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Description: Emulsifying agent consisting of sorbitol, ethylene oxide & stearic acid (polyoxyethylene-60 sorbitan monostearate), stearic acid is derived from vegetable oil, purity > 95%. Yellow-brownish viscous liquid, no or weak odor. Soluble in water & alcohols, insoluble in oils. HLB value: 14.9 (gives oil-in-water emulsions).
CAS No.: 9005-67-8
EC No.: 500-020-4
Synonyms:
POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; peg-4 sorbitan stearate; UNII-90SOR12GHG; 90SOR12GHG; POLYOXYETHYLENE SORBITAN MONOSTEARATE; Polyoxyethylene (20) sorbitan monostearate; UNII-CAL22UVI4M; CAL22UVI4M; UNII-HD40WR33LC; HD40WR33LC; UNII-X61U1UH01B; UNII-073G38N8GC; X61U1UH01B; Sorbitan monostearate, ethoxylated; 073G38N8GC; UNII-3453J8557N; Polysorbate 60 [USAN:INN:BAN:NF]; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; 3453J8557N; Sorbitan, monostearate polyoxyethylene deriv.; EC 500-020-4; Sorbitan, monostearate, polyoxyethylene derivs.; Q27271344; UNII-X9E1MY2JQG component DEKFZWMENCCOFU-LIKAHPKFSA-N; 2-[(2R)-2-[(2R,3S,4R)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl octadecanoate; emasol S-120V; glycosperse S-20; glycosperse S-20 KFG; hetsorb S-20; kaopan TW-S-120; liposorb S-20; lonzest SMS-20; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; monebat - 60; nikkol TS-10MV; norfox sorbo T-60; poe-20 sorbitan monostearate; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; polyethyleneglycol sorbitan monostearate; polyoxyethylene (20) sorbitan monostearate; polysorbate 60 FCC; polysorbate 60 USP/NF; rheodol TW-S120V; tween 60; T-61; TWEEN 61; TWEEN 60; Twain 60; FEMA 2916; TWEEN NO 60; TWEEN(R) 60; TWEEN(TM) 61; TWEEN(TM) 60; Tween 60 1LT; TWEEN(R) 61; Tween 60; Tween 60 250ML; Poylsorbate 60; Polysorbat 60; EmulsifierT-61; POLYSORBATE 60; POLYSORBATE 61; POLYSORBATUM 60; glycosperses-20; Glycos S-20 KFG; Lonzest(R) SMS-20; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; Tween-60(Tween60); POLYSORBATE,60,NF; POLYSORBATE,60,FCC; Polysorbate 60 (2 g); Tween60=Polysorbate60; POLYSORBATE 60 USP/NF; POLYSORBAT 60, PH EUR; PEG-3; SORBITAN STEARATE; PEG-6 SORBITAN STEARATE; Glycosperse(R) S-20 KFG; POLYSORBATE 60 extrapure; PEG-40 SORBITAN STEARATE; PEG-60 SORBITAN STEARATE; TWEEN(R) 60 75-175 MPA.S; EZNA KIT SOIL RNA (V-SPIN); KIT SOIL RNA MIDI EZNA 2 TESTS; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POE (20) SORBITAN MONOSTEARATE; Polysorbatum 60, Tween(R) 60; TWEEN 60 (POLYSORBATE) PH EUR NF; POLYOXYETHYLENE SORBITAN MONOSTEARATE; POLYOXYETHYLENE(6)SORBITANMONOSTEARATE; polyoxyethylene-40-sorbitanmonostearate; Polysorbat 60,Polysorbatum 60, Tween 60; po1yoxyethylene(20)sorbitan monostearate; POLYETHYLENE GLYCOL SORBITAN MONOSTEARATE; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYOXYETHYLENE (4) SORBITAN MONOSTEARATE; POLYOXYETHYLENE-1,4-SORBITAN-MONOSTEARATE; sorbitan,monostearatepolyoxyethylenederiv.; POLYOXYETHYLENE (20) SORBITAN MONOSTEARATE; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYOXYETHYLENE(20) SORBITAN MONOISOSTEARATE; POLYOXYETHYLENESORBITAN MONOSTEARATE*TWE EN 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYOXYETHYLENESORBITAN MONOSTEARATE*(TW EEN 61); Tween 60 (=Polyoxyethylene Sorbitan Monostearate); Sorbitan monostearate, ethoxylated, EO 4 or 20 mol; Sorbitan,monooctadecanoate,Poly(oxy-1,2-ethanediyl)derivs.; Tween 60 (=Polyoxyethylene Sorbitan Monostearate) [for Biochemical Research]; Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate; TWEEN 60,Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate; Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate, TWEEN(R) 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; peg-4 sorbitan stearate; UNII-90SOR12GHG; 90SOR12GHG; POLYOXYETHYLENE SORBITAN MONOSTEARATE; Polyoxyethylene (20) sorbitan monostearate; UNII-CAL22UVI4M; CAL22UVI4M; UNII-HD40WR33LC; HD40WR33LC; UNII-X61U1UH01B; UNII-073G38N8GC; X61U1UH01B; Sorbitan monostearate, ethoxylated; 073G38N8GC; UNII-3453J8557N; Polysorbate 60 [USAN:INN:BAN:NF]; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; 3453J8557N; Sorbitan, monostearate polyoxyethylene deriv.; EC 500-020-4; Sorbitan, monostearate, polyoxyethylene derivs.; Q27271344; UNII-X9E1MY2JQG component DEKFZWMENCCOFU-LIKAHPKFSA-N; 2-[(2R)-2-[(2R,3S,4R)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl octadecanoate; emasol S-120V; glycosperse S-20; glycosperse S-20 KFG; hetsorb S-20; kaopan TW-S-120; liposorb S-20; lonzest SMS-20; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; monebat - 60; nikkol TS-10MV; norfox sorbo T-60; poe-20 sorbitan monostearate; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; polyethyleneglycol sorbitan monostearate; polyoxyethylene (20) sorbitan monostearate; polysorbate 60 FCC; polysorbate 60 USP/NF; rheodol TW-S120V; tween 60; T-61; TWEEN 61; TWEEN 60; Twain 60; FEMA 2916; TWEEN NO 60; TWEEN(R) 60; TWEEN(TM) 61; TWEEN(TM) 60; Tween 60 1LT; TWEEN(R) 61; Tween 60; Tween 60 250ML; Poylsorbate 60; Polysorbat 60; EmulsifierT-61; POLYSORBATE 60; POLYSORBATE 61; POLYSORBATUM 60; glycosperses-20; Glycos S-20 KFG; Lonzest(R) SMS-20; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; Tween-60(Tween60); POLYSORBATE,60,NF; POLYSORBATE,60,FCC; Polysorbate 60 (2 g); Tween60=Polysorbate60; POLYSORBATE 60 USP/NF; POLYSORBAT 60, PH EUR; PEG-3; SORBITAN STEARATE; PEG-6 SORBITAN STEARATE; Glycosperse(R) S-20 KFG; POLYSORBATE 60 extrapure; PEG-40 SORBITAN STEARATE; PEG-60 SORBITAN STEARATE; TWEEN(R) 60 75-175 MPA.S; EZNA KIT SOIL RNA (V-SPIN); KIT SOIL RNA MIDI EZNA 2 TESTS; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POE (20) SORBITAN MONOSTEARATE; Polysorbatum 60, Tween(R) 60; TWEEN 60 (POLYSORBATE) PH EUR NF; POLYOXYETHYLENE SORBITAN MONOSTEARATE; POLYOXYETHYLENE(6)SORBITANMONOSTEARATE; polyoxyethylene-40-sorbitanmonostearate; Polysorbat 60,Polysorbatum 60, Tween 60; po1yoxyethylene(20)sorbitan monostearate; POLYETHYLENE GLYCOL SORBITAN MONOSTEARATE; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYOXYETHYLENE (4) SORBITAN MONOSTEARATE; POLYOXYETHYLENE-1,4-SORBITAN-MONOSTEARATE; sorbitan,monostearatepolyoxyethylenederiv.; POLYOXYETHYLENE (20) SORBITAN MONOSTEARATE; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYOXYETHYLENE(20) SORBITAN MONOISOSTEARATE; POLYOXYETHYLENESORBITAN MONOSTEARATE*TWE EN 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60; POLYOXYETHYLENESORBITAN MONOSTEARATE*(TW EEN 61); Tween 60 (=Polyoxyethylene Sorbitan Monostearate); Sorbitan monostearate, ethoxylated, EO 4 or 20 mol; Sorbitan,monooctadecanoate,Poly(oxy-1,2-ethanediyl)derivs.; Tween 60 (=Polyoxyethylene Sorbitan Monostearate) [for Biochemical Research]; Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate; TWEEN 60,Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate; Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate, TWEEN(R) 60; POLYSORBATE 60; POLİSORBAT 60; Polysorbate 60; polisorbat 60
POLYSORBATE 60
Description: Emulsifying agent consisting of sorbitol, ethylene oxide & stearic acid (polyoxyethylene-60 sorbitan monostearate), stearic acid is derived from vegetable oil, purity > 95%. Yellow-brownish viscous liquid, no or weak odor. Soluble in water & alcohols, insoluble in oils. HLB value: 14.9 (gives oil-in-water emulsions).
CAS: 9005-67-8
INCI Name: Polysorbate-60
Benefits:
Non-ionic, multi-purpose emulsifier (enables water and oil to mix)
Emulsifying efficacy is increased when combined with cetyl alcohol or sorbitan stearate
Acts as dispersing agent and anti-static thickener
Very useful as solubilizer and stabilizer of essential oils
Use: Warm to melt before use. Typical use level is 1 - 10%. For external use only.
Applications: Lotions, creams, hair loss treatments, skin cleansers, makeup products requiring emulsification.
Country of Origin: USA
Raw material source: Sorbitol, vegetable oils
Manufacture: Polysorbate 60 is obtained by esterification of sorbitol with one or three molecules of a fatty acid including stearic, lauric, oleic, and palmitic acid.
Animal Testing: Not animal tested
GMO: GMO-free
Vegan: Does not contain animal-derived components
Polysorbate 60
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Polysorbate 60 60, a compound used as a food additive in some pudding mixes to prevent scorching during preparation
Polysorbate 60s are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbate 60s are oily liquids derived from ethoxylated sorbitan (a derivative of sorbitol) esterified with fatty acids. Common brand names for Polysorbate 60s include Scattics, Alkest, Canarcel.[1]
Contents
1 Examples
2 See also
3 References
4 External links
Examples
Polysorbate 60 20 (polyoxyethylene (20) sorbitan monolaurate)
Polysorbate 60 40 (polyoxyethylene (20) sorbitan monopalmitate)
Polysorbate 60 60 (polyoxyethylene (20) sorbitan monostearate)
Polysorbate 60 80 (polyoxyethylene (20) sorbitan monooleate)
The number 20 following the 'polyoxyethylene' part refers to the total number of oxyethylene -(CH2CH2O)- groups found in the molecule. The number following the 'Polysorbate 60' part is related to the type of fatty acid associated with the polyoxyethylene sorbitan part of the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
Polysorbate 60 or Tween 60, the full name polyoxyethylene (20) sorbitan monostearate, is an ingredient made from sorbitol, stearic acid (C18) and ethylene oxide. It is primarily used as an emulsifier in food (the European food additive number E435) and a solubilizer & surfactant in cosmetics.
Like other polysorbates, the number 60 after polysorbate means the type of fatty acid, here is monostearate; the number 20 following polyoxyethylene indicates the total number of oxyethylene groups in the molecule structure.
How is it made?
According to the FDA, polysorbate 60 is manufactured by reacting stearic acid with sorbitol to obtain sorbitan monostearate first and then condensed with ethylene oxide. (1)
What is it made of?
As the commercial food grade stearic acid usually contains palmitic acid, so polysorbate 60 is a mixture of ethoxylated ethers of stearic and palmitic acid esters of sorbitol and its mono- and dianhydrides and other related compounds.
Specification
Other Names Tween 60
CAS Number 9005-67-8
Chemical formula C64H126O26
Molecular Weight 1312
Properties
Appearance
A lemon to orange-coloured oily liquid or semi-gel at 25°C. (2)
Structure
Polysorbate 60 chemical structure
Image Source
Hydrophilic groups: long polyoxyethylene groups
Lipophilic group: stearic acid
Hydrophile-Lipophile Balance (HLB)
14.9, gives oil-in-water emulsions, O/W.
It is more lipophilic than polysorbate 20 and 40 due to the long length of the fatty acids – stearic acid, compared with other fatty acids, lauric acid (C14) and palmitic acid (C16) that linked to the polyoxyethylene sorbitan part of the molecule, respectively.
Solubility
Soluble in water, insoluble in mineral oil and vegetable oils.
Soluble in ethyl acetate and toluene.
What’re the Uses of Polysorbate 60?
Polysorbate 60 is a synthetic multi-ingredient that can be used as a surfactant, emulsifier, solubilizer, stabilizer in food, cosmetics and personal care products.
Food
Polysorbate 60 helps water-based and oil-based ingredients blend easily and prevent their separation in food. Polysorbate 60 and 80 are mostly used in food among the category of polysorbates, but the latter is used more than 60 in food.
As a high HLB emulsifier, its food grade can be blended with a low HLB emulsifier (e.g. sorbitan stearate, mono and diglycerides) to provide a suitable HLB value for the various food uses, either oil in water, or water in oil emulsion.
Cosmetics
Its general purpose in cosmetics is to mix water and oil together. Polysorbate 60 functions as a surfactant, emulsifier, solubilizer and dispersing agent.
Some of its applications as follows:
Help wash away body dirties by lowering the surface tension on the skin when used in shampoos and body washes.
Distribute essential oils, fragrances and colorants evenly in water.
Following cosmetic products may with it:
Lotions
Creams
Hair products
Skin care products
Makeup products
Is Polysorbate 60 Safe to Eat?
Yes, it has been approved as a safe ingredient by the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA), as well as the Joint FAO/WHO Expert Committee on Food Additives (JECFA).
FDA
Polysorbate 60 may be safely used in food with multifunctions, such as an emulsifier, foaming agent, dough conditioner, dispersing agent, and surfactant & wetting agent.
The following food may contain it and the maximum usage (3):
Whipped edible oil topping 0.4%
Shortenings and edible oils 1%
Ice cream 0.1%
Dressings 0.3%
Cakes and cake mixes, icings and fillings 0.46%
Sugar confection coatings 0.2%
Vegetable fat-water emulsions 0.4%
Yeast-leavened bakery products 0.5%
EFSA
Polyoxyethylene (20) sorbitan monostearate (E435) is listed in Commission Regulation (EU) No 231/2012 as an authorised food additive and categorized in “Additives other than colours and sweeteners” (4).
Safety re-evaluation in 2018
Its safety was re-evaluated in 2018, together with other polysorbates (20, 40, 65, 80). (5)
UK Food Standards Agency
Categorized in “Emulsifiers, stabilisers, thickeners and gelling agents” (6)
Food Standards Australia New Zealand
It is approved ingredient in Australia and New Zealand with the code number 435. (7)
JECFA
Function Class: food additives, emulsifier. (8)
Acceptable daily intake: ADI “0-25mg/kg bw” set in 1973. (9)
What are the possible Side Effects of Polysorbate 60?
When we talk about the side effects of polysorbates, mostly focus on two carcinogens, one is ethylene oxide (Group 1), the raw material for the production; another one is 1,4-dioxane (Group 2B), a by-product of polysorbate ethoxylation.
However, the safety of these two substances in polysorbates have been approved due to the very few assay.
See also:
Details of the safety of two carcinogens
Frequently asked questions
What is the difference with polysorbate 65?
Polysorbate 65, the full name polyoxyethylene (20) sorbitan tristearate. There are three stearic acids in its molecule structure while polysorbate 60 only has one.
Is it Natural?
It is not natural as it is made from chemical synthesis between sorbitan fatty acid with ethylene oxide.
Is it Halal?
Yes, polysorbate 60 would be halal if the fatty acid stearic acid is sourced from vegetable oils.
Is it Vegan?
Yes, it is vegan if the fatty acid stearic acid derived from vegetable oils which are suitable for vegetarians. Stearic acid used to synthesize polysorbate 60 may also come from animal sources.
Conclusion
Now you may have a knowledge of the emulsifier – polysorbate 60 (E435), from the following aspects:
Production process
Uses
Safety
Side effects
FAQs: compare with polysorbate 65 and 80
I’m probably forgetting some information about polysorbate 60, and if you have any questions or remarks about this additive, feel free to let me know in the comments.
Polysorbate 60
Messages
Overview(active tab)
Safety
Resources
What Is It?
Polysorbate 20 and the other Polysorbate ingredients (Polysorbate 21, Polysorbate 40, Polysorbate 60, Polysorbate 61, Polysorbate 65, Polysorbate 65, Polysorbate 80, Polysorbate 81, Polysorbate 85) are a series of general purpose hydrophilic, nonionic surfactants. The Polysorbates are used in a variety of products including skin fresheners, skin care products, skin cleansing products, makeup bases and foundations, shampoos, permanent waves and fragrance powders.
Why is it used in cosmetics and personal care products?
The Polysorbate ingredients help other ingredients to dissolve in a solvent in which they would not normally dissolve. They also help to form emulsions by reducing the surface tension of the substances to be emulsified.
Scientific Facts:
Polysorbates are surfactants that are produced by reacting the polyol, sorbitol, with ethylene oxide. The number in the name of the Polysorbate indicates the average number of moles of ethylene oxide that has been reacted per mole of sorbitol. The polyoxyethylenated sorbitan is then reacted with fatty acids obtained from vegetable fats and oils such as lauric acid, palmitic acid, stearic acid and oleic acid. Polysorbates function to disperse oil in water as opposed to water in oil
Safety Information:
The Food and Drug Administration (FDA) permits Polysorbate 20, Polysorbate 60, Polysorbate 65 and Polysorbate 80 to be directly added to food as adjuvants of flavoring agents or as multipurpose additives. FDA also includes Polysorbate 20, Polysorbate 40, Polysorbate 60, Polysorbate 65, Polysorbate 80 and Polysorbate 85 on its list of indirect food additives as emulsifiers and/or surface active agents. Polysorbate 80 has FDA approval as an ophthalmic demulcent and may be used in Over-The-Counter (OTC) ophthalmic drug products. The safety of Polysorbate 20, Polysorbate 21, Polysorbate 40, Polysorbate 60, Polysorbate 61, Polysorbate 65, Polysorbate 80, Polysorbate 81 and Polysorbate 85 has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that Polysorbate 20, 21, 40, 60, 61, 65, 80, 81 and 85 were safe as cosmetic ingredients.
More safety Information:
CIR Safety Review: The Polysorbates are a series of polyoxyethylenated sorbitan esters that differ with respect to the number of polymerized oxyethylene subunits and the number and type of fatty acid groups present. The CIR Expert Panel reviewed data showing that Polysorbates were not mutagens or complete carcinogens. The available data indicated that these ingredients were used in numerous preparations without clinical reports of significant adverse effects.
FDA: Link to Code of Federal Regulations for information about the direct food uses for Polysorbate 20, Polysorbate 60, Polysorbate 65 and Polysorbate 80
FDA: Link to Code of Federal Regulations for information about the indirect food uses for Polysorbates
FDA: Link to Code of Federal Regulations for information about the OTC drug uses for Polysorbate 80
The Polysorbate ingredients may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union.
The Joint FAO/WHO Expert Committee on Food Additives has established an Acceptable Daily Intake of 0-25 mg/kg body weight for the sum of Polyoxyethylene (20) sorbitan esters of lauric, oleic, palmitic, and stearic acid.
