PRODUCTS

PROPYLPARABEN

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs.
As a food additive, Propylparaben has the E number E216.
To increase the activity and reduce Propylparaben is dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives.

CAS Number: 94-13-3
EC Number: 202-307-7
Chemical Formula: C10H12O3
Molecular Weight: 180.20

Propylparaben, the n-propyl ester of p-hydroxybenzoic acid, occurs as a natural substance found in many plants and some insects, although Propylparaben is manufactured synthetically for use in cosmetics, pharmaceuticals, and foods.
Propylparaben is a member of the class of parabens.

Propylparaben is a preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos, and bath products.
As a food additive, Propylparaben has the E number E216.

Sodium propyl p-hydroxybenzoate, the sodium salt of propylparaben, a compound with formula Na(C3H7(C6H4COO)O), is also used similarly as a food additive and as an anti-fungal preservation agent.
Propylparaben is E number is E217.

In 2010 the European Union Scientific Committee on Consumer Safety stated that Propylparaben considered the use of butylparaben and propylparaben as preservatives in finished cosmetic products as safe to the consumer, as long as the sum of their concentrations does not exceed 0.19%.

Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions.
Chemically Propylparaben is an ester of p-hydroxybenzoic acid.

Propylparaben is in the paraben family of preservatives used by the food, pharmaceutical, and personal care product industries.
Parabens mimic estrogen and can act as potential hormone (endocrine) system disruptors.

Propylparaben is a type of paraben having the chemical formula C10H12O3.
The molar mass of Propylparaben is 180.2 g/mol.

The density of Propylparaben is 1.06 g/cm3, and Propylparaben is melting point can range from 96 to 99 degrees Celsius.
We can name Propylparaben in IUPAC nomenclature as propyl 4-hydroxybenzoate.

Propylparaben is the n-propyl ester of p-hydroxybenzoic acid.
Propylparaben occurs naturally in plants and some insects.

However, Propylparaben can be manufactured synthetically to be used in the cosmetic industry, pharmaceutical industry, and food industry.
This is because Propylparaben can act as a preservative for various products.

The Propylparaben compound has anti-fungal and antimicrobial properties and can be used in a variety of water-based cosmetics and personal-care products due to this property.
Moreover, we can use Propylparaben as a food additive, and Propylparaben has the E number E216.
In addition, Propylparaben is a standardized chemical allergen, and Propylparaben is important in allergenic testing.

Propylparaben, the n-propyl ester of p-hydroxybenzoic acid, occurs as a natural substance found in many plants and some insects, although Propylparaben is manufactured synthetically for use in cosmetics, pharmaceuticals and foods.
Propylparaben is one of the most commonly used preservatives in cosmetics since Propylparaben is stable in most pH levels.

Propylparaben is a paraben, which is a group of controversial preservatives that also includes butylparaben, isobutylparaben, methylparaben, and ethylparaben.
All of these were at one time the most widely used group of preservatives used in cosmetics.

Parabens were so popular because of their gentle, non-sensitizing, and highly effective profile in comparison to other preservatives but also because they were derived naturally from plants, a rare phenomenon for a preservative.
Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens for a plants own protection.

Over the past 10 years parabens have become criticized and condemned for use in cosmetics due to their alleged relation to health concerns affecting women and men.
The research about parabens is conflicting and polarizing.

Some research indicates they are safe as used in cosmetics and are preferred over other preservatives to keep a formula stable.
These studies also showed parabens did not have any effect when compared to natural hormones in the body.

However, other research has concluded they are indeed problematic: Some studies determined a 100% concentration of parabens caused skin samples (meaning not intact skin on a person) to break down.
However, these studies don’t apply to the tiny amount (1% or less) of parabens typically used in cosmetics.
In low amounts, parabens were not shown to harm skin; in fact, they offer a benefit due to their ability to thwart the growth of mold, fungi, and harmful pathogens.

Other studies casting parabens in a negative light were based on force-feeding them to rats, a practice that is not only cruel but unrelated to what happens when parabens are applied to skin.
There are studies indicating absorption of parabens through skin associated with application of skin care products, but those studies did not take into consideration that parabens are still used as food-grade preservatives or found naturally in plants and that could have been the source not the cosmetics.

Propylparaben is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Propylparaben is used by consumers, by professional workers (widespread uses) and in formulation or re-packing.

Propylparaben is a preservative used in skincare and cosmetic formulations.

Propylparaben is classed as a paraben, a group of preservatives with slightly different functions and anti-microbial activity based on their size.
Other common parabens include methylparaben, butylparaben, isobutylparaben, and ethylparaben.

Propylparaben is used to extend the shelf-life of a product life by preventing microbial contamination.
Microbial contamination can occur from exposure to bacteria and molds in the air and general use of Propylparaben from your hands.

Preservatives like parabens are designed to reduce the likelihood that bacteria and molds can grow in your product.
This is important for ensuring the safety of a product.

Propylparaben naturally occurs in some fruit and vegetable products, such as barley, flaxseed, and grapes.
Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens to protect the plant.

The parabens used in cosmetics are identical to those found in nature.
If parabens are absorbed through the skin, the human body can quickly metabolize them to PHBA and eliminate them.

Parabens have up until recently been the most widely used group of preservatives in skincare and cosmetic products.
Parabens were so popular because of their gentle, non-sensitizing, and highly effective in comparison to other preservatives.
However, the use of parabens is now controversial due to their alleged relation to health concerns.

Propylparaben is an antimicrobial preservative used in cosmetics and personal care.
Parabens are the most commonly used preservatives in personal care products.

They are non-irritating, have low toxicity levels, and are active against a wide spectrum of fungi and bacteria at low concentrations.
In addition to meeting the NF standards of USP, our Propylparaben also complies with BP and PhEur requirements.
Propylparaben is recommended for toothpaste, mascara, eyeliner, lipstick, and eyeshadow.

Propylparaben, also known as propyl chemosept or propyl parasept, belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters.
These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group.

Propylparaben is a sweet, burnt, and hawthorn tasting compound.
Propylparaben is a potentially toxic compound.
Propylparaben is an antimicrobial agent, preservative, flavouring agent.

Propylparaben is the benzoate ester that is the propyl ester of 4-hydroxybenzoic acid.
Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products.

Propylparaben is also used as a food additive.
Propylparaben has a role as an antifungal agent and an antimicrobial agent.

Propylparaben is a benzoate ester, a member of phenols and a paraben.
Propylparaben is functionally related to a propan-1-ol and a 4-hydroxybenzoic acid.

Propylparaben is an antimicrobial agent, preservative, flavouring agent.
Propylparaben belongs to the family of Hydroxybenzoic Acid Derivatives.
These are compounds containing an hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxylic acid.

Propylparaben is a Standardized Chemical Allergen.
The physiologic effect of propylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.

Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria.
Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods.

Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways.
Propylparaben also decreases sperm number and motile activity in rats.

Uses of Propylparaben:
Propylparaben has antifungal and antimicrobial properties and is typically used in a variety of water-based cosmetics and personal-care products.
Propylparaben is also used as a food additive, and is designated with E number E216.
Propylparaben is also a Standardized Chemical Allergen and is used in allergenic testing.

Propylparaben is used as antimicrobial preservatives in pharmaceuticals, foods, cosmetics, and shampoos.
The parabens (methyl, ethyl, propyl, and butyl) were the most widely used preservatives in cosmetics (0.1% to 0.8%) until their sensitizing potential was recognized.

Widespread uses by professional workers:
Propylparaben is used in the following products: cosmetics and personal care products.
Other release to the environment of Propylparaben is likely to occur from: indoor use as processing aid.

Industry Uses:
Not Known or Reasonably Ascertainable

Consumer Uses:
Propylparaben is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Other release to the environment of Propylparaben is likely to occur from: indoor use as processing aid.

Other Consumer Uses:
Laboratory chemicals

Properties of Propylparaben:
Propylparaben is a fine white powder with a peculiar odor somewhat reminiscent of algae.
The purity is at least 98% and Propylparaben has a reasonably long shelf life.

Propylparaben is a widely used preservative in cosmetics, due to a combination of pleasant properties:
Propylparaben is very active against fungi and Gram positive bacteria
Propylparaben is, especially for a preservative, little harmful to the health of humans, animals and plants

Propylparaben usually breaks down easily and quickly in the environment
Propylparaben occurs naturally in various plants and animals and could therefore be called “natural”

Propylparaben is active in a fairly wide pH range, a pH of 5-6 is ideal, but 3-8 is also possible in many cases
Propylparaben has been used as a preservative in food, medicine and cosmetics for a century and is very well researched

Parabens do not always go well with highly ethoxylated substances such as polysorbate 20 and polysorbate 80 and to a lesser extent proylparaben becomes completely or partially inactive with, for example, lecithin and proteinaceous substances such as hyaluronic acid.
Furthermore, propylparaben may work well against fungi, but Propylparaben does not or hardly work against Gram-negative bacteria in particular.
Thus, an additional preservative is usually required.

Although rare, hypersensitivity to benzoic acid and related substances such as parabens does occur.
In that case, also do not use sodium benzoate, benzoic acid and benzoin tincture.
Incidentally, this hypersensitivity mainly affects damaged skin, a reaction is unusual on intact skin.

Paraben madness:
A disadvantage of a completely different nature is the fact that parabens received a lot bad press in recent decades.
In addition to many nonsense stories, there is also a more serious concern.

Parabens were found to have the potential to disrupt hormones in laboratory research.
For this reason, a lot of additional research has been done.

For the time being, Propylparaben seems that Propylparaben does not act as a hormone disruptor in mammals, but not all studies have yet been completed.
Because parabens have been used in food and cosmetics for more than a century, we know that there is no obvious great danger in the use of this group of substances, but Propylparaben would be nice if we could also exclude the possible hormone disruption completely.

Manufacturing Methods of Propylparaben:
Produced by esterifying p-hydroxybenzoic acid with n-propanol, using an acid catalyst such as sulfuric acid and an excess of propanol.
Propylparabens are heated in a glass-lined reactor under reflux.

The acid is then neutralized with caustic soda and Propylparaben is crystallized by cooling.
The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

Propylparaben is produced by the n-propanol esterification of p-hydroxybenzoic acid in the presence of sulfuric acid, with subsequent distillation.

Parabens are prepared by esterifying PHBA parahydroxybenzoic acid with the corresponding alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol.
The acid is then neutralized with caustic soda, and Propylparaben is crystallized by cooling, centrifuged, washed, dried under vacuum, milled, and blended.

Clinical Laboratory Methods of Propylparaben:
Bisphenol A (BPA), benzophenones and parabens are commonly used in the production of polycarbonate plastics, as UV-filters and as antimicrobial preservatives, respectively, and they are thought to exhibit endocrine disrupting properties.
Exposure to these compounds remains poorly characterized in developing countries, despite the fact that certain behaviors related to westernization have the potential to influence exposure.

The aim of this pilot study was to measure urinary concentrations of BPA, six different benzophenones and four parabens in 34 Tunisian women.
In addition, we identified some socio-demographic and dietary predictors of exposure to these compounds.

Chemical analyses were carried out by dispersive liquid-liquid microextraction (DLLME) and ultra-high performance liquid chromatography with tandem mass spectrometry detection (UHPLC-MS/MS).
Detection frequencies of methylparaben (MP), ethylparaben (EP) and propylparaben (PP) ranged between 67.6 and 94.1%. Butylparaben (BP) was found in 38.2% of the analyzed samples; BPA in 64.7%; and benzophenone-1 (BP-1) and benzophenone-3 (BP-3) were detected in 91.2 and 64.7% of the analyzed samples, respectively.

Urinary geometric mean concentrations of MP, EP, PP, and BP were 30.1, 1.4, 2.0 and 0.5 ng/L, respectively.
Geometric mean concentrations of BPA, BP-1, and BP-3 were 0.4, 1.3 and 1.1 ng/L, respectively.

Our results suggest that Tunisian women are widely exposed to BPA, parabens and some benzophenones.
Further studies on the general Tunisian population are needed in order to assess the levels of exposure to these compounds and to identify sources of exposure and population groups at higher risk.

Parabens are the most widely used preservative and are considered to be relatively safe compounds.
However, studies have demonstrated that they may have estrogenic activity, and there is ongoing debate regarding the safety and potential cancer risk of using products containing these compounds. In the present work, liquid chromatography-tandem mass spectrometry was applied to determine methylparaben and propylparabenconcentrations in serum, and the results were correlated with lipstick application.

Samples were analyzed using liquid-liquid extraction, followed by liquid chromatography-tandem mass spectrometry.
The validation results demonstrated the linearity of the method over a range of 1-20 ng/mL, in addition to the method's precision and accuracy.
A statistically significant difference was demonstrated between serum parabens in women who used lipstick containing these substances compared with those not using this cosmetic (p = 0.0005 and 0.0016, respectively), and a strong association was observed between serum parabens and lipstick use (Spearman correlation = 0.7202).

Two rugged liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the determination of propylparaben, Propylparaben is major metabolite, p-hydroxybenzoic acid (pHBA), and their sulfate conjugates have been developed and validated in citric acid-treated rat plasma.
To prevent propylparaben being hydrolyzed to pHBA ex vivo, rat plasma was first treated with citric acid; then collected and processed at a reduced temperature (ice bath).

Stable isotope labeled internal standards, d4-propylparaben, (13)C6-pHBA, and the d4-labeled internal standards of their sulfate conjugates were used in the methods.
The analytes were extracted from the matrix using protein precipitation, followed by chromatographic separation on a Waters ACQUITY UPLC HSS T3 column.

Quantification using negative ion electrospray was performed on a Sciex API 4000 mass spectrometer.
The analytical ranges were established from 2.00 to 200 ng/mL for propylparaben, 50.0-5000 ng/mL for pHBA, 50.0-10,000 ng/mL for the sulfate conjugate of propylparaben (SPP) and 200-40,000 ng/mL for the sulfate conjugate of pHBA (SHBA).

Inter- and intra-run precision for the quality control samples were less than 5.3% and 4.4% for all analytes; and the overall accuracy was within +/-5.7% of the nominal values.
The validated bioanalytical methods demonstrated excellent sensitivity, specificity, accuracy and precision and were successfully applied to a rat toxicology study under the regulations of Good Laboratory Practices (GLP).
Strategies have been developed and applied toward overcoming the challenges related to analyte stability, and environmental and endogenous background.

Action Mechanism of Propylparaben:
The mechanism of Propylparaben may be linked to mitochondrial failure dependent on induction of membrane permeability transition accompanied by the mitochondrial depolarization and depletion of cellular ATP through uncoupling of oxidative phosphorylation.

Reactivity Profile of Propylparaben:
Maximum stability of Propylparaben occurs at a pH of 4 to 5.
Incompatible with alkalis and iron salts.
Also incompatible with strong oxidizing agents and strong acids.

Handling and Storage of Propylparaben:

Nonfire Spill Response:

SMALL SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container.
Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material.

Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution.
Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS:
You should store Propylparaben under ambient temperatures.

Storage Conditions:
Keep container tightly closed in a dry and well-ventilated place.
Containers should be stored in a dry place & kept tightly sealed when not in use.

First Aid Measures of Propylparaben:

EYES:
First check the victim for contact lenses and remove if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.

Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN:
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital.

Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.

Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.

DO NOT INDUCE VOMITING.
IMMEDIATELY transport the victim to a hospital.

Fire Fighting of Propylparaben:
Fires involving Propylparaben can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
A water spray may also be used.

Fire Fighting Procedures:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

Accidental Release Measures of Propylparaben:

Personal precautions, protective equipment and emergency procedures:
Avoid dust formation.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Disposal Methods of Propylparaben:
Recycle any unused portion of Propylparaben for its approved use or return Propylparaben to the manufacturer or supplier.

Ultimate disposal of the chemical must consider:
Propylparaben's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations.
If Propylparaben is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Preventive Measures of Propylparaben:

Personal precautions, protective equipment and emergency procedures:
Avoid dust formation.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Precautions for safe handling:
Further processing of solid materials may result in the formation of combustible dusts.
The potential for combustible dust formation should be taken into consideration before additional processing occurs.
Provide appropriate exhaust ventilation at places where dust is formed.

Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with Propylparaben.

Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Identifiers of Propylparaben:
CAS Number: 94-13-3
ChEBI: CHEBI:32063
ChEMBL: ChEMBL194014
ChemSpider: 6907
ECHA InfoCard: 100.002.098
EC Number: 202-307-7
E number: E216 (preservatives)
KEGG: D01422
PubChem CID: 7175
UNII: Z8IX2SC1OH
CompTox Dashboard (EPA): DTXSID4022527
InChI: InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3
Key: QELSKZZBTMNZEB-UHFFFAOYSA-N
InChI=1/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3
Key: QELSKZZBTMNZEB-UHFFFAOYAD
SMILES: O=C(OCCC)c1ccc(O)cc1

CAS number: 94-13-3
EC number: 202-307-7
Grade: Ph Eur,BP,JP,NF
Hill Formula: C₁₀H₁₂O₃
Molar Mass: 180.2 g/mol
HS Code: 2918 29 00

Synonyms: Propyl 4-hydroxybenzoate, 4-Hydroxybenzoic acid propyl ester, Propylparaben
Linear Formula: HOC6H4CO2CH2CH2CH3
CAS Number: 94-13-3
Molecular Weight: 180.20
EC Number: 202-307-7

EC / List no.: 202-307-7
CAS no.: 94-13-3
Mol. formula: C10H12O3

Typical Properties of Propylparaben:
Chemical formula: C10H12O3
Molar mass: 180.203 g·mol−1
Density: 1.0630 g/cm3
Melting point: 96 to 99 °C (205 to 210 °F; 369 to 372 K)

Density: 1.287 g/cm3 (20 °C)
Flash point: 180 °C
Ignition temperature: >600 °C
Melting Point: 96 - 97 °C
pH value: 6 - 7 (H₂O, 20 °C) (saturated solution)
Vapor pressure: 0.67 hPa (122 °C)
Bulk density: 350 kg/m3
Solubility: 0.4 g/l

Molecular Weight: 180.20
XLogP3: 3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 180.078644241
Monoisotopic Mass: 180.078644241
Topological Polar Surface Area: 46.5 Å²
Heavy Atom Count: 13
Complexity: 160
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Propylparaben:
Assay (HPLC, Ph. Eur., JP): 98.0 - 102.0 %
Assay (HPLC, NF): 98.0 - 102.0 %
Identity (IR-spectrum): passes test
Identity (melting range): passes test
Appearance of solution (100 g/l, Ethanol 96 %): clear and not more intense in color than reference solution BY₆
Acidic substances: passes test
Melting range (lower value): ≥ 96 °C
Melting range (upper value): ≤ 99 °C
Heavy metals (as Pb): ≤ 10 ppm
Related substances (HPLC, Ph. Eur., JP): passes test
p-Hydroxybenzoic acid (Ph. Eur., JP): ≤ 0.5 %
Sum of all impurities (Ph. Eur., JP): ≤ 1.0 %
Largest unspecified impurity (Ph. Eur., JP): ≤ 0.5 %
Related substances (HPLC, NF): passes test
p-Hydroxybenzoic acid (NF): ≤ 0.5 %
Sum of all impurities (NF): ≤ 1.0 %
Largest unspecified impurity (NF): ≤ 0.5 %
1-Propylalcohol (HS-GC): ≤ 5000 ppm
Other residual solvents (ICH Q3C): excluded by manufactoring process
Sulfated ash: ≤ 0.1 %

Related Products of Propylparaben:
1,1-Dimethoxybutane
(E)-6,6-Dimethyl-2-hept-1-en-4-yn-1-amine
2,2-dimethoxybutane
Dimethyl trans-3-Hexenedioate
Dimethyl Hydroxyaspartate, Mixture of Diastereomers

Related compounds of Propylparaben:
Paraben
Butylparaben
Ethylparaben
Methylparaben

Names of Propylparaben:

Regulatory process names:
4-hydroxybenzoic acid, propyl ester
Propyl 4-hydroxybenzoate
Propyl 4-hydroxybenzoate
propyl 4-hydroxybenzoate
Propylparaben

CAS names:
Benzoic acid
4-hydroxy-
propyl ester

IUPAC names:
4-Hydroxybenzoic acid, propylester
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER
hydroxybenzoate 4 propylique
Hydroxybenzoic acid propylester, 4-
p-Hydroxybenzoic acid, propyl ester
Propyl 4-Hydroxybenzoate
Propyl 4-hydroxybenzoate
propyl 4-hydroxybenzoate
Propylparaben
Propylparaben
Propylparaben
propyl-4-hydroxybenzoate
Propylparaben

Preferred IUPAC name:
Propyl 4-hydroxybenzoate

Trade names:
Faracide P
Microcare OHB
Paratexin P
Solbrol P

Other names:
4-Hydroxybenzoesäurepropylester
Propylparaben
Propyl p-hydroxybenzoate
Propyl parahydroxybenzoate
Nipasol
E216

Other identifiers:
58339-85-8
58339-85-8
59593-07-6
59593-07-6
94-13-3

Synonyms of Propylparaben:
PROPYLPARABEN
Propyl 4-hydroxybenzoate
94-13-3
Propylparaben
Propyl p-hydroxybenzoate
Nipasol
Nipazol
Propyl parahydroxybenzoate
4-Hydroxybenzoic acid propyl ester
Propagin
Tegosept P
Nipagin P
n-Propyl 4-hydroxybenzoate
Propyl Butex
Betacide P
Propylparasept
Chemacide pk
Chemocide pk
N-Propyl p-hydroxybenzoate
Propyl Parasept
Aseptoform P
Propyl Chemosept
Protaben P
Propyl aseptoform
Nipasol P
Solbrol P
4-Hydroxybenzoic acid, propyl ester
Paseptol
p-Hydroxypropyl benzoate
Preserval P
Betacine P
Bonomold OP
Nipasol M
p-Hydroxybenzoic acid propyl ester
p-Hydroxybenzoic propyl ester
Parasept
N-Propylparaben
Propyl-4-hydroxybenzoate
Propyl chemsept
Propyl-paraben
Benzoic acid, 4-hydroxy-, propyl ester
n-Propylparaben
FEMA No. 2951
Benzoic acid, p-hydroxy-, propyl ester
Paratexin p
Paraben p
Chemoside PK
Lexgard P
propyl para-hydroxybenzoate
Pulvis conservans
p-Hydroxybenzoic acid, propyl ester
Propylparaben e216
n-PROPYL-p-HYDROXYBENZOATE
NSC-8511
propyl 4-oxidanylbenzoate
NSC-23515
Z8IX2SC1OH
MLS002152934
DTXSID4022527
CHEBI:32063
4-Hydroxybenzoic acid-propyl ester
NSC23515
p-Hydroxybenzoic acid n-propyl ester
NCGC00090965-03
NCGC00090965-04
SMR000112070
WLN: QR DVO3
Propyl parahydroxybenzoate;Propyl 4-hydroxybenzoate
DTXCID602527
Caswell No. 714
Propylparaben [USAN]
Propyl 4-hydroxybenzoate, >=99%
Bayer D 206
FEMA Number 2951
Pulvis conservans (VAN)
4-Hydroxybenzoic acid-propyl ester 1000 microg/mL in Acetonitrile
CAS-94-13-3
HSDB 203
p-Oxybenzoesaurepropylester [German]
EINECS 202-307-7
UNII-Z8IX2SC1OH
MFCD00002354
NSC 23515
p-Oxybenzoesaurepropylester
Propylparaben [USAN:NF]
EPA Pesticide Chemical Code 061203
4-Hydroxybenzoic acid-propyl ester D7 (propyl D7)
BRN 1103245
AI3-01341
Propylester kyseliny p-hydroxybenzoove [Czech]
4-Hydroxybenzoic acid propylester
(Propylparaben)
36M
Propylparaben (NF)
Propylester kyseliny p-hydroxybenzoove
Propylparaben-[d7]
Propylparaben, USAN
Propylis hydroxybenzoas
85403-59-4
Propyl 4-?Hydroxybenzoate
SCHEMBL977
PROPYLPARABEN [II]
PROPYLPARABEN [MI]
p-Oxybenzoesaeurepropylester
EC 202-307-7
PROPYLPARABEN [FCC]
cid_7175
n-propyl-p-hydroxy-benzoate
PROPYLPARABEN [HSDB]
PROPYLPARABEN [INCI]
PROPYLPARABEN [VANDF]
4-10-00-00374 (Beilstein Handbook Reference)
MLS002222346
MLS006011654
BIDD:ER0229
Propyl-4-Hydroxybenzoate,(S)
Propylparaben [VANDF]
PROPYLPARABEN [USP-RS]
PROPYLPARABEN [WHO-DD]
CHEMBL194014
Propyl parahydroxybenzoate (TN)
BDBM70190
NSC8511
HMS2268K21
Propyl 4-hydroxybenzoate, BioXtra
PROPYL (4-HYDROXYBENZOATE)
Propyl parahydroxybenzoate (JP17)
HY-N2026
PROPYL PARA HYDROXY BENZOATE
ZINC1586788
Tox21_111048
Tox21_400012
BBL023754
s5405
STL294815
4-Hydroxybenzoic acid, n-propyl ester
AKOS008948099
component of Heb-Cort MC (Salt/Mix)
PROPYL HYDROXYBENZOATE [MART.]
CCG-266432
DB14177
DS-3427
PROPYL HYDROXYBENZOATE [WHO-IP]
PROPYL P-HYDROXYBENZOATE [FHFI]
PROPYL PARAHYDROXYBENZOATE [JAN]
NCGC00090965-01
NCGC00090965-02
NCGC00090965-05
NCGC00090965-06
NCGC00090965-07
AC-34533
E216
CS-0018518
FT-0618698
H0219
P1955
PROPYLIS HYDROXYBENZOAS [WHO-IP LATIN]
D01422
PROPYL PARAHYDROXYBENZOATE [EP IMPURITY]
EN300-7419478
PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
A844839
Propyl 4-hydroxybenzoate, p.a., 99.0-100.5%
Propyl Parahydroxybenzoate 0.01 mg/ml in Methanol
Propyl Parahydroxybenzoate 1.0 mg/ml in Methanol
Q511627
4-Arm PEG-OMs, 95%, average M.W. 20,000
Q-201635
Propyl 4-hydroxybenzoate, SAJ first grade, >=98.0%
Propyl 4-hydroxybenzoate, tested according to Ph.Eur.
Propyl 4-hydroxybenzoate, Vetec(TM) reagent grade, 98%
METHYL PARAHYDROXYBENZOATE IMPURITY C [EP IMPURITY]
Propylparaben, certified reference material, TraceCERT(R)
Propylparaben, United States Pharmacopeia (USP) Reference Standard
Propyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard
Propylparaben, Pharmaceutical Secondary Standard; Certified Reference Material
Propylparaben [NF] [USAN] [Wiki]
202-307-7 [EINECS]
4-10-00-00374 [Beilstein]
4-Hydroxybenzoate de propyle [French] [ACD/IUPAC Name]
4-Hydroxybenzoic acid n-propyl ester
4-hydroxybenzoic acid propyl ester
4-Hydroxybenzoic acid, n-propyl ester
94-13-3 [RN]
Benzoic acid, 4-hydroxy-, propyl ester [ACD/Index Name]
Benzoic acid, p-hydroxy-, propyl ester
DH2800000
Mekkings P [Trade name]
MFCD00002354 [MDL number]
Nipasol M [Trade name]
n-propyl 4-hydroxybenzoate
n-Propyl p-hydroxybenzoate
n-Propylparaben
N-Propyl-p-hydroxybenzoate
p-Hydroxybenzoic acid n-propyl ester
p-Hydroxybenzoic acid, propyl ester
p-Oxybenzoesaurepropylester [German]
Propyl 4-hydroxybenzoate [ACD/IUPAC Name]
Propyl chemosept [Trade name]
Propylparaben
Propyl parahydroxybenzoate [JP15]
PROPYL PARASEPT [Trade name]
propyl p-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoat [German] [ACD/IUPAC Name]
Propylester kyseliny p-hydroxybenzoove [Czech]
Propylis parahydroxybenzoas
Solbrol P [Trade name]
Z8IX2SC1OH
1219802-67-1 [RN]
1246820-92-7 [RN]
4-Hydroxy-benzoic acid propyl ester
4-Hydroxybenzoic acid propylester
4-hydroxybenzoic acid, propyl ester
4-Hydroxybenzoic acid-propyl ester
Aseptoform P
Bayer D 206
Benzoic acid, 4-(aminomethyl)- (9CI)
Bonomold OP
Chemocide pk
DS-3427
Lexgard P
Nipagin P
NIPASEPT
Nipasol
Nipasol P
Nipazol
n-Propyl 4-Hydroxybenzoate--d4
n-Propylparaben
N-Propyl-4-hydroxybenzoate
n-Propyl-p-hydroxy-benzoate
Parasept
Paseptol
PEPH
P-HYDROXY PROPYL BENZOATE
p-hydroxybenzoic acid propyl ester
p-Hydroxybenzoic propyl ester
p-Hydroxypropyl benzoate
p-Oxybenzoesaeurepropylester
Preserval P
Propagin
propilparabeno [Portuguese]
Propyl aseptoform
Propyl butex
PROPYL PARA HYDROXY BENZOATE
Propyl Parahydroxybenzoate 0.01 mg/ml in Methanol
Propyl Parahydroxybenzoate 1.0 mg/ml in Methanol
Propyl-4-hydroxybenzoate
Propyl-d7 Paraben
Propyl-paraben
Propylparasept
Propyl-p-Hydroxybenzoate
Protaben P
QR DVO3 [WLN]
Tegosept P
UNII:Z8IX2SC1OH
UNII-Z8IX2SC1OH