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Riboflavin-5'-Phosphate, designated as E101(ii), is the phosphorylated and water-soluble form of vitamin B₂ (riboflavin).
E101(ii) Riboflavin-5'-Phosphate is widely used as a yellow to orange food coloring, as well as a bioavailable vitamin supplement in pharmaceutical and nutritional products.
E101(ii) Riboflavin-5'-Phosphate plays a vital role as a coenzyme in cellular metabolism and energy production, particularly in redox reactions involving flavoproteins.
CAS Number: 130-40-5 (sodium salt)
EC Number: 205-758-4
Molecular Formula: C17H20N4NaO9P
Molecular Weight: 478.32 g/mol
Synonyms: E101(ii), Riboflavin-5'-phosphate sodium, Flavin mononucleotide sodium salt, FMN sodium salt, Riboflavin phosphate sodium, Riboflavin phosphate sodium salt, Vitamin B2 phosphate, Riboflavin-5-monophosphate, Riboflavin phosphate monosodium salt, Sodium riboflavin phosphate, Sodium flavin mononucleotide, Sodium FMN, Riboflavin phosphate USP, Riboflavin monophosphate sodium, Water-soluble vitamin B2, E101 water-soluble yellow color, FMN vitamin B2, Riboflavin phosphate vitamin additive, Vitamin B2 phosphate coenzyme, Riboflavin 5-phosphate food grade, Riboflavin 5-phosphate pharmaceutical grade, Flavin mononucleotide food colorant, Yellow vitamin B2 supplement, Riboflavin-5'-monophosphate sodium, Riboflavin 5' phosphate sodium
APPLICATIONS
E101(ii) Riboflavin-5'-Phosphate is used in functional foods, beverages, and supplements to provide an active and bioavailable form of vitamin B₂.
E101(ii) Riboflavin-5'-Phosphate is applied in pharmaceutical formulations for treating vitamin B₂ deficiencies and metabolic disorders.
E101(ii) Riboflavin-5'-Phosphate is used as a yellow-orange colorant in nutritional drinks, baby food, cereals, and fortified products.
E101(ii) Riboflavin-5'-Phosphate is included in cosmetic products such as creams and lotions for its potential antioxidant and vitamin-supportive properties.
E101(ii) Riboflavin-5'-Phosphate is utilized in diagnostic reagents and biochemical research as a coenzyme in enzymatic reactions.
E101(ii) Riboflavin-5'-Phosphate is also used in injectable and parenteral nutrition solutions.
E101(ii) Riboflavin-5'-Phosphate is used in the food industry as a natural food coloring agent, where it imparts a yellow color to products such as drinks, dairy products, and baked goods.
E101(ii) Riboflavin-5'-Phosphate is employed in the pharmaceutical industry as a vitamin supplement, where it is used in formulations to provide riboflavin, an essential nutrient for energy metabolism.
E101(ii) Riboflavin-5'-Phosphate is used in the production of functional foods, where it adds riboflavin while also providing a natural yellow color to products like breakfast cereals and snack bars.
E101(ii) Riboflavin-5'-Phosphate is applied in the formulation of dietary supplements, where it is used to provide riboflavin in tablet, capsule, or powder form, supporting metabolic functions and eye health.
E101(ii) Riboflavin-5'-Phosphate is used in the beverage industry to color drinks such as fruit juices, sports drinks, and vitamin waters, providing a yellow hue while contributing to the nutritional value of the product.
E101(ii) Riboflavin-5'-Phosphate is employed in the creation of dairy-based products, such as yogurt and cheese, where it helps enhance the color and appearance of the product while contributing essential nutrients.
E101(ii) Riboflavin-5'-Phosphate is used in the production of confectionery items like candies and gummies, where it provides a stable yellow color that enhances the product's visual appeal.
E101(ii) Riboflavin-5'-Phosphate is used in the preparation of processed foods such as soups and sauces, where it helps color the product and improve its overall appearance.
E101(ii) Riboflavin-5'-Phosphate is used in the production of vitamin-fortified snacks, where it enhances the nutritional profile and imparts a natural yellow hue to the snack food.
E101(ii) Riboflavin-5'-Phosphate is employed in the formulation of breakfast cereals, where it serves both as a natural colorant and a source of essential vitamins for consumers.
E101(ii) Riboflavin-5'-Phosphate is used in animal feed products to fortify the diet of livestock with riboflavin, enhancing the health of animals and contributing to their nutritional needs.
E101(ii) Riboflavin-5'-Phosphate is used in the production of health drinks and energy supplements, where it provides riboflavin to support energy metabolism and adds color to the beverage.
E101(ii) Riboflavin-5'-Phosphate is applied in the production of liquid dietary supplements, where it provides a convenient and stable form of riboflavin for easy consumer intake.
E101(ii) Riboflavin-5'-Phosphate is employed in the formulation of skin care products like creams and lotions, where it provides a yellow color and contributes to the product’s nutritional profile.
E101(ii) Riboflavin-5'-Phosphate is used in the creation of fortified fruit spreads, where it helps color the spread and enhances its nutritional content with riboflavin.
E101(ii) Riboflavin-5'-Phosphate is used in pet food products to enhance their nutritional content, providing essential vitamins while adding a natural yellow color to the product.
E101(ii) Riboflavin-5'-Phosphate is used in the production of fortified pasta and noodles, where it contributes to the nutritional profile and provides a subtle yellow color to the product.
E101(ii) Riboflavin-5'-Phosphate is employed in the preparation of processed meats, such as sausages and deli products, where it helps achieve a natural color and adds riboflavin to the food’s nutritional content.
E101(ii) Riboflavin-5'-Phosphate is used in the production of plant-based products, such as vegan cheeses and plant milks, where it helps fortify the product with essential nutrients while maintaining its appearance.
E101(ii) Riboflavin-5'-Phosphate is used in the creation of bakery fillings, where it provides color and contributes essential vitamins to the filling, enhancing its nutritional value.
E101(ii) Riboflavin-5'-Phosphate is applied in the formulation of nutraceuticals, where it helps deliver riboflavin to consumers in a convenient and bioavailable form, supporting eye and skin health.
E101(ii) Riboflavin-5'-Phosphate is used in the production of vitamin-fortified beverages, where it adds a yellow tint and contributes to the nutritional content of the drink.
E101(ii) Riboflavin-5'-Phosphate is used in the formulation of dietary shakes and meal replacements, where it enhances the nutritional profile and adds a natural yellow color to the product.
E101(ii) Riboflavin-5'-Phosphate is used in the production of ice cream and frozen desserts, where it contributes both to the color and nutritional content, enriching the product with riboflavin.
E101(ii) Riboflavin-5'-Phosphate is employed in the manufacturing of fortified health snacks, where it provides riboflavin and enhances the color of the snack with a subtle yellow hue.
E101(ii) Riboflavin-5'-Phosphate is applied in the creation of breakfast smoothies, where it fortifies the product with riboflavin while enhancing the drink’s natural yellow color.
E101(ii) Riboflavin-5'-Phosphate is used in the formulation of fortified herbal teas, where it contributes to the color and nutritional profile of the beverage.
E101(ii) Riboflavin-5'-Phosphate is used in the production of vitamin-infused bottled water, where it provides essential nutrients and a natural yellow tint to the water.
E101(ii) Riboflavin-5'-Phosphate is employed in the preparation of whole food-based supplements, where it adds both color and nutritional benefits to the product.
E101(ii) Riboflavin-5'-Phosphate is used in the creation of enriched cereal bars, where it helps fortify the bars with essential vitamins while contributing to their visual appeal with a subtle yellow color.
DESCRIPTION
E101(ii) Riboflavin-5'-Phosphate appears as a yellow to orange crystalline powder or granular substance, depending on the grade.
E101(ii) Riboflavin-5'-Phosphate is highly soluble in water, making it ideal for clear liquid formulations and stable suspensions.
E101(ii) Riboflavin-5'-Phosphate is more bioavailable and stable in aqueous systems compared to riboflavin itself.
E101(ii) Riboflavin-5'-Phosphate exhibits good chemical and thermal stability under controlled conditions.
E101(ii) Riboflavin-5'-Phosphate functions as a coenzyme in oxidation-reduction reactions, particularly in flavoprotein systems such as flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
E101(ii) Riboflavin-5'-Phosphate is compatible with most vitamin and mineral blends.
E101(ii) Riboflavin-5'-Phosphate is used as a natural colorant in processed foods, dairy products, and beverages, where it provides a consistent, appealing yellow hue without altering the flavor.
E101(ii) Riboflavin-5'-Phosphate is a non-toxic and safe ingredient for use in food and cosmetic products, approved for use in many countries, including the United States and the European Union.
E101(ii) Riboflavin-5'-Phosphate is known for its stability under various processing conditions, making it ideal for use in products requiring long shelf life, such as fortified cereals, snacks, and energy bars.
E101(ii) Riboflavin-5'-Phosphate provides essential riboflavin to support metabolic functions, including the conversion of carbohydrates, fats, and proteins into energy, making it a valuable ingredient in health-focused products.
E101(ii) Riboflavin-5'-Phosphate is commonly used in the vitamin fortification of food and beverages, where it helps meet nutritional requirements for populations that may have insufficient riboflavin intake.
E101(ii) Riboflavin-5'-Phosphate is a widely recognized and trusted ingredient for fortifying foods and supplements with riboflavin, contributing to both the appearance and nutritional value of the product.
PROPERTIES
Chemical Formula: C17H20N4NaO9P
Molecular Weight: 478.32 g/mol
Common Name: Riboflavin-5'-Phosphate Sodium
Appearance: Yellow to orange crystalline powder
Odor: Odorless
Solubility: Freely soluble in water; slightly soluble in ethanol
pH (1% solution): 6.0–7.5
Melting Point: Decomposes above 280°C
Stability: Stable when stored away from light and moisture
Storage Temperature: 10–25°C
Shelf Life: 24–36 months in sealed containers
FIRST AID
Inhalation:
Move the exposed person to fresh air.
Seek medical attention if symptoms such as coughing or irritation persist.
Skin Contact:
Wash with soap and water.
Discontinue use and seek medical advice if irritation develops.
Eye Contact:
Flush eyes thoroughly with water for at least 15 minutes. Seek medical assistance if irritation continues.
Ingestion:
Rinse mouth.
If discomfort or unusual symptoms occur, seek medical attention.
Typically considered non-toxic in small nutritional amounts.
Note to Physicians:
Treat symptomatically.
Riboflavin-5'-Phosphate is a nutritional compound with a high safety margin under standard exposure levels.
HANDLING AND STORAGE
Handling:
Use personal protective equipment such as gloves and safety goggles during bulk handling.
Avoid contact with eyes, skin, and clothing.
Prevent dust formation and ensure good ventilation.
Spill and Leak Procedures:
Sweep up and collect in a suitable container.
Avoid generating dust.
Dispose of in accordance with local environmental regulations.
Storage:
Store in a dry, cool, and well-ventilated area away from direct sunlight and moisture.
Keep the container tightly closed and labeled properly.
Handling Cautions:
Riboflavin-5'-Phosphate is light-sensitive; minimize exposure to light during handling and storage.
Avoid contact with oxidizing agents and strong acids or alkalis.
