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Polyoxyethylene sorbitan monostearate; Polysorbate 60, the full name polyoxyethylene (20) sorbitan monostearate, is an ingredient made from sorbitol, stearic acid (C18) and ethylene oxide.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is primarily used as an emulsifier in food (the European food additive number E435) and a solubilizer & surfactant in cosmetics.
Like other polysorbates, the number 60 after polysorbate means the type of fatty acid, here is monostearate; the number 20 following polyoxyethylene indicates the total number of oxyethylene groups in the molecule structure.
CAS: 9005-67-8
MF: C64H126O26
EINECS: 500-020-4
Synonyms
FEMA 2916;POLYSORBATE 60 USP/NF;POLYSORBATE 60 extrapure;Polysorbat 60;Polysorbatum 60, Tween(R) 60;Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate;TWEEN(R) 61;Lonzest(R) SMS-20
A polymer composed of Polyoxyethylene sorbitan monostearate; Polysorbate 60, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a stearate group.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is a polyoxyethylene-polyoxypropylene block copolymer that is composed of two different saturated fatty acid chains.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 has been used as a surfactant and stabilizer in the manufacture of pharmaceuticals, foods, cosmetics, and other products.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 has been shown to inhibit the growth of epidermal cells by binding to epidermal growth factor (EGF) receptors on the cell surface.
The effects of Polyoxyethylene sorbitan monostearate; Polysorbate 60 are also mediated through hydrogen bonding with the EGF receptor.
The pharmacokinetic properties of polysorbate 60 have been studied in vitro using human serum.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is used as an excipient in solid dispersions for oral administration and can be administered intravenously or subcutaneously.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is chemically stable at acidic pH levels and hydrochloric acid does not affect its structure.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 also has protease activity against trypsin at high temperatures,
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is the abbreviation of “polyoxyethylene (20) sorbitan monostearate”.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is primarily used as an emulsifier in food and a solubilizer and surfactant in cosmetics.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 helps water-based and oil-based ingredients blend easily and prevent their separation in food.
Sorbitan monooctadecanoate, a derivative of poly(1,2-ethylene oxide), commonly known as Polyoxyethylene sorbitan monostearate; Polysorbate 60, is a nonionic surfactant and emulsifier widely used in food, pharmaceuticals, and cosmetics.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is derived from sorbitan, a sugar alcohol, and octadecanoic acid (stearic acid), with poly(1,2-ethylene oxide) chains providing hydrophilic properties.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is characterized by its ability to reduce surface tension, allowing for the stabilization of emulsions and the solubilization of hydrophobic substances in aqueous solutions.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is typically a yellowish to amber liquid with a mild odor and is soluble in water, oils, and organic solvents.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is known for its low toxicity and is Generally Recognized As Safe (GRAS) for use in food products.
Polyoxyethylene sorbitan monostearate; Polysorbate 60's applications extend beyond food and pharmaceuticals to include personal care products, where it helps improve texture and consistency.
In addition, Polyoxyethylene sorbitan monostearate; Polysorbate 60 has been used in various industrial applications due to its emulsifying and dispersing properties.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 Chemical Properties
Melting point: 45-50 °C
Boiling point: 802.68°C (rough estimate)
density: 1.044 g/mL at 25 °C(lit.)
vapor pressure: <10 hPa (20 °C)
FEMA: 2916 | POLYSORBATE 60
refractive index: n20/D 1.474
Fp: >230 °F
storage temp.: Store below +30°C.
solubility: 100 g/L
pka: 0[at 20 ℃]
form: powder to lump to clear liquid
color: White or Colorless to Yellow
Odor: mild alcoholic
PH: 5.5-7.7 (50g/l, H2O, 25℃)
Odor Type: alcoholic
Water Solubility: 100 g/L
FreezingPoint: 21.0 to 25.0 ℃
Merck: 14,7582
Hydrophilic-Lipophilic Balance (HLB): 15
Cosmetics Ingredients Functions SURFACTANT - CLEANSING
SURFACTANT - EMULSIFYING
Cosmetic Ingredient Review (CIR): Tween 60 (9005-67-8)
InChI: 1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChIKey: HMFKFHLTUCJZJO-UHFFFAOYSA-N
LogP: 3.938 at 25℃
EPA Substance Registry System: Polyoxyethylene sorbitan monostearate; Polysorbate 60 (9005-67-8)
Polyoxyethylene sorbitan monostearate; Polysorbate 60 has a faint, characteristic odor and a warm, somewhat bitter taste.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is a mixture of stearate and palmitate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
Uses
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is used as an emulsifier for plastic & polymers, personal care and industrial applications.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is used as an emulsifier.
Suggested applications: cakes, shortenings, milk substitute, chocolate flavored syrup.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is reacted with ethylene oxide.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is a nonionic, waterdispersible surface-active agent which is very hydrophilic.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is also termed polysorbate 60.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is used in whipped vegetable toppings for overrun and lightness; in cakes for increased volume and fine grain; in icings and confectionery for lightness and syneresis control; and in salad dressing for emulsion stability.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is frequently used with sorbitan monostearate or monoand diglycerides.
The typical usage range is 0.10–0.40%.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 is a synthetic multi-ingredient that can be used as a surfactant, emulsifier, solubilizer, stabilizer in food, cosmetics and personal care products.
Food
Polyoxyethylene sorbitan monostearate; Polysorbate 60 helps water-based and oil-based ingredients blend easily and prevent their separation in food.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 are mostly used in food among the category of polysorbates, but the latter is used more than 60 in food.
As a high HLB emulsifier, its food grade can be blended with a low HLB emulsifier (e.g. sorbitan stearate, mono and diglycerides) to provide a suitable HLB value for the various food uses, either oil in water, or water in oil emulsion.
Cosmetics
Polyoxyethylene sorbitan monostearate; Polysorbate 60's general purpose in cosmetics is to mix water and oil together.
Polyoxyethylene sorbitan monostearate; Polysorbate 60 functions as a surfactant, emulsifier, solubilizer and dispersing agent.
Some of its applications as follows:
Help wash away body dirties by lowering the surface tension on the skin when used in shampoos and body washes.
Distribute essential oils, fragrances and colorants evenly in water.
Following cosmetic products may with Polyoxyethylene sorbitan monostearate; Polysorbate 60:
Lotions
Creams
Hair products
Skin care products
Makeup products
