid (Malonic Acid) is acts as a building block in organic synthesis.
Methandicarboxylic acid (Malonic Acid) is also useful as a precursor for polyesters and alkyd resins, which is used in coating applications, thereby protecting against UV light, corrosion and oxidation.

Methandicarboxylic acid (Malonic Acid) acts as a cross linker in the coating industry and surgical adhesive.
Methandicarboxylic acid (Malonic Acid) finds application in the production of specialty chemicals, flavors and fragrances, polymer cross linkers and pharmaceuticals.
Methandicarboxylic acid (Malonic Acid) is a precursor to specialty polyesters.

Methandicarboxylic acid (Malonic Acid) can be converted into 1,3-propanediol for use in polyesters and polymers (whose usefulness is unclear though).
Methandicarboxylic acid (Malonic Acid) can also be a component in alkyd resins, which are used in a number of coatings applications for protecting against damage caused by UV light, oxidation, and corrosion.
One application of Methandicarboxylic acid (Malonic Acid) is in the coatings industry as a crosslinker for low-temperature cure powder coatings, which are becoming increasingly valuable for heat sensitive substrates and a desire to speed up the coatings process.

Potential growth of these markets could result from advances in industrial biotechnology that seeks to displace petroleum-based chemicals in industrial applications.
In 2004, Methandicarboxylic acid (Malonic Acid) was listed by the US Department of Energy as one of the top 30 chemicals to be produced from biomass.
In food and drug applications, Methandicarboxylic acid (Malonic Acid) can be used to control acidity, either as an excipient in pharmaceutical formulation or natural preservative additive for foods.

Starch-based polymers comprised 38% of the global biodegradable polymers market in 2014 with food packaging, foam packaging, and compost bags as the largest end-use segments.
Eastman Kodak company and others use Methandicarboxylic acid (Malonic Acid) and derivatives as a surgical adhesive.
Methandicarboxylic acid (Malonic Acid) and its derivatives can be used in polymerization reactions to produce polymers with specific properties.

For example, Methandicarboxylic acid (Malonic Acid) diesters can undergo polymerization to form polyester resins, which are used in coatings, adhesives, and molding applications.
Methandicarboxylic acid (Malonic Acid) derivatives are utilized in the textile industry as dye intermediates and as components of dye formulations.
They help improve the stability and color fastness of dyes, contributing to vibrant and long-lasting colors in textiles.

Methandicarboxylic acid (Malonic Acid) can form complexes with various metal ions, making it useful in metal coordination chemistry.
These complexes have applications in catalysis, metal extraction, and analytical chemistry.
Methandicarboxylic acid (Malonic Acid) derivatives have pharmacological properties and are investigated for their potential therapeutic applications.

Some Methandicarboxylic acid (Malonic Acid) derivatives exhibit antimicrobial, antiviral, and anticancer activities, making them targets for drug discovery and development.
Methandicarboxylic acid (Malonic Acid) and its derivatives are used in the formulation of photographic chemicals, such as developers and fixers.
They play a role in image formation, stabilization, and processing in traditional and digital photography.

Methandicarboxylic acid (Malonic Acid) derivatives are employed in the formulation of adhesives and sealants due to their adhesive properties and ability to cross-link with other compounds.
They contribute to the strength, flexibility, and durability of adhesive bonds in various applications.
Methandicarboxylic acid (Malonic Acid) derivatives are utilized in the electronics industry as components of photoresists and etchants for semiconductor manufacturing processes.

They help define patterns and features on semiconductor wafers during the fabrication of integrated circuits and electronic devices.
Researchers are exploring the use of Methandicarboxylic acid (Malonic Acid) derivatives in the development of biodegradable polymers and environmentally friendly materials.
These polymers have potential applications in packaging, agriculture, and biomedical fields as sustainable alternatives to conventional plastics.

Methandicarboxylic acid (Malonic Acid) and its derivatives can be employed in waste water treatment processes to remove heavy metals and other contaminants through chelation and precipitation reactions, contributing to environmental remediation efforts.
Methandicarboxylic acid (Malonic Acid) acts as a precursor for conversion to 1,3-propanediol, which is a compound used in polyesters and polymers with the huge market size.
Methandicarboxylic acid (Malonic Acid) is used for the preparation of cinnamic acid, a compound used for the formation of cin metacin which is an anti-inflammatory.

The malonates are used in syntheses of B1 and B6, barbiturates, and several other valuable compounds.
Methandicarboxylic acid (Malonic Acid) is used in cosmetics as a buffering and as a flavouring agent in food.
Methandicarboxylic acid (Malonic Acid) is used as a component of alkyd resins, used in coating applications to protect from UV rays, oxidation, and corrosion.

Methandicarboxylic acid (Malonic Acid) is a building block to many valuable compounds in food and drug applications, pharmaceutical, electronics industry, fragrances, specialty polymer, specialty solvents, and many more.
Methandicarboxylic acid (Malonic Acid) is widely used as a building block in organic synthesis to introduce the malonyl functional group (-CH2COOH) into molecules.
Methandicarboxylic acid (Malonic Acid) serves as a precursor in various reactions, such as the malonic ester synthesis and the Methandicarboxylic acid (Malonic Acid) synthesis, to produce a wide range of organic compounds.

Methandicarboxylic acid (Malonic Acid) is utilized in the synthesis of pharmaceuticals, agrochemicals, flavors, fragrances, and other fine chemicals.
The malonic ester synthesis, for example, is a key step in the synthesis of barbiturates, vitamin B1 (thiamine), and other important compounds.
Methandicarboxylic acid (Malonic Acid) is approved for use as a food additive by regulatory agencies such as the Food and Drug Administration (FDA) in the United States and the European Food Safety Authority (EFSA) in the European Union.

Methandicarboxylic acid (Malonic Acid) is used as an acidity regulator and flavoring agent in various food and beverage products.
In some cases, it can enhance the sourness or tartness of foods while also serving as a buffering agent to control pH.
Methandicarboxylic acid (Malonic Acid) is employed in cosmetics and personal care products for its exfoliating and skin conditioning properties.

Methandicarboxylic acid (Malonic Acid) is found in formulations such as facial cleansers, moisturizers, and anti-aging creams.
Methandicarboxylic acid (Malonic Acid) can help promote skin renewal by gently exfoliating dead skin cells, leading to smoother and brighter-looking skin.
Methandicarboxylic acid (Malonic Acid) derivatives, such as malonic esters and malonamides, serve as important intermediates in the production of various chemicals.

These derivatives undergo further reactions to yield diverse compounds used in pharmaceuticals, agrochemicals, and materials science.
Methandicarboxylic acid (Malonic Acid) is utilized in chemical research and laboratory experiments as a starting material for organic synthesis and as a standard compound for analytical purposes.
Methandicarboxylic acid (Malonic Acid) serves as a model compound for studying various organic reactions, including substitution, esterification, decarboxylation, and condensation reactions.

Health Hazards of Methandicarboxylic acid (Malonic Acid):
Upon exposure, Methandicarboxylic acid (Malonic Acid) can cause a range of symptoms in the eyes, skin, and respiratory tract.
Methandicarboxylic acid (Malonic Acid) can irritate eyes, skin.
Methandicarboxylic acid (Malonic Acid) if inhaled can irritate the respiratory tract.

Methandicarboxylic acid (Malonic Acid) may also cause serious eye damage or eye irritation.
Hence, if exposed eyes should be washed with normal water or with a saline solution.
If redness or irritation is observed in the affected skin, the area should be immediately washed with water.

The contaminated clothes should be removed.
If ingested Methandicarboxylic acid (Malonic Acid) may cause gastrointestinal irritation such as nausea, vomiting, etc.
The mouth should be immediately rinsed with water several times and further medical help should be taken.

Methandicarboxylic acid (Malonic Acid) is a strong irritant that can affect both skin and mucous membranes.
If heated the compound releases toxic fumes of carbon dioxide and monoxide and gases that may irritate the respiratory tract if inhaled.