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CAS NUMBER: 1338-41-6
EC NUMBER: 215-664-9
MOLECULAR FORMULA: C24H46O6
MOLECULAR WEIGHT: 430.6
IUPAC NAME: [2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] octadecanoate
Polyoxyethylene Sorbitan Monooleate is a fatty acid ester.
Polyoxyethylene Sorbitan Monooleate is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.
Polyoxyethylene Sorbitan Monooleate is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
The full chemical names for Polyoxyethylene Sorbitan Monooleate are:
*Polyoxyethylene (20) sorbitan monooleate
*(x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)
The critical micelle concentration of Polyoxyethylene Sorbitan Monooleate in pure water is reported as 0.012 mM
Other Names:
E number: E433
Brand Names:
*Kolliphor PS 80 - Kolliphor is a registered trademark of BASF
*Alkest TW 80
*Scattics
*Canarcel
*Poegasorb 80
*Montanox 80 – Montanox is a registered trademark of Seppic
*Tween 80 – Tween is a registered trademark of Croda Americas
*Kotilen-80 - Kotilen is a registered trademark of Kolb AG
USES:
Food:
Polyoxyethylene Sorbitan Monooleate is used as an emulsifier in foods.
For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding this substance prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Health and beauty:
Polyoxyethylene Sorbitan Monooleate is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of Polyoxyethylene Sorbitan Monooleate may have more impurities than the food grade.
Medical:
Polyoxyethylene Sorbitan Monooleate is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Polyoxyethylene Sorbitan Monooleate is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polyoxyethylene Sorbitan Monooleate is also used as an excipient in some European and Canadian influenza vaccines.
Influenza vaccines contain 2.5 μg of Polyoxyethylene Sorbitan Monooleate per dose.
Polyoxyethylene Sorbitan Monooleate is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
Polyoxyethylene Sorbitan Monooleate is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Polyoxyethylene Sorbitan Monooleate is also used as an emulsifier in the estrogen-regulating drug Estrasorb
Polyoxyethylene Sorbitan Monooleate is also used in granulation for stabilization of drugs and excipients when IPA binding.
Laboratory:
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of polysorbate 80 and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate
On RODAC agar plates used in microbiological control, Polyoxyethylene Sorbitan Monooleate counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.
Polyoxyethylene Sorbitan Monooleate, is a nonionic emulsifier and surfactant
Polyoxyethylene Sorbitan Monooleate, (=Polyoxyethylene Sorbitan Monooleate), also known as Polyoxyethylene Sorbitan Monooleate, is a nonionic emulsifier and surfactant and used in cosmetics and foods.
Polyoxyethylene Sorbitan Monooleate is a lipophilic emulsifier that is a sorbitan fatty acid ester, being a sorbitol-derived analog of glycerol monostearate.
Polyoxyethylene Sorbitan Monooleate is a nonionic, oil-dispersible surface-active agent.
Polyoxyethylene Sorbitan Monooleate is used as a gloss enhancer in chocolate coatings; as a dispersant aid in coffee whiteners; to increase volume in cakes and icings; and often in combination with polysorbates
Polyoxyethylene Sorbitan Monooleate is an emulsifier for water-in-oil creams and lotions, and a solubilizer of essential oils in water.
Polyoxyethylene Sorbitan Monooleate results from the reaction of stearic acid with sorbitol and is, therefore, synthetically produced from naturally derived materials.
Polyoxyethylene Sorbitan Monooleate is used as emulsifier for baked goods, icings & filings and whipped toppings.
Polyoxyethylene Sorbitan Monooleate is also used as a rehydration aid (production of active dry yeast) and as synthetic flavoring substances and adjuvants
Polyoxyethylene Sorbitan Monooleate has the chemical formula C24H44O6.
The molecular weight of Polyoxyethylene Sorbitan Monooleate is 430.6 g/mol.
Polyoxyethylene Sorbitan Monooleate has a transparent and clear appearance.
Polyoxyethylene Sorbitan Monooleate has a unique smell.
Polyoxyethylene Sorbitan Monooleate is a raw material in the form of a viscous liquid.
Polyoxyethylene Sorbitan Monooleate is used as a stabilizer and emulsifier in the production of different industrial products, especially in the food industry.
Polyoxyethylene Sorbitan Monooleate is used in agriculture as a wetting and emulsifying agent in the production of pesticides.
Polyoxyethylene Sorbitan Monooleate, including its raw material, is used for:.
-plant nutrition
-plant protection
-insecticides
-fungicides
-acaricides
-Physical and chemical properties of raw materials of herbaceous
PHYSICAL PROPERTIES:
-Molecular Weight: 430.6
-XLogP3-AA: 6.9
-Exact Mass: 430.32943918
-Monoisotopic Mass: 430.32943918
-Topological Polar Surface Area: 96.2 Ų
-Physical Description: White crystalline powder
-Color: White to tan
-Form: waxy solid
-Odor: Slight odor
-Taste: Bland taste
-Melting Point: 56-58°C
-Solubility: Soluble in ethanol, isopropanol, mineral oil, and vegetable oil.
-Density: 1.0
-Chemical Classes: Other Classes -> Stearates
Polyoxyethylene Sorbitan Monooleate is a fatty acid ester.
Polyoxyethylene Sorbitan Monooleate is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
Polyoxyethylene Sorbitan Monooleate is a viscous
Polyoxyethylene Sorbitan Monooleate is water-soluble yellow liquid.
Polyoxyethylene Sorbitan Monooleate is derived from polyethoxylated sorbitan and oleic acid.
Polyoxyethylene Sorbitan Monooleate is used as an emulsifier in foods.
Polyoxyethylene Sorbitan Monooleate is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
CHEMICAL PROPERTIES:
-Hydrogen Bond Donor Count: 3
-Hydrogen Bond Acceptor Count: 6
-Rotatable Bond Count: 20
-Heavy Atom Count: 30
-Formal Charge: 0
-Complexity: 417
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 0
-Undefined Atom Stereocenter Count: 4
-Defined Bond Stereocenter Count: 0
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 1
-Compound Is Canonicalized: Yes
The cosmetic grade of Polyoxyethylene Sorbitan Monooleate may have more impurities than the food grade.
Polyoxyethylene Sorbitan Monooleate is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Polyoxyethylene Sorbitan Monooleate is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polyoxyethylene Sorbitan Monooleate is also used as an excipient in some European and Canadian influenza vaccines.
Polyoxyethylene Sorbitan Monooleate is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
Polyoxyethylene Sorbitan Monooleate is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Polyoxyethylene Sorbitan Monooleate is also used as an emulsifier in the estrogen-regulating drug Estrasorb
Polyoxyethylene Sorbitan Monooleate is also used in granulation for stabilization of drugs and excipients when IPA binding.
Polyoxyethylene Sorbitan Monooleate, is a nonionic emulsifier and surfactant
Polyoxyethylene Sorbitan Monooleate, (=Polyoxyethylene Sorbitan Monooleate), also known as Polyoxyethylene Sorbitan Monooleate, is a nonionic emulsifier and surfactant and used in cosmetics and foods.
Polyoxyethylene Sorbitan Monooleate is a lipophilic emulsifier that is a sorbitan fatty acid ester, being a sorbitol-derived analog of glycerol monostearate.
Polyoxyethylene Sorbitan Monooleate is a nonionic, oil-dispersible surface-active agent.
Polyoxyethylene Sorbitan Monooleate is used as a gloss enhancer in chocolate coatings; as a dispersant aid in coffee whiteners; to increase volume in cakes and icings; and often in combination with polysorbates
Polyoxyethylene Sorbitan Monooleate is an emulsifier for water-in-oil creams and lotions, and a solubilizer of essential oils in water.
Polyoxyethylene Sorbitan Monooleate results from the reaction of stearic acid with sorbitol and is, therefore, synthetically produced from naturally derived materials.
Polyoxyethylene Sorbitan Monooleate is used as emulsifier for baked goods, icings & filings and whipped toppings.
Polyoxyethylene Sorbitan Monooleate is also used as a rehydration aid (production of active dry yeast) and as synthetic flavoring substances and adjuvants
Polyoxyethylene Sorbitan Monooleate has the chemical formula C24H44O6.
The molecular weight of Polyoxyethylene Sorbitan Monooleate is 430.6 g/mol.
Polyoxyethylene Sorbitan Monooleate has a transparent and clear appearance.
Polyoxyethylene Sorbitan Monooleate has a unique smell.
Polyoxyethylene Sorbitan Monooleate is a raw material in the form of a viscous liquid.
Polyoxyethylene Sorbitan Monooleate is used as a stabilizer and emulsifier in the production of different industrial products, especially in the food industry.
Polyoxyethylene Sorbitan Monooleate is used in agriculture as a wetting and emulsifying agent in the production of pesticides.
SYNONYMS:
Span 60
Sorbitan stearate
SORBITAN MONOSTEARATE
1338-41-6
Glycomul S
Liposorb S
Sorbitan C
Armotan MS
Sorbitan 0
Drewsorb 60
Crill 3
Montane 60
Liposorb S-20
Durtan 60
Newcol 60
Sorgen 50
Crill K 3
Nonion SP 60R
Nikkol SS 30
Nonion SP 60
Rikemal S 250
Sorbon S 60
Ionet S 60
Nissan nonion SP 60
Span 55
Emsorb 2505
2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl octadecanoate
Sorbitan, monooctadecanoate
Polyoxyethylene sorbitan monooleate
Stearic acid, monoester with sorbitan
D-Glucitol, anhydro-, monooctadecanoate
Sorbitan, esters, monooctadecanoate
Sorbester P18
Sorbitan monostearate
1,4-Anhydro-D-glucitol, 6-octadecanoate
Spantrade mark 60
D-Glucitol, 1,4-anhydro-, 6-octadecanoate
Sorbitan stearate, INN
[2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] octadecanoate
Sorbitan monostearate, BAN, USAN
3,6-Anhydro-1-O-octadecanoylhexitol
Sorbitane Monostearate - Polysorbate 60 in-source fragment
Stearic acid 2-(3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl ester
