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CAS NUMBER: 100-51-6
MOLECULAR FORMULA: C6H5CH2OH
MOLECULAR WEIGHT: 108.14
Phenylcarbinol is a very useful fixative and is an indispensable fragrance in the preparation of jasmine, moonlight, ylang-ylang and other fragrances.
Phenylcarbinol is a very useful fixative.
Phenylcarbinol is an indispensable spice in the preparation of jasmine, moonshine and other fragrances.
For the preparation of soap; daily cosmetic essence.
However, Phenylcarbinol can be slowly oxidized naturally, and a part of it generates benzaldehyde and benzyl ether, so that the commercial products often have almond fragrance, so it is not suitable for long-term storage.
Phenylcarbinol is widely used in the production of industrial chemicals.
Phenylcarbinol is used as paint solvent; photographic developer; polyvinyl chloride stabilizer; medicine; synthetic resin solvent; solvent for vitamin B injection; preservative for ointment or liquid medicine.
Phenylcarbinol can be used as nylon yarn; desiccant for fiber and plastic film, dye; cellulose ester; solvent for casein, intermediate for preparing benzyl ester or ether.
At the same time, Phenylcarbinol is widely used in pen making; paint solvent, etc.
Phenylcarbinol is used as a local anesthetic.
Phenylcarbinol is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
Phenylcarbinol is produced naturally by many plants and is commonly found in fruits and teas.
Phenylcarbinol is also found in a variety of essential oils including jasmine, hyacinth, and ylang-ylang.
Phenylcarbinol is an ingredient used in the manufacture of soaps, topical creams, skin lotions, shampoos, and facial cleansers and is popular due to its anti-bacterial and anti-fungal properties.
Phenylcarbinol is a common ingredient in a variety of household products.
Phenylcarbinol is also used as a solvent in food due to its low polarity, low toxicity, and low vapor pressure.
Phenylcarbinol is approved to use as food additive (E1519) and cosmetics in EU.
Phenylcarbinol is a water-white liquid with a faint aromatic odor and a sharp burning taste.
In industry, Phenylcarbinol is used in the manufacture of other benzyl compounds, and in perfumery and flavoring.
As a pharmaceutical product, Phenylcarbinol is used as an anti-parasite medication used to treat head lice.
Phenylcarbinol is also used as a common preservative in many injectable drugs.
Phenylcarbinol is used in nasal sprays as a preservative.
Phenylcarbinol is one of the simplest aromatic alcohols,which can be regarded as phenyl substituted methanol.
Phenylcarbinol is a naturally ocurring and synthetic ingredient used as solvent and preservative; has been associated with contact allergy.
Phenylcarbinol is a colorless liquid with a mild, pleasant odor.
Phenylcarbinol is partially soluble in water and completely miscible in alcohols, with essential and fatty oils and with ethyl ether.
Phenylcarbinol is a useful solvent due to its low toxicity, its polarity and its low vapour pressure.
Phenylcarbinol is commonly used as an antimicrobial, preservative, solvent and disinfectant in various applications, making it a very versatile product for different uses both industrial and consumer.
Phenylcarbinol has been used as an antimicrobial agent in pharmaceutical preparations for many years.
Phenylcarbinol is oxidised by alcohol dehydrogenase, a cytoplasmic enzyme present mainly in the liver, but also in the intestine and kidney.
This reaction is saturable.
The benzaldehyde formed is oxidised by aldehyde dehydrogenases (AldDH), cytoplasmic and mitochondrial enzymes mainly present in the liver, but also in the intestine and numerous organs.
Phenylmethanol is added in small amounts to surface-coating materials to improve their flow and gloss.
In the textile industry, Phenylmethanol is used as anauxiliary in the dyeing of wool, polyamides, and polyesters.
In pharmacy Phenylmethanol is used as a local anesthetic ingredient in over-the-counter anorectal, oral healthcare and topical analgesic drug products and, because of its antimicrobial effect, as an ingredient of ointments and other preparations.
Phenylmethanol is also a starting material for the preparation of numerous benzyl esters that are used as odorants, flavors, stabilizers for volatile perfumes, and plasticizers and is also employed in the extractive distillation of m- and p-xylenes and m- and p-cresols.
Other uses include or have included heat-sealing of polyethylene films,in color photography as a development accelerator and in microscopy as embedding material.
Phenylmethanol occurs in many essential oils and foods.
Phenylmethanol is a colorless liquid with a weak, slightly sweet odor.
Phenylmethanol can be oxidized to benzaldehyde, for example, with nitric acid.
Dehydrogenation over a copper–magnesium oxide–pumice catalyst also leads to the aldehyde.
Esterification of Phenylmethanol results in a number of important fragrance and flavor materials.
By heating Phenylmethanol in the presence of strong acids or strong bases, dibenzyl ether is formed.
Phenylcarbinol is an aromatic primary alcohol. Phenylmethanol is synthesized by Cannizzaro’s reaction, which involves the simultaneous oxidation and reduction of benzenecarbaldehyde (benzaldehyde) by refluxing in an aqueous solution of sodium hydroxide:
2C6H5CHO → C6H5CH2OH + C6H5COOH
Phenylmethanol undergoes the reactions characteristic of alcohols, especially those in which the formation of a stable carbonium ion as an intermediate (C6H5CH2 +) enhances the reaction.
Substitution onto the benzene ring is also possible; the –CH2OH group directs into the 2- or 4-position by the donation of electrons to the ring.
USAGE:
Phenylcarbinol is used as a general solvent for inks, waxes, shellacs, paints, lacquers, and epoxy resin coatings.
Phenylcarbinol can be used in paint strippers, especially when combined with compatible viscosity enhancers to encourage the mixture to cling to painted surfaces.
Phenylcarbinol is a precursor to a variety of esters and ethers, used in the soap, perfume, and flavor industries.
Phenylcarbinol is also used in e-liquid for e-cigarettes to enhance the flavors used.
Phenylcarbinol can be used as a local anesthetic, especially with epinephrine.
Phenylcarbinol can be utilized as a degreaser in rug cleaning products.
As a dye solvent, it enhances the process of dying wool, nylon, and leather.
Phenylcarbinol also has use as a photographic film developer and as an insect repellent.
Phenylcarbinol is used as a bacteriostatic preservative at low concentration in intravenous medications, cosmetics, and topical drugs.
Some caution is necessary if a high percent of Phenylcarbinol is used as benzaldehyde arises from Phenylcarbinol when used as preservative in an injectable formulation solution.
APPLICATION:
-Coatings
-Pigments and Dyes
-Inks
-Epoxy Hardeners
-Resin Solvent
-Personal Care
-Flavors
-Pharmaceutical
-Fragrances and Perfumery
PRODUCT DEATILS:
-Chemical formula: C7H8O
-Simplified structure: C6H5CH2OH
-Molecular weight: 108.138
-CAS number: 100-51-6
-EINECS Number: 202-859-9
-Appearance and Properties: Colorless liquid with aromatic smell.
-Melting point: -15.3℃
-Density: 1.04g/cm3
-Boiling point: 205.7℃
-Ignition temperature (℃): 436
-Solubility: slightly soluble in water, easily soluble in alcohol, ether and aromatic hydrocarbon.
-Refractive index: 1.5396
PURIFICATION:
Phenylcarbinol is usually purified by careful fractional distillation under reduced pressure in the absence of air.
Phenylcarbinol can be detected by UV absorption at 283nm.
Phenylcarbinol has also been purified by shaking with aqueous KOH and extracting with peroxide-free diethyl ether.
After washing with water, the extract is treated with saturated NaHS solution, filtered, washed, dried with CaO and distilled under reduced pressure.
FUNCTION:
-Bacteriostatic Agent - Prevents, slows or inhibits bacteria growth
-Drug / Medicine - Treats, alleviate, cure, or prevents sickness.
-As officially declared by a governmental drug/medicine regulatory body
-Fragrance / Fragrance Component - Provides or enhances a particular smell or odor.
-Insecticide / Pesticide - Kills or inhibits unwanted organisms
-Preservative - Prevents and inhibits the growth of unwanted microorganisms which may be harmful
-Viscosity Controlling Agent - Maintains or alters the thickness of a liquid, mostly used in cosmetics
PROPERTIES:
-Linear Formula: C6H5CH2OH
-Molecular Weight: 108.14
-Physical Appearance: Clear Colourless Liquid
-Odour: Faintly Aromatic
-Sp. Gravity At 20oC: 1.040 – 1.050
-Aldehyde Content(by Gc): 0.1%
-Solubility: Comply As Per Bp
-Assay(by Gc): Nlt 99.0 %
-Presence Of Chlrinated Compound: Free From Chlorine
-Acid Value: Nmt 0.2 %
CHEMICAL PROPERTIES:
-Chemical Formula: C7H8O
-Appearance: Colourless liquid
-Assay: >97%
-Boiling point: 205oC
-Flash point: 101oC
PHYSICAL PROPERTIES:
-Appearance: colorless crystals (est)
-Assay: 95.00 to 100.00
-Melting Point: 67.00 °C. at 760.00 mm Hg
-Boiling Point: 308.00 to 309.00 °C. at 760.00 mm Hg
-Vapor Pressure: 0.000301 mmHg at 25.00 °C.
-Flash Point: 265.00 °F. TCC ( 129.40 °C. )
-logP (o/w): 2.971
PRODUCT INFORMATION:
-CAS number: 100-51-6
-EC index number: 603-057-00-5
-EC number: 202-859-9
-Hill Formula: C₇H₈O
-Chemical formula: C₆H₅CH₂OH
-Molar Mass: 108.14 g/mol
-HS Code: 2906 21 00
PHYSICAL AND CHEMICAL INFORMATION:
-Boiling point: 205 °C (1013 hPa)
-Density: 1.05 g/cm3 (20 °C)
-Explosion limit: 1.3 - 13 %(V)
-Flash point: 101 °C DIN 51758
-Ignition temperature: 435 °C DIN 51794
-Melting Point: -15.3 °C
-Vapor pressure: 0.07 hPa (20 °C)
-Solubility: 40 g/l
GENERAL INFORMATION:
-Appearance: Colorless Transparent liquid
-Purity: 99%
-Specific Gravity,20ºC: 1.043-1.048
-Refractive index,20ºC: 1.538-1.541
-Benzaldehyde,ppm: 200max
-Peroxide number: 5max
-Residue on evaporation,%: 0.1max
-chloride,%: 0.005max
-water,%: 0.1max
-Acidity(as benzoic acid),%: 0.1max
PRODUCTION METHOD:
Benzyl chloride with potassium or sodium is heated for a long timg, and hydrolyzes to yield Phenylcarbinol.
Benzaldehyde in methanol and sodium hydroxide solution react to Phenylcarbinol at 65~75 ℃.
The product has high purity.
Using benzyl chloride as raw materials, it is heated and hydrolyzes to yield Phenylcarbinol in the presence of the sodium catalyst.
Specification of spices Phenylcarbinol(QB792-81): the relative density of 1.041-1.046; refractive index of 1.538-1.541; boiling range 203-206℃ and distillate volume more than 95%; dissolving completely in 30 volumes of distilled water; containing more than 98 percent of alcohol; chlorine test (NF) as the side reaction.
Raw material consumption quota: benzyl chloride 1600kg/t; soda ash 1000kg/t.
Phenylcarbinol exists naturally in orange flower, ylang-ylang, jasmine, gardenia, acacia, lilac and hyacinth.
Benzyl chloride or benzaldehyde is used as raw materials to prepare Phenylcarbinol in the industry.
Add chlorobenzyl to 12% sodium carbonate solution, heat to 93 ℃ and stir for 5h.
Then warm the mixture to 101~103℃ and react for 10h.
After the reaction, cool it to the room temperature, and add salt to saturation.
After still standing for stratification, take the upper liquid and get crude products through pressure distillation.
Then refine to gain the target products.
The yield is 70%～72%.
C6H5CH2Cl+H2O[Na2CO3]→C6H5CH2OH+NaCl+CO2↑
In the presence of sodium hydroxide, formaldehyde and benzaldehyde react to produce Phenylcarbinol by disproportionation reaction.
C6H5CHO+HCHO[NaOH]→C6h5CH2OH+HCOONa
PHYSICAL PROPERTIES:
Phenylcarbinol is colorless, hygroscopic, air sensitive liquid with a faint, pleasant, aromatic odor.
Odor threshold concentration in water is 10 ppm.
REACTIVITY PROFILE:
They are readily obtained by reacting hypochlorous acid and alcohols either in aqueous solution or mixed aqueous-carbon tetrachloride solutions.
Chlorine plus alcohols would similarly yield alkyl hypochlorites.
They decompose in the cold and explode on exposure to sunlight or heat.
Tertiary hypochlorites are less unstable than secondary or primary hypochlorites.
Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents.
Such reactions in the absence of solvents often occur with explosive violence.
SAFETY:
Phenylcarbinol is used in a wide variety of pharmaceutical formulations.
Phenylcarbinol is metabolized to benzoic acid, which is further metabolized in the liver by conjugation with glycine to form hippuric acid, which is excreted in the urine.
Ingestion or inhalation of Phenylcarbinol may cause headache, vertigo, nausea, vomiting, and diarrhea.
Overexposure may result in CNS depression and respiratory failure.
However, the concentrations of Phenylcarbinol normally employed as a preservative are not associated with such adverse effects.
Reports of adverse reactions to Phenylcarbinol used as an excipient include toxicity following intravenous administration; neurotoxicity in patients administered Phenylcarbinol in intrathecal preparations; hypersensitivity, although relatively rare; and a fatal toxic syndrome in premature infants.
HANDLING:
Wear personal protective equipment/face protection.
Ensure adequate ventilation.
Do not get in eyes, on skin, or on clothing.
Avoid ingestion and inhalation.
Keep away from open flames, hot surfaces and sources of ignition.
STORAGE:
Store below +30°C.
Stored in a cool, ventilated warehouse.
Stay away from fire and heat.
Storage should be kept separate from oxidant.
Equipped with corresponding varieties and quantities of fire equipment.
The storage area shall be equipped with leakage emergency treatment equipment and suitable shelter materials.
Keep in a dry, cool and well-ventilated place.
Keep container tightly closed.
Keep containers tightly closed in a dry, cool and well-ventilated place.
Keep away from heat, sparks and flame.
Incompatible Materials.
SYNONYM:
Phenylmethanol
phenylmethanol
benzenemethanol
100-51-6
phenylcarbinol
Benzoyl alcohol
benzylalcohol
Benzenecarbinol
Hydroxytoluene
Phenylmethyl alcohol
alpha-Toluenol
(Hydroxymethyl)benzene
Phenolcarbino
Benzal alcohol
alpha-hydroxytoluene
benzylic alcohol
Alcool benzylique
Benzylicum
Methanol, phenyl-
Phenylcarbinolum
hydroxymethylbenzene
Phenyl-Methanol
BENZYL-ALCOHOL
Euxyl K 100
Bentalol
Ulesfia
.alpha.-Hydroxytoluene
Aromatic alcohol
66072-40-0
Caswell No. 081F
FEMA No. 2137
.alpha.-Toluenol
Phenylmethanol (natural)
Alcool benzilico [DCIT]Itch-X
alcoholum benzylicum
NCI-C06111
benzenmethanol
Benzylalkohol
Aromatic primary alcohol
Alcohol,benzyl
Alcool benzylique
Benzyl alkohol
Alcohol bencilico
Methanol benzene
Alcoholum benzylicum
NSC 8044
HOCH-Ph-polymer
BnOH
Phenylmethanol, polymer-boun
Phenylmethanol Natural
NSC-8044
MFCD00004599
Hydroxymethyl resin
TOLUENE,ALPHA-HYDROXY
LKG8494WBH
CHEBI:17987
INS NO.1519INS-1519
Hydroxymethyl resin
NCGC00091865-01
Phenyl Methanol
DSSTox_CID_152
E-1519
DSSTox_RID_75404
DSSTox_GSID_20152
185532-71-2
MBN
Alcool benzilico
Alcohol, Benzyl
Alcohol bencilico
phenylmethan-1-ol
CAS-100-51-6
HSDB 46
Ulesfia (TN)
CCRIS 2081
Phenylmethanol
EINECS 202-859-9
UNII-LKG8494WBH
EPA Pesticide Chemical Code 009502
BRN 0878307
enzylalcohol
Benzalalcohol
Benzalcohol
Bentanol
Alcoolbenzylique
benzene-methanol
Phenylmethanole
a-Hydroxytoluene
a-Toluenol
AI3-01680
Phenylmethanol
Alcohol benzylicus
HOCH2-Ph-polymer
Sunmorl BK 20
Nat. Phenylmethanol
PhCH2OH
201740-95-6
Bn-OH
Phenylmethanol-13C6
SCHEMBL147
Phenylmethanol, ACS grade
bmse000407
C6H5CH2OH
CHEMBL720
EC 202-859-9
WLN: Q1R
Phenylmethanol
Phenylmethanol
PINAPUR™ 9 BA-R
Phenylmethanol
Phenylmethanol
Phenylmethanol
Phenylmethanol
4-06-00-02222
Phenylmethanol
BIDD:ER0248
ALCOHOL,BENZYL
Phenylmethanol
TB 13G
Phenylmethanol
Phenylmethanol, LR, >=99%
Phenylmethanol
Phenylmethanol
Phenylmethanol
Phenylmethanol
DTXSID5020152
BDBM16418
NSC8044
Phenylmethanol
Phenylmethanol Reagent ACS Grade
HMS3264B16
HMS3885F10
Pharmakon1600-01502555
ZINC895302
Phenylmethanol, analytical standard
Phenylmethanol, AR, >=99.5%
HY-B0892
Phenylmethanol, anhydrous, 99.8%
Tox21_111172
Tox21_202447
Tox21_300044
BBL011938
Phenylmethanol
MFCD03792087
NSC760098
s4600
STL163453
Phenylmethanol
Phenylmethanol, >=99%, FCC, FG
AKOS000119907
Phenylmethanol, natural, >=98%, FG
CCG-213843
DB06770
LS41488
NSC-760098
Benzylalcohol 100 microg/mL in Methanol
NCGC00091865-02
NCGC00091865-03
NCGC00091865-04
NCGC00254154-01
NCGC00259996-01
ALCOHOL BENZYLICUS
Phenylmethanol, ACS reagent, >=99.0%
Phenylmethanol, ReagentPlus(R), >=99%
Phenylmethanol, USP, 98.0-100.5%
Benzylalcohol 1000 microg/mL in Ethanol
Phenylmethanol on polystyrene, 3.5 mmol/g
B2378
Phenylmethanol, tested according to Ph.Eur.
Benzylalcohol 100 microg/mL in Acetonitrile
E1519
FT-0622812
Phenylmethanol, p.a., ACS reagent, 99.0%
Phenylmethanol, SAJ first grade, >=98.5%
A14564
Phenylmethanol, SAJ special grade, >=99.0%
Phenylmethanol, Vetec(TM) reagent grade, 98%
C00556
C03485
D00077
D70182
Q52353
AB01563201_01
A800221
SR-01000872610
J-000153
