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Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a viscous, water-soluble yellow liquid.
In laboratory, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is occasionally used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.
CAS: 9005-65-6
MF: C24H44O6
MW: 428.600006103516
EINECS: 500-019-9
Synonyms
CHROMOGENIC SELECTIVE E.COLI 55MM;TRYPTONE SOY BROTH 120X15ML;TRYPTONE SOY BROTH 20X15ML;TWEEN(R) 80 Vetec(TM) reagent grade;CCA COLIFORMS CHROMOGENIC A. (ISO) 55MM;armotanpmo-20;atlox1087;atlox8916tf
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80, commonly known as polysorbate 80, is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics.
In food production, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach.
Besides, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive.
A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a synthetic surfactant composed of fatty acid esters of polyoxyethylene sorbitan.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is usually available as a chemically diverse mixture of different fatty acid esters, with the oleic acid comprising>58% of the mix.
However, the main component of polysorbate 80 is polyoxyethylene-20-sorbitan monooleate, which is structurally similar to polyethylene glycols.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 has a molecular weight of 1309.7 Da and a 1.064 g/ml density.
Amber-colored viscous liquid.
pH (5% aqueous solution) 5-7.
Faint odor and bitter taste.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is an ingredient commonly used in cosmetics as an emulsifier and surfactant.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 acts as a bridge between water and oil-based ingredients, allowing them to mix and form stable emulsions.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is derived from natural sources and is commonly produced by the esterification of sorbitol with fatty acids derived from vegetable oils.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80's chemical formula is C64H124O26.
Polysorbate 80 appears as a yellowish, viscous liquid.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is utilized in a wide range of cosmetic products, including creams, lotions, serums, and even some makeup formulations, to create smooth textures and ensure proper dispersion of ingredients.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is an additive used in processed food products for its emulsifying properties (ability to prevent fats from separating out).
Commercially produced frozen desserts, shortenings, baking mixes and icings, and canned vegetables are some of the foods that may contain polysorbate 80.
Additionally, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used as a dispersing agent for fat-soluble vitamins in vitamin-mineral dietary supplements and is commonly used in many pharmaceutical drugs.
If Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is included in a product, it should be noted on the list of ingredients found on the label.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 may compromise proper gastrointestinal function.
Research studies have repeatedly shown that it can increase intestinal membrane permeability (how much the intestinal membrane allows to pass through into the bloodstream) through a variety of means including causing the release of enzymes that damage the structure of the cells that make up the intestinal membrane.
Because polysorbate 80 increases intestinal permeability, it has been shown to also increase both the absorption and action of some pharmaceutical drugs.
Additionally, polysorbate 80 may affect the body's ability to absorb nutrients, notably of ionic minerals such as potassium and calcium.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a mild, nonionic surfactant.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 can be used as a surfactant for skin and hair cleansing products, a solubiliser for lipophilic oils and an emulsifier for O/W emulsions.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is suitable for cosmetic and pharmaceutical applications and complies with the current European Pharmacopoeia.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80, is a non-ionic surfactant and emulsifier widely used in food, pharmaceuticals, and cosmetics.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is derived from sorbitol and oleic acid, with a polyoxyethylene chain that enhances its solubility in water.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is characterized by its ability to reduce surface tension, allowing for the stabilization of emulsions and the dispersion of oils in aqueous solutions.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is known for its mildness and compatibility with various formulations, making it suitable for use in products such as salad dressings, ice creams, and topical creams.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 exhibits good thermal stability and is generally recognized as safe (GRAS) by regulatory agencies when used within specified limits.
Additionally, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 has emulsifying, wetting, and solubilizing properties, which contribute to its versatility in various applications.
However, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is essential to consider potential allergic reactions in sensitive individuals, as well as its impact on the microbiome when used in food products.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80, is a non-ionic surfactant, also known as Tween 80.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 also acts as an emulsifier and a solubilizer, making it a useful tool in scientific industries such as pharmaceuticals, food and cosmetics.
Chemistry
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
The full chemical names for Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 are:
Polyoxyethylene (80) sorbitan monooleate
(x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)
The critical micelle concentration of polysorbate 80 in pure water is reported as 0.012 mM.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 Chemical Properties
Melting point: -25 °C
Boiling point: >100°C
density: 1.08 g/mL at 20 °C
vapor pressure: <1 mm Hg ( 20 °C)
refractive index: n20/D 1.473
FEMA: 2917 | POLYSORBATE 80
Fp: >230 °F
storage temp.: -20°C
solubility: DMSO (Soluble), Methanol (Slightly)
form: viscous liquid
color: Amber
Specific Gravity: 1.080 (25/4℃)
PH Range: 6
Odor: mild alcoholic
PH: 5-7 (50g/l, H2O, 20℃)
Odor Type: alcoholic
biological source: synthetic
Water Solubility: 5-10 g/100 mL at 23 ºC
Merck: 14,7582
Hydrophilic-Lipophilic Balance (HLB): 10
Major Application: (ELISA and immunoassays)
Cosmetics Ingredients Functions: CLEANSING SURFACTANT - EMULSIFYING DENATURANT EMULSION STABILISING SURFACTANT - CLEANSING
Cosmetic Ingredient Review (CIR): Tween 80 (9005-65-6)
InChIKey: RGPBUVUVZKQNHD-MDZDMXLPSA-N
LogP: 4.392 (est)
EPA Substance Registry System: Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 (9005-65-6)
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a polyethylene sorbitol ester, with a calculated molecular weight of 1,310 daltons, assuming 20 ethylene oxide units, sorbitol, and 1 oleic acid as the primary fatty acid.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 are a series of nonionic surfactants derived from sorbitan esters.
They are soluble or dispersible in water but differ widely in organic and oil solubilities.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 has been widely used in biochemical applications including: solubilizing proteins, isolating nuclei from cells in culture,5 growing of tubercule bacilli,6 and emulsifying and dispersing substances in medicinal and food products.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 has little or no activity as an anti-bacterial agent except it has been shown to have an adverse effect on the antibacterial effect of methyl paraben and related compounds.
Polysorbates have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid.
They may reduce the activity of many preservatives.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 has a faint, characteristic odor and a warm, somewhat bitter taste.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
Physical Effects
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 may compromise proper gastrointestinal function.
Research studies have repeatedly shown that it can increase intestinal membrane permeability through a variety of means including causing the release of enzymes that damage the cellular structure.
As an outcome of its ability to increase intestinal permeability, polysorbate 80 has been shown to increase both the absorption and action of some pharmaceutical drugs.
Additionally, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 may alter nutrient absorption, notably of ionic minerals such as potassium and calcium.
Characteristics
Tween 80, commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid.
Tween 80 is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v).
A number of anticancer drugs can be formulated by Tween 80.
Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
Pharmacokinetics
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is rapidly removed from systemic circulation.
The Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (polysorbate 80 1.75 g) showed a polysorbate 80 peak concentration of 304 μg/ml.
The AUC for Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h.
The distribution of Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 at steady state was similar to the total blood volume (4.16 l), suggesting that Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 circulates as large micelles and does not significantly distribute outside the central compartment.
In vitro studies suggest that polysorbate 80 is metabolized by rapid carboxylesterase-mediated hydrolysis.
Uses
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is the trade name of a detergent that can be useful in identifying mycobacteria that possess a lipase that splits the compound into oleic acid and polyoxyethylated sorbitol.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used as an additive for cell culture media.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 has numerous effects, e.g. increasing the transformation frequency of Brevibacterium lactofermentum or enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
Food
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used as an emulsifier in foods.
For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding polysorbate prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Research using a ex vivo model suggests it may "profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states."
Health and beauty
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 may have more impurities than the food grade.
Medical
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is also used as an excipient in some European and Canadian influenza vaccines.
Influenza vaccines contain 2.5 μg of polysorbate 80 per dose.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is also used in granulation for stabilization of drugs and excipients when IPA binding.
Laboratory
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules).
When these species are added to a mixture of polysorbate 80 and phenol red, they break down Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 and cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
On RODAC agar plates used in microbiological control, Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.
Biochem/physiol Actions
Polyoxyethylene sorbitan mono-oleate; Polysorbate 80 is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.
