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DESCRIPTION:
Sodium lactate is an organic sodium salt having lactate as the counterion.
Sodium lactate has a role as a food preservative and a food acidity regulator.
Sodium lactate is an organic sodium salt and a lactate salt.
Sodium lactate contains a lactate.
CAS: 72-17-3
European Community (EC) Number: 200-772-0
IUPAC Name: sodium;2-hydroxypropanoate
Molecular Formula: C3H5NaO3
SYNONYMS
Lactate, Sodium,Sodium Lactate,compound sodium lactate solution,SODIUM LACTATE,72-17-3,Sodium DL-lactate,Lactic acid sodium salt,Monosodium lactate,sodium 2-hydroxypropanoate,Lacolin,Per-glycerin,Lactic acid, monosodium salt,Sodium alpha-hydroxypropionate,Monosodium 2-hydroxypropanoate,Propanoic acid, 2-hydroxy-, monosodium salt,Sodium (dl)-lactate,Natrum lacticum,312-85-6,CCRIS 7316,DL-Lactic acid sodium salt,2-Hydroxypropanoic acid, monosodium salt,E325,UNII-TU7HW0W0QT,Mediject L,TU7HW0W0QT,AI3-03131,Sodium (lactate) anhydrous,Lactate (sodium),EINECS 200-772-0,EINECS 206-231-5,NSC 31718,INS NO.325,CHEBI:75228,INS-325,Sodium lactate in plastic container,MFCD00065400,NSC-31718,sodium;2-hydroxypropanoate,Sodium 2-Hydroxypropionate,Sodium lactate [USP:JAN],(+/-)-2-Hydroxypropionic acid sodium salt,E-325,Sodium lactate 1/6 molar in plastic container,EC 200-772-0,Sodium lactate 0.167 molar in plastic container,SODIUM LACTATE, (+/-)-,C3H5NaO3,Sodium lactate (USP:JAN),SODIUM LACTATE (II),SODIUM LACTATE [II],Lactic acid, sodium salt,SODIUM DL-LACTATE-D4,SODIUM LACTATE (USP-RS),SODIUM LACTATE [USP-RS],CHEMBL1357,Lactate, Sodium,SODIUM LACTATE (USP IMPURITY),SODIUM LACTATE [USP IMPURITY],Sodium DL-Lactate (60% w/w in H2O),NSC31718,Sodium l-lactate-1-13c,Lactic acid, sodium salt (VAN),Sodium lactate; sodium 2-hydroxypropanoate; LAC,(2R)-2-Hydroxypropanoate (sodium),SodiumDL-lactate,Mediject L (TN),Purasal S/SP 60,Sodium lactate (7CI),sodium2-hydroxypropanoate,Sodium DL-lactate solution,SCHEMBL4360,Sodium lactate (JAN/USP),SODIUM LACTATE [MI],SODIUM LACTATE [JAN],NATRUM LACTICUM [HPUS],Propanoic-3-13C acid, 2-hydroxy-, monosodium salt, (2S)- (9CI),SODIUM,LACTATE [VANDF],DTXSID6052829,SODIUM LACTATE [WHO-DD],HY-B2227B,Pharmakon1600-01300036,2-hydroxypropionic acid sodium salt,201595-71-3,2-Hydroxypropanoic Acid Sodium Salt,Sodium (2RS)-2-hydroxypropanoate,Lactic acid, monosodium salt (8CI),NSC760108,SODIUM LACTATE [ORANGE BOOK],AKOS015915154,Lacolin and DL-Lactic acid sodium salt,NSC-760108,SB44210,CID 23696276,DA-77925,DB-079226,DL-Lactic acid sodium salt, 60% in water,CS-0030973,E 325,NS00079058,S0928,D02183,EN300-296318,H11285,Propanoic acid, 2-hydroxy-, sodium salt (1:1),Q418235,2-Hydroxypropionic acid sodium salt, 60% in water,Propanoic acid, 2-hydroxy-, monosodium salt (9CI),W-104498
Sodium Lactate is a sodium salt of racemic or inactive lactic acid with alkalinizing and electrolyte replenishing property.
Upon metabolism, sodium lactate is converted to bicarbonate, thereby increasing plasma bicarbonate, which facilitates removal of hydrogen ion and lactate from blood stream and leads to raised blood pH.
Sodium lactate is the sodium salt of lactic acid and is one of the hydrating substances that are produced by the skin to preserve the moisture and physiological pH.
Sodium lactate is used not only in cosmetics but also in the food industry as a humectant and an acid regulator.
On the skin, the growth of foreign microorganisms is inhibited by maintaining the skin's natural acid barrier.
In addition, sodium lactate is a well-tolerated form of hydration that also keeps emulsions chemically stable.
Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste.
Sodium Lactate is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the resulting lactic acid[4] to create a compound having the formula NaC3H5O3.
Sodium lactate, in the form of Ringer's lactate solution, is used as a medication, and is included on the World Health Organization's List of Essential Medicines.[5][6]
USES:
Food industry
As a food additive, sodium lactate has the E number E325 and is naturally a liquid product, but also is available in powder form.
It acts as a preservative, acidity regulator, and bulking agent.[7]
Despite the similarity in name, sodium lactate itself is not chemically similar to lactose (milk sugar), so need not be restricted by those with lactose intolerance.[4][8]
Cosmetics and personal care products
Sodium lactate is sometimes used in shampoo products and other similar items such as liquid soaps, as it is an effective humectant and moisturizer.[9]
Medical use
Sodium lactate is used to treat arrhythmias caused by overdosing of class I antiarrythmics, as well as pressor sympathomimetics which can cause hypertension.[10]
Sodium Lactate can be given intravenously as a source of bicarbonate for preventing or controlling mild to moderate metabolic acidosis in patients with restricted oral intake (for sodium bicarbonate) whose oxidative processes are not seriously impaired.
However, the use in lactic acidosis is contraindicated.[11]
Sodium lactate may induce panic attacks in persons with existing panic disorder;[12] up to 72% of individuals with panic disorder experience a panic attack when administered sodium lactate intravenously.
Sodium lactate may therefore also be used to confirm a diagnosis of panic disorder.[13]: 19
Chemistry and biochemistry
Sodium lactate is not chemically similar to lactose (milk sugar).
PRODUCTION
In general, lactates such as sodium, calcium, and potassium lactate are salts derived from the neutralization of lactic acid and most commercially used lactic acids are fermented from dairy-free products such as cornstarch, potatoes, or molasses.[14]
Sugar or tapioca additionally may be used.[4]
In some rare instances, some lactic acid is fermented from dairy products such as whey[4] and lactose.[14]
Whey is made of up 6.5% solids of which 4.8% is solid lactose.[15]
Waste whey is infrequently used to produce lactic acid when the whey itself is produced as waste during the manufacture of certain dairy products.[16]
Such dairy-type lactic acid generally goes back into dairy products, such as ice cream and cream cheese,[14] rather than into non-dairy products.
Moreover, although the lactic-acid starter culture to ferment corn or beets may contain milk,[4] sodium lactate does not contain milk protein and need not be restricted by someone avoiding milk or those with a milk allergy
Compound Sodium Lactate Solution is a multiple electrolyte, isotonic, crystalloid solution for intravenous infusion containing sodium chloride, potassium chloride, calcium chloride dihydrate, and sodium lactate, which can restore the electrolyte balance, normalize pH, and provide water for hydration.
Upon intravenous administration, the compound sodium lactate solution will replace any lost body fluids and electrolytes thereby providing hydration as well as normalizing electrolyte concentrations.
In addition, conversion of sodium lactate to bicarbonate increases plasma bicarbonate levels, which facilitates the removal of hydrogen ions from the blood stream, raises blood pH and normalizes the acid-base balance.
CHEMICAL AND PHYSICAL PROPERTIES
Molecular Weight
112.06 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Hydrogen Bond Donor Count
1
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Hydrogen Bond Acceptor Count
3
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Rotatable Bond Count
1
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Exact Mass
112.01363830 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Monoisotopic Mass
112.01363830 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Topological Polar Surface Area
60.4Ų
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Heavy Atom Count
7
Computed by PubChem
Formal Charge
0
Computed by PubChem
Complexity
63.2
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Isotope Atom Count
0
Computed by PubChem
Defined Atom Stereocenter Count
0
Computed by PubChem
Undefined Atom Stereocenter Count
1
Computed by PubChem
Defined Bond Stereocenter Count
0
Computed by PubChem
Undefined Bond Stereocenter Count
0
Computed by PubChem
Covalently-Bonded Unit Count
2
Computed by PubChem
Compound Is Canonicalized
Yes
Chemical formula C3H5NaO3
Molar mass 112.06 g/mol[1]
Appearance White powder
Density 1.33 g/mL,[1] 1.31 g/ml (60 % syrup)[1]
Melting point 161 to 162 °C (322 to 324 °F; 434 to 435 K)
17 °C (60 % syrup)[2]
Boiling point 113 °C (235 °F; 386 K) (60 % syrup)[2]
Solubility in water > 1.5 g/mL
Hazards
Flash point < 25
SAFETY INFORMATION ABOUT SODIUM LACTATE
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.
