POLYSORBATE 65

Polysorbate 65 is a sorbitan fatty acid ester ethoxylate and is an effective emulsifier.
Polysorbate 65 is a polyoxyethylene sorbitan monooleate (polysorbate) surfactant that is used as a film-forming polymer and dispersing agent in solid preparations. 
Polysorbate 65 has been shown to inhibit the proliferation of prostate cancer cells, which may be due to its ability to bind to anti-prostate specific antigen (anti-pcsk9) antibody causing the antibody to aggregate and form a particle. 

CAS:    9005-71-4
EINECS:    500-019-9

Synonyms
Polysprbate65;Tween 65 Polysorbate 65;POE20;POLYETHYLENEGLYCOLSORBITANTRISTEARATE;POLYOXYETHYLENE-1,4-SORBITAN-TRISTEARATE;Sorbitantristearat, EO 20 mol;POLYOXYETHYLENE(20) SORBITAN TRISTEARATE(TWEEN (R) 65);Ahco 7166T

This process inhibits the interaction between the antibody and its target, preventing it from binding with PCSK9 protein. 
The addition of propranolol hydrochloride has been shown to increase the effectiveness of Polysorbate 65.
Synthetic food additive with emulsifying and flavoring role. 
Polysorbate 65 is also used as a solvent for other food additives. 
Polysorbate 65 is used in fine bakery products, sauces, desserts, confectioneries, fat emulsions for pastry, instant soups, ice, dietetic foods for body weight control. 
Polysorbate 65 is not recommended for vegetarians, because it can come from animal fats.

Polysorbate 65 Chemical Properties
Fp: 149 °C
storage temp.: Store at RT.
form: solid
color: Colorless to light yellow
Hydrophilic-Lipophilic Balance (HLB): 10.5
Cosmetics Ingredients Functions    SURFACTANT - EMULSIFYING
SURFACTANT - CLEANSING
EPA Substance Registry System: Polysorbate 65 (9005-71-4)

Tan, waxy solid; faint odor, bitter taste. 
Sol in mineral oil, vegetable oil, mineral spirits, acetone, ether, dioxane, alc, methanol; dispersible in water, carbon tetrachloride.

Uses    
Polysorbate 65 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is then reacted with ethylene oxide. 
Polysorbate 65 is a nonionic surfaceactive agent which is dispersible in fat, oil, and water. 
Polysorbate 65 is also termed polysorbate 65. 
Polysorbate 65 is used in frozen desserts, cakes, and coffee whiteners. 
Polysorbate 65 is frequently used with sorbitan monostearates or monoand diglycerides. 
Typical usage range is 0.10–0.40%.
Polysorbate 65 is a mid-range HLB, nonionic surfactant suggested for use in textile chemicals (lubricant, emulsifier), household products (o/w emulsifier) and cosmetic formulations (o/w emulsifier).
Polysorbate 65 is used as an emulsifier. 
Suggested applications: ice cream, cakes and cake icings.