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CAS NUMBER: 7681-93-8




E235 (Natamycin) is a Polyene Antimicrobial.
E235 (Natamycin) is an antifungal medication used to treat fungal infections around the eye.

E235 (Natamycin) is used as eyedrops.
E235 (Natamycin) is also used in the food industry as a preservative.

E235 (Natamycin) is unclear if medical use during pregnancy or breastfeeding is safe.
E235 (Natamycin) is in the macrolide and polyene families of medications.

E235 (Natamycin) results in fungal death by altering the cell membrane.
E235 (Natamycin) was discovered in 1955 and approved for medical use in the United States in 1978.

E235 (Natamycin) is produced by fermentation of certain types of the bacterium 
E235 (Natamycin) is used to treat fungal infections.

E235 (Natamycin) is applied topically as a cream, in eye drops, or (for oral infections) in a lozenge. 
E235 (Natamycin) shows negligible absorption into the body when administered in these ways. 

When taken orally, little or none is absorbed from the gastrointestinal tract, making it inappropriate for systemic infections.
E235 (Natamycin) lozenges are also prescribed to treat yeast infections and oral thrush.

E235 (Natamycin) has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. 
Potential advantages for the usage of E235 (Natamycin) might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. 

E235 (Natamycin) can be applied in a variety of ways: as an aqueous suspension (such as mixed into a brine) sprayed on the product or into which the product is dipped, or in powdered form (along with an anticaking agent such as cellulose) sprinkled on or mixed into the product.
While not currently approved for use on meats in the United States, some countries allow E235 (Natamycin) to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. 

E235 (Natamycin) is approved for various dairy applications in the United States. 
E235 (Natamycin) is commonly used in products such as cream cheeses, cottage cheese, sour cream, yogurt, shredded cheeses, cheese slices, and packaged salad mixes. 

One of the reasons for food producers to use E235 (Natamycin) is to replace the artificial preservative sorbic acid.
As a food additive, E235 (Natamycin) has E number E235. 

Throughout the European Union, E235 (Natamycin) is approved only as a surface preservative for certain cheese and dried sausage products. 
E235 (Natamycin) must not be detectable 5 mm below the rind. 

While E235 (Natamycin) is approved in different applications at different levels in the world, E235 (Natamycin) is approved in over 150 countries worldwide.
E235 (Natamycin) inhibits the growth of fungi by specifically binding to ergosterol present in fungal cell membranes. 

E235 (Natamycin) inhibits amino acid and glucose transport proteins leading to a loss of nutrient transport across the plasma membrane. 
While this binding is reversible, ergosterol binding acts as a universal mechanism of fungal inhibition, allowing E235 (Natamycin) to act on diverse fungal pathogens from Saccharomyces yeast to Aspergillus moulds. 

E235 (Natamycin) is unique amongst related antifungals specifically because it does not directly cause membrane permeabilization.
Structurally-related antibiotics with similar binding properties are thought to produce hydrophilic channels that allow leakage of potassium and sodium ions from the cell.[17]

E235 (Natamycin) has very low solubility in water; however, E235 (Natamycin) is effective at very low levels. 
E235 (Natamycin)s minimum inhibitory concentration is less than 10 ppm for most molds.

E235 (Natamycin) is produced as a secondary metabolite.
Structurally, E235 (Natamycin)s core is a macrolide containing a polyene segment, with carboxylic acid and mycosamine groups attached. 

As with other polyene antimycotics, the biosynthesis begins with a series of polyketide synthase modules, followed by additional enzymatic processes for oxidation and attachment of the substituents.
E235 (Natamycin) is an antibiotic naturally produced by Streptomyces natalensis.

E235 (Natamycin) is used in many food products to prevent spoilage caused by mold and yeast.
Unlike chemical preservatives such as potassium sorbate and sodium benzoate, E235 (Natamycin) has no antibacterial activity and is only effective on molds and yeasts, so it can be easily applied in fermented milk and meat products.

E235 (Natamycin) is a polyene amphoteric macrolide antibiotic with antifungal properties. 
E235 (Natamycin) exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. 

E235 (Natamycin) leads to a leakage and loss of essential cellular constituents. 
Following ocular application, E235 (Natamycin) is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.

E235 (Natamycin) is used for a variety of fungal infections, mainly topically.
E235 (Natamycin) occurs naturally in soil, as a result of natural biological bacterial fermentation.

E235 (Natamycin) is effective in extremely small quantities.
E235 (Natamycin) (indicated on the label as preservative E235) is a chemical, antibiotic and antifungal compound used primarily in the dairy sector. 

E235 (Natamycin) protects cheese and prevents the growth of fungal species, such as yeasts and moulds.
E235 (Natamycin) is used in order to avoid problems that might arise during the ripening phase as this is when mould tends to grow on the outer surface of the cheese.

E235 (Natamycin) is used for a variety of fungal infections, mainly topically.
E235 (Natamycin) is used in the treatment of fungal infections of eye.

E235 (Natamycin) is an antifungal medication. 
E235 (Natamycin) kills fungi by destroying the fungal cell membrane.

E235 (Natamycin) is a naturally occurring antifungal agent used to inhibit the growth of moulds and yeasts.
E235 (Natamycin) is a natural antimicrobial peptide produced by the strains of Streptomyces natalensis. 

E235 (Natamycin) effectively acts as an antifungal preservative on various food products like yogurt, khoa, sausages, juices, wines, etc. 
E235 (Natamycin) has been used as a bio preservative and is listed as generally recognized as a safe ingredient for various food applications. 

In this review, E235 (Natamycin) properties, production methods, toxicity, and application as a natural preservative in different foods are emphasized.
E235 (Natamycin) is a natural antimicrobial preservative with a particularly high antimycotic activity. 

Unlike some organic acids, it inhibits the growth of fungus without killing the fungi population.
E235 (Natamycin) has the empirical formula C33H47NO13. 

E235 (Natamycin) is a natural antimicrobial that is derived from Streptomyces natalensis fermentation.
In food systems, E235 (Natamycin) is technically considered an antibiotic which belongs to the polyene macrolide compounds group. 

E235 (Natamycin)s name is derived from the Natal Province in South Africa where it was discovered in 1955 in a soil sample. 
E235 (Natamycin) is produced as a commercial food preservative.

E235 (Natamycin) is a secondary microbial metabolite which has strong antimycotic activity. 
E235 (Natamycin) is produced by fermentation of bacteria Streptomyces natalensis and closely related species. 

After fermentation, E235 (Natamycin) is concentrated and purified by filtration processes or solvent extraction, and then spray-dried.
E235 (Natamycin) is produced by a pure culture of Streptomyces natalensis bacteria following a strictly controlled fermentation process. 

After extraction, the E235 (Natamycin) is centrifuged, filtered, and washed, to ensure the purity and quality of the end product. 
E235 (Natamycin) is an antibiotic and under others it is not. 

E235 (Natamycin) is technically called an antibiotic in food preservation as it can prevent the growth of yeasts and molds, which are living organisms.
E235 (Natamycin) (pimaricin) is a polyene macrolide antibiotic produced by submerged aerobic fermentation of Streptomyces natalensis and related species. 

Fermentation is conducted for several days, and the antibiotic is isolated either by broth extraction or by extraction of the mycelium. 
E235 (Natamycin) is used as a food additive to control the growth of yeasts and moulds on the surface of cheese and other non-sterile products, such as meat and sausages.

E235 (Natamycin) is used topically in veterinary medicine to treat mycotic infections, such as ringworm in cattle and horses. 
E235 (Natamycin) was used topically against fungal infections of the skin and mucous membranes in humans. 

E235 (Natamycin)s medical use is now confined to topical treatment of corneal fungal infections and the prevention of such infections in users of contact lens.
E235 (Natamycin) is a polyene macrolide found in Streptomyces natalensis that exhibits antifungal and immunostimulatory activities.

E235 (Natamycin) binds ergosterol, inhibiting membrane fusion. 
E235 (Natamycin) is an antimicrobial compound.

E235 (Natamycin) (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. 
E235 (Natamycin) inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. 

E235 (Natamycin) is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research.
E235 (Natamycin) is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. 

E235 (Natamycin) exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. 
E235 (Natamycin) does not change the permeability of the plasma membrane. 

E235 (Natamycin) is used in the food industry for surface treatment of cheeses as a mould inhibitor.
E235 (Natamycin) is a preservative for use as a coating on the surface of italian cheeses to prevent the growth of mold or yeast. 

E235 (Natamycin) is tasteless, odorless, colorless, and does not penetrate the cheese. 
E235 (Natamycin) is very active against virtually all molds and yeasts, but does not affect bacteria, thus not affecting the ripening and flavor improvement process of cheese. 

E235 (Natamycin) can be applied as a dip, spray, or by other methods such as incorporation into the cheese coatings. 
E235 (Natamycin) is used at levels ranging from 300 to 2,000 ppm.



E235 (Natamycin) is commonly used in food products such as cheese and sausages to prevent the growth of molds and yeasts, and to naturally extend shelf life and reduce food waste.
E235 (Natamycin) is also used in other products such as bread, cakes, beverages and yoghurt.

E235 (Natamycin) is suitable for use in the laboratory study of fungal keratitis and other infections of fungal origin
E235 (Natamycin) may also be used in laboratory research of cell physiology and mechanisms of antibiotic resistance

E235 (Natamycin) is a member of the macrolide antibiotic class, compounds originally derived from Saccharopolyspora erythraea, a type of soil bacteria
E235 (Natamycin) is an amphoteric compound with both acid and basic properties

E235 (Natamycin) exhibits antifungal activity • E235 (Natamycin) exerts its effects by binding sterols within fungal cell walls and increasing membrane permeability, leading to a loss of homeostasis within the cell.
E235 (Natamycin) is a macrolide polyene antifungal agent isolated from Streptomyces species. 

E235 (Natamycin) is effective against fungi
E235 (Natamycin) works by binding ergosterol and preventing carbohydrate and amino acid transport. 

Unlike other polyene antifungals, E235 (Natamycin) does not prevent ergosterol synthesis or alter cell membrane permeability. 
E235 (Natamycin) has been used to study the lipid bilayer and as a fungicidal agent in agar media. 

E235 (Natamycin) is sparingly soluble in aqueous solution.
E235 (Natamycin) belongs to a naturally occurring antifungal agent produced through the fermentation of the bacterium Streptomyces natalensis. 

E235 (Natamycin) is a kind of macrolide polyene antifungal used for the treatment of fungal keratitis, which is a kind of eye infection. 
E235 (Natamycin) can be used as a natural preservative to prevent fungal outgrowth. 

E235 (Natamycin)s mechanism of action is through binding to the ergosterol in the plasma membrane of fungi, inhibiting the process of ergosterol-dependent fusion of vacuoles and membrane fusion, further inhibiting the fungal growth. 
E235 (Natamycin) also inhibit the transport of amino acid and glucose through inhibiting membrane transport proteins. 

E235 (Natamycin) has a low solubility in water (approximately 40 ppm), but the activity of neutral aqueous suspensions is very stable. 
E235 (Natamycin) is stable to heat and it is reported that heating processes for several hours at 100 C lead to only slight activity losses. 

E235 (Natamycin) is active against almost all foodborne yeasts and molds but has no effect on bacteria or viruses. 
The sensitivity to E235 (Natamycin) in vitro (minimal inhibitory concentration) is in most cases below 20 ppm.

E235 (Natamycin) acts by binding irreversibly with ergosterol and other sterols, which are present in the cell membranes of yeasts and vegetative mycelium of molds. 
E235 (Natamycin) disrupts the cell membrane and increases the cell permeability, which finally leads to cell death. 

The fungicidal of E235 (Natamycin) is an ‘‘all-or-none’’ effect, which destroys the cell membrane of the target cells.
Due E235 (Natamycin)s interaction with ergosterol, which is a major constituent of fungal cells, it is unlikely that fungi will develop resistance. 
E235 (Natamycin) is mostly used for surface applications, particularly for treating surfaces of hard cheese and salamitype sausages.



-E235 (Natamycin) is a white to creamy-white, almost odorless, crystalline powder.

-E235 (Natamycin) is practically insoluble in water, in lipids and in mineral oils. 

-E235 (Natamycin) is slightly soluble in ethanol, methanol, and glacial acetic acid.

-E235 (Natamycin) has a purity not less than 95.0% calculated on a dry basis. 

-Depending on the commercial production process, E235 (Natamycin) may contain up to 8% moisture.

-One major drawback of E235 (Natamycin) is its low thermal-stability. Temperatures above 50°C virtually deactivate the functionality of this preservative as the molecule undergoes structure degradation.

-E235 (Natamycin) is not recommended to add E235 (Natamycin) to dough or batter formulations.

-In addition to spraying, E235 (Natamycin) can be used as a dip or by incorporation into cheese coating films. 

-E235 (Natamycin) is used at levels ranging from 300 to 2,000 ppm.

-E235 (Natamycin) is active against nearly all yeasts and molds but has no effect on bacteria, protozoa or viruses. 

-E235 (Natamycin)  is active at very low concentrations: most molds are inhibited at 0.5–6.0 μg/mL, although some species require higher concentrations.



-E235 (Natamycin) is effective against a broad list of mould, fungi and yeast that prevents all food deterioration caused by these strains.

-Prevents formation of toxic mycotoxins.

-Improves shelf life of food products.

-Has no effect on desirable culture activity in fermented products.

-Does not affect the appearance, flavor, aroma or color of food products.



E235 (Natamycin) is believed that E235 (Natamycin) acts by binding to ergosterol in fungal cell membranes, which results in loss of enzyme function and inhibition of cell division.



-Solubility Information: Soluble in DMSO

-Formula Weight: 665.72

-Physical Form: Powder

-Percent Purity: 95%

-Color: White

-Melting Point: 280°C

-Flash Point: >110°C (230°F)

-Sensitivity: Light sensitive



-20°C, Inert atmosphere, Light sensitive



Antibiotic A-5283
CL 12625
CL 12,625
Antibiotic A 5283
ene-25-carboxylic acid
E235 (Natamycin)e
E235 (Natamycin)um














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