POLYSORBATE (E432)

Polysorbate (E432) improves the stability of water-based products by helping oily ingredients spread evenly throughout the formulation.
Polysorbate (E432) is commonly selected for formulations that require good solubilizing power, mild performance, and consistent dispersion.
Polysorbate (E432) supports product clarity, texture, and uniformity in food, cosmetic, pharmaceutical, and industrial applications.

CAS Number: 9005-64-5
EC Number: 500-018-3
Molecular Formula: C58H114O26
Molecular Weight: 1226.48

Synonyms: Polysorbate 20, Tween 20, E432, INS 432, Polyoxyethylene sorbitan monolaurate, Polyoxyethylene (20) sorbitan monolaurate, PEG-20 sorbitan monolaurate, Sorbitan monolaurate ethoxylated, Ethoxylated sorbitan monolaurate, Polyethylene glycol sorbitan monolaurate, Sorbitan monododecanoate polyoxyethylene ether, Polyoxyethylene sorbitan laurate, POE sorbitan monolaurate, Non-ionic emulsifier, Non-ionic surfactant

Polysorbate (E432) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.
Polysorbate (E432)'s stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.

As the name implies, the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.[3]
Polysorbate (E432) consists of sorbitol, ethylene oxide, and lauric acid.

Polysorbate (E432) has a molecular formula of C58H114O26.
At room temperature, Polysorbate (E432) is in the form of a pale-yellow to yellow viscous liquid at room temperature.

Polysorbate (E432) is an O/W emulsifier with a Polysorbate (E432) HLB of 16.7.
Polysorbate (E432) is great at emulsifying and stabilizing oils in water.

Polysorbate (E432) uses as a solubilizers and penetrants and dispersants in food, pharmaceutical, and cosmetic formulations.
Polysorbate (E432) can also use as a softener, finishing agent, antistatic agent, and lubricant in the textile industry.

Polysorbate (E432) is a non-ionic surfactant, emulsifier, and solubilizer produced from sorbitan, lauric acid, and ethylene oxide.
Polysorbate (E432) is used to disperse oils, flavors, fragrances, and other hydrophobic ingredients into water-based formulations.
In food and industrial applications, Polysorbate (E432) helps improve emulsion stability, uniformity, clarity, and ingredient distribution.

Polysorbate (E432) is an organic chemical compound that is a derivative of sorbitol and lauric acid.
Polysorbate (E432) is an emulsifier, meaning that it helps to bind together substances that don’t normally mix, such as fats and water.
Polysorbate (E432) is commonly used in the food industry as a food additive.

Applications of Polysorbate (E432):
Polysorbate (E432) is widely used in the food industry as an emulsifier, stabilizer and thickening agent.
Polysorbate (E432) can be used in a variety of food products, such as sauces, dressings, ice creams, margarines, and creams to ensure consistency and prevent ingredients from delaminating.

Polysorbate (E432) is used in food, cosmetic, pharmaceutical, cleaning, and industrial formulations.
Polysorbate (E432) is commonly applied in beverages, flavor systems, sauces, dressings, bakery products, confectionery, creams, lotions, shampoos, sprays, oral liquids, topical products, detergents, and water-based mixtures.
Polysorbate (E432) is especially useful in oil-in-water systems where stable dispersion of oils, fragrances, flavors, or active ingredients is required.

Food Applications:
Polysorbate (E432) is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.

Biotechnical Applications:
In biological techniques and sciences, Polysorbate (E432) has a broad range of applications.

For example, Polysorbate (E432) is used:

as a washing agent in immunoassays, such as Western blots and ELISAs.
Polysorbate (E432) helps to prevent non-specific antibody binding.

In this major application, Polysorbate (E432) is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.
These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.

To saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
To stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure

As a solubilizing agent of membrane proteins
For lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.

Pharmaceutical Applications:
Polysorbate (E432) is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Industrial and domestic applications:
Polysorbate (E432) is used in many brands of baby wipes.
Polysorbate (E432) is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate (E432) is also used as wetting agent in rubber balers in the elastomer industry.
Polysorbate (E432) has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.

Advantages of Polysorbate (E432):
Polysorbate (E432) is soluble in water, ethanol, ethyl acetate, and toluene.
Polysorbate (E432) has multiple functions in numerous formulations.
Polysorbate (E432) can be used in food, cosmetic, pharmaceutical and industry.

Properties of Polysorbate (E432):
Polysorbate (E432) is a colorless or slightly yellowish liquid with a characteristic odor.
Polysorbate (E432) has the ability to emulsify fats, which means that it can help maintain the homogeneous consistency of food products that include both aqueous and fatty ingredients.

Stability and Reactivity of Polysorbate (E432):

Chemical stability:
Polysorbate (E432) is stable under recommended storage and handling conditions.

Reactivity:
No dangerous reaction is expected under normal conditions of use.
Polysorbate (E432) may react with strong oxidizing agents, strong acids, or strong bases.

Conditions to avoid:
Avoid excessive heat, open flames, direct sunlight, freezing, moisture, and contamination.

Incompatible materials:
Strong oxidizing agents, strong acids, strong bases, and reactive chemicals.

Hazardous decomposition products:
Thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, smoke, and irritating organic fumes.

Handling and Storage of Polysorbate (E432):

Handling:
Handle in accordance with good industrial hygiene and safety practices.
Avoid contact with eyes, skin, and clothing.
Avoid breathing mist, vapors, or aerosols.

Storage:
Store in a cool, dry, and well-ventilated area.
Keep container tightly closed when not in use.

Storage conditions:
Protect from heat, direct sunlight, moisture, freezing, and contamination.
Store away from incompatible materials.

Packaging materials:
Keep in original sealed containers or suitable plastic drums, metal drums, IBC containers, or lined industrial packaging.

Shelf life:
Stable under recommended storage conditions.

First Aid Measures of Polysorbate (E432):

Inhalation:
Move person to fresh air.
If breathing difficulty, coughing, or irritation occurs, seek medical attention.

Skin contact:
Wash affected area with soap and plenty of water.
Remove contaminated clothing if necessary.
Seek medical attention if irritation persists.

Eye contact:
Rinse cautiously with clean water for several minutes.
Remove contact lenses if present and easy to do.
Continue rinsing and seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Do not induce vomiting unless instructed by medical personnel.
Seek medical attention if discomfort occurs.

Most important symptoms:
May cause mild irritation to eyes, skin, or respiratory tract depending on exposure level.

Firefighting Measures of Polysorbate (E432):

Suitable extinguishing media:
Use water spray, foam, dry chemical powder, or carbon dioxide.

Unsuitable extinguishing media:
Do not use a direct high-pressure water jet, as Polysorbate (E432) may spread the material or fire.

Specific hazards:
Product may burn under fire conditions.
Combustion may produce carbon monoxide, carbon dioxide, smoke, and irritating organic fumes.

Protective equipment for firefighters:
Firefighters should wear self-contained breathing apparatus and full protective clothing.

Firefighting instructions:
Cool containers exposed to fire with water spray.
Prevent contaminated firefighting water from entering drains or waterways.

Accidental Release Measures of Polysorbate (E432):

Personal precautions:
Avoid contact with eyes, skin, and clothing.
Avoid breathing mist, vapors, or aerosols.

Spilled material may create a slippery surface.
Use appropriate personal protective equipment.

Environmental precautions:
Prevent material from entering drains, soil, surface water, or waterways.

Methods for containment:
Stop the leak if it is safe to do so.
Contain spilled material with inert absorbent material.

Methods for cleaning up:
Absorb with sand, earth, vermiculite, or other inert absorbent material.
Collect into suitable labeled containers for disposal.
Clean the contaminated area with water and detergent.

Disposal:
Dispose of collected material according to local, regional, and national regulations.

Exposure Controls / Personal Protective of Polysorbate (E432):

Engineering controls:
Use adequate ventilation, especially where mist, vapor, or aerosols may be generated.

Respiratory protection:
Normally not required under standard handling conditions.
Use suitable respiratory protection if ventilation is insufficient or aerosol formation occurs.

Hand protection:
Wear protective gloves suitable for chemical handling.

Eye protection:
Wear safety glasses or chemical splash goggles.

Skin and body protection:
Wear suitable protective clothing to prevent prolonged or repeated skin contact.

Hygiene measures:
Wash hands after handling and before eating, drinking, or smoking.
Remove contaminated clothing and wash before reuse.
Keep away from food, beverages, and animal feed.

Identifiers of Polysorbate (E432):
Product name: Polysorbate (E432)
Chemical name: Polysorbate (E432)
E No.: E432
INS No.: 432
CAS No.: 9005-64-5
EC No.: 500-018-3
Functional class: Emulsifier, Solubilizer, Surfactant, Stabilizer
Chemical type: Non-ionic surfactant

CAS NO.: 9005-64-5
E NO.: E432
MOLECULAR FORMULA: C58H114O26
MOLECULAR WEIGHT: 1226.48

Identifiers
CAS Number: 9005-64-5
ChemSpider: none
ECHA InfoCard: 100.105.528
E number: E432 (thickeners, ...)
RTECS number: TR7400000
UNII: 239B50Y732
CompTox Dashboard (EPA): DTXSID3031949

Properties of Polysorbate (E432):
Appearance: Clear to yellow viscous liquid
Odor: Mild characteristic odor
Solubility: Soluble or dispersible in water and alcohol
HLB value: Approximately 16.7
Ionic nature: Non-ionic

Chemical formula: C58H114O26
Molar mass: 1226 g/mol
Appearance: Clear, yellow to yellow-green viscous liquid.
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)

Surface tension:
CMC: 8.04×10−5 M at 21 °C
HLB: 16.7

Specifications of Polysorbate (E432):
Acid value: mg KOH/g, ≤2.0
Saponification value: mg KOH/g, 40~50
Hydroxyl value: mg KOH/g, 96~108
Moisture: w/%, ≤3.0
Residue on ignition: w/%, ≤0.25
Pb: mg/kg, ≤2
Oxyethylene: w/%, 70.0~74.0

Names of Polysorbate (E432):

IUPAC name:
Polyoxyethylene (20) sorbitan monolaurate

Other names:
Kolliphor PS 20
Montanox 20
Polysorbate (E432)
PEG(20)sorbitan monolaurate
Alkest TW 20
Tween 20
Kotilen-20