PIPERIDINE

Piperidine is a six-membered saturated heterocyclic compound (C₅H₁₁N) consisting of five methylene (-CH₂-) groups and one nitrogen atom, structurally resembling cyclohexane and widely used as a base and nucleophile in organic chemistry.
Piperidine's most significant use is as a key intermediate in pharmaceutical synthesis, serving as the structural core for numerous active pharmaceutical ingredients such as haloperidol, risperidone, and raloxifene.
The global piperidine market is growing steadily, driven by its diverse applications in pharmaceuticals, agrochemicals, and industrial manufacturing, with a projected value of over USD 114 million by 2032.

CAS Number: 110-89-4
EC Number: 203-813-0
Chemical Formula: C5H11N
Molar Mass: 85.150 g·mol−1

Synonyms: PIPERIDINE, 110-89-4, Hexahydropyridine, Cyclopentimine, Azacyclohexane, Piperidin, Cypentil, Hexazane, Pentamethyleneimine, Pentamethylenimine, Perhydropyridine, Pyridine, hexahydro-, Pentamethyleneamine, azinane, FEMA No. 2908, CCRIS 967, HSDB 114, EINECS 203-813-0, DTXSID6021165, UNII-67I85E138Y, CHEBI:18049, AI3-24114, 67I85E138Y, DTXCID101165, EC 203-813-0, PENTAMETHSENEIMINE, 203-813-0, piperdine, Piperidine, homopolymer, MFCD00005979, CHEMBL15487, PIP, Piperidin [German], 89014-30-2, Piperidine, puriss. p.a., >=99.0% (GC/T), UN2401, piperadine, pyperidine, N-piperidine, Piperidine [UN2401] [Corrosive], Piperidine, 99%, Hexazane; Azacyclohexane, PIPERIDINE [MI], PIPERIDINE [FCC], PIPERIDINE [FHFI], PIPERIDINE [HSDB], TOLPERISONE_met028, Piperidine on Rasta Resin, NCIMech_000312, Piperidine (Peptide Grade), NCIOpen2_007828, PIPERIDINE [WHO-DD], Piperidine, >=99%, FG, Piperidine, >=99%, FCC, Piperidine, analytical standard, GTPL5477, FEMA 2908, Piperidine (Peptide Grade), 99%, Piperidine, ReagentPlus(R), 99%, STR00031, Tox21_201175, BDBM50026449, Piperidine [UN2401] [Corrosive], AKOS002309795, UN 2401, Piperidine, biotech. grade, >=99.5%, NCGC00248946-01, NCGC00258727-01, CAS-110-89-4, Piperidine, purum, >=96.0% (GC/T), Piperidine, SAJ first grade, >=99.0%, DB-188863, NS00009032, P0453, Piperidine, puriss. plus, >=99.5% (GC), C01746, P-6865, Piperidine, >=99.5%, purified by redistillation, Q410234, InChI=1/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H, 52167-54-1, StratoSpheres(TM) PL-PIP (Piperidine) resin, 50-100 mesh, extent of labeling: 3.0-4.0 mmol/g loading, 1 % cross-linked

Piperidine is an organic compound with the molecular formula (CH2)5NH.
This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–).

Piperidine is a colorless liquid with an odor described as objectionable, typical of amines.
The name comes from the genus name Piper, which is the Latin word for pepper.
Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins.

Piperidine can be prepared either by nickel catalyzed hydrogenation of pyridine or by cobalt catalyzed hydrogenolysis of tetrahydrofurylamine, Piperidine forms adducts with α,β,γ,δ-tetraphenylporphyriniron(II) and protoporphyriniron(II).
Mossbauer spectra of these adducts have been evaluated.

Piperidine constitutes the skeleton of various alkaloids.
Piperidine's chemical reactivity has been discussed.

Extensively finds applications as a base, a nucleophile and a solvent.
Piperidine is used for the production of dipiperidinyl dithiuram tetrasulfide, which is used as a rubber vulcanization accelerator.
Piperidine is commonly used in solid phase peptide synthesis (F-MOC Chemistry) and in chemical degradation reactions (sequencing of DNA).

Piperidine is used in making rubber, curing epoxy resins and in fine chemicals, and pharmaceuticals.

Piperidine appears as a clear colorless liquid with a pepper-like odor.
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen.

Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine.
Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. 

Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines.
Piperidine is a conjugate base of a piperidinium.

Piperidine is a six-membered saturated heterocyclic organic compound with the molecular formula C₅H₁₁N.
Structurally, Piperidine consists of a five methylene (–CH₂–) chain and one nitrogen atom forming a cyclic secondary amine.
Piperidine is a colorless to pale yellow liquid with a pungent, amine-like odor, and is highly soluble in water and most organic solvents.

Piperidine is an important chemical intermediate widely used in pharmaceutical synthesis, organic chemistry, and polymer production.
Piperidine occurs naturally in black pepper (Piper nigrum), from which its name is derived.

Piperidine is most notably used as a base catalyst in organic reactions, including condensations, alkylations, and polymerizations, and as a building block in the manufacture of pharmaceuticals (e.g., antipsychotics, analgesics, and antituberculosis drugs like isoniazid derivatives).

Chemically, piperidine is a weak base and can form salts with acids.
Piperidine is readily hydrogenated from pyridine and can also undergo N-substitution reactions, making it versatile for synthesizing more complex compounds.
Piperidine's flexible ring structure allows conformational adaptations, making it an ideal scaffold in medicinal chemistry for targeting biological receptors.

Due to its high reactivity and toxicity, piperidine must be handled in well-ventilated areas with appropriate personal protective equipment, as it can cause skin and respiratory irritation upon exposure.

Piperidine is a saturated heterocyclic organic compound with the molecular formula C₅H₁₁N, consisting of a six-membered ring containing five methylene (-CH₂-) units and one nitrogen atom. 
Piperidine is classified as a secondary amine and represents one of the simplest and most fundamental nitrogen-containing heterocycles.
In Piperidine's pure form, piperidine is a colorless to pale yellow, fuming liquid with a penetrating, fish-like, ammoniacal odor, characteristic of aliphatic amines.

Structurally, piperidine adopts a chair conformation, similar to cyclohexane, where the nitrogen atom is sp³ hybridized and partakes in hydrogen bonding, making the molecule polar.
This conformation gives Piperidine flexibility, which is important in its biological interactions and synthetic applications.
Piperidine is miscible with water and most organic solvents including ethanol, ether, and chloroform, and it shows basicity due to the lone pair of electrons on the nitrogen atom (pKa of the conjugate acid ≈ 11.2).

Market Overview of Piperidine:
The global piperidine market is witnessing consistent growth, driven by its critical role in pharmaceuticals, agrochemicals, and industrial manufacturing. 
In 2023, the market was valued at approximately USD 68.3 million and is projected to reach over USD 114.3 million by 2032, reflecting a compound annual growth rate (CAGR) of 5.89%.

One of the primary drivers of this growth is the pharmaceutical industry's increasing demand for piperidine as a key building block in the synthesis of various therapeutic agents, including antipsychotics, analgesics, and anticancer drugs.
The rising prevalence of chronic illnesses and intensive drug development efforts have significantly boosted its consumption.

In the agrochemical sector, piperidine is used in the formulation of herbicides and pesticides, and with global emphasis on sustainable agriculture, its relevance continues to expand.
Additionally, piperidine plays a role in the production of rubber accelerators and specialty chemicals, further diversifying its industrial applications.

Regionally, North America holds a dominant share due to Piperidine's mature pharmaceutical landscape and robust R&D investment, with the U.S. market alone expected to grow at a CAGR of 6.49%.
Meanwhile, the Asia-Pacific region is forecasted to experience the fastest growth owing to rapid industrialization and expanding pharmaceutical and agricultural sectors in countries like China and India.

Market segmentation by purity shows that 98% grade piperidine is primarily used in agrochemicals and rubber, while 99% purity is increasingly demanded by pharmaceutical manufacturers.
Overall, the market outlook remains strong, supported by growing applications, technological advancements, and the ongoing pursuit of high-efficiency, high-purity chemical intermediates.

Uses of Piperidine:
Piperidine is used as a solvent and as a base.

The same is true for certain derivatives:
N-formylpiperidine is a polar aprotic solvent with better hydrocarbon solubility than other amide solvents, and 2,2,6,6-tetramethylpiperidine is a highly sterically hindered base, useful because of its low nucleophilicity and high solubility in organic solvents.
A significant industrial application of piperidine is for the production of dipiperidinyl dithiuram tetrasulfide, which is used as an accelerator of the sulfur vulcanization of rubber.

Piperidine is a highly versatile chemical compound with a wide range of industrial, pharmaceutical, and agricultural applications.
Piperidine's most significant use is as a key intermediate in pharmaceutical synthesis, where it serves as the structural core for numerous active pharmaceutical ingredients (APIs), including antipsychotic drugs, analgesics, antidepressants, and antihypertensives.

Many well-known medications, such as haloperidol, risperidone, and raloxifene, contain piperidine rings, highlighting its importance in medicinal chemistry.
In peptide synthesis, piperidine is commonly used to remove protecting groups (especially Fmoc) during solid-phase peptide assembly.

Beyond pharmaceuticals, piperidine finds application in the agrochemical industry, where it is used in the formulation of herbicides, insecticides, and fungicides, contributing to crop protection and yield enhancement.
Piperidine also serves as a catalyst or base in various organic reactions, such as aldol condensations and Michael additions, due to its nucleophilic nitrogen atom.

Additionally, piperidine is utilized in the rubber and plastics industry as a component in the production of rubber accelerators and curing agents.
In the field of analytical chemistry, Piperidine is occasionally employed as a derivatizing agent.
Overall, piperidine’s chemical reactivity, structural flexibility, and biological compatibility make it a valuable multifunctional reagent across multiple scientific and industrial sectors.

Piperidine is a highly functional and broadly utilized heterocyclic compound that serves as a critical intermediate in various industries due to its chemical stability, basicity, and compatibility with a wide range of reactions.
The most prominent application of piperidine lies in the pharmaceutical industry, where it is a central building block in the synthesis of numerous therapeutic agents.

Piperidine rings are present in a variety of active pharmaceutical ingredients (APIs) including antipsychotics (e.g., haloperidol, risperidone), antidepressants, antihypertensives, analgesics, and antituberculosis agents.
Piperidine's nitrogen atom contributes significantly to receptor binding and biological activity, making it a privileged scaffold in drug discovery and development.
Additionally, hydrogenated piperidine derivatives are used in CNS drugs and muscle relaxants, and the compound’s conformational flexibility allows it to mimic various bioactive molecular shapes.

In peptide chemistry, piperidine is indispensable for the removal of Fmoc protecting groups during solid-phase peptide synthesis (SPPS), which is a crucial step in assembling synthetic peptides for research, diagnostics, and therapeutic use.
In the agrochemical sector, piperidine and its derivatives are used in the formulation of a wide range of insecticides, herbicides, and fungicides, providing effective protection against pests and enhancing agricultural productivity.
These compounds act on neural or enzymatic targets in pests, making them effective at low concentrations while reducing environmental load.

From an industrial chemistry perspective, piperidine serves as a non-nucleophilic base and catalyst in various organic transformations such as Mannich reactions, Michael additions, aldol condensations, and Knoevenagel reactions.
Piperidine's basicity and ability to donate electron pairs make it particularly useful in synthesis pathways where control over reaction selectivity and pH is critical.
Piperidine is also employed in the manufacturing of rubber accelerators and polymer additives, where it helps control polymerization processes and improves the durability and elasticity of rubber products.

In material science and electronics, piperidine derivatives have been studied for their use in photoconductive materials and electrode surface modifications, although these applications remain more specialized.
Furthermore, piperidine has been investigated as a solvent for resins, esters, and terpenes, owing to its ability to dissolve a broad range of organic compounds.
Piperidine's presence in natural products such as alkaloids, including coniine and lobeline, also highlights its biological significance in nature.

Given its wide-ranging functionality, piperidine remains a compound of strategic importance in modern chemistry, serving roles that extend from synthetic methodology and catalysis to agricultural and medical applications.
As industries shift toward greener and more efficient synthesis routes, the demand for piperidine is expected to continue rising, particularly in the development of next-generation drugs, sustainable pesticides, and specialty chemicals.

Organic Synthesis:

Base and catalyst:
Piperidine serves as a mild organic base in many chemical reactions such as the Knorr synthesis and Mannich reactions.

Precursor for heterocycles:
Piperidine is used in making various heterocyclic compounds and fine chemicals.

Agrochemical Industry:
Piperidine is used in the production of pesticides and herbicides.
Piperidine acts as an intermediate for compounds like fungicides or plant growth regulators.

Polymer Industry:
Piperidine derivatives are used as stabilizers in plastics to prevent degradation caused by UV light and oxidation (e.g., HALS – Hindered Amine Light Stabilizers).

Corrosion Inhibitors:
Incorporated into corrosion prevention formulations, especially in oil and gas pipelines and industrial systems.

Industry Uses:
Laboratory chemicals
Intermediates

Applications of Piperidine:
Piperidine may be employed as protective and structure-directing agent in the post synthesis of MCM (Mobil Composition of Matter)-49 zeolites.

Piperidine is a versatile heterocyclic compound widely used in the pharmaceutical, agrochemical, and polymer industries. 
In pharmaceuticals, Piperidine serves as a core structural unit or intermediate in the synthesis of many drugs, including antipsychotics, antidepressants, and analgesics, due to its ability to enhance lipophilicity and biological activity.

In the agrochemical sector, piperidine derivatives are used to develop effective insecticides, herbicides, and fungicides.
Additionally, piperidine plays a crucial role in polymer chemistry as a building block for hindered amine light stabilizers (HALS), which protect plastics from UV degradation.
Piperidine's applications extend further into organic synthesis as a mild base and into industrial systems as a corrosion inhibitor, making piperidine a fundamental component in the development of advanced chemical products.

Industrial and Laboratory Applications:
Piperidine is widely used as a chemical intermediate in organic synthesis and industrial production.

Piperidine's most prominent uses include:

Pharmaceutical Synthesis:
Piperidine is a crucial building block for the production of antidepressants, antipsychotics, analgesics, vasodilators, and antihistamines.
Piperidine is part of the structure of drugs like paroxetine, haloperidol, risperidone, raloxifene, and sunitinib.

Peptide Chemistry:
Piperidine is extensively used for deprotecting Fmoc (fluorenylmethyloxycarbonyl) groups during solid-phase peptide synthesis.

Catalysis:
Piperidine is used as a base or catalyst in aldol condensations, Knoevenagel reactions, and esterifications.

Polymers and Resins:
Piperidine derivatives are incorporated into various thermoplastic and thermosetting resins, especially in the development of flame retardants and high-performance materials.

Agrochemicals:
Piperidine acts as a precursor for the synthesis of herbicides and pesticides, often contributing to the biological activity of the final molecule.

Conformation of Piperidine:
Piperidine prefers a chair conformation, similar to cyclohexane.
Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.

After much controversy during the 1950s–1970s, the equatorial conformation was found to be more stable by 0.72 kcal/mol in the gas phase.
In nonpolar solvents, a range between 0.2 and 0.6 kcal/mol has been estimated, but in polar solvents the axial conformer may be more stable.

The two conformers interconvert rapidly through nitrogen inversion; the free energy activation barrier for this process, estimated at 6.1 kcal/mol, is substantially lower than the 10.4 kcal/mol for ring inversion.
In the case of N-methylpiperidine, the equatorial conformation is preferred by 3.16 kcal/mol, which is much larger than the preference in methylcyclohexane, 1.74 kcal/mol.

Reactions of Piperidine:
Piperidine is widely used to convert ketones to enamines.
Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction.

Upon treatment with calcium hypochlorite, piperidine converts to N-chloropiperidine, a chloramine with the formula C5H10NCl.
The resulting chloramine undergoes dehydrohalogenation to afford the cyclic imine.

Natural Occurrence and Biosynthesis of Piperidine:
Piperidine naturally occurs in black pepper (Piper nigrum) and other members of the Piperaceae family, and this plant-derived origin is the basis for its name.
Piperidine is also found in trace amounts in tobacco and some alkaloid-containing plants.
Piperidine is a key structural motif in many naturally occurring alkaloids, such as lobeline, coniine, and piperine, and plays a vital role in plant defense mechanisms and signaling.

Natural occurrence of piperidine and derivatives:
Piperidine itself has been obtained from black pepper, from Psilocaulon absimile (Aizoaceae), and in Petrosimonia monandra.

The piperidine structural motif is present in numerous natural alkaloids.
These include piperine, which gives black pepper its spicy taste.

This gave the compound Piperidine's name.
Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco, and the toxic alkaloid coniine from poison hemlock, which was used to put Socrates to death.

Production of Piperidine:
Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist Auguste Cahours, who named it.
Both of them obtained piperidine by reacting piperine with nitric acid.

Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst:
C5H5N + 3 H2 → C5H10NH

Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.

General Manufacturing Information of Piperidine:

Industry Processing Sectors:
Pharmaceutical and Medicine Manufacturing
All Other Chemical Product and Preparation Manufacturing
All Other Basic Organic Chemical Manufacturing

History of Piperidine:
Piperidine was first isolated in 1850 by the German chemist Thomas Anderson, who obtained it by distilling piperine, the pungent alkaloid from black pepper (Piper nigrum), with potassium hydroxide.
Piperidine's name is derived from the Latin word "piper," meaning pepper, reflecting its botanical origin.

As organic chemistry advanced during the 19th and early 20th centuries, piperidine became a key compound in the synthesis of alkaloid analogs and nitrogen-containing heterocycles.
By the mid-20th century, Piperidine's simple six-membered ring structure and favorable chemical properties led to its widespread use as a reagent, base, and building block in pharmaceutical and industrial chemistry.

In the following decades, piperidine became central to the development of several important drug classes, particularly in analgesics, antihistamines, and psychotropics.
Today, Piperidine remains a critical component in modern synthetic chemistry, valued for both its chemical reactivity and its ability to improve the pharmacokinetics of therapeutic agents.

Stability and Reactivity of Piperidine:

Stability:
Stable under normal storage conditions.

Incompatible Materials:
Strong oxidizing agents (e.g., nitric acid, peroxides)
Acids
Acid chlorides and anhydrides

Hazardous Decomposition Products:
Carbon monoxide (CO)
Carbon dioxide (CO₂)
Nitrogen oxides (NOₓ)

Polymerization:
Not known to undergo hazardous polymerization.

Handling and Storage of Piperidine:

Handling:
Use only in well-ventilated areas or chemical fume hoods.
Avoid inhalation, skin, and eye contact.

Keep away from heat, sparks, open flames, and oxidizing agents.
Wear appropriate PPE (gloves, goggles, lab coat).

Storage:
Store in a tightly sealed container in a cool, dry, well-ventilated place.
Keep away from oxidizers, acids, and moisture.
Recommended storage temperature: Room temperature (15–25°C), away from direct sunlight.

First Aid Measures of Piperidine:

Inhalation:
Remove the person to fresh air immediately.
If breathing is difficult, administer oxygen.
Seek medical attention.

Skin Contact:
Remove contaminated clothing.
Wash affected area with soap and water for at least 15 minutes.
Seek medical attention if irritation develops.

Eye Contact:
Rinse cautiously with water for at least 15 minutes, lifting eyelids.
Seek immediate medical attention.

Ingestion:
Do not induce vomiting.
Rinse mouth thoroughly with water.
Seek medical attention immediately.

Firefighting Measures of Piperidine:

Flammability:
Piperidine is flammable and can form explosive mixtures with air.

Suitable Extinguishing Media:
Carbon dioxide (CO₂)
Dry chemical powder
Alcohol-resistant foam

Hazards from Combustion:
Toxic gases such as carbon monoxide (CO) and nitrogen oxides (NOₓ) may form.

Protective Equipment:
Wear full fire-resistant gear and self-contained breathing apparatus (SCBA).

Accidental Release Measures of Piperidine:

Personal Precautions:
Evacuate personnel from the area.

Wear PPE: gloves, goggles, respirator.

Environmental Precautions:
Prevent from entering drains, soil, or surface water.

Clean-up Procedure:
Absorb with inert material (e.g., sand, vermiculite).
Collect in sealed containers for proper disposal.
Ventilate area thoroughly.

Exposure Controls / Personal Protection of Piperidine:

Engineering Controls:
Use with adequate ventilation or under a chemical fume hood.
Use explosion-proof equipment if necessary.
Personal Protective Equipment (PPE):

Eyes:
Safety goggles or face shield

Skin:
Nitrile gloves, lab coat

Respiratory:
If vapor concentrations are high, use NIOSH-approved respirator

Body:
Flame-retardant lab coat or apron for large-scale handling

Exposure Limits:
OSHA PEL (TWA): 1 ppm (3 mg/m³)
ACGIH TLV (TWA): 1 ppm (skin)

Identifiers of Piperidine:
CAS Number: 110-89-4
ChEBI: CHEBI:18049
ChEMBL: ChEMBL15487
ChemSpider: 7791
ECHA InfoCard: 100.003.467
EC Number: 203-813-0
IUPHAR/BPS: 5477
KEGG: C01746
PubChem CID: 8082
RTECS number: TM3500000
UNII: 67I85E138Y
UN number: 2401
CompTox Dashboard (EPA): DTXSID6021165
InChI: InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
Key: NQRYJNQNLNOLGT-UHFFFAOYSA-N check
InChI=1/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
InChI=1/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
Key: NQRYJNQNLNOLGT-UHFFFAOYAY
SMILES: C1CCNCC1

CAS number: 110-89-4
EC index number: 613-027-00-3
EC number: 203-813-0
Hill Formula: C₅H₁₁N
Molar Mass: 85.15 g/mol
HS Code: 2933 32 00

CAS: 110-89-4
Molecular Formula: C5H11N
InChI Key: NQRYJNQNLNOLGT-UHFFFAOYSA-N
SMILES: C1CCNCC1
Molecular Weight (g/mol): 85.15

Properties of Piperidine:
Chemical formula: C5H11N
Molar mass: 85.150 g·mol−1
Appearance: Colorless liquid
Odor: Semen-like,[3] fishy-ammoniacal, pungent
Density: 0.862 g/mL
Melting point: −7 °C (19 °F; 266 K)
Boiling point: 106 °C (223 °F; 379 K)
Solubility in water: Miscible
Acidity (pKa): 11.22 (protonated)[4]
Magnetic susceptibility (χ): −64.2·10−6 cm3/mol
Viscosity: 1.573 cP at 25 °C

Boiling point: 106 °C (1013 hPa)
Density: 0.86 g/cm3 (20 °C)
Explosion limit: 1.5 - 10.3 %(V)
Flash point: 16 °C
Ignition temperature: 320 °C
Melting Point: -7 °C
pH value: 12.6 (100 g/l, H₂O, 20 °C)
Vapor pressure: 19.58 hPa (20 °C)
Viscosity kinematic: 1.77 mm2/s (20 °C)

vapor density:
2.94 (vs air)
3 (vs air)

Quality Level: 200

vapor pressure:
23 mmHg ( 20 °C)
23 mmHg ( 20 °C)

product line: ReagentPlus®
Assay: 99%
impurities: ≤0.5% water (Karl Fischer)
refractive index: n20/D 1.452 (lit.)
bp: 106 °C (lit.)
mp: −13 °C (lit.)

solubility:
organic solvents: soluble(lit.)
water: miscible(lit.)

density: 0.862 g/mL at 20 °C (lit.)
SMILES string: C1CCNCC1
InChI: 1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
InChI key: NQRYJNQNLNOLGT-UHFFFAOYSA-N

Molecular Weight: 85.15 g/mol
XLogP3: 0.8
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 85.089149355 Da
Monoisotopic Mass: 85.089149355 Da
Topological Polar Surface Area: 12 Ų
Heavy Atom Count: 6
Complexity: 30.9
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Piperidine:
Color according to color reference solution Ph Eur not more intensely colored than reference standard Y6: conforms
Purity (GC): ≥ 99.0 %
Density (d 20 °C/ 4 °C): 0.861 - 0.863
Color: ≤ 150 Hazen
Water: ≤ 0.50 %
Identity (IR): conforms

Related compounds of Piperidine:
Pyridine
Pyrrolidine
Piperazine
Phosphorinane
Arsinane

Names of Piperidine:

IUPAC name:
Piperidine

Preferred IUPAC name:
Piperidine

Other names:
Hexahydropyridine
Azacyclohexane
Pentamethyleneamine
Azinane