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Tocopherols also provide protection against secondary oxidation products, meaning they not only slow initial lipid oxidation but also reduce formation of aldehydes and ketones that cause off-flavors.
Tocopherols improves overall sensory stability.
Tocopherols maintains product quality.
CAS Number: 1406-66-2
Molecular Formula: C28H48O2
Molecular Weight: 416.67952
EINECS Number: 604-195-9
Synonyms: Tocopherols, 1406-66-2, Methyltocols, R0ZB2556P8, Lasar, UnoVit, VitaE, Vitamin Emp, E Vicotrat, Micorvit E, E Mulsin, VitaPlus E, Vitamin E mp, Vitamin E-mp, Uno Vit, Vitamin E Dragees, Dal E, Vitamin E, Mowivit, Vitamin E, Togasan, Antioxidans E-Hevert, Vitamin E, Vitagutt, VitaminE EVIMIRALE, Vitamin E EVI MIRALE, BatanaOil, Conju Princess, Tocopherol 5%, CVC Hair Vitamin, Q7 Carrot Body, Stretch Warks Cream, Cocoa Butter Formula, TUREMRIC, VITAMINOIL, Massage Eaethworm Cream, GZE LIP BALM, DRUGGIST HAIR VITAMIN, COVI-OX T 50 C, COVI-OX T 70 C, MIXED TOCOPHEROLS 95, Conju Princess Cleansing Balm, Skin Care and Hair Care Set, CVC VITAMIN C VITAMIN E, ORISTAR MIXED TOCOPHEROLS, DTXSID8021357, CHEBI:27013, Guangzhou Yilong Cosmetics Co., Ltd, 604-195-9, 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol, Tocopherol, Vita Plus E, 7616-22-0, 73980-80-0, Rac-gamma-tocopherol, (+/-)-gamma-Tocopherol, 3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol, E-MIX 80, 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-, delta-A-Tocopherol, C28H48O2, (Rac)-gamma-Tocopherol, UNII-ECY0XG64DO, 7,8-Dimethyltocolo-xylotocopherol, CCRIS 3610, CCRIS 4506, gamma-Tocopherol, EINECS 231-523-4, DL-gamma-tocopherol, Tocopherol [JAN], gamma-Tocopherol DL-form, SCHEMBL39640, CHEMBL420898, MFCD00036172, (+/-)-7,8-Dimethyltocol, ALL-RAC-gamma-Tocopherol, DB-323925, EC 604-195-9, 2,7,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol;Controx VP;Covi-Ox T 30P;Covi-Ox T 50;Covi-Ox T 70;Dry E-Mix 20;E 306;E-Mix 40A
Tocopherols also have vitamin E activity, playing a role in biological antioxidant defense systems.
Tocopherols support cellular protection.
Tocopherols adds nutritional value.
Tocopherols show good stability under moderate processing conditions, but are sensitive to oxygen, light, and prolonged high heat.
Proper storage is required.
Tocopherols are best described as natural, lipid-soluble antioxidants with vitamin E activity, widely used to protect fats and oils and improve stability in food and industrial systems.
Tocopherols are highly effective in bulk oils and fats, where oxidation occurs throughout the matrix.
Tocopherols distribute evenly in lipid phases.
This enhances protection uniformity.
Tocopherols include alpha-, beta-, gamma-, and delta-tocopherol, all sharing a chromanol ring with a hydroxyl group and a hydrophobic phytyl side chain.
Differences in methyl group substitution define each isomer.
This affects their antioxidant behavior.
Tocopherols can act as oxygen scavengers indirectly, reducing available oxygen in lipid environments through radical termination reactions.
This slows oxidative stress.
Tocopherols improves shelf life.
Tocopherols are commonly used in refined vegetable oils, especially those rich in polyunsaturated fatty acids.
They stabilize oils during storage and transport.
This prevents rancidity.
Tocopherols are also used in animal-derived fats, such as fish oil and lard.
Tocopherols help prevent rapid oxidation of highly unsaturated marine oils.
Tocopherols show compatibility with emulsifiers and phospholipids, allowing use in complex food systems such as dressings and spreads.
They distribute well in emulsions.
This improves formulation performance.
Tocopherols are widely used in nutritional supplements and fortified foods, contributing both antioxidant protection and vitamin E intake.
This supports functional nutrition.
Tocopherols are multi-functional natural antioxidants with strong lipid protection, synergistic regeneration ability, and dual nutritional and preservative roles, widely used in food, cosmetic, and pharmaceutical systems.
Physically, Tocopherols appear as viscous oily liquids ranging from light yellow to brown.
Tocopherols are insoluble in water but soluble in fats and organic solvents.
They have a mild characteristic odor.
Tocopherols exhibit strong antioxidant activity, protecting lipids by scavenging free radicals.
Tocopherols interrupt oxidation chain reactions.
This prevents rancidity.
Tocopherols are particularly effective in stabilizing unsaturated fats and oils, which are prone to oxidative degradation.
Tocopherols slow peroxide formation.
This extends shelf life.
Tocopherols are a group of natural fat-soluble antioxidants belonging to the vitamin E family, widely used to protect fats and oils from oxidation in food, cosmetics, and pharmaceutical applications.
Tocopherols consist of several isomers.
Tocopherols are derived mainly from vegetable oils.
Density: 0.930 g/mL at 25 °C
refractive index: n20/D 1.501
Flash point: >200℃
form: Viscous
color: Colorless to light yellow
biological source: vegetable oil
Boiling point: >200°C
Major Application: flavors and fragrances
Cosmetics Ingredients Functions: FRAGRANCE; SKIN CONDITIONING - MISCELLANEOUS; ANTIOXIDANT; SKIN CONDITIONING - OCCLUSIVE
InChI: InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3
InChIKey: QUEDXNHFTDJVIY-UHFFFAOYSA-N
SMILES: C1(C)(CCCC(C)CCCC(C)CCCC(C)C)OC2=C(C=C(O)C(C)=C2C)CC1
LogP: 10.724 (est)
Tocopherols exhibit synergistic effects with other antioxidants, such as ascorbic acid and citric acid.
Tocopherols are particularly effective in unsaturated and polyunsaturated fatty acid systems, which are highly prone to oxidation.
This improves product quality.
Tocopherols demonstrate carry-through activity, meaning they remain active after processing steps like baking or mild frying.
They continue protecting during storage.
This extends shelf life.
Tocopherols have low volatility, so they are retained in products during storage and moderate heating.
This ensures long-lasting effectiveness.
This improves reliability.
Tocopherols may interact with oxygen and trace metals, helping reduce oxidative pathways indirectly.
This supports comprehensive antioxidant systems.
Tocopherols improves performance.
Tocopherols are often used as mixed tocopherols, providing broader antioxidant coverage than a single isomer.
This increases stability across different conditions.
Tocopherols are natural, fat-soluble antioxidants with strong radical-scavenging ability, synergistic performance, and dual role as preservatives and nutrients, widely used in food, cosmetic, and pharmaceutical applications.
Tocopherols exhibit temperature-dependent stability, remaining effective at moderate heat but gradually degrading under prolonged high-temperature exposure.
This limits their use in extreme frying conditions.
Tocopherols defines application boundaries.
Tocopherols can be recycled in antioxidant cycles when combined with other compounds like ascorbate.
This regenerates active antioxidant forms.
Tocopherols show compatibility with emulsifiers and phospholipids, allowing use in complex food systems such as dressings and spreads.
Tocopherols is stable to heat and alkalis in the presence of oxygen, and is not affected by acids up to 212° F.
Tocopherols is slowly oxidized by atmospheric oxygen and rapidly oxidized by ferric and silver salts.
Tocopherols gradually darkens on exposure to light. .
Tocopherols function as chain-breaking antioxidants, donating hydrogen atoms from their phenolic hydroxyl group to neutralize lipid radicals.
This interrupts oxidation propagation.
Tocopherols slows rancidity formation.
Tocopherols are highly lipophilic, allowing them to localize in fat and oil phases where oxidation primarily occurs.
This ensures targeted protection.
Tocopherols improves efficiency in lipid systems.
Different isomers show varying antioxidant performance, with gamma- and delta-tocopherol often more effective in food preservation, while alpha-tocopherol has higher vitamin activity.
This allows tailored use.
Tocopherols improves formulation flexibility.
Uses:
Tocopherols are also used in industrial applications, such as lubricants and specialty oils.
They slow oxidative degradation of materials.
Tocopherols are used wherever natural antioxidant protection, lipid stabilization, and vitamin E enrichment are needed across food, cosmetic, pharmaceutical, feed, and industrial systems.
Tocopherols are also used in functional foods and fortified products to combine antioxidant protection with nutritional vitamin E value.
Tocopherols support both preservation and health benefits.
This improves product functionality.
In infant and specialized nutrition formulas, they help stabilize sensitive fats such as polyunsaturated fatty acids.
Tocopherols protect essential nutrients from oxidation.
This ensures product safety and quality.
Tocopherols are applied in fish oil and omega-3 supplements, where oxidation risk is very high.
They prevent formation of fishy odors and rancid compounds.
This improves supplement stability.
Tocopherols are used in confectionery products containing fats, such as chocolate, coatings, and fillings.
Tocopherols reduce fat bloom and oxidative flavor loss.
This improves appearance and taste.
In bakery fillings and creams, they stabilize oils and fat-based ingredients.
Tocopherols prevent rancidity during storage.
This extends shelf life.
Tocopherols are widely used in cosmetic serums, sunscreens, and anti-aging creams.
They protect oils and active ingredients from oxidative damage.
This improves product performance.
In pharmaceutical lipid emulsions and softgel capsules, they help maintain chemical stability of active compounds.
Tocopherols reduce oxidation of carriers.
This supports formulation integrity.
Tocopherols are used in pet food products, especially those containing fish oils or high-fat content.
They preserve nutritional quality during storage.
This improves feed stability.
Tocopherols are also applied in biodegradable packaging materials and bio-based polymers.
They slow oxidative degradation of natural components.
Tocopherols are used wherever natural, multifunctional protection of fats, oils, and sensitive nutrients is required, particularly in food, cosmetic, pharmaceutical, feed, and emerging bio-based industrial systems.
Tocopherols are a class or organic molecules. Many exhibit the activity of Vitamin E. They are commonly found in Olive and sunflower oils.
Tocopherols are widely used in the food industry as natural antioxidants to prevent oxidation of fats and oils.
They help stop rancidity and off-flavor formation.
In edible oils and fats, they stabilize vegetable oils, fish oils, and animal fats.
Tocopherols protect unsaturated fatty acids from degradation.
This improves storage stability.
Tocopherols are applied in processed foods such as snacks, baked goods, and ready meals.
They preserve fat quality during storage and distribution.
This maintains product taste.
Tocopherols are used in nut and seed products, such as nut butters and mixed nuts.
They prevent oxidation of natural oils.
This improves freshness.
In frozen foods, they help protect fats during long-term storage at low temperatures.
Tocopherols remain active during freezing and thawing.
This improves product consistency.
Tocopherols are widely used in cosmetics and personal care products, including creams, lotions, and oils.
They stabilize lipid components and fragrances.
This improves product durability.
Tocopherols are applied in pharmaceutical formulations, especially lipid-based capsules and ointments.
In animal feed, they help preserve fat-rich ingredients and provide vitamin E nutrition.
They prevent spoilage during storage.
Safety Profile:
Tocopherols inhalation is generally not a concern, as tocopherols have very low volatility.
However, aerosolized formulations may cause minor irritation in sensitive respiratory systems.
Tocopherols present very low hazard potential, as they are natural vitamin E compounds widely used in foods, cosmetics, and supplements.
They are generally recognized as safe at approved dietary levels.
However, some precautions apply in concentrated or industrial forms.
Skin contact is typically low risk, and tocopherols are often used in topical skincare products.
Rarely, they may cause mild irritation or allergic reactions in sensitive individuals.
Patch testing may be useful for sensitive users.
Eye contact may cause mild irritation, especially with concentrated oily formulations.
Symptoms can include redness or slight discomfort.
Rinsing with water is recommended if exposure occurs.
