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Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is a nonionic surfactant and emulsifier used to stabilize oil-in-water emulsions, produced from sorbitol and oleic acid by esterification followed by ethoxylation.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is effective as a solubilizer, dispersant, wetting agent, and stabilizer in food, cosmetic, pharmaceutical, and industrial applications.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433)'s high HLB value of approximately 15 makes it the most widely used product in the polysorbate series and particularly suitable for dispersing oils, flavors, fragrances, and active ingredients in water-based systems.
CAS Number: 9005-65-6
EC Number: 500-019-9
Molecular Formula: C64H124O26
Molecular Weight: 1310 g/mol
Synonyms: Polysorbate 80, E433, INS 433, Polyoxyethylene Sorbitan Monooleate, Polyoxyethylene(20) Sorbitan Monooleate, PEG-20 Sorbitan Monooleate, Sorbitan Monooleate Ethoxylate, Ethoxylated Sorbitan Monooleate, POE(20) Sorbitan Monooleate, Oleic Acid Sorbitan Ester Ethoxylate, Tween 80, UNII 6OZP39ZG8H
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is an organic chemical compound from the polysorbate group, derived from polyethoxylated sorbitan and oleic acid, in which the hydrophilic groups are polyoxyethylene groups (polymers of ethylene oxide) and the lipophilic group is the oleic acid moiety.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is an amber to yellow colored viscous liquid that is easily soluble in water, methanol, and ethanol, soluble in cottonseed oil, corn oil, ethyl acetate, and toluene, but insoluble in mineral oil.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) lowers the interfacial tension between oil and water phases, allowing them to share a larger contact surface and form stable emulsions, with its hydrophilic head facing the water phase and its lipophilic tail facing the oil phase.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) has a critical micelle concentration in pure water of approximately 0.012 mM.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in the food industry as an emulsifier in dairy products, ice creams, sauces, desserts, baked goods, confectionery, processed meats, and margarine to stabilize emulsions, improve texture, and promote uniformity.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) can be applied to various industries including medicine, cosmetics, food, paint and pigment, textiles, and pesticides.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is compatible with a wide range of ingredients including oils, surfactants, and both hydrophilic and hydrophobic substances, making it versatile across diverse formulations.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) acts as an emulsifier, dispersant, wetting agent, solubilizer, stabilizer, and foaming agent depending on the application.
Uses of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in ice cream at up to 0.5% concentration to produce a smoother texture, improve handling, and increase resistance to melting by preventing milk proteins from completely coating fat droplets, allowing them to form chains and nets that hold air in the mixture.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in processed cheese to enhance meltability and texture, in bread and baked goods to improve texture and shelf life, and in cake mixes and frosting to improve consistency and stability.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used as an emulsifier in salad dressings to prevent separation and achieve a smooth texture, and in sauces and gravies to improve texture and stability.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in chocolate and candy coatings to improve flow properties and prevent blooming, and in chewing gum to enhance texture and consistency.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in processed meat products such as sausages to improve texture and moisture retention, in instant noodles to prevent sticking, and in margarine and spreads to achieve a smooth consistency.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in cosmetics including creams, lotions, serums, soaps, eyedrops, and mouthwashes as an emulsifier, solubilizing agent, and texture enhancer.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in pharmaceuticals as a surfactant and solubilizer in oral and topical products, as an excipient to stabilize aqueous formulations for parenteral administration, and as an emulsifier in the production of the antiarrhythmic drug amiodarone.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used as an excipient in influenza vaccines at 2.5 μg per dose, and is found in various other vaccines.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth, and on RODAC agar plates in microbiological control to counteract disinfectants and allow microbes to grow.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in granulation for stabilization of drugs and excipients during IPA binding, and as an emulsifier in the estrogen-regulating drug Estrasorb.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used as a co-foaming agent and stabilizer in polyurethane foam production.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is used in industrial applications as an emulsifier in pesticide production and as a surface active agent in cleaning and chemical formulations.
Benefits or Advantages of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) has an HLB value of approximately 15, providing strong oil-in-water emulsifying performance across a wide range of food, pharmaceutical, cosmetic, and industrial applications.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is a nonionic surfactant with a neutral charge, making it compatible with a broad range of formulation systems including ionic, cationic, and anionic components.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) exhibits solubilizing properties that enable it to dissolve hydrophobic substances in aqueous solutions, improving the solubility and bioavailability of poorly water-soluble drugs and active ingredients.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) acts as a stabilizer in formulations, preventing aggregation or precipitation of particles and enhancing the stability of suspensions and emulsions over time.
Features of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is an amber to yellow colored viscous oily liquid with a mild characteristic odor and a warm, slightly bitter taste.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) has a density of 1.102 g/mL, a viscosity of 300 to 500 centistokes at 25 degrees C, and a pH of 6 to 8 in a 5% aqueous solution.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) has an HLB value of approximately 15, a melting point of approximately -6 degrees C, a boiling point above 100 degrees C, and a flash point of approximately 113 degrees C.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) has a water solubility of 100 mL/L and is soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, and toluene, but insoluble in mineral oil.
Chemical Properties of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is derived from polyethoxylated sorbitan and oleic acid, with the full chemical name (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl); the designation 80 refers to the oleic acid (C18:1) lipophilic group and 20 indicates approximately 20 moles of ethylene oxide per molecule.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) has a chemical formula of C64H124O26 and a molecular weight of 1310 g/mol; the oleic acid used in its production is a mixture of different fatty acids rather than a pure compound.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is stable under recommended conditions and does not react dangerously under normal use conditions.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) may react with strong oxidizing agents, strong acids, or strong bases, and thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, and irritating organic fumes.
Production and Chemical Reactions of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is produced commercially in three main stages: dehydration of sorbitol to form sorbitan, esterification with oleic acid, and ethoxylation with approximately 20 moles of ethylene oxide to form the final polyoxyethylene chain.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) production is carried out under controlled conditions to ensure consistent HLB value, saponification value, hydroxyl value, and acid value within specification limits.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) quality control checks parameters such as acid value, saponification value, hydroxyl value, moisture content, oxyethylene content, residue on ignition, arsenic, and lead content.
Material Safety Data Sheet (MSDS) of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Handling of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) should be handled in accordance with good industrial hygiene and safety practices.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) handling requires avoiding contact with eyes, skin, and clothing, and avoiding breathing mist or aerosols.
SDS of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Stability and Reactivity of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Chemical stability:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) is stable under recommended storage and handling conditions.
Reactivity:
No dangerous reaction is expected under normal conditions of use.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) may react with strong oxidizing agents, strong acids, or strong bases.
Conditions to avoid:
Excessive heat.
Open flames.
Direct sunlight.
Freezing.
Contamination.
Incompatible materials:
Strong oxidizing agents.
Strong acids.
Strong bases.
Reactive chemicals.
Hazardous decomposition products:
Carbon monoxide (CO).
Carbon dioxide (CO2).
Irritating organic fumes.
Handling and Storage of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Handling:
Handle in accordance with good industrial hygiene and safety practices.
Avoid contact with eyes, skin, and clothing.
Avoid breathing mist or aerosols.
Storage:
Store in a cool, dry, and well-ventilated area.
Keep container tightly closed when not in use.
Protect from heat, direct sunlight, freezing, and contamination.
Keep in original sealed containers or suitable HDPE/plastic packaging.
First Aid Measures of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Inhalation:
Move person to fresh air.
If breathing difficulty or irritation occurs, seek medical attention.
Skin contact:
Wash affected area with plenty of water and soap.
Remove contaminated clothing.
Seek medical advice if irritation persists.
Eye contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Do not induce vomiting unless instructed by medical personnel.
Seek medical advice if symptoms occur.
Firefighting Measures of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Suitable extinguishing media:
Water spray.
Foam.
Dry chemical powder.
Carbon dioxide (CO2).
Specific hazards:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433) may burn under fire conditions.
Combustion may produce carbon monoxide, carbon dioxide, and irritating organic fumes.
Protective equipment for firefighters:
Wear self-contained breathing apparatus (SCBA).
Wear full protective clothing during firefighting operations.
Accidental Release Measures of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Personal precautions:
Avoid contact with skin and eyes.
Use suitable protective equipment.
Surfaces may become slippery after spillage.
Environmental precautions:
Prevent large spills from entering drains, waterways, or soil.
Cleanup methods:
Absorb with inert material such as sand, earth, or absorbent granules.
Collect into suitable labeled containers for disposal.
Wash spill area with water after collection.
Exposure Controls / Personal Protective Equipment of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Engineering controls:
Use adequate ventilation, especially where mist or aerosols may be generated.
Eye protection:
Wear safety goggles or face shield.
Skin protection:
Wear chemical-resistant gloves and protective clothing.
Respiratory protection:
Not normally required under good ventilation.
Use suitable respiratory protection if mist or aerosols are generated.
Hygiene measures:
Wash hands after handling.
Do not eat, drink, or smoke while using the product.
Identifiers of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
E Number: E433
INS Number: 433
CAS No.: 9005-65-6
EC No.: 500-019-9
RTECS Number: WG2932500
UNII: 6OZP39ZG8H
ECHA InfoCard: 100.105.529
CompTox Dashboard (EPA): DTXSID0021175
HLB value: Approximately 15
Chemical class: Nonionic surfactant / Polysorbate / Sorbitan ester
Function: Emulsifier, solubilizer, dispersant, wetting agent, stabilizer, foaming agent
Properties of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Physical state: Liquid
Appearance: Amber to yellow colored viscous oily liquid
Odor: Mild characteristic odor
Taste: Warm, slightly bitter
Density: 1.102 g/mL
Melting point: Approximately -6 degrees C
Boiling point: Above 100 degrees C
Flash point: Approximately 113 degrees C
Viscosity: 300 to 500 centistokes at 25 degrees C
pH (5% solution): 6 to 8
CMC: Approximately 0.012 mM in pure water
Solubility in water: 100 mL/L
Solubility in other solvents: Soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene
Insoluble in: Mineral oil
Ionic character: Nonionic
Emulsion type: Oil-in-water (O/W)
HLB value: Approximately 15
Specifications of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Chemical name: Polyoxyethylene(20) Sorbitan Monooleate (Polysorbate 80)
Acid value (mg KOH/g): ≤2.0
Saponification value (mg KOH/g): 45-55
Hydroxyl value (mg KOH/g): 65-80
Moisture (w/%): ≤3.0
Residue on ignition (w/%): ≤0.25
Oxyethylene (w/%): 65.0-69.5
Storage conditions: Store in a cool, dry, well-ventilated area in original sealed containers
Names of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) (E433):
Polyoxyethylene Sorbitan Monooleate
Polysorbate 80
E433
INS 433
Polyoxyethylene(20) Sorbitan Monooleate
PEG-20 Sorbitan Monooleate
POE(20) Sorbitan Monooleate
Sorbitan Monooleate Ethoxylate
Ethoxylated Sorbitan Monooleate
Tween 80
