BROMELAIN

EC Number: 253-387-5 / 232-572-4
CAS NO: 37189-34-7/ 9001-00-7

Bromelain is an enzyme extract derived from the stems of pineapples, although it exists in all parts of the fresh pineapple.
The extract has a history of folk medicine use. 
As an ingredient, it is used in cosmetics, as a topical medication, and as a meat tenderizer.

The term "bromelain" may refer to either of two protease enzymes extracted from the plants of the family Bromeliaceae, or it may refer to a combination of those enzymes along with other compounds produced in an extract.
Bromelain enzymes are called fruit bromelain and stem bromelain.

Although tested in a variety of folk medicine and research models for its possible efficacy against diseases, bromelain has as its only approved clinical application, issued in 2012 by the European Medicines Agency, a topical medication called NexoBrid, used to remove dead tissue in severe skin burns.

Extract components

Bromelain extract is a mixture of protein-digesting (proteolytic) enzymes and several other substances in smaller quantities. 
The proteolytic enzymes are sulfhydryl proteases; a free sulfhydryl group of a cysteine amino acid side chain is required for function. 

History
The first isolation of bromelain was recorded by the Venezuelan chemist Vicente Marcano in 1891 by fermenting the fruit of pineapple.
In 1892, Russell Henry Chittenden, assisted by Elliott P. Joslin and Frank Sherman Meara, investigated the matter more completely, and called it 'bromelin'. 
Later, the term 'bromelain' was introduced and originally applied to any protease from any member of the plant family Bromeliaceae.
Sources
Bromelain is present in all parts of the pineapple plant (genus Ananas), but the stem is the most common commercial source, presumably because usable quantities are readily extractable after the fruit has been harvested.

Production
Produced mainly in parts of the world where pineapples are grown, such as Thailand or Malaysia, bromelain is extracted from the peel, stem, leaves or waste of the pineapple plant after processing the fruit for juice or other purposes.
The starting material is blended and pressed through a filter to obtain a supernatant liquid containing the soluble bromelain enzyme.
Further processing includes purification and concentration of the enzyme.

Physical characteristics
Bromelain is a white to tan powder, soluble in water, and is stable at temperatures of 50–60 °C (122–140 °F).

Temperature stability
After an hour at 50 °C (122 °F), 83% of the enzyme remains active, while at 40 °C (104 °F), practically 100% remains active.
8 minutes at 80 °C (176 °F) is sufficient to almost completely inactivate the enzyme.
The proteolytic activity of concentrated bromelain solutions remains relatively stable for at least 1 week at room temperature, with minimal inactivation by multiple freeze-thaw cycles or exposure to the digestive enzyme trypsin.

Uses:
Meat tenderizing and other uses
Along with papain, bromelain is one of the most popular proteases to use for meat tenderizing.
Bromelain is sold in a powdered form, which is combined with a marinade, or directly sprinkled on the uncooked meat.

Cooked or canned pineapple does not have a tenderizing effect, as the enzymes are heat-labile and denatured in the cooking process. 
Some prepared meat products, such as meatballs and commercially available marinades, include pineapple and/or pineapple-derived ingredients.

Although the quantity of bromelain in a typical serving of pineapple fruit is probably not significant, specific extraction can yield sufficient quantities for domestic and industrial processing, including uses in baking, anti-browning of cut fruit, textiles and cosmetics manufacturing.

Potential medical uses
Bromelain has not been scientifically proven to be effective in treating any diseases and has not been approved by the U.S. Food and Drug Administration for the treatment of any disorder.
In the United States, the passage of the Dietary Supplement Health and Education Act (DSHEA, 1994) allows the sale of bromelain-containing dietary supplements, even though efficacy has not been confirmed. 
Ingestion of bromelain may cause an allergic reaction in some people who are sensitive to pineapples.

While there have been studies into the medical use of bromelain, "the majority of [them] have methodological issues that make it difficult to draw definite conclusions", as none definitively established efficacy, recommended dosage, long term safety, or adverse interaction with other medications.[10]

A concentrate of proteolytic enzymes enriched in bromelain is approved in Europe for the debridement (removal of dead tissue) of severe burn wounds under the trade name NexoBrid.
Systemic enzyme therapy (consisting of combinations of proteolytic enzymes such as bromelain, trypsin, chymotrypsin, and papain) has been investigated in Europe to evaluate the efficacy in breast, colorectal, and plasmacytoma cancer patients.
Bromelain may be effective as an adjunct therapy in relieving symptoms of acute rhinosinusitis in patients not treated with antibiotics.

Uses:
Bromelain is also used as a natural anti-inflammatory for conditions such as arthritis. It's one of the most popular supplements in Germany, where it is approved by the Commission E for the treatment of inflammation and swelling of the nose and sinuses du
Tenderizing meat, chill-proofing beer, production of protein hydrolyzates.

Definition    
A milk-clotting proteolytic enzyme. 
It is precipitated from pineapple juice with acetone or ammonium sulfide.

Manufacturing Process    
According to US Patent 3,002,891, the following describes pilot plant production of bromelain. 
Stripped pineapple stumps were passed four times through a three roll sugar mill press, In the second and following passes through the press, water was added to the pulp to increase the efficiency of the extraction procedure. 
The crude juice was screened to remove the coarse particles. 
Hydrogen sulfide gas was bled into the collected juice to partially saturate it. 
The pH was adjusted to pH 4.8 and then the juice was centrifuged.
To 50 gallons of juice were added 30 gallons of cold acetone. 
The precipitate which formed was removed by centifuging in a Sharples centrifuge. This precipitate was discarded. 
To the supernatant liquor an additional 35 gallons of acetone was added and the precipitate was collected in a Sharples centrifuge. 
The wet precipitate was dropped into fresh acetone, mixed well, and then recovered by settling. 
The paste was then dried in a vacuum oven at a shelf temperature of 110°F. 
Yield: 8 pounds of enzyme per 100 gallons of juice. Activity: 4,000 MCU/g.

Bromelain is a group of enzymes found in pineapple juice and in the pineapple stem. 
People sometimes use it as a medicine.

Bromelain is used for pain, muscle soreness, burns, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?
Bromelain seems to cause the body to produce substances that fight pain and swelling (inflammation). 
Bromelain also contains chemicals that interfere with the growth of tumor cells and slow blood clotting.

Uses & Effectiveness 
Possibly Ineffective for
Muscle soreness caused by exercise. 
Taking bromelain by mouth after intense exercise does not seem to prevent muscle soreness. 
It also doesn't reduce pain or weakness or improve flexibility.
Insufficient Evidence for
Burns. Early research shows that applying gel containing bromelain enzymes under a wound dressing helps remove dead tissue from burns.
Kidney stones. 
Early research found that adding bromelain to tamsulosin might help the body get rid of kidney stones.
Knee pain. 
Early research shows that taking bromelain by mouth might reduce mild knee pain.
Osteoarthritis. 
Early research shows that taking bromelain by mouth alone doesn't seem to help arthritis pain.
A skin condition that causes small, scaling, raised spots (pityriasis lichenoides chronica or PLC). Early research shows that bromelain might help treat episodes of PLC.
Pain after surgery. 
Some research shows that bromelain slightly reduces pain after removal of wisdom teeth. 
But it doesn't seem to reduce lockjaw or swelling.
Swelling (inflammation) of the nasal cavity and sinuses (rhinosinusitis). 
Early research shows that taking bromelain along with decongestants, antihistamines, or antibiotics helps reduce nasal swelling in people with sinusitis. 
But this research is not very reliable.
Nerve damage in the hands and feet caused by cancer drug treatment.
Acute pain.
Cancer.
Childbirth.
Hay fever.
Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs).
Painful conditions caused by overuse of tendons (tendinopathy).
Swelling in the arms or legs caused by damage to the lymph system (lymphedema).
Other conditions.

Bromelain is a mixture of enzymes found naturally in the juice and stems of the pineapple plant (Ananas comosus). 
Available in dietary supplement form, bromelain is considered a proteolytic enzyme, a class of enzymes thought to aid in the digestion of protein. 
Bromelain supplements are said to treat a variety of health conditions, especially those associated with chronic inflammation, such as allergies, osteoarthritis, sinusitis, and ulcerative colitis.

Bromelain is also said to stimulate digestion and improve heart health, as well as protect against some forms of cancer. 
The medicinal qualities of pineapple are recognized in many traditions in South America, China, and Southeast Asia.

Health Benefits
According to the National Center for Complementary and Integrative Health (NCCIH), the best evidence for bromelain relates to the relief of symptoms of acute nasal and sinus inflammation when used in combination with standard medications.

Research for other benefits for which bromelain has been used is either conflicting (osteoarthritis and muscle soreness after exercise) or lacking (cancer and gastrointestinal problems).

Here's a look at several findings from the available research on the potential health benefits of bromelain:

Bromelain is a group of enzymes found in the fruit and stem of the pineapple plant. 
Pineapple is native to the Americas but is now grown throughout the world in tropical and subtropical regions. 
Historically, natives of Central and South America used pineapple for a variety of ailments, such as digestive disorders.
Bromelain is promoted as a dietary supplement for reducing pain and swelling, especially of the nose and sinuses, gums, and other body parts after surgery or injury. 
It is also promoted for osteoarthritis, cancer, digestive problems, and muscle soreness. Topical bromelain is promoted for burns.

General Description    
Bromelains (Ananase) is a mixture of proteolyticenzymes obtained from the pineapple plant. 
It isproposed for use in the treatment of soft-tissue inflammationand edema associated with traumatic injury, localized inflammation,and postoperative tissue reactions. 
Theswelling that accompanies inflammation may be caused byocclusion of the tissue spaces with fibrin. 
If this is true,enough Ananase would have to be absorbed and reach thetarget area after oral administration to act selectively on thefibrin. 
This is yet to be established, and its efficacy as ananti-inflammatory agent is inconclusive. 
An apparent inhibitionof inflammation, however, has been demonstratedwith irritants such as turpentine and croton oil (granulomapouch technique). 
Ananase is available in 50,000-U tabletsfor oral use.

Bromelain is a mixture of enzymes found in pineapples (Ananas comosus) that digest protein (proteolytic). 
Pineapple has been used for centuries in Central and South America to treat indigestion and reduce inflammation. 
Bromelain, which is derived from the stem and juice of the pineapple, was first isolated from the pineapple plant in the late 1800s. 
The German Commission E approved bromelain to treat swelling and inflammation after surgery, particularly sinus surgery.

Bromelain can be used to treat a number of conditions, but it is particularly effective in reducing inflammation from infection and injuries.

Surgery, Sprains and Strains, and Tendinitis
Although studies show mixed results, bromelain may reduce swelling, bruising, healing time, and pain after surgery and physical injuries. 
It is often used to reduce inflammation from tendinitis, sprains and strains, and other minor muscle injuries. 
Studies of people having dental, nasal, and foot surgeries found it reduced inflammation. 
In Europe, bromelain is used to treat sinus and nasal swelling following ear, nose, and throat surgery or trauma.

Wounds and Burns
Studies in animals suggest that bromelain, when applied to the skin, may be useful in removing dead tissue from third-degree burns, a process called debridement. 
One preliminary study of a debridement agent that is derived from bromelain to treat people with second- and third-degree burns showed a benefit. 
Severe burns require a doctor's care. Do not apply bromelain to broken skin.

Sinusitis (Sinus Inflammation)
Although not all studies agree, bromelain may help reduce cough and nasal mucus associated with sinusitis. 
It may also relieve the swelling and inflammation caused by hay fever.

Bromelain, also called ‘pineapple extract,’ is a combination of several compounds, including a large amount of a special protein-digesting enzyme. 
This enzyme is able to be digested and thus affect the blood and body, rather than just the stomach and intestines.

When Bromelain is in the stomach, it will help the body break down and digest protein. 
Supplementation of bromelain can also reduce nasal inflammation, meaning it acts as a decongestant.

If taken between meals, bromelain can benefit the immune system and protect the body from cancer. 
Bromelain’s effects on fat cells are also under investigation, with promising preliminary evidence.

Bromelain’s anti-inflammatory properties are responsible for several of its effects, including its ability to decongest the nasal cavity. 
Further research is needed to determine the mechanism through which bromelain survives the digestive system.

Bromelain belongs to a group of protein digesting enzymes obtained commercially from the fruit or stem of pineapple. 
Fruit bromelain and stem bromelainare prepared differently and they contain different enzymatic composition. 
“Bromelain” refers usually to the “stem bromelain.” 
Bromelain is a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors. 
In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. 
Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects. 
Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics. 
It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. 
Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.

Pineapple is the common name of Ananas comosus (syns. A. sativus, Ananassa sativa, Bromelia ananas, B. comosa). 
Pineapple is the leading edible member of the family Bromeliaceae, grown in several tropical and subtropical countries including Philippines, Thailand, Indonesia, Malaysia, Kenya, India, and China. 
It has been used as a medicinal plant in several native cultures and these medicinal qualities of pineapple are attributed to bromelain (EC 3.4.22.32), which is a crude extract from pineapple that contains, among other compounds, various closely related proteinases, exhibiting various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities in vitro and in vivo. 
Bromelain has been chemically known since 1875 and is used as a phytomedical compound. 
Bromelain concentration is high in pineapple stem, thus necessitating its extraction because, unlike the pineapple fruit which is normally used as food, the stem is a waste byproduct and thus inexpensive. 
A wide range of therapeutic benefits have been claimed for bromelain, such as reversible inhibition of platelet aggregation, sinusitis, surgical traumas, thrombophlebitis, pyelonephriti angina pectoris, bronchitis, and enhanced absorption of drugs, particularly of antibiotics. 
Several studies have been carried out indicating that bromelain has useful phytomedical application. 
However, these results are yet to be amalgamated and critically compared so as to make out whether bromelain will gain wide acceptance as a phytomedical supplement. 
Bromelain acts on fibrinogen giving products that are similar, at least in effect, to those formed by plasmin. 
Experiment in mice showed that antacids such as sodium bicarbonate preserve the proteolytic activity of bromelain in the gastrointestinal tract. 
Bromelain is considered as a food supplement and is freely available to the general public in health food stores and pharmacies in the USA and Europe. 
Existing evidence indicates that bromelain can be a promising candidate for the development of future oral enzyme therapies for oncology patients. 
Bromelain can be absorbed in human intestines without degradation and without losing its biological activity.

The crude aqueous extract from stem and fruit of pineapple is known as bromelain. 
It is a mixture of different thiol endopeptidases and other components like phosphatases, glucosidase, peroxidases, cellulases, glycoproteins, carbohydrates, and several protease inhibitors. 
Stem bromelain (EC.3.4.22.32) is different from fruit bromelain (EC.3.4.22.33). 
The enzymatic activities of bromelain comprise a wide spectrum with pH range of 5.5 to 8.0. 
Different protein fractions were obtained by mean of various “biochemical techniques as sodium dodecyl sulphate polyacrylamide gel electrophoresis” (SDS-PAGE), isoelectric focusing (IEF), and multicathodal-PAGE. 
Nowadays, bromelain is prepared from cooled pineapple juice by centrifugation, ultrafiltration, and lyophilization. 
The process yields a yellowish powder, the enzyme activity of which is determined with different substrates such as casein (FIP unit), gelatin (gelatin digestion units), or chromogenic tripeptides.

bromelain may help in the treatment of several disorders.

Pineapple, a South American native and a cherished part of Hawaiian folk medicine, is one of the richest sources in the world of the enzyme bromelain. 
It is composed of several endopeptidases and compounds like phosphatase, glucosidase, peroxidase, cellulase, escharase and protease inhibitors. 
Usually “bromelain” sold in extract or supplement form refers to enzymes extracted from pineapple stems or cores, rather than from the fruit’s flesh.

Used widely as a natural remedy to treat everything from indigestion to allergies, pineapple is not only brimming with this enzyme, but also vitamin C, vitamin B1, potassium, manganese and phytonutrients. 
While pineapple has many benefits, the real secret to its healing powers is definitely bromelain.

What is bromelain used to treat? In the medical world, this fascinating compound has traditionally been used as a potent anti-inflammatory and anti-swelling agent. 
Research have also shown that it has fibrinolytic, antiedematous and antithrombotic properties, meaning it helps prevent blood clots, edema and swelling.

In the past, this enzyme was also used as a meat tenderizer, reason being it helps to soothe and relax tense, inflamed muscles and connective tissue. 
Additionally, recent studies have found evidence that this enzyme stops lung metastasis in its tracks, which suggests that bromelain can be used to treat a wide variety of diseases, potentially including cancer.

A look at the scientific literature, which includes 1,600-plus articles evaluating the medicinal benefits of bromelain, shows that it has been used to treat a wide range of health problems, including:

Connective tissue injuries, such as ACL tears
Sprained ankles
Tendonitis
Allergies
Arthritis, joint pain and osteoarthritis
Digestive issues like heartburn or diarrhea
Cardiovascular disorders
Asthma
Autoimmune diseases
Cancer
Inflammatory bowel disease
Sinus infections, such as bronchitis and sinusitis
Surgical trauma and slow healing of skin wounds or burns
Poor absorption of drugs, especially antibiotics, and symptoms due to taking medications

Benefits and Uses:
1. May Help Prevent Cancer
In studies, bromelain has been found to have natural anti-cancer effects, including promoting apoptotic cell death and preventing tumor growth. 
It’s been shown in animal studies that it can induce the production of distinct cytokines, that it has antimetastatic efficacy and that it inhibits metastasis by reducing platelet aggregation.

Studies have linked bromelain to increased protection against breast and lung cancer, and recently the journal Anticancer Drugs published results from a clinical trial that suggested it affects malignant peritoneal mesothelioma — a rare cancer caused by asbestos exposure. 
According to the study, it was uncovered that “The addition of bromelain increased the die off of cancer cells (cytotoxicity) significantly… Bromelain has the potential of being developed as a therapeutic agent in treating malignant cancer.”

2. Helps Treat Digestive Disorders
Why is bromelain good for you if you suffer from indigestion or a gastrointestinal disorder? Because it’s an enzyme that specifically helps with digesting proteins and has been found to help your body absorb nutrients and even medications more efficiently. 
Studies suggest that it decreases colonic inflammation and reduces secretion of pro-inflammatory cytokines that damage the gut lining.
Because it’s very effective at healing tissues within the gastrointestinal tract, bromelain is beneficial for people with any of the following GI problems:

Inflammatory bowel disease
Ulcerative colitis
Dyspepsia, or peptic ulcers due to heliobactor pylori infections
Colon cancer
Constipation
Crohn’s disease
Heartburn
Diarrhea

3. Supports Faster Recovery from Surgery and Injuries
Bromelain’s anti-inflammatory properties make it a great natural alternative to taking pain-killing medications, such as aspirin. 
One study that evaluated bromelain’s ability to treat patients who had impacted third molars extracted found that it supported wound healing and helped decrease pain and swelling following the patients’ operations.

Most patients who undergo this surgery experience significant post-operative symptoms, and unfortunately, antibiotics and painkillers are not always effective at preventing infections or other discomfort during the healing process. 
Of the 80 people who participated in the study, those who were prescribed bromelain reported “significantly lower” post-operation pain, swelling and even redness compared to the control group prescribed a generic painkiller.

4. Fights Allergies and Asthma
The journal Evidenced-Based Complementary and Alternative Medicine highlighted the results of a study that investigated how bromelain affected mice suffering from asthma. 
The study produced some interesting results — for example, that bromelain reduces allergic sensitization and stops development of other inflammatory responses affecting the airways.

These findings suggests that this enzyme helps modulate the entire immune system. 
It can actually help prevent allergies by addressing the root cause — a hyperactive, oversensitive immune system. 
It was observed in the study that CD11c (+) dendritic cells and DC44 antigen-presenting cells were kept at bay when supplementing with bromelain, a sign that this enzyme is capable of targeting the underlying cause of asthma and allergies. 
This is why it helps most people suffering from symptoms like a stuffy/runny nose, itchy eyes, swollen lymph nodes, congestion and trouble breathing.

5. Helps Prevent or Treat Sinus Infections (Rhinosinusitis)
To see whether or not a daily dose of bromelain (300 FIP units, 600-milligram tablets) could help people suffering from chronic sinusitis (inflammation of the sinuses), researchers at the University of Cologne in Germany took 12 patients who had already had sinus surgery and treated them with bromelain for three months. 
They discovered the following bromelain benefits: 
Total symptom scores improved, total rhinoscopy scores improved, overall quality of life was enhanced and there were no adverse effects reported. 
Because surgery can oftentimes be ineffective at treating sinusitis, this research brings a lot of hope to people suffering from chronic sinus problems.

6. Helps Decrease Joint Pain
Due to its powerful anti-inflammatory and analgesic characteristics, bromelain is fantastic for reducing acute or chronic joint pain. 
The journal Alternative Therapies in Health and Medicine published a research trial that evaluated 42 osteoarthritis patients with degenerative spine or painful joint conditions.

Two 650-milligram capsules of bromelain were given to the patients two to three times each day on an empty stomach (depending on whether they had acute or chronic pain). 
Researchers discovered that pain decreased up to 60 percent in participants dealing with acute pain and more than 50 percent in those with chronic disorders. 
The researchers’ conclusion was that “Bromelain has been demonstrated to show anti-inflammatory and analgesic properties and may provide a safer alternative or adjunctive treatment for osteoarthritis.”

7. May Support Weight Loss
Does research suggest there’s any link between bromelain and weight loss? Its effects on weight management and fat cells are still under investigation, but there’s reason to believe that it may help with weight loss due to its anti-inflammatory effects, ability to reduce pain, and capability of improving physical abilities and digestion.

According to a 2017 article published in PLOS One, “stem bromelain (SBM) is used as an anti-obesity alternative medicine.” 
Some studies have found that bromelain helps downregulate adipocyte fatty acid-binding protein, fatty acid synthase and lipoprotein lipase. 
It may also inhibit adipogenesis (cell differentiation that can contribute to formation of fat cells) and reduce triglyceride accumulation.

Foods and Sources
Wondering what fruits have bromelain in them, other than pineapple, and are there any other ways to get it other than from eating certain foods?

There are three primary ways to incorporate bromelain into your natural health regimen:

1. Pineapple Core
First, of course, is eating the fiber-rich core of a juicy, ripe pineapple. 
Bromelain is not found in significant quantities in other fruits, although pineapple is sometimes eaten along with immature, green papaya to increase absorption and provide the beneficial enzyme called papain.

Eating pineapple (fresh or frozen) is the very best way to consume natural bromelain. 
It’s found in all parts of the pineapple but most concentrated in the core. 
Keep in mind that the riper the fruit is, the softer the core will be. 

So, make sure you keep your pineapple out on your counter for an extra day or two — this way you’re not gnawing on a tough stem. 
Note that the flesh of a pineapple is also good for you but doesn’t have the high bromelain content like the core does. 
The core is where the highest concentration is found.

2. Juicing Pineapples
Juicing the core of the pineapple or throwing it into a smoothie along with other vegetables like cucumber is an easy way to consume bromelain. 
Drinking fresh pineapple juice has been suggested to be a powerful remedy against inflammatory diseases.
I recommend drinking four ounces a day to help prevent digestive issues and up to eight ounces to treat illnesses like ulcerative colitis, inflammatory bowel disease or constipation.

3. Bromelain Supplements/Extract
Bromelain supplements are usually found in the form of dried yellow powder, extracted from pineapple juice that is subjected to centrifugation, ultrafiltration and lyophilization. 
Taking a natural bromelain supplement or proteolytic enzyme supplement with bromelain can be quite effective if you’re treating a specific inflammatory or chronic disease. 
If you are trying to improve digestion you should take bromelain supplements with meals, but for all other health conditions you should take it on an empty stomach.

IUPAC NAMES:
Bromelain
Bromelain, juice
Bromelains
EC 3.4.22.33
Maltodextrin
maltodextrin
Bromelain, stem
Bromelain, stem
Bromelian, stem
Stem bromelain

SYNONYMS:
Einecs 253-387-5
Bromelain from pineapple stem min. 0.4 DMC-U/mg
ANANAS COMOSUS
BroMelain froM pineapple steM Min. 0.4 DMC-U/Mg powder
Pineapple stem bromelain
Bromelain POS
BROMELAIN FROM PINEAPPLE STEM 2 U/MG
Bromelain from pineapple stem
Bromelain pineapple stem
Bromelain, stem
BROMELAIN FROM PINEAPPLE STEMCHROMATOGRA PHICALLY P
Native Pineapple Bromelain
Bromelain from pineapple stem >=3 units/mg protein
BROMELAIN FROM PINEAPPLE STEM 2 U/MG USP/EP/BP
ananase
bromelains
CATHEPSIN B1
CATHEPSIN B (LIVER)
BroMelain topical
Bromelain Powder 1200gdu/G
Bromelain Joyce
e.c.3.4.4.24
plantproteaseconcentrate
BroMelain, 2500 GDU/g
BroMelain, pure, 1200 GDU,g
STEM BROMELAIN
3.4.22.32
BROMELAIN
BROMELAIN PINEAPPLE
BROMELIN
EC 3.4.22.1
EC 3.4.22.32
EC 3.4.22.4
EC: 3.4.22.4
EC 3.4.22.5
CATHEPSIN B, HUMAN
CATHEPSIN B, HUMAN LIVER
Edemase D
Bromelain, juice
BromelainExPineappleStemJuice
Bromelain(Bromelin)
Bromelain, pure
Bromelain from pineapple stem ca. 0.5 DMC-U/mg
BROMELASIN
BROMELAIN,1200GDU
BROMELAIN,120GDU
BROMELAIN,600GDU
BROMELAIN,80GDU
BROMELAIN(RG)
Bromezyme
Bromelein
Bromelain for food
Bromelain, Technical Grade
Bromelain fandachem
Bromelain USP/EP/BP
Pineapple Extract – Bromelain