PRODUCTS

NEOHESPERIDINE DC

Neohesperidine DC may be used in a wide range of foods such as soft drinks, desserts, ice cream, confectionery, certain pastries, fruit and vegetable preparations, high-fibre breakfast cereals, jams, marmalades, jellies, certain soups, vitamin or mineral supplements, sauces, certain snacks, alcoholic beverages and low alcoholic beverages.
Neohesperidine DC is used food - Beverages, desserts and related products, confectionery, bakery, savory products (paté, sauces, seasonings, mayonnaise, soups, fish and meat preserves).

CAS Number: 20702-77-6
EC Number: 243-978-6
Molecular Formula: C₂₈H₃₆O₁₅
Molecular Weight: 612.58 g/mol

SYNONYMS:
Neohesperidin dihydrochalcone, NHDC, Neohesperidine DC, E959, Neohesperidin DC sweetener, IUPAC name: 1-{2,6-Dihydroxy-4-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyloxy]phenyl}-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, Systematic IUPAC name: (12S,13R,14R,15R,16S,32S,33R,34S,35S,36R)-13,14,15,34,35,53,55,93-Octahydroxy-36-(hydroxymethyl)-94-methoxy-16-methyl-2,4-dioxa-1(2),3(3,2)-bis(oxana)-5(1,4),9(1)-dibenzenanonaphan-6-one, neohesperidin dihydrochalcone, 20702-77-6, Nhdc, Neohesperidin dc, Neohesperidin dhc, Neohesperidine dihydrochalcone, Citrosa, neohesperidine DC, DTXSID3025706, NCI-C60764, neohesperidin dihydrochalone, 3X476D83QV, 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, DTXCID305706, 1-Propanone, 1-[4-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-, FEMA NO. 3811, CHEBI:83535, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-, 1-Propanone, 1-(4-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-, 1-(4-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, RefChem:832306, 1-(4-((2S,4R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,4S,5R)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, 243-978-6, GLUCOPYRANOSIDE, 3,5-DIHYDROXY-4-(3-HYDROXY-4-METHOXYHYDROCINNAMOYL)PHENYL 2-O-ALPHA-L-RHAMNOPYRANOSYL-, Neosperidin dihydrochalcone, Neohesperidin-dihydrochalcone, MFCD00017711, 1-(4-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, C28H36O15, 1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-2,6-dihydroxy-phenyl]-3-(3-hydroxy-4-methoxy-phenyl)propan-1-one, 3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside, CCRIS 4848, Neohesperidin dihydrochalcone hydrate, EINECS 243-978-6, UNII-3X476D83QV, Neohesperidin Dihydrochalcone (Nhdc), E959, hoxyphenyl)propan-1-one, Neosperidin-dihydrochalcone, NeohesperidinDihydrochalcone, 1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-, 1-Propanone, 1-(4-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-me, 3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside, SCHEMBL909958, orb1305047, orb3140769, CHEMBL1159645, SCHEMBL29352176, HY-N0154R, ITVGXXMINPYUHD-CUVHLRMHSA-, Neohesperidin-dihydrochalcone CRS, Neohesperidin dihydrochalcone ,EP, HMS3884H13, HMS6019G04, HY-N0154, MSK40285, Tox21_200303, s2331, AKOS015895239, CCG-270237, CS-6419, EBC-615856, ON07510, Neohesperidin dihydrochalcone (Standard), NCGC00091109-01, NCGC00091109-02, NCGC00091109-04, NCGC00257857-01, 1-(4-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, AC-34860, AS-15190, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-, .beta.-D-, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-, NEOHESPERIDIN DIHYDROCHALCONE [MI], SY074064, Neohesperidin dihydrochalcone, >=96%, FG, NEOHESPERIDIN DIHYDROCHALONE [FHFI], CAS-20702-77-6, NEOHESPERIDINE DIHYDROCHALCONE [FCC], N0675, NS00000402, NEOHESPERIDIN DIHYDROCHALCONE [USP-RS], Neohesperidin dihydrochalcone, >=95% (HPLC), NEOHESPERIDINE DIHYDROCHALCONE [USP-RS], Neohesperidin dihydrochalcone, analytical standard, Q424595, SR-01000883756, NEOHESPERIDIN-DIHYDROCHALCONE [EP MONOGRAPH], SR-01000883756-1, BRD-K61032563-001-02-9, HESPERETIN DIHYDROCHALCONE-4'-.BETA.-NEOHESPERIDOSIDE, Neohesperidin dihydrochalcone, European Pharmacopoeia (EP) Reference Standard, 1-(4-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-met, 1-(4-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-DIHYDROCHALCONE GLUCOPYRANOSYL)OXY)-2,6-DIHYDROXYPHENYL)-3-(3-HYDROXY-4-METHOXYPHENYL)PROPAN-1-ONE, 1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone, 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5, 1-[4-[[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]tetrahydro-2H-pyran-2-yl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone, 1-[4-[[2-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone, 1-PROPANONE, 1-(4-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,6-DIHYDROXYPHENYL)-3-(3-HYDROXY-4-METHOXYPHENYL)-, 1-Propanone, 1-[4-[[2-O-(6-deoxy-|A-L-mannopyranosyl)-|A-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-, GLUCOPYRANOSIDE, 3,5-DIHYDROXY-4-(3-HYDROXY-4-METHOXYHYDROCINNAMOYL)PHENYL 2-O-.ALPHA.-L-RHAMNOPYRANOSYL-, InChI=1/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1, 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, 1-(4-((2-O-(6-deoxy-alpha-1-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, 1-(4-((2-O-(6-deoxy-alpha-1-mannopyranosyl)-beta-dextro-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl) propan-1-one, 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, neohesperidin DC, NEOHESPERIDIN DIHYDROCHALCONE,FEMA 3811,E-959,Neo-DHC,nci-c60764,Happy Sweet,Neohesperidin DC,Neohesperidin DHC,NEOHESPERIDINE DC,Hesperidin Impurity 4, Neohesperidin DC, NHDC, Neohesperidin dihydrochalcone, Neohesperidin dihydrochalcone, E959, 1-[4-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone, NHDC, Neohesperidin DC, Neohesperidin DHC, NHDC, Neohesperidine Dihydrochalcone, 1-Propanone,1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-,Glucopyranoside,3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-,β-D-,Glucopyranoside,3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-α-L-rhamnopyranosyl-,1-[4-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone,Neohesperidin dihydrochalcone,Neohesperidin DHC,Neohesperidine dihydrochalcone,NHDC,Neohesperidin DC,Citrosa,71552-53-9

Neohesperidine DC (E959) is an intense sweetener extracted from the peel of unripe bitter oranges (Citrus aurantium).
Neohesperidine DC is therefore not a fully synthetic additive, but rather a semi-natural product: the raw material comes from nature but is subsequently chemically processed into the final sweetener.

The result is a white, odorless powder, Neohesperidine DC, that is no less than 1,000 to 1,800 times sweeter than regular sugar.
Consequently, only very small amounts are needed, and Neohesperidine DC provides virtually no calories in products.
You primarily encounter neohesperidine DC in chewing gum, dairy products, soft drinks, desserts, candy, and toothpaste.

Neohesperidine DC (neohesperidin dihydrochalcone) is roughly 1500-1800 times sweeter than sugar, its sweet tastes like licorice.
Neohesperidine DC is derived from natural ingredients of citrus (naringin or hesperidin) by bio-transformation or chemical transformation.

Neohesperidine DC is an efficient sweetener, sweetness and flavor enhancer with non-toxic, low calorific, flavor and bitterness masking characteristics.
Neohesperidine DC also has some physiological activity, such as antioxidant, reduction of cholesterol and blood glucose.

Neohesperidine DC is used in a wide range of products including foods, medicines, dietary supplements, cosmetics and feeds.
Neohesperidine DC is a non-calorific sweetener and flavor enhancer.
Neohesperidine DC is 1.5 to 1.8 times sweeter than sucrose at threshold limit concentration.

Neohesperidine DC is very important it's synergic sweetening when combined with other sweeteners, both bulk and high intensity.
Neohesperidine DC is obtained by chemical processes from neohesperidin, which is a natural compound (flavonoid) and it is found in bitter oranges (Citrus aurantium).

Neohesperidine DC is, depending on the substance concentration, from 400 up to 1800 sweeter than sugar.
For food use, there are usually used preparations with a sweetening capacity of 400-600 times, often in combination with other sweeteners, that act synergistically.

Neohesperidine DC is frequently used in medication, because of its capacity to reduce bitter taste.
Neohesperidine DC is also appreciated in foods because it enhances and modifies natural flavors and is stable at high temperatures and in low pH.
Thus, Neohesperidine DC is added in non-alcoholic beverages based on water, milk or fruit juice, in beers and other alcoholic beverages.

Quantities of 50 mg/kg are used in desserts based on cocoa, milk, eggs, fats, cereals, fruits, in confectionery, pastry and bakery products, in preserved fruit products, in soups, sauces, salads, mustard etc.
In special products for wight control, in preparations administered under medical supervision and in some nutritional supplements, neohesperidine DC is added in quantities of 100 mg/kg, and chewing gum and drops can contain 400 mg/kg

Neohesperidine DC is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage.
Neohesperidine DC is found in sweet orange.

Neohesperidine DC has a role as an environmental contaminant, a xenobiotic, a plant metabolite and a sweetening agent.
Neohesperidine DC is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.
Neohesperidine DC is a flavonoid present naturally in citrus, mainly in the bitter Seville orange (Citrus aurantium).

Neohesperidine DC is found mainly in the peels of citrus fruits, but they are also found in:
*Citrus pulps
*Citrus purees
*Citrus juice

Neohesperidine DC is from all of them: pulps, purees and juices.
Neohesperidine DC is always manufactured making an exhaustive selection of the highest quality raw materials.
Neohesperidine DC is off-white crystals or powder.

Neohesperidine DC is insoluble in water.
Neohesperidine DC, sometimes abbreviated to neohesperidin DC or simply Neohesperidine DC, is an artificial sweetener derived from citrus.
Neohesperidine DC is particularly effective in masking the bitter tastes of other compounds found in citrus, including limonin and naringin.

Industrially, it is produced by extracting neohesperidin from the bitter orange, and then hydrogenating this to make Neohesperidine DC.
Food additive E 959, Neohesperidine DC is a semi-synthetic sweetener with high sweetening power .
Neohesperidine DC is a derivative of natural flavones from the inner layer of the citrus peel, for example narginine (the bitter principle in grapefruit peel), neohesperidine from Seville oranges, and prunine.

Neohesperidine DC is a high-intensity sweetener derived from neohesperidin, a flavonoid naturally found in bitter oranges (Citrus aurantium).
Neohesperidine DC is produced through catalytic hydrogenation followed by alkaline treatment, converting the flavanone glycoside into a dihydrochalcone structure.

Neohesperidine DC is a high-intensity, low-calorie sweetener and flavor enhancer derived from bitter citrus fruits.
Neohesperidine DC is 1500–1800 times sweeter than sucrose, offering excellent heat stability for cooking and a lingering licorice-like aftertaste.

USES and APPLICATIONS of NEOHESPERIDINE DC:
Neohesperidine DC is good at masking bitterness—especially from citrus fruits.
Neohesperidine DC was for this particular application that the substance was first produced.
Today, Neohesperidine DC is also used to mask bitterness in medicine and animal feed.

Neohesperidine DC is also sweet—up to 3,000 times sweeter than ordinary sugar.
But how sweet Neohesperidine DC is perceived depends on the amount.
Neohesperidine DC is “only” 400–600 times sweeter than sugar in practical use.

Neohesperidine DC also makes other sweet substances taste even sweeter.
Neohesperidine DC has this synergistic effect on saccharin, aspartame, cyclamates, sucralose, acesulfame K and sugar alcohols.
This means that less of these sweeteners are needed to achieve the same sweetness.

It’s not just sweetness that is enhanced by Neohesperidine DC, but also other flavours and the mouthfeel.
For example, Neohesperidine DC can be added to dairy products, such as yoghurt and ice cream, to enhance the mouthfeel of ‘creaminess.’
Neohesperidine DC may be used in a wide range of foods such as soft drinks, desserts, ice cream, confectionery, certain pastries, fruit and vegetable preparations, high-fibre breakfast cereals, jams, marmalades, jellies, certain soups, vitamin or mineral supplements, sauces, certain snacks, alcoholic beverages and low alcoholic beverages.

Neohesperidine DC is used food - Beverages, desserts and related products, confectionery, bakery, savory products (paté, sauces, seasonings, mayonnaise, soups, fish and meat preserves).
At very low levels (1 - 5 ppm), Neohesperidine DC enhances the food flavor.
Neohesperidine DC is used cosmetic - Toothpaste, mouthwash, etc.

Feedstuff - The addition of Neohesperidine DC improves the feed taste and therefore the daily feed intake.
Neohesperidine DC is also used as a flavor enhancer, for example, to mask bitter flavors in pharmaceutical products and dietary supplements.
Because Neohesperidine DC is used in relatively few product categories and in very low concentrations, your daily exposure generally remains limited.

Beverages: Neohesperidine DC is used soft drinks, energy drinks, and dairy-based drinks.
Confectionery: Neohesperidine DC is used Chewing gum, candies, and desserts.
Pharmaceuticals: Neohesperidine DC is used masking bitter tastes in medicines and vitamins.

Feed Additives: Neohesperidine DC is used to improve the palatability of animal feed.
Neohesperidine DC is used in various industries due to its multifunctional properties.
In the food and beverage industry, Neohesperidine DC is used in soft drinks, fruit juices, dairy products, confectionery, and chewing gum.

Its ability to mask bitterness makes Neohesperidine DC particularly useful in products containing bitter ingredients such as caffeine, vitamins, or plant extracts.
In pharmaceutical applications, Neohesperidine DC is used to improve the taste of oral medications, syrups, and chewable tablets.
Neohesperidine DC enhances palatability and helps mask unpleasant flavors of active pharmaceutical ingredients.

Neohesperidine DC is also used in nutraceuticals and dietary supplements, especially in formulations where both sweetness and bitterness masking are required.
Neohesperidine DC hydrate, is a flavonoid sweetening agent with potent antioxidant activity.
Neohesperidine DC is antioxidant agent.

Neohesperidine DC is a preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit.
Neohesperidine DC is used as sweetening agent, especially in chewing gum and dentifrices.
In the pharmaceutical industry, Neohesperidine DC is used primarily as a masking agent.

Neohesperidine DC is widely used for bitterness masking in food, beverages, and pharmaceuticals.
Neohesperidine DC is widely used as a sweetener and flavor enhancer due to its strong sweetness and ability to mask bitterness.

-SWEETENER
As sweetener and taste enhancer, Neohesperidine DC is widely used in:
*Desserts, ice cream and dairy products.
*Confectionery.
*Beverage, soft drinks and juice industries.
*Candies.
*Personal care products such as mouth rinses, toothpastes …

-ENHANCING POWER
Neohesperidine DC's flavour enhancing power is highly appreciated in the following industries:
*Sauces and soups.
*Animal feed and health industries.

PHARMACEUTICAL APPLICATIONS of NEOHESPERIDINE DC:
Neohesperidine DC is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin.
Structurally, Neohesperidine DC is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium).
Neohesperidine DC is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer.
Neohesperidine DC profile is characterized by a lingering sweet/menthol-like aftertaste.
The typical level of Neohesperidine DC used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum.
Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, Neohesperidine DC is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins.
In antacid preparations, levels of 10–30 ppm result in improved palatability.
Neohesperidine DC acts as a purpose-built excipient meticulously crafted to ameliorate the lingering bitterness in medicinal formulations.
Adhering to the highest quality benchmarks set by EP and USP standards, Neohesperidine DC guarantees excellence and appropriateness for pharmaceutical applications.
Neohesperidine DC finds its principal applications in the healthcare and pharmaceutical sectors, where it is frequently employed in the development of oral formulations and the manufacturing of Active Pharmaceutical Ingredients (APIs).
Neohesperidine DC's role extends to refining the taste and overall palatability of medicinal products, ensuring a more pleasant and patient-friendly experience.

KEY CHARACTERISTICS AND USES of NEOHESPERIDINE DC:
*Source:
Produced by hydrogenation of neohesperidin, a flavonoid found in Seville oranges.

*Sweetening Intensity:
~1500–1800 times sweeter than sugar; often used in low concentrations.

*Flavor Modification:
Neohesperidine DC effectively masks bitterness and metallic notes while enhancing creamy flavors.

*Synergy:
Combined with other sweeteners (e.g., aspartame, acesulfame K), Neohesperidine DC enhances the overall sweetening effect, according to the International Sweeteners Association.

*Stability:
Stable in high temperatures and various pH conditions

BENEFITS of NEOHESPERIDINE DC:
Neohesperidine DC offers several advantages:
Neohesperidine DC provides intense sweetness at very low concentrations
Effectively masks bitter and metallic tastes
Enhances overall flavor profile of products
Suitable for low-calorie and sugar-free formulations
Stable in acidic and moderately high-temperature conditions

ADVANTAGES AND BENEFITS of NEOHESPERIDINE DC:
*Versatility:
Neohesperidine DC has a particular feature since, in addition to its use as a sweetener in food formulations it can also act as a flavour enhancer as well as a masking agent, which makes it different from the rest of alternative sweeteners used in the industry.

*Pleasant taste:
Neohesperidine DC's pleasant and intense sweet taste makes Neohesperidin widely accepted in different applications and sectors, always pleasing the final consumer.

*Flavour enhancer:
As a flavour enhancer,Neohesperidine DC works by increasing fruit and cocoa derivatives flavours.

*Masking agent:
As a masking agent, Neohesperidine DC reduces undesirable flavours in different food formulations such as acidity, bitterness, etc.

*Low concentrations:
Neohesperidine DC is one of the sweeteners of natural origin with higher sweetness intensity.

*Better consumer experience:
The persistence of the pleasant taste in the mouth of Neohesperidine DC is longer than the rest of sweeteners, making the intake more enjoyable for the final consumer.

*Pleasant to the palate:
Neohesperidine DC improves the sensation and texture in mouth, providing creaminess to different food formulations.

*Healthy:
Both, the caloric intake of Neohesperidine DC and its glycemic index, are zero.
This advantage allows the use of Neohesperidine DC in more products than other sweeteners, including products addressed to populations that suffer pathologies associated with obesity or metabolic syndrome.

*Stability:
Its high stability at different temperatures allows the Neohesperidine DC to be used in different sectors and in different stages of the production process.

*Economic:
Its versatility as a sweetener, enhancer or flavour masker using effective quantities of the order of ppm, less than other known sweeteners would require, makes Neohesperidine DC an economic food ingredient.

*Cost savings:
Neohesperidine DC has the capacity of achieving its desired effects using low quantities of it, and has also synergistic effects with other more expensive sweeteners.
That allows it to reach, with a smaller amount of the usual more expensive sweetener and a small amount of Neohesperidine DC, a similar taste effect for which it would require a higher amount of the usual individual sweetener.

PHYSICAL AND CHEMICAL PROPERTIES of NEOHESPERIDINE DC:
Neohesperidine DC is typically a white to slightly yellow crystalline powder.
Neohesperidine DC has an intensely sweet taste, approximately 1,500–1,800 times sweeter than sucrose, often accompanied by a delayed onset and lingering sweetness.

Neohesperidine DC is moderately soluble in water and more soluble in alkaline solutions.
Neohesperidine DC is relatively stable under acidic conditions and maintains its sweetness across a broad pH range, making it suitable for beverages and acidic food products.
Neohesperidine DC does not have a sharp melting point but decomposes upon heating at elevated temperatures.

Neohesperidine DC exhibits good thermal stability under typical food processing conditions.
Chemically, Neohesperidine DC belongs to the class of flavonoid-derived dihydrochalcones.
Neohesperidine DC is non-reducing and shows resistance to enzymatic hydrolysis compared to its precursor compounds.

CHARACTERISTICS of NEOHESPERIDINE DC:
Neohesperidine DC is characterized by:
*Very high sweetness intensity (1,500–1,800× sucrose)
*Strong flavor-modifying properties (bitterness masking)
*Synergistic effects when combined with other sweeteners
*Low caloric contribution due to low usage levels
*Stability in acidic environments
*Slightly delayed sweetness onset with lingering aftertaste

WHICH FOODS CONTAIN NEOHESPERIDINE DC?
According to Regulation (EU) No 1129/2011 Neohesperidine DC can be used in the following products:
Flavoured fermented milk products, including heat-treated products;
Fat and oil emulsions, including spreads,

Ice cream;
Fruit and vegetables in vinegar, oil or brine;
Fruit and vegetables preserved in tins or jars;
Fruit and vegetable preparations, except compotes;

Extra jams and extra jellies
Jams, jellies and marmalades and sweetened chestnut puree as defined;

Other similar fruit and vegetable spreads;
Cocoa and chocolate products;

Other confectionery, including breath freshening drops;
Decorations, coatings and fillings, except fruit-based fillings;
Chewing gum;

Breakfast cereals;
Fine bakery products;
Non-heat treated processed meat;

Heat-treated processed meat;
Processed fish and fishery products, including molluscs and crustaceans;
Table-top sweeteners in liquid form;

Powdered table sweeteners;
Table-top sweeteners in tablet form;
Mustard;

Soups and broths;
Sauces;
Salads and spicy spreads;

Protein products;
Dietary foods for special medical purposes;
Dietary foods for weight control, intended to completely replace the daily food intake or an individual meal (in whole or in part the total daily food intake);

Fruit nectars,
Flavoured drinks;

Beer and malt beverages;
Apple and pear cider;

Other alcoholic and spirituous beverages containing less than 15% alcohol, including mixtures of alcoholic and non-alcoholic beverages;
Potato, cereal, flour or starch-based snacks;
Processed nuts;

Desserts;
Food supplements supplied in solid form, including capsules and tablets and other similar forms, with the exception of chewable forms;
Food supplements supplied in liquid form;
Food supplements supplied in syrup or chewable form.
Food additive with flavor enhancing and sweetening role.

HOW IS NEOHESPERIDIN DC MADE?
Neohesperidine DC is not found in nature.
Neohesperidine DC is produced chemically from neohesperidin (without DC at the end), extracted from bitter orange or created by chemically converting naringin found in grapefruit.
The process consists of five steps:
Neohesperidin and potassium hydroxide are dissolved in water.

In the presence of a metal, hydrogen is added to the mixture under high pressure.
The metal, often palladium, acts as a landing site where neohesperidin, potassium hydroxide and hydrogen combine to become neohesperidin dihydrochalcone—i.e. Neohesperidine DC.
None of the metal is carried along; it’s just a catalyst.

The strongly basic mixture is neutralised with sulphuric acid.
The mixture is heated to form crystals.
These crystals are not pure; they contain particles and microorganisms.

They are therefore dissolved in hot water, filtered and then heated to form crystals of purer Neohesperidine DC.
This is called recrystallisation and is repeated until the crystals consist of at least 96 % Neohesperidine DC.
The thus extracted and purified Neohesperidine DC crystals are then dried, ground and packaged.

OTHER PROPERTIES of NEOHESPERIDINE DC:
In addition to masking bitterness, tasting sweet, enhancing flavour and improving mouthfeel, Neohesperidine DC has some other interesting properties.
Neohesperidine DC is heat resistant.
Neohesperidine DC has a long shelf life.

Neohesperidine DC is stable in both acidic and alkaline environments.
All are favourable properties.
But compared to regular sugar, Neohesperidine DC has some properties that can be positive or negative depending on the application.

Neohesperidine DC takes time before the sweetness is felt in the mouth.
Neohesperidine DC has a menthol/liquorice aftertaste.
And, of course, Neohesperidine DC provides no energy (0 kcal), has no effect on blood sugar levels (GI = 0) and does not cause caries.

PROPERTIES AND CHARACTERISTICS of NEOHESPERIDINE DC:
Worldwide approved food additive: Neohesperidine DC is approved as a food additive in Europe (E-959 code), being regulated according to the food categories where it is used.
In addition, Neohesperidine DC's use is also approved and regulated in the United States and Japan.

*High sweetening power:
Neohesperidine DC has a sweetness intensity around 1800 times compared to sucrose at threshold levels

*Taste Enhancer:
In addition to its sweetening power, Neohesperidine DC can also act as a product flavour enhancer.

*Masking agent:
Neohesperidine DC is also known as a less pleasant taste masking agent.
This property differentiates Neohesperidine DC from the rest of the alternative sweeteners used in the industry.

*Pleasant to taste:
The organoleptic profile of Neohesperidine DC is characterized by an intense sweet taste.
Using high concentrations, Neohesperidine DC presents an aftertaste with notes similar to liquorice.

*Persistence:
As an intensive sweetener, Neohesperidine DC has a very characteristic intensity-time profile.
Due to this, Neohesperidine DC produces a longer and more persistent sweetness sensation.

*Synergistic effects:
Neohesperidine DC has remarkable synergistic effects used together with other sweeteners currently used in the food industry.
These synergistic effects have been widely corroborated in different studies.

*Final product unaltered:
Many studies have proven that Neohesperidine DC, even improving the taste and flavour organoleptic properties, does not alter other organoleptic characteristics such as the smell of the product.

*Stability:
Neohesperidine DC is stable under normal processing and storage conditions of foods with a solubility at room temperature of 0.4 g / L, although this increases exponentially with the temperature reaching values up to 650 g / L at 80 ° C.
However, this is far to be an inconvenience for its use, due to that just ppm quantity of Neohesperidine DC is required to achieve perceptible effects.

*Healthy:
Neohesperidine DC is a sweetener that does not provide calories and has a zero glycemic index.

HOW IS NEOHESPERIDINE DC OBTAINED?
Industrially, Neohesperidine DC is obtained from narginine (a flavonoid from the peel of citrus fruits) by treating it with alkali, followed by its condensation with isovanillin.
The resulting Neohesperidine DC is hydrogenated in an alkaline medium, resulting in dihydrochalcone neohesperidin (Neo DHC).

Neohesperidine DC appears as off-white crystals or powder.
Neohesperidine DC is insoluble in water.
Neohesperidine DC is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage.

Neohesperidine DC is found in sweet orange.
Neohesperidine DC has a role as a xenobiotic, a sweetening agent, a plant metabolite and an environmental contaminant.
Neohesperidine DC is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.

Neohesperidine DC has been reported in Citrus reticulata, Vicia faba, and Citrus deliciosa with data available.
Neohesperidine DC is a chemical compound obtained from Neosperidine, a flavonoid found in oranges.
Neohesperidine DC appears in the form of a white powder.

WHAT NEOHESPERIDINE DC IS USED FOR AND WHERE?
*Food
Ingredient included in the list of European food additives as Neohesperidine DC as a sweetener and flavour enhancer.
Its sweetening power is about 1,550 times that of sucrose (1) and Neohesperidine DC has few calories.
In the USA Neohesperidine DC is a GRAS so an additive that poses no problem to human health, but is authorised as a flavouring ingredient and not as a sweetener.

*Safety
Ingredient deemed safe by the European Commission on Foodstuffs (SCF) in 1988.

*Medical:
Neohesperidine DC can be administered to people with diabetes and does not promote caries.

PREPARATION of NEOHESPERIDINE DC:
Neohesperidine DC is produced from Neohespendin (an isomer of Hesperidin), derived from the peel of the Seville Orange.

REACTIVITY PROFILE of NEOHESPERIDINE DC:
Neohesperidine DC is a ether-alcohol derivative.
The ether being relatively unreactive.
They react with oxoacids and carboxylic acids to form esters plus water.
Oxidizing agents convert alcohols to aldehydes or ketones.
Alcohols exhibit both weak acid and weak base behavior.
They may initiate the polymerization of isocyanates and epoxides.

PRODUCTION METHODS of NEOHESPERIDINE DC:
Neohesperidine DC is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidine DC is obtained by the alkaline hydrogenation of neohesperidin.

CHEMICAL PROPERTIES of NEOHESPERIDINE DC:
Neohesperidine DC occurs as a white or yellowish white powder with an intensely sweet taste.
Neohesperidine DC is about 1500-1800 times that of sucrose, and its sweetness time is slightly later than saccharin sodium and much faster than glycyrrhizin (5:7:23s).
Neohesperidine DC retention time of the three is 42:57:133s, which is also between Between the two, it is closer to sodium saccharin.
Neohesperidine DC is soluble in water, slightly soluble in ethanol, but insoluble in ether and benzene.

DISCOVERY of NEOHESPERIDINE DC:
Neohesperidine DC was discovered during the 1960s as part of a United States Department of Agriculture research program to find methods for minimizing the taste of bitter flavorants in citrus juices.
Neohesperidin is one such bitter compound.
When treated with potassium hydroxide or another strong base, and then catalytically hydrogenated, it becomes Neohesperidine DC.

PROFILE of NEOHESPERIDINE DC:
Neohesperidine DC in pure form is found as a white substance not unlike powdered sugar.
Neohesperidine DC is roughly 1500–1800 times sweeter than sugar at threshold concentrations; around 340 times sweeter than sugar.
Its potency is naturally affected by such factors as the application in which Neohesperidine DC is used, and the pH of the product.

Like other highly sweet glycosides, such as glycyrrhizin and those found in stevia, Neohesperidine DC's sweet taste has a slower onset than sugar's and lingers in the mouth for some time.
Unlike aspartame, Neohesperidine DC is stable to elevated temperatures and to acidic or basic conditions, and so can be used in applications that require a long shelf life.
Neohesperidine DC itself can stay foodsafe for up to five years when stored in optimal conditions.

Neohesperidine DC is well known for having a strong synergistic effect when used in conjunction with other artificial sweeteners such as aspartame, saccharin, acesulfame potassium, and cyclamate, as well as sugar alcohols such as xylitol.
Neohesperidine DC usage boosts the effects of these sweeteners at lower concentrations than would otherwise be required; smaller amounts of other sweeteners are needed.
This provides a cost benefit.

PHYSICAL and CHEMICAL PROPERTIES of NEOHESPERIDINE DC:
Molecular Formula: C₂₈H₃₆O₁₅
Molecular Weight: 612.58
Appearance: Off-white to light yellow powder
Purity: ≥95% (HPLC)
Melting Point: >143°C (dec.)
Heavy Metals: ≤0.001%
Water (KF): ≤12%
Solubility: Methanol (Slightly), Water (Slightly, Heated, Sonicated)
Product Name： Neohesperidin dihydrochalcone

Appearance： white or yellowish white powder
Assay: ≥ 98%
CAS No.： 20702-77-6
Molecular Formula： C28H36O15
Product Name: Neohesperidin dihydrochalcone
CAS No.: 20702-77-6
Molecular Formula: C28H36O15
InChIKeys: InChIKey=ITVGXXMINPYUHD-CUVHLRMHSA-N
Molecular Weight: 612.58
Exact Mass: 612.58

EC Number: 243-978-6
UNII: 3X476D83QV
DSSTox ID: DTXSID3025706
HScode: 2932999099
Categories: Sweeteners
PSA: 245
XLogP3: -0.3
Appearance: light yellow crystalline

Density: 1.6±0.1 g/cm3
Melting Point: 156-158 °C(lit.)
Boiling Point: 927.1°C at 760 mmHg
Flash Point: 302.6±27.8 °C
Refractive Index: 1.684
Water Solubility: Freely soluble in hot water, very slightly soluble in cold water, practically insoluble in ether and benzene
Storage Conditions: −20°C
Vapor Pressure: 0mmHg at 25°C
Air and Water Reactions: Insoluble in water.
Reactive Group: Alcohols and Polyols

CAS NUMBER: 20702-77-6
EC NUMBER: 243-978-6
MOLECULAR FORMULA: C₂₈H₃₆O₁₅
MOLECULAR WEIGHT: 612.58 g/mol
CHEMICAL FORMULA C28H36O15
MOLAR MASS 612.58 g/mol
MOLECULAR WEIGHT 612.6 g/mol
XLOGP3-AA -0.3

HYDROGEN BOND DONOR COUNT 9
HYDROGEN BOND ACCEPTOR COUNT 15
ROTATABLE BOND COUNT 10
EXACT MASS 612.20542044 Da
MONOISOTOPIC MASS 612.20542044 Da
TOPOLOGICAL POLAR SURFACE AREA 245 Å²
HEAVY ATOM COUNT 43
FORMAL CHARGE 0

COMPLEXITY 882
ISOTOPE ATOM COUNT 0
DEFINED ATOM STEREOCENTER COUNT 10
UNDEFINED ATOM STEREOCENTER COUNT 0
DEFINED BOND STEREOCENTER COUNT 0
UNDEFINED BOND STEREOCENTER COUNT 0
COVALENTLY-BONDED UNIT COUNT 1
COMPOUND IS CANONICALIZED Yes
ECHA EINECS - REACH PRE-REG: 243-978-6

FDA UNII: 3X476D83QV
NIKKAJI WEB: J2.757J
MDL: MFCD00017711
XLOGP3-AA: -0.30 (est)
MOLECULAR WEIGHT: 612.58292000
FORMULA: C28 H36 O15
APPEARANCE: white to pale yellow powder (est)
ASSAY: 96.00 to 100.00 sum of isomers
FOOD CHEMICALS CODEX LISTED: No

MELTING POINT: 156.00 to 158.00 °C. @ 760.00 mm Hg
BOILING POINT: 927.13 °C. @ 760.00 mm Hg (est)
FLASH POINT: > 200.00 °F. TCC ( > 93.33 °C. )
LOGP (O/W): 0.205 (est)
SOLUBLE IN:
water, 342.1 mg/L @ 25 °C (est)
CBNUMBER:CB3218194
MOLECULAR FORMULA:C28H36O15
MOLECULAR WEIGHT:612.58

MDL NUMBER:MFCD00017711
MOL FILE:20702-77-6.mol
Melting point: 156-158 °C(lit.)
Boiling point: 927.1±65.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
Vapor pressure: 0Pa at 20℃
FEMA: 3811 | Neohesperidin dihydrochalcone
FLAVIS Number: 16.061 | Neohesperidin dihydrochalcone

Storage temp.: Sealed in dry,Store in freezer, under -20°C
Solubility: Practically insoluble in water, freely soluble in dimethyl sulfoxide,
soluble in methanol, practically insoluble in methylene chloride.
Form: crystalline
pKa: 6.85±0.40(Predicted)
Color: light yellow
Odor: at 100.00 %. bland odor
Odor Type: odorless
Biological source: synthetic
Water Solubility: Insoluble
Merck: 14,6452

Stability: Hygroscopic
Major Application: flavors and fragrances
Cosmetics Ingredients Functions: FLAVOURING
FRAGRANCE
PERFUMING
InChIKey: ITVGXXMINPYUHD-CUVHLRMHSA-N
SMILES: COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3OC@H
C@@H
C@H
[C@H]3O[C@@H]4OC@@H
C@H
C@@H
[C@H]4O)cc2O)cc1O

LogP: 0.67 at 20℃
CAS DataBase Reference: 20702-77-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS): Neohesperidin dihydrochalcone
EWG's Food Scores: 1
FDA UNII: 3X476D83QV
EPA Substance Registry System: Neohesperidin dihydrochalcone (20702-77-6)
UNSPSC Code: 85151701
NACRES: NA.25
CAS Number: 20702-77-6

FIRST AID MEASURES of NEOHESPERIDINE DC:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of NEOHESPERIDINE DC:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of NEOHESPERIDINE DC:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of NEOHESPERIDINE DC:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of NEOHESPERIDINE DC:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of NEOHESPERIDINE DC:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available