SORBITOL SI

CAS NO:50-70-4
EC NO: 200-061-5

Synonyms:
 D-Sorbitol; sorbitol; D-Glucitol; glucitol; 50-70-4; L-Gulitol(-)-Sorbitol; Glucarine; Diakarmon; Multitol; Sorbilande; Sorbostyl; Esasorb; Karion; Neosorb; Nivitin; Sionit; Sionite; Sionon; Siosan ;Sorbite; Sorbol; Karion instant; Sorbitol F; Sorbex Rp; Sorbitol FP; D-Sorbol; Sionit K; Sorbex M; Sorbex R; Sorbex S; Sorbex X; Sorbitol syrup C; Neosorb P 60; D-(-)-Sorbitol; Foodol D 70; Sorbicolan; Sorvilande; Cholaxine; Neosorb 20/60DC; Neosorb 70/02; Neosorb 70/70; Neosorb P 20/60; D-Sorbite; Sorbo; Karion (carbohydrate); (2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexaol; Probilagol; Sorbilax; Hexahydric alcohol; D-1,2,3,4,5,6-Hexanehexol; Gulitol; Sorbitol solutions; CCRIS 1898; Glucitol, D-; Sorbit; AI3-19424; Resulax; Sorbitur; d-Sorbit; Sorbitol S; Sorbitol FK; Sorbit D-Powder; Sorbit S; Sorbit W-Powder; Glc-ol; Sorbit DP; Sorbit WP; NSC 25944; G-ol; Kyowa Powder 50M; Sorbogem 712; Neosorb P 60W; (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol; Sorbit D 70; Sorbit DP 50; Sorbit L 70; Sorbit T 70; Sorbit W 70 ;Sorbit W-Powder 50; Sorbitol 3% in plastic container; EINECS 200-061-5; Sorbitolum liquidum non cristallisabile; ŞEKER ALKOLÜ; şeker alkolü; glusitol; SORBITOL; SORBİTOL; sorbitol; sorbıtol; glusitol; GLUSİTOL; polihidrik alkol.; SORBITOL SI ; D-Glucitol; E 420; E420; sorbitol; Le sorbitol; CAS 50-70-4; CAS:50-70-4; CAS:50 70 4; Parteck®; Parteck ; SORBITOL SI ; D-GLUCİTOL; E 420; E420; SORBİTOL; LE SORBİTOL ; CAS 50-70-4; CAS:50-70-4; CAS:50 70 4; PARTECK®; PARTECK ;  D GLUCİTOL;  SORBİTOL Sİ; SORBİTOL; SORBİTOL-Sİ; Sorbıtol Sı ; D-Glucitol; E 420; E420; Sorbitol; Le Sorbitol ;D-Sorbitol; sorbitol; D-Glucitol; glucitol; 50-70-4; L-Gulitol(-)-Sorbitol; Glucarine; Diakarmon; Multitol; Sorbilande; Sorbostyl; Esasorb; Karion; Neosorb; Nivitin; Sionit; Sionite; Sionon; Siosan ;Sorbite; Sorbol; Karion instant; Sorbitol F; Sorbex Rp; Sorbitol FP; D-Sorbol; Sionit K; Sorbex M; Sorbex R; Sorbex S; Sorbex X; Sorbitol syrup C; Neosorb P 60; D-(-)-Sorbitol; Foodol D 70; Sorbicolan; Sorvilande; Cholaxine; Neosorb 20/60DC; Neosorb 70/02; Neosorb 70/70; Neosorb P 20/60; D-Sorbite; Sorbo; Karion (carbohydrate); (2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexaol; Probilagol; Sorbilax; Hexahydric alcohol; D-1,2,3,4,5,6-Hexanehexol; Gulitol; Sorbitol solutions; CCRIS 1898; Glucitol, D-; Sorbit; AI3-19424; Resulax; Sorbitur; d-Sorbit; Sorbitol S; Sorbitol FK; Sorbit D-Powder; Sorbit S; Sorbit W-Powder; Glc-ol; Sorbit DP; Sorbit WP; NSC 25944; G-ol; Kyowa Powder 50M; Sorbogem 712; Neosorb P 60W; (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol; Sorbit D 70; Sorbit DP 50; Sorbit L 70; Sorbit T 70; Sorbit W 70 ;Sorbit W-Powder 50; Sorbitol 3% in plastic container; EINECS 200-061-5; Sorbitolum liquidum non cristallisabile; ŞEKER ALKOLÜ; şeker alkolü; glusitol; SORBITOL; SORBİTOL; sorbitol; sorbıtol; glusitol; GLUSİTOL; polihidrik alkol.; SORBITOL SI ; D-Glucitol; E 420; E420; sorbitol; Le sorbitol; CAS 50-70-4; CAS:50-70-4; CAS:50 70 4; Parteck®; Parteck ; SORBITOL SI ; D-GLUCİTOL; E 420; E420; SORBİTOL; LE SORBİTOL ; CAS 50-70-4; CAS:50-70-4; CAS:50 70 4; PARTECK®; PARTECK ;  D GLUCİTOL;  SORBİTOL Sİ; SORBİTOL; SORBİTOL-Sİ; Sorbıtol Sı ; D-Glucitol; E 420; E420; Sorbitol; Le Sorbitol ; Cas 50-70-4; Cas:50-70-4; Cas:50 70 4; Parteck®; Parteck ;  D Glucitol;  Sorbitol Si; Sorbitol; Sorbitol-Si; sorbıtol sı ; d-glucitol; e 420; e420; Cas 50-70-4; Cas:50-70-4; Cas:50 70 4; Parteck®; Parteck ;  D Glucitol;  Sorbitol Si; Sorbitol; Sorbitol-Si; sorbıtol sı ; d-glucitol; e 420; e420; sorbitol; le sorbitol ; cas 50-70-4; cas:50-70-4; cas:50 70 4; parteck®; parteck ;  d glucitol;  sorbitol si; sorbitol; sorbitol-si; Sorbitol-Si; C6H14O6; glucide ; 50-70-4; Parteck® SI 150 (sorbitol) ; Parteck® SI 400 (Sorbitol); Parteck® SI (Sorbitol); Sorbitol SI 200 (Sorbitol) ; Sorbitol SI 150 (sorbitol) ; Sorbitol SI 400 ; Sorbitol SI ; Sorbitol SI 200  ; Sorbıtol si

SORBITOL SI

Product information
CAS Number 50-70-4
EC number 200-061-5
Grade Ph Eur, BP, JP, NF, JSFA, E 420
Hill Formula C₆H₁₄O₆
Molar mass 182.17 g / mol
HS Code 2905 44 91
Structural formula Image Structural formula Image
MQ500 quality level
Physicochemical information
Density 1.49 g / cm3 (20 ° C)
Flash point> 100 ° C
Ignition temperature 420 ° C
Melting point 94-96 ° C
PH value 6-7 (100 g / l, H₂O, 20 ° C)
Apparent density 450 kg / m3
Solubility 2350 g / l
Toxicological information
LD 50 oral LD50 Rat 15,900 mg / kg
Safety information according to GHS
RTECS LZ4290000
Storage class 10-13 Other liquids and solids
WGK NWG does not endanger the water
Elimination 3
Relatively unreactive organic reagents should be collected in container A. If they are halogenated, they should be collected in container B. For solid residues, use container C.
Storage and shipping information
Storage Store between + 2 ° C and + 25 ° C.
Transport information
Declaration (rail and road) ADR, RID Kein Gefahrgut
Declaration (air transport) IATA-DGR No Dangerous Good
Declaration (transport by sea) IMDG code No Dangerous Good
Characteristics
Assay (HPLC, cal. On anhydrous substance) 97.0 - 100.5%
Identity passes the test
PH value (10%; water) 3.5 - 7.0
Free acid passes the test
The appearance of the solution (25%; water) passes the test
Spec. rotation (α20 / D, 10%, borate complex, calc. on anhydrous substance) +4.0 - +7.0 °
Conductivity (25 ° C) (20%; water) ≤ 20
Chloride (Cl) ≤ 0.002%
Sulphate (SO₄) ≤ 0.006%
Heavy metals (as Pb) ≤ 5 ppm
As (Arsenic) ≤ 1.0 ppm
Ni (Nickel) (#) ≤ 1 ppm
Pb (lead) ≤ 0.5 ppm
Ru (Ruthenium) (#) ≤ 1 ppm
Related substances (HPLC, EP) (major impurity (mannitol)) ≤ 2.0%
Related substances (HPLC, EP) (Sum of all impurities) ≤ 3.0%
Reduction of sugars after hydrolysis / total sugar (as glucose) ≤ 0.5
Reducing sugars (as glucose) ≤ 0.11%
Sulphated ash ≤ 0.02%
Loss on drying ≤ 2.0
Water ≤ 1.5%
Particle size (<53 µm (270 mesh)) ≤ 5%
Particle size (> 500 µm (35 mesh)) ≤ 5%
Residual solvents (ICH Q3C) excluded from the manufacturing process
The microbiological test passes the test
Number of colonies (aerobic bacteria (TAMC)) ≤ 5 * 10²
Number of colonies (yeasts and molds (TYMC)) ≤ 10²
Salmonella spp. in 10g Undetectable substance
E. coli in 1 g of non-detectable substance
Staphylococcus aureus in 1 g of undetectable substance
Pseudomonas aeruginosa in 1 g of undetectable substance
Candida albicans in 1g non-detectable substance

Sorbitol

Sorbitol
Illustrative image of the item Sorbitol
Illustrative image of the item Sorbitol
Identification
IUPAC name (2S, 3R, 4R, 5R) -hexane-1,2,3,4,5,6-hexol
Synonyms
D - (-) - glucitol
Gulitol
Hexahydric alcohol

CAS No 50-70-4
ECHA No 100.000.056
CE No 200-061-5
ATC code V04CC01
PubChem 82170 [archive]
No E E420 (i), E420 (ii)
FEMA 3029
Appearance White powder1
Chemical properties
Molecular formula C6H14O6 [Isomers]
Molar mass3 182.1718 ± 0.0076 g / mol
C 39.56%, H 7.75%, O 52.7%,
pKa 13.572
Physical properties
Melting temperature 95 ° C (88 to 102 ° C1)
Boiling temperature 296 ° C
Solubility Soluble in water (2 750 g · l − 1 at 30 ° C) 2,
poorly soluble in ethanol 1.

Density 1.5 gcm-34
Thermochemistry
Cp
[+]
Crystallography
Crystal class or space group P216
Mesh parameters a = 4.791 Å
b = 9.488 Å
c = 17.731 Å
α = 90.00 °
β = 94.45 °
γ = 90.00 °
Z = 4 (−173.0 ° C) 6

Volume 803.57 Å36
Ecotoxicology
LD50 15.9 gkg-1 (rats, oral)
17.8 gkg-1 (mouse, oral) 2
LogP -2.24
Related compounds
Isomer (s) Dulcitol, Mannitol, Iditol
SI and CNTP units, unless otherwise indicated.
modify Consult the model documentation
Sorbitol or glucitol is a natural polyol, with a sweetening power twice as low as sucrose. Unlike oses, its structure contains no ketone or aldehyde functions. It is mainly used as a mass sweetener to replace sucrose. It is also used as a sequestering agent, excipient, humectant or stabilizer, in drugs, cosmetics and food. It is slowly metabolized by the body and provides few calories. It is also a laxative when consumed in high doses.

Sorbitol takes its name from the mountain ash whose berries contain a lot of sorbitol. But the fruit with the highest sorbitol content is actually the prune.

Sorbitol is the major product of photosynthesis, the main carbohydrate exported in the phloem, and a product for temporary carbon storage in woody species of the Rosaceae family. In so-called sorbitol species, the synthesis of this competes with that of sucrose because these two sugars have a common precursor, glucose-6-phosphate. The mechanisms that control and regulate the partition of C between these two pathways are unknown. Nevertheless, the effects of environment and growing conditions can play an important role in modifying metabolic fluxes between sorbitol, sucrose and starch. The accumulation of sorbitol is considered to be an adaptive response of plants to salt, water and low temperature constraints. Sorbitol synthesis is confined to source organs. Its degradation takes place only in the sink organs7.

Sorbitol is also produced naturally by the human body, but it is poorly digested by the body. Too much sorbitol in the blood can cause:

a cataract: a deposit of sorbitol on the lens makes it more opaque; it has nothing to do with diabetic retinopathy;
neuropathy (for the nerves).
Properties
Chemical properties
Sorbitol is a polyol like glycerol or glycol. It is composed of a carbon chain of six carbon atoms and six alcohol groups (one group per carbon). Its chemical formula is C6H14O6 and it is the isomer of three other polyols: dulcitol, mannitol and iditol.

Its pKa is 13.572.

Physical properties
Sorbitol is a white solid which is very soluble in water (2750 g · l − 1 at 30 ° C2) and sparingly soluble in ethanol8.

Metabolism
The maximum dose of sorbitol above which it is not tolerated by intestinal transit is 0.15–0.17 g · kg-1 body weight for humans and 0.24–0.3 g · Kg-1 body mass for women 9.

Sweetening properties
The sweetening power of sorbitol is 0.5-0.6 compared to sucrose (equal weight) 9 and 0.2510 compared to sucrose (equal number of moles). At equal weight, it is sweeter than isomalt (sweetening power of 0.3-0.4) but less than xylitol (sweetening power of 1).

Uses
In the food industry, this sweetener has many advantages. In humans, sorbitol is metabolized in the same way as glucose: it provides the same energy. However, its metabolism being non-insulin dependent, it does not increase blood sugar. This property is particularly advantageous for products intended for diabetics. It is not fermentable by yeasts. Possessing a great capacity for water retention, sorbitol is responsible for the soft consistency of a large number of food products. The fixed water evaporates with difficulty. Sorbitol is also used as an agent for retarding the crystallization of sucrose in chocolate products.

Analytical Chemistry
Sorbitol is used as an internal standard in the quantitative analysis of sugars by gas chromatography with silylation.

Food
It is a sweetener11 (E42012) used in diet foods but also in a number of products produced by the agri-food industry in which it acts as an anti-crystallizer and emollient. It is also used as an excipient, humectant, stabilizer and sequestrant13,14. It provides 2.6−3.4 kilocalories per gram9, so less than sugar (> 3.5 calories per gram9) and only slightly increases blood sugar. Sorbitol, like erythritol and xylitol, has a fresh taste in the mouth useful for chewing gum, toothpaste and oral care products15. The chronic abuse of sweets sweetened with sorbitol can cause gastric disorders and can represent a significant caloric intake (contrary to industrial claims) 16.

Breeding
Providing energy in the form of sorbitol to cattle before slaughter has been shown to prevent the production of high pH meat17,18.

Medicine
Sorbitol is used as a medicine (without a prescription) to treat constipation, thanks to its laxative effect.

Microbiology
Sorbitol replaces lactose in Mac Conkey agars for identification of Escherichia coli O157: H7 (hamburger disease) strain E. coli O157: H7 is sorbitol-, it cannot metabolize sorbitol, whereas the other non-pathogenic E. coli of the digestive system are sorbitol +, they can metabolize sorbitol.

Cosmetic
Sorbitol is often used in modern cosmetics as a moisturizing and thickening agent. It is often found as an ingredient in most toothpastes. Its fresh taste in the mouth, conferred by its polyol quality, justifies its presence in oral hygiene solutions.

Fuel
Sorbitol is widely known as a rocket propellant in combination with potassium nitrate (saltpeter) (65% potassium nitrate and 35% sorbitol). Thanks to its low melting temperature, it binds very well with potassium nitrate to form solid propellant19.

The terrorist organization Islamic State thus obtained several tonnes of sorbitol for food in 2016 to mix it with potassium nitrate in order to manufacture rockets20.

Contraindications
In case of pregnancy or breastfeeding, the ingestion of sorbitol is not recommended.

Composition
Sorbitol intended for food is composed of a minimum of 97% glycitols and not less than 91% D-sorbitol in dry matter. Glycitols are compounds whose structural formula is CH2OH- (CHOH) n-CH2OH, where n is an integer1.

Sorbitol is a sweetener with half the sweetening power of sucrose (known as "table sugar"). It is mainly found as a food additive but it is also used in the composition of many drugs. In excess, however, it can become laxative and expose the body to certain dangers.

Characteristics of sorbitol:

Sweetener used in food, pharmacology and cosmetology
Does not influence blood sugar because it is non-insulin dependent
Has a laxative and depurative effect on the liver and gallbladder
May be responsible for malabsorption
Found mostly in fruits
Why eat foods rich in sorbitol?
Sorbitol: definition and benefits
Has no influence on blood sugar
Sorbitol can be used to make foods taste sweet without increasing blood sugar (blood sugar) levels. It can therefore be consumed by people with diabetes without the risk of unbalancing their diabetes.

Laxative effect of sorbitol to fight against constipation
In controlled amounts, sorbitol can help fight constipation through its mild laxative effect. It is part of the composition of certain laxative drugs widely used in Europe. In some cases, it is also used to purify the liver system.

Sorbitol in cosmetics
Sorbitol powder is used in cosmetics for its moisturizing, stabilizing and thickening power.

Foods rich in sorbitol
Sorbitol is found in most sweets for people with diabetes (food additive listed under the name E420), and naturally in fruit.

Food

Portion

Quantity of sorbitol (g)

Confectionery for diabetics

100g

35 to 95

Jams for diabetics

100g

8 to 10

Prunes

100g

8

Dry peach

100g

5

Blueberry jam

100g

5

Dried apricot

100g

5

Pear juice

100g

2

Cherry

100g

2

Plum

100g

2

Sultanine grape

100g

1

Apricot

100g

1

Apple

100g

0.5

Beer

100g

0 to 0.5

How to use sorbitol properly?
Use of sorbitol
There are no nutritional recommendations to date for sorbitol.

Sorbitol is used in the composition of certain osmotic laxatives. It creates a call for water in the intestine and increases the volume of the stool, thus facilitating the intestinal transit. Sorbitol-based laxatives contain an average of 5g of sorbitol per dose and are indicated for the treatment of constipation. They may also be indicated to purge the liver and gallbladder. These laxatives must be taken on the advice of a doctor, they can indeed cause side effects that should not be neglected.

Side effects and dangers of sorbitol
Consequence of sorbitol deficiency
There are no studies demonstrating problems linked to a deficiency of sorbitol in the body.

Consequence of excess sorbitol
Consumed in excess, sorbitol has a significant laxative effect. It can also cause digestion problems in the body. its accumulation is often involved in the occurrence of cataracts or certain neuropathies.

Sorbitol malabsorption and allergy
Sorbitol can, in some people, cause malabsorption and significant digestive discomfort. Even if it is not an allergy strictly speaking, this difficulty in digesting sorbitol can be the cause of various unpleasant symptoms: bloating, gas, stomach pain, diarrhea, etc. In this case, there is an accumulation of sorbitol in the intestine which prevents its normal digestion. As with fructose intolerance, poorly absorbed sorbitol remains accumulated in the intestine and is fermented by the intestinal flora. It is this fermentation which is responsible for digestive discomfort. In case of sorbitol malabsorption, it may be wise to follow the FODMAP diet.

Interactions with hyperkalaemia and hypokalaemia
In case of treatment against hyperkalaemia or hypokalaemia, it is strongly advised not to consume excess sorbitol. Its laxative effect can precipitate the elimination of electrolytes and cause colonic necrosis which can lead to death.

Chemical properties
Sorbitol is a sugar alcohol, or sweetener. its crude formula is C6H14O6 and its molar mass is 182.1718 g / mol. It is a natural polyol which has a much lower sweetening power than that of table sugar.

It is made up of 6 carbon atoms and 6 alcohol groups. Unlike oses, it does not have a ketone or aldehyde function.

This sugar alcohol has three isomers, the best known of whichmannitol. It is soluble in water and very little in ethanol.

Historical
Sorbitol is a major product of photosynthesis in plants. It takes its name from the rowan tree since its fruits are very rich in sorbitol.

Discovered in 1872 by a French chemist, it has since been used in very large fields. In food, sorbitol is the additive E420 used in many dietetic products but also as an emollient and anti-crystallizer. It barely provides 3kcal per gram and only slightly raises blood sugar, which gives it a strong nutritional value. More and more, its non-insulin-dependent character is used in the development of products for diabetics.

Sorbitol Si is also found in cosmetic products, in certain specific fuels, but also in certain drugs.

Sorbitol Si, a directly compressible sorbitol, is available in a variety of particle sizes and has qualities that make it suitable for any application. Sorbitol Si's unique particle structure gives it distinctive physical properties, making it the ideal excipient for combining many ingredients into an elegant and robust tablet formulation.

Benefits:

Excellent direct compression properties
High dilution and adsorption capacity
Larger and very structured area
Low hygroscopicity
Low amount of reducing sugars
Emprove® documentation and regulatory support
We offer several specialty grades of Sorbitol Si with different particle sizes and grades designed to meet the specific requirements of your applications.

Sorbitol Si: unique structure, exceptional characteristics
The filamentous and porous surface of Sorbitol SI allows more homogeneous powder mixes, more uniform content and less dust during manufacturing.

Tablets made with Sorbitol Si show much slower water absorption than tablets made with standard sorbitol. Its exceptional characteristics - including good fluidity and excellent mouthfeel - make Sorbitol SI the right choice for chewable pastes, effervescent tablets and sugar-free lozenges.

All Sorbitol Si products are part of our Emprove® program which provides exceptional documentation to make it easier to prepare for your approval and get your product to market faster.

Sorbitol (/ ˈsɔərbᵻˌtɒl /), less known as glucitol (/ ˈɡluːsᵻˌtɒl /), is a sweet tasting alcohol that the human body slowly metabolizes. It can be obtained by reducing glucose, changing the aldehyde group to a hydroxyl group. Most sorbitol is made from corn syrup, but it is also found in apples, pears, peaches, and prunes. Sorbitol Si is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar alcohol; the two differ only in the orientation of the hydroxyl group on carbon 2. Although similar, the two sugar alcohols have very different sources, melting points and uses.

Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. Sorbitol was once used as a diuretic and can still be used as a laxative and in irrigation solutions for certain surgical procedures. Sorbitol is also used in many manufacturing processes, as a pharmaceutical aid and in several research applications. Fermentation of ascorbic acid; in the form of a solution for conditioning the humidity of cosmetic creams and lotions, toothpaste, tobacco, gelatin; body agent for paper, textiles and liquid pharmaceuticals; softener for candies; sugar crystallization inhibitor; surfactants; urethane resins and rigid foams; plasticizer, stabilizer for vinyl resins; food additive (sweetener, humectant, emulsifier, thickener, anti-caking agent); dietary supplement. (Hawley's Condensed Chemical Dictionary) Biological Source: Occurs widely in plants ranging from algae to higher orders. Fruits of the Rosaceae plant family, which include apples, pears, cherries, apricots, contain appreciable amounts. Rich sources are fruits of the Sorbus and Crataegus species Use / Importance: Used for the manufacture of sorbose, propylene glycol, ascorbic acid, resins, plasticizers and as antifreeze mixtures with glycerol or glycol.

Uses
Sweetener
Sorbitol is a sugar substitute. Sorbitol may be listed under the inactive ingredients listed for certain foods and products