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E250 (Sodium nitrite)

CAS NUMBER: 7632-00-0 

EC NUMBER: 231-555-9

MOLECULAR FORMULA: NaNO2 

MOLECULAR WEIGHT: 68.995

DESCRIPTION:


E250 (Sodium nitrite) is an inorganic compound with the chemical formula NaNO2. 
E250 (Sodium nitrite) is a white to slightly yellowish crystalline powder that is very soluble in water and is hygroscopic. 
From an industrial perspective, E250 (Sodium nitrite) is the most important nitrite salt. 

E250 (Sodium nitrite) is a precursor to a variety of organic compounds, such as pharmaceuticals, dyes, and pesticides, but it is probably best known as a food additive used in processed meats and (in some countries) in fish products.
E250 (Sodium nitrite) is  liable to deliquesce, dissolved in water,soluble in liquid ammonia,slightly soluble in ethanol and glycerin,Melting Point:271℃.
Decomposition temperature is 320℃,E250 (Sodium nitrite) has oxidability and also has reducibility. 

E250 (Sodium nitrite) will slowly be oxidized into sodium nitrate in atmosphere, it can form nitrogen compound with nitrilo at low temperature.
Sodium  nitrite is a white to pale yellow crystalline powder or granule, taste salty.  
Easy absorption of moisture in the air, and can slow absorption oxygen in the  air, gradually become sodium nitrate. 

Soluble in water, aqueous solution pH is  9, slightly soluble in alcohol.
In organic synthesis isotope enriched E250 (Sodium nitrite)-15N can be used instead of normal E250 (Sodium nitrite) as their reactivity is nearly identical in most reactions.
The obtained products carry isotope 15N and hence Nitrogen NMR can be efficiently carried out.

Other uses of E250 (Sodium nitrite) include the production of herbicides, organic pesticides, printing on cast iron and steel, as polymer inhibitors, antifreeze, lubricants, rubber processing, pulp and paper, industrial and household cleaners, and raw materials used in the production of caffeine and saccharin.
E250 (Sodium nitrite) appears as a yellowish white crystalline solid. 
Noncombustible but will accelerate the burning of combustible material. 

If large quantities are involved in a fire or if the combustible material is finely divided, an explosion may result. 
If contaminated by ammonium compounds, spontaneous decomposition can occur and the resulting heat may ignite surrounding combustible material. 
Prolonged exposure heat may result in an explosion. 

Toxic oxides of nitrogen are produced in fires involving this material. Used as a food preservative, and to make other chemicals.
E250 (Sodium nitrite) is an inorganic sodium salt having nitrite as the counterion. 
E250 (Sodium nitrite) is used as a food preservative and antidote to cyanide poisoning. 
E250 (Sodium nitrite) has a role as an antimicrobial food preservative, an antihypertensive agent, a food antioxidant, a poison and an antidote to cyanide poisoning. 

E250 (Sodium nitrite) is a nitrite salt and an inorganic sodium salt.
E250 (Sodium nitrite) solution appears as a clear colorless to yellow solution. 
Harmful to the environment and somewhat toxic. Used as a preservative, and to make other chemicals.
E250 (Sodium nitrite) is a component in heat transfer salts used by many branches of industry such as the chemical, petrochemical and metalworking industries. 

Easily soluble in water, results in weak alkaline solutions. 
The preparation of solutions is accompanied by a decrease in temperature. 
E250 (Sodium nitrite) is soluble in aqueous ammonia and various organic solvents (such as ethanediol, propanediol and methanol). 
E250 (Sodium nitrite) can act as an oxidizing and reducing agent.

Iron-steel, Al and many other metals do not decompose with E250 (Sodium nitrite) and its solutions. 
The presence of chlorides and sulfates can promote corrosion of metals. 
Rubber, plastics, glass, porcelain and ceramics are resistant to E250 (Sodium nitrite) solutions. 
Treatment of E250 (Sodium nitrite) solutions with acids can result in the formation of nitric acid, which rapidly decomposes into nitro gases with a pale to dark brown color. In deisotization and nitrosation processes, nitric acid can react with other reactants before decomposing into nitrous oxide phases. It reacts with E250 (Sodium nitrite), ammonium salts, amides and mixtures containing them at room temperature. This reaction can go as far as a violent explosion. Subsequently, exacerbation follows. Similar reactions can occur with rapidly oxidizing products such as sodium and potassium metabisulfite. Powdered with E250 (Sodium nitrite), wool and cotton and other textile tissues are quickly flammable.

E250 (Sodium nitrite), chemical formula NaNO2, is a pale straw-colored material that is highly soluble in water. 
E250 (Sodium nitrite) is used in many industrial applications including the manufacturing of diazo dyes, and other organic compounds used in the manufacture of organic pigments for the paint, dye and printing ink industries. 
In metal processing, it is used in phosphatizing and detinning applications. 
As a molten salt bath, it is used in heat treating of metal parts in the automotive and aircraft industries and as a high temperature heat-transfer medium. 

E250 (Sodium nitrite) is also used in the manufacture of synthetic rubbers and rubber chemicals. 
Due to its anti-corrosion properties, E250 (Sodium nitrite) solution is also used as a heat transfer fluid in Thermal Energy Storage units for large air-conditioning or process cooling applications.
E250 (Sodium nitrite) Technical Solution / GenClear™ N is a E250 (Sodium nitrite)/nitrate solution with a relatively high concentration of sodium nitrate. 

This high nitrate content allows GenClear™ N to be used to control odours and corrosion caused by hydrogen sulphide (H2S) in wastewater systems. 
E250 (Sodium nitrite) also has applications as a low temperature thermal fluid in large industrial chiller and stratified thermal storage systems. 
E250 (Sodium nitrite) controls H2S throughout a system from relatively few feed points by providing a food source which is consumed in a preferred metabolic pathway by bacteria over the reduction of sulphur, hence eliminating the formation of H2S.
Sodium nitrate is an inorganic salt with a chemical formula NaNO2. 
E250 (Sodium nitrite) is a solid white salt that is a powerful oxidising agent which used as a preservative due to its ability to prevent the bacteria from colonising the food.


USES:


E250 (Sodium nitrite) is used in the manufacture of dyes,medicines,etc.,and also in organic synthesis.
E250 (Sodium nitrite) has been widely used in making nitro-compound and azo dye, mordant of textile dyeing, bleaching agent, metal heat finishing agent, cement early strength agent, and deicing agent etc.

-medicine

-dye 

-preservative

-antifreeze

-metal surface treatment (antirust) 

-pharmaceutical intermediates

-pesticide intermediates

-dye intermediates 

-antifreeze

-nitromethane 

-glycol

-Industrial chemistry:

The main use of E250 (Sodium nitrite) is for the industrial production of organonitrogen compounds. 
E250 (Sodium nitrite) is a reagent for conversion of amines into diazo compounds, which are key precursors to many dyes, such as diazo dyes.
E250 (Sodium nitrite)s are produced from nitrites. These are used in the rubber industry.
E250 (Sodium nitrite) is used in a variety of metallurgical applications, for phosphatizing and detinning.
E250 (Sodium nitrite) is an effective corrosion inhibitor and is used as an additive in industrial greases, as an aqueous solution in closed loop cooling systems, and in a molten state as a heat transfer medium.

-Food additive and preservative:

E250 (Sodium nitrite) is used to speed up the curing of meat and also impart an attractive pink color.
Nitrite reacts with the meat myoglobin to cause color changes, first converting to nitrosomyoglobin (bright red), then, on heating, to nitrosohemochrome (a pink pigment).
Historically, salt has been used for the preservation of meat. 

The salt-preserved meatproduct was usually brownish-gray in color. 
When E250 (Sodium nitrite) is added with the salt, the meat develops a red, then pink color, which is associated with cured meats such as ham, bacon, hot dogs, and bologna.
This led to further research surrounding the use of E250 (Sodium nitrite) as an additive in food, standardizing the amount present in foods to minimize the amount needed while maximizing its food additive role.
Through this research, E250 (Sodium nitrite) has been found to give taste and color to the meat and inhibit lipid oxidation that leads to rancidity, with varying degrees of effectiveness for controlling growth of disease-causing microorganisms.

The ability of E250 (Sodium nitrite) to address the above-mentioned issues has led to production of meat with extended storage life and has improved desirable color and taste. 
According to scientists working for the meat industry,[12] nitrite has improved food safety.
This view is disputed in the light of its ineffectiveness against botulism and the possible carcinogenic effects caused by adding nitrites to meat.

E250 (Sodium nitrite) is approved for usage in the EU, USA and Australia and New Zealand.
In meat-processing, E250 (Sodium nitrite) is never used in a pure state but always mixed with common salt. 
This mixture is known as nitrited salt, curing salt or nitrited curing salt. 
In Europe, nitrited curing salt contains between 99.1% and 99.5% common salt and between 0.5% and 0.9% nitrite. 
In the US, nitrited curing salt is dosed at 6% and must be remixed with salt before use.

-Color and taste:

The appearance and taste of meat is an important component of consumer acceptance.
E250 (Sodium nitrite) is responsible for the desirable red color (or shaded pink) of meat. 
Very little nitrite is needed to induce this change.
E250 (Sodium nitrite) has been reported that as little as 2 to 14 parts per million (ppm) is needed to induce this desirable color change.

However, to extend the lifespan of this color change, significantly higher levels are needed.
The mechanism responsible for this color change is the formation of nitrosylating agents by nitrite, which has the ability to transfer nitric oxide that subsequently reacts with myoglobin to produce the cured meat color.
The unique taste associated with cured meat is also affected by the addition of E250 (Sodium nitrite).
However, the mechanism underlying this change in taste is still not fully understood.

-Inhibition of microbial growth:

E250 (Sodium nitrite) has shown varying degrees of effectiveness for controlling growth of other spoilage or disease causing microorganisms.
Although the inhibitory mechanisms are not well known, its effectiveness depends on several factors including residual nitrite level, pH, salt concentration, reductants present and iron content.
The type of bacteria also affects E250 (Sodium nitrite)'s effectiveness.
E250 (Sodium nitrite) is generally agreed that E250 (Sodium nitrite) is not effective for controlling Gram-negative enteric pathogens such as Salmonella and Escherichia coli.
Other food additives (such as lactate and sorbate) provide similar protection against bacteria, but do not provide the desired pink color.

-Inhibition of lipid peroxidation:

E250 (Sodium nitrite) is also able to effectively delay the development of oxidative rancidity.
Lipid peroxidation is considered to be a major reason for the deterioration of quality of meat products (rancidity and unappetizing flavors).
E250 (Sodium nitrite) acts as an antioxidant in a mechanism similar to the one responsible for the coloring effect.
Nitrite reacts with heme proteins and metal ions, neutralizing free radicals by nitric oxide (one of its byproducts).
Neutralization of these free radicals terminates the cycle of lipid oxidation that leads to rancidity.

-Medication:

E250 (Sodium nitrite) is used as a medication together with sodium thiosulfate to treat cyanide poisoning.
E250 (Sodium nitrite) is recommended only in severe cases of cyanide poisoning.
In those who have both cyanide poisoning and carbon monoxide poisoning sodium thiosulfate by itself is usually recommended.
E250 (Sodium nitrite) is given by slow injection into a vein.

Side effects can include low blood pressure, headache, shortness of breath, loss of consciousness, and vomiting.
Greater care should be taken in people with underlying heart disease.
The patient's levels of methemoglobin should be regularly checked during treatment.
While not well studied during pregnancy, there is some evidence of potential harm to the baby.

E250 (Sodium nitrite) is believed to work by creating methemoglobin that then binds with cyanide and thus removes it from the mitochondria.
E250 (Sodium nitrite) came into medical use in the 1920s and 1930s.
E250 (Sodium nitrite) is on the World Health Organization's List of Essential Medicines.

APPLICATION:

Mainly used in the manufacture of nitro compounds, azo dyes, mordant for fabric dyeing, bleach, metal thermal treatment agent and pharmaceutical industry.
Sodium nitrate was used extensively as a fertilizer and a raw material for the manufacture of gunpowder in the late nineteenth century.
E250 (Sodium nitrite) is found naturally in leafy green vegetables.
Sodium nitrate should not be confused with the related compound, E250 (Sodium nitrite).
The presence of E250 (Sodium nitrite) in food is controversial due to the development of nitrosamines when the food, primarily bacon, is cooked at high temperatures. 

The nitrate compound itself is not harmful, however, and is among the antioxidants found in fresh vegetables.
E250 (Sodium nitrite)s usage is carefully regulated in the production of cured products; in the United States, the concentration in finished products is limited to 200 ppm, and is usually lower.
E250 (Sodium nitrite) can be used in the production of nitric acid by combining it with sulfuric acid and subsequent separation through fractional distillation of the nitric acid, leaving behind a residue of sodium bisulfate. 
Less common applications include its use as a substitute oxidizer used in fireworks as a replacement for potassium nitrate commonly found in black powder and as a component in instant cold packs

STORAGE:

E250 (Sodium nitrite) should be stored in a cool, dry place to prevent it from moisture, heat and sunlight. 
E250 (Sodium nitrite) can not be mixed with  strong reductant, inflammable and explosive materials, food, feed and additives. 
E250 (Sodium nitrite) is toxic and should be properly kept and can not be eaten.
E250 (Sodium nitrite) shall be stored in the place of ventilation and dry, avoiding dampened, heated and exposure under sunlight.
E250 (Sodium nitrite) shall not be delivered or stored together with strong reducing agent, inflammable and detonatable substances, foods, feed, and additives(3)This product is venomous. 
Please keep E250 (Sodium nitrite) safely. Don' t eat it by mistake.

SPECIFICATION:

Grade: Food grade

CAS: 7632-00-0

Purity: ≥99.0%

Relative molecular weight: 68.99

Relative density: 2.168

Arsenic: ≤0.0002%

Heavy metals: ≤0.002%

Lead: ≤0.001%

Loss on drying: ≤0.25%

TOXICITY:

E250 (Sodium nitrite) is toxic.
The LD50 in rats is 180 mg/kg and in human LDLo is 71 mg/kg.
Yet, death by E250 (Sodium nitrite) ingestion can happen at lower dose.
E250 (Sodium nitrite) is sometimes used for homicide.
The online marketplace eBay has globally prohibited the sale of E250 (Sodium nitrite) since 2019.

To prevent accidental intoxication, E250 (Sodium nitrite) (blended with salt) sold as a food additive in the US is dyed bright pink to avoid mistaking it for plain salt or sugar. 
In other countries, nitrited curing salt is not dyed but is strictly regulated.
Nitrites are not naturally occurring in vegetables in significant quantities.
Boiling vegetables does not affect nitrite levels.
The presence of nitrite in animal tissue is a consequence of metabolism of nitric oxide, an important neurotransmitter.
E250 (Sodium nitrite) can be created de novo from nitric oxide synthase utilizing arginine or from ingested nitrite.

PRODUCTION:

Industrial production of E250 (Sodium nitrite) follows one of two processes, the reduction of nitrate salts, or the oxidation of lower nitrogen oxides.
One method uses molten sodium nitrate as the salt, and lead which is oxidized, while a more modern method uses scrap iron filings to reduce the nitrate.
A more commonly used method involves the general reaction of nitrogen oxides in alkaline aqueous solution, with the addition of a catalyst. 
The exact conditions depend on which nitrogen oxides are used, and what the oxidant is, as the conditions need to be carefully controlled to avoid over oxidation of the nitrogen atom.
E250 (Sodium nitrite) has also been produced by reduction of nitrate salts by exposure to heat, light, ionizing radiation, metals, hydrogen, and electrolytic reduction.

SYNONYM:

7632-00-0
Nitrous acid, sodium salt
sodium;nitrite
Nitrite, sodium
E250 (Sodium nitrite) solution
Natrium nitri
Nitrito sodico
Nitrite de sodium
UNII-M0KG633D4FNaNO2
E250 (Sodium nitrite) [USP]
MFCD00011118
CHEMBL93268
M0KG633D4F
CHEBI:78870
E250 (Sodium nitrite) (USP
DSSTox_CID_941
DSSTox_RID_75879
DSSTox_GSID_20941
Caswell No. 782
Dusitan sodny 
Azotyn sodowy 
Azotyn sodowy
Natrium nitrit 
Nitrito sodico 
Nitrite de sodium 
CCRIS 559
CAS-7632-00-0
HSDB 757
E250 (Sodium nitrite) solution, 40 wt. % in H2O
EINECS 231-555-9
NSC 77391
UN1500
EPA Pesticide Chemical Code 076204
natrium nitrite
sodium nitrit
Natrum nitrosum
Natrii nitris
Nitrous acid soda
Nitrous acid, sodium salt (1:1)
NNaO2
E250 (Sodium nitrite) (TN)
E250 (Sodium nitrite) ACS grade
EC 231-555-9
INS NO.250
E250 (Sodium nitrite), AR, >=98%
E250 (Sodium nitrite), LR, >=98%
DTXSID0020941
INS-250
s209
HMS3652K08
E250 (Sodium nitrite), analytical standard
E250 (Sodium nitrite), granular, 99.5%
E250 (Sodium nitrite), Trace metals grade
Tox21_202155
Tox21_300025
s4074
AKOS024427981
CCG-266007
NCGC00090737-01
NCGC00090737-02
NCGC00254137-01
NCGC00259704-01
E250 (Sodium nitrite) [UN1500] [Oxidizer]
BP-31053
E250
E250 (Sodium nitrite), ACS reagent, >=97.0%
E250 (Sodium nitrite), 0.1M Standardized Solution
E250 (Sodium nitrite), p.a., ACS reagent, 99%
FT-0645124
S0565
E250 (Sodium nitrite), 99.5%, super free-flowing
E250 (Sodium nitrite), ReagentPlus(R), >=99.0%
SW219150-1
E250 (Sodium nitrite), 99.999% trace metals basis
E250 (Sodium nitrite), SAJ first grade, >=97.0%
D05865
E78844
E250 (Sodium nitrite), >=99.99% trace metals basis
E250 (Sodium nitrite), JIS special grade, >=98.5%
E250 (Sodium nitrite), purum p.a., >=98.0% (RT)
Q339975
E250 (Sodium nitrite), puriss. p.a., ACS reagent, >=99.0% (RT)
E250 (Sodium nitrite), United States Pharmacopeia (USP) Reference Standard
Nitrite ion standard solution, 0.01 M NO2-, for ion-selective electrodes
Nitrite ion standard solution, 0.1 M NO2-, for ion-selective electrodes
E250 (Sodium nitrite), anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=97%
E250 (Sodium nitrite), puriss. p.a., ACS reagent, reag. Ph. Eur., >=99%
E250 (Sodium nitrite), puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E 250, 99-100.5% (calc. to the dried substance)

USAGE AREAS:

E250 (Sodium nitrite) is used in tank rinsers used for the production of azo dyes, the production of diazo compounds, the production of nitroso and isonitrozo compounds, the stabilization of nitric acid gases, the delivery and storage of butadiene.
For textile dyeing and printing: Dyeing and printing diazotization; oxidation of printing and dyeing with colorless barrel dyes; protection against reduction during printing and dyeing with certain vat dyes, It is used to trigger accelerated oxidation of barrel paints that resist reoxidation.
accelerator during phosphating; in the preparation of baths for hot-worked metals; steel deposition and cast iron; as an additive to alkaline pickling baths of aluminum and aluminum alloys; It is used in neutral cleaner and deactivating baths.
In water recovery systems, cooling water and cooling liquids (antifreezes); in crushing oils, hydraulic fluids, lubricants, extinguishers; in chemical processes; in the production of solid and liquid anti-corrosion agents; in the production of emulsion paints; antioxidant for special soaps; additive for glazing of glass raw materials; in water circulation systems; as an additive in concrete with special properties; as an anti-corrosion agent for steel and iron; It is used in the production of products used to protect oil fuel tanks from corrosion.
E250 (Sodium nitrite) is used as a preservative in foods. Inhibits bacterial growth and discoloration, generally

WHAT IS E250 (Sodium nitrite):

E250 (Sodium nitrite) is similar in name and use to sodium nitrate. 
Both are preservatives used in processed meats, such as salami, hot dogs, and bacon. E250 (Sodium nitrite) has been synthesized by several chemical reactions that involve the reduction of sodium nitrate. 
Industrial production of E250 (Sodium nitrite) is primarily by the absorption of nitrogen oxides into aqueous sodium carbonate or sodium hydroxide. 
Over the years, E250 (Sodium nitrite) has raised some concerns about its safety in foods, but it remains in use and there are indications that it may actually be healthy. 

E250 (Sodium nitrite) was developed during the 1960s.
E250 (Sodium nitrite) is a multifunctional food additive, responsible for the characteristic color and flavor associated with cured meats and at the same time providing protection against growth and toxin formation by C. botulinum in cured meats subjected to temperature abuse. 
The exact mechanism of botulinum inhibition by nitrite is not known. 
E250 (Sodium nitrite)s efficacy depends on interactions involving pH, salt, heat treatment, storage temperature and time, and the composition of the food matrix. 
E250 (Sodium nitrite) is an odorless, white or slightly yellow, hygroscopic and air-sensitive solid (it slowly oxidizes to nitrate), having both reducing and oxidizing properties. 

E250 (Sodium nitrite) presents a fire risk when in contact with reducing materials; for example, it is liable to render any organic matter (wood, paper and textiles) dangerously combustible when dry. 
E250 (Sodium nitrite) is decomposed by acids (even weak acids) with evolution of a brown mixture of nitrogen oxides (NOx). 
E250 (Sodium nitrite) is very toxic and dangerous to the environment, and it is an irritant and harmful substance that may damage the cardiovascular and central nervous systems. 
E250 (Sodium nitrite) (or nitrate) is the most important cure additive responsible for the typical color and flavor associated with cooked cured meats. 

E250 (Sodium nitrite) also provides oxidative stability to meat by preventing lipid oxidation and helps in controlling the development of warmed-over flavor in cooked, stored meats. 
Nitrite also serves as a vital bacteriostatic agent for control of the outgrowth of C. botulinum, particularly under conditions of product mishandling. 
However, addition of E250 (Sodium nitrite) to meat and meat products is highly regulated owing to the possible risk of formation of N-nitrosamine.
E250 (Sodium nitrite) (NaNO2) and sodium nitrate (NaNO3), also known as curing salts, are added at low levels (usually 120–200 ppm) and provide several attributes. 

The main function is to suppress C. botulinum spore germination. 
The active compound is nitric oxide (NO). 
Only a very small amount is needed and using the salt form provides an easy and efficient way of introducing the active compound to the meat (i.e., NO gas can be introduced as well, but it is a much more expensive process).
E250 (Sodium nitrite) (NaNO2) is a compound with broad practical applications in food preservation.
E250 (Sodium nitrite) (NaNO2) is a water-soluble, white-yellow-colored crystalline powder with various practical applications including use as a food preservative, antimicrobial, and coloring agent. 
E250 (Sodium nitrite) is also a corrosion inhibitor found in antifreeze.

E250 (Sodium nitrite) is an inorganic compound with the chemical formula NaNO2. 
E250 (Sodium nitrite) is a white to slightly yellowish crystalline powder, highly soluble in water and hygroscopic. 
From an industrial point of view, it is the most important nitrite salt. 
E250 (Sodium nitrite) is a precursor to various organic compounds such as pharmaceuticals, dyes and pesticides, while it is a food additive best known for its use in processed meats and fish products.
E250 (Sodium nitrite) is toxic and overexposure can cause death in humans.

HOW IS E250 (Sodium nitrite) PRODUCED?

The industrial production of E250 (Sodium nitrite) consists of one of two processes, such as reduction of nitrate salts or oxidation of lower nitrogen oxides.
One method uses molten sodium nitrate and oxidised lead as salt, while a more modern method uses scrap iron shavings to reduce nitrate.
A more commonly used method involves the general reaction of nitrogen oxides in alkaline aqueous solution with the addition of a catalyst. 
The exact conditions depend on which oxides of nitrogen are used and what the oxidant is, as conditions must be carefully controlled to avoid excessive oxidation of the nitrogen atom.
E250 (Sodium nitrite) is also produced by the reduction of nitrate salts by exposure to heat, light, ionizing radiation, metals, hydrogen, and electrolytic reduction.

WHAT DOES E250 (Sodium nitrite) LOOK LIKE?

Hygroscopic white to yellowish crystalline powder.

IN WHICH SECTORS IS E250 (Sodium nitrite) USED?

-rubber industry

-metallurgical applications

-Additive in industrial greases

-cooling systems

-Pharmaceuticals – cyanide poisoning

-Food industry spoilage, colorant, preservative

WHAT ARE THE USAGE AREAS OF E250 (Sodium nitrite)?

-The main use of E250 (Sodium nitrite) is for the industrial production of organonitrogen compounds. 

-E250 (Sodium nitrite) is the reagent for the conversion of amines to diazo compounds, which are the basic precursors of many dyes, such as diazo dyes. 

-E250 (Sodium nitrite)s are produced from nitrites. These are used in the rubber industry.

-E250 (Sodium nitrite) is used in various metallurgical applications for phosphating and detination.

-E250 (Sodium nitrite) is an effective corrosion inhibitor and is used as an additive in industrial greases.

-E250 (Sodium nitrite) is used as an aqueous solution and as a molten heat transfer medium in closed-loop cooling systems.

-E250 (Sodium nitrite) is an effective remedy in case of cyanide poisoning. 

-E250 (Sodium nitrite) is used together with sodium thiosulfate. 

-E250 (Sodium nitrite) is on the World Health Organization's List of Essential Medicines.

-E250 (Sodium nitrite) is used to accelerate the curing of meat and also to impart a pink color to meat.

-E250 (Sodium nitrite) is used in the meat packaging industry to prevent spoilage and microbial growth.

-E250 (Sodium nitrite) ensures that the taste of the packaged meat preserves its freshness for a long time.

-E250 (Sodium nitrite) has the E number E250. 

E250 (Sodium nitrite) IN TREATMENT:

E250 (Sodium nitrite) is the most prevalent drug for cyanide poisoning. 
E250 (Sodium nitrite) takes approximately 12 min to generate approximately 40% of methemoglobin after intravenous administration of the recommended dose

DESCRIPTION:

E250 (Sodium nitrite) is a salt and an anti-oxidant that is used to cure meats like ham, bacon and hot dogs. 
E250 (Sodium nitrite) serves a vital public health function.
E250 (Sodium nitrite) blocks the growth of botulism-causing bacteria and prevents spoilage. 
E250 (Sodium nitrite) also gives cured meats their characteristic color and flavor.
Also, USDA-sponsored research indicates that E250 (Sodium nitrite) can help prevent the growth of Listeria monocytogenes, an environmental bacterium that can cause illness in some at-risk populations.

PRODUCT INFORMATION:

-CAS number: 7632-00-0

-EC index number: 007-010-00-4

-EC number: 231-555-9

-Grade: ACS,Reag. Ph Eur

-Chemical formula: NaNO₂

-Molar Mass: 69.00 g/mol

-HS Code: 2834 10 00

-Quality Level: MQ300

PHYSICAL AND CHEMICAL INFORMATION:

-Density: 2.168 g/cm3 (20 °C)

-Melting Point: 280 °C (decomposition)

-pH value: 9 (100 g/l, H₂O, 20 °C)

-Bulk density: 1200 kg/m3

-Solubility: 820 g/l

SPECIFICATION:

-Assay (manganometric): ≥ 99.0 %

-Insoluble matter: ≤ 0.01 %

-Chloride (Cl): ≤ 0.005 %

-Sulfate (SO₄): ≤ 0.005 %

-Heavy metals (as Pb): ≤ 0.001 %

-Ca (Calcium): ≤ 0.002 %

-Fe (Iron): ≤ 0.001 %

-K (Potassium): ≤ 0.001 %


GENERAL INFORMATION:

E250 (Sodium nitrite)s chemical formula is NaNO2.
E250 (Sodium nitrite) is a white, slightly yellowish fine crystalline, hygroscopic chemical with high water solubility. 
E250 (Sodium nitrite) is sodium salt of nitric acid, it is used as a preservative additive in foods. 
Many studies have been done by the researchers on the carcinogenic effect and no clear opinion has yet been reached. 

In addition, studies have shown that E250 (Sodium nitrite) in the human body carries out the formation of new vessels and studies on this subject are continuing.
E250 (Sodium nitrite) is a white crystalline powder.  
If someone ingests enough of this substance, it can interfere with the body’s red blood cell’s ability to transport oxygen.  
This dangerous and potentially fatal condition is called methemoglobinemia.

PRODUCTION AND REACTION:

Sodium hydroxide can be obtained by treatment with nitrogen dioxide and nitric oxide.

2 NaOH + NO2 + NO? 2 NaNO2 + H2O

E250 (Sodium nitrite) can be reduced to enter the reaction to destroy excess sodium products.

2 NaN 3 + 2 NaNO 2 + 2 H +? 3 N2 + 2 NO + 2 Na + 2 H2O

E250 (Sodium nitrite) can be converted to nitric acid by reacting with gastric acid.

USAGE AREAS:

-Medicinei:

E250 (Sodium nitrite) is used as an antidote to treat cyanide poisoning.

-food:

In the food sector, E250 (Sodium nitrite) with the E 250 number is used as a preservative. 
E250 (Sodium nitrite) also combines with the myoglobin in the meat to produce and maintain the bright pink-red color of the processed meat.

-Health

E250 (Sodium nitrite) is used to prevent the growth of clostridium botulinum bacteria, which is very dangerous for human health.

-Chemistry:

E250 (Sodium nitrite) is used in laboratories to remove excess sodium products.

WHAT IS E250 (Sodium nitrite) USED FOR?

E250 (Sodium nitrite) is used for a variety of reasons. 
E250 (Sodium nitrite)’s a common preservative often used in cured meat to preserve its shelf life. 
E250 (Sodium nitrite) can also be used for automotive maintenance, animal control, and as part of the treatment for severe cases of cyanide poisoning. 

DESCRIPTION:

E250 (Sodium nitrite) is well known that E250 (Sodium nitrite) may be manufactured by the absorption of nitrogen oxides in solutions of sodium carbonate or sodium hydroxide. 
These nitrogen oxides may be produced by the catalytic oxidation of ammonia mixed with air in well known manner. 
The gas formed by the oxidation of ammonia is at a high temperature and contains, for example, about 9% NO mixed with oxygen and nitrogen from the air used for the oxidation of the ammonia. 
As this gas is cooled, reaction between the NO and oxygen takes place to form NO2. 

REACTIVITY PROFILE:

E250 (Sodium nitrite) is an oxidizing agent. 
E250 (Sodium nitrite) reacts with reducing agents to generate heat and products that may be gaseous (causing pressurization inside closed containers). 
E250 (Sodium nitrite)s may themselves be capable of further reactions (such as combustion). 

Dissolution in water reduces but does not nullify the oxidizing power of nitrites. 
E250 (Sodium nitrite) reacts with acids to form toxic nitrogen dioxide gas. 
Mixtures with phosphorus, tin(II) chloride or other reducing agents may react explosively. 
When a mixture with sodium thiosulfate was heated to dryness, a violent explosion occurred. 


PROPERTIES:

-Compound Formula: NNaO2

-Molecular Weight: 69

-Appearance: Slightly yellowish or white crystals

-Melting Point: 271 °C

-Density:2.17 g/cm3

-Exact Mass: 68.982673

-Monoisotopic Mass: 68.982673 

E250 (Sodium nitrite) HEALTH AND SAFETY INFORMATION:

-Signal Word: Danger

-Hazard Statements: H272-H301-H400

-Hazard Cod: 8-25-50

-Safety Statements: 45-61

-RTECS Number: RA1225000

-Transport Information: UN 1500 5.1/PG 3

CHEMICAL IDENTIFIERS:

-Linear Formula: NaNO2

-MDL Number: MFCD00011118

-EC No.: 231-555-9

-Pubchem CID: 23668193

-IUPAC Name: sodium; nitrite

-InchI Identifier: InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1

-InchI Key: LPXPTNMVRIOKMN-UHFFFAOYSA-M

E250 (Sodium nitrite) has the chemical formula NaNO2.
E250 (Sodium nitrite), with chemical formula NaNO2, and molar mass of 69.00 g/mol is used as a color fixative and preservative in meats and fish. 
E250 (Sodium nitrite) is a white to slight yellowish crystalline powder. 
E250 (Sodium nitrite) is very soluble in water and is hygroscopic. 

E250 (Sodium nitrite) is also slowly oxidized by oxygen in the air to sodium nitrate, NaNO3. 
E250 (Sodium nitrite) is a strong reducing agent.
E250 (Sodium nitrite) is also used in manufacturing diazo dyes, nitroso compounds, and other organic compounds; in dyeing and printing textile fabrics and bleaching fibers; in photography; as a laboratory reagent and a corrosion inhibitor; in metal coatings for phosphatizing and detinning; and in the manufacture of rubber chemicals. 
E250 (Sodium nitrite) also has been used in human and veterinary medicine as a vasodilator, a bronchodilator, an intestinal relaxant or a laxative, and an antidote for cyanide poisoning.

As a food additive, it serves a dual purpose in the food industry since it both alters the color of preserved fish and meats and also prevents growth of Clostridium botulinum, the bacteria which causes botulism. 
In the European Union it may be used only as a mixture with salt containing at most 0.6% E250 (Sodium nitrite). 
E250 (Sodium nitrite) has the E number E250. Potassium nitrite (E249) is used in the same way.
While this chemical will prevent the growth of bacteria, it can be toxic for mammals.

For this reason, E250 (Sodium nitrite) sold as a food additive is dyed bright pink to avoid mistaking it for something else. 
Cooks and makers of charcuterie often simply refer to E250 (Sodium nitrite) as "pink salt".
Recently, E250 (Sodium nitrite) has been found to be an effective means to increase blood flow by dilating blood vessels, acting as a vasodilator. 
Research is ongoing to investigate its applicability towards treatments for sickle cell anemia, cyanide poisoning, heart attacks, brain aneurysms, and pulmonary hypertension in infants.

Sodium nitrate is the chemical compound with the formula NaNO3. and molecular mass of 84.9947 g/mol. 
This salt, also known as "Chile saltpeter" (to distinguish it from ordinary saltpeter, potassium nitrate), is a white solid which is very soluble in water. 
Sodium nitrate is used as an ingredient in fertilizers, explosives, and in solid rocket propellants, as well as in glass and pottery enamels; the compound has been mined extensively for those purposes.

Sodium nitrate is also synthesized industrially by neutralizing nitric acid with soda ash.
Doctors are among those calling for tighter regulation of E250 (Sodium nitrite) as a growing number of Canadians are dying after intentionally ingesting unsafe quantities of the common food preservative in its pure form.
E250 (Sodium nitrite) is commonly used to preserve meats, but can be lethal when ingested in certain doses. 
Forensic pathologists say people with intent to self-harm have been purchasing it online following advice found in pro-suicide forums for several years.
E250 (Sodium nitrite) can be used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning.


PROPERTIES:

-Name: E250 (Sodium nitrite)

-Appearance: White crystalline solid

-Chemical Formula: NaNO2

-Melting Point: 271 °C

-Boiling Point: Decomposes above 320 °C

-Density: 2.17 g/cm³

-Molar Mass: 68.9953 g/mol

-Solubility in Water: Soluble

USES:

-Listed in the World Health Organization’s List of Essential Medicines, E250 (Sodium nitrite) is an effective drug for cyanide poisoning.

-E250 (Sodium nitrite) is used as a humane toxin for wild boar control

-E250 (Sodium nitrite) is responsible for the desirable red colour in meat

-Used as a food additive

PRODUCT DESCRIPTION:

E250 (Sodium nitrite) (NaNO2) is an industrial chemical that is sold as a solid that may or may not be treated with an anti-caking agent, or a liquid, typically a 40 percent solution with water. 
E250 (Sodium nitrite) is used in a wide range of end uses, including producing chemicals and dyes, metal coating, detinning, plating, wastewater treating, meat curing for food preservatives, ammunition for military applications, treating lumber, and some medical applications, including as an antidote to cyanide poisoning.
E250 (Sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. 
E250 (Sodium nitrite) is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. 
There is also research to investigate its applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and Pseudomonas aeruginosa infections.

E250 (Sodium nitrite) finds its application in several industries including pharmaceuticals, food and beverage, and textiles. 
E250 (Sodium nitrite) is employed as a preservative, particularly in the meat processing sector, because it serves as a color fixative and inhibits the growth of dangerous bacteria, making the meat safe to eat. 
The utilization of E250 (Sodium nitrite) has grown over the years as the pharmaceutical industry is involved in research and development. 
E250 (Sodium nitrite)s most recent application has been in the treatment of coronavirus-induced lung damage.
E250 (Sodium nitrite) is used as a starting material in the production of a variety of compounds, including saccharines. 
E250 (Sodium nitrite) also acts as an antioxidant and antiozonant used in the rubber industry. 

The product is available in several grades such as food grade, technical grade, anti-caking technical grade, and others.
E250 (Sodium nitrite) can be utilized as an electrolyte in electrochemical grinding production processes. 
E250 (Sodium nitrite) is used as a bleaching agent in the textiles industry. 

E250 (Sodium nitrite) is also utilized in the manufacturing of dye colors, making it an important component of the textiles industry. 
As the global textiles industry is expected to grow at a consistent rate over the next few years, the demand for dying materials is expected to rise worldwide.
E250 (Sodium nitrite) is a common preservative used in cured meat products including bacon, deli meat, and jerky. 
E250 (Sodium nitrite) has been linked to the development of heart disease and diabetes. 
This additive has been cut out from some foods due to these concerns.

-Catalogue Number: S648002

-Chemical Name: E250 (Sodium nitrite)-15N

-CAS Number: 68378-96-1

-Alternate CAS: 7632-00-0

-Molecular Formula: 15NNaO2

-Appearance: White to Off-White Solid


PURPOSE AND FUNCTIONS:

Sodium nitrate and nitrite are added to processed and cured meats to preserve shelf life and to give them flavor and a pink color. 
Nitrates and nitrites are also found in vegetables such as celery and spinach, and as contaminants in tap water.
The human body needs nitrates and nitrites. These additives serve an important bodily function. 
Your body breaks down nitrates into nitrites, which it then converts into either nitric oxide or nitrosamines.
Most of our nitrates and nitrites come naturally from vegetables. 
In fact, around 85% of the nitrates and nitrites in our diet come from vegetables.


-Melting Point: 278 - 280°C

-Molecular Weight: 69.99

-Storage: Refrigerator

-Solubility: Water


GENERAL INFORMATION:

-Product Number: S0565

-Purity / Analysis Method: >98.5%(T)

-Molecular Formula / Molecular Weight: NaNO2 = 68.99  

-Physical State (20 deg.C): Solid

-Store Under Inert Gas: Store under inert gas

-Condition to Avoid: Hygroscopic

-CAS RN: 7632-00-0

-Reaxys Registry Number: 906771

-Merck Index (14): 8648

-MDL Number: MFCD00011118

PROPERTIES:


-Melting Point: 280 °C(dec.)

-Solubility in water: Soluble

-Degree of solubility in water: 820 g/l   20 °C

-Solubility (soluble in): Methanol

-Solubility (slightly sol. in): Ether


E250 (Sodium nitrite), with chemical formula NaNO2, is used as a color fixative and preservative in meats and fish. 
E250 (Sodium nitrite) is a white to slight yellowish crystalline powder. 
E250 (Sodium nitrite) is very soluble in water and is hygroscopic. 
E250 (Sodium nitrite) is also slowly oxidized by oxygen in the air to sodium nitrate, NaNO3. 
E250 (Sodium nitrite) is a strong reducing agent.

E250 (Sodium nitrite) is also used in manufacturing diazo dyes, nitroso compounds, and other organic compounds; in dyeing and printing textile fabrics and bleaching fibers; in photography; as a laboratory reagent and a corrosion inhibitor; in metal coatings for phosphatizing and detinning; and in the manufacture of rubber chemicals. 
E250 (Sodium nitrite) also has been used in human and veterinary medicine as a vasodilator, a bronchodilator, an intestinal relaxant or a laxative, and an antidote for cyanide poisoning.
As a food additive, E250 (Sodium nitrite) serves a dual purpose in the food industry since it both alters the color of preserved fish and meats and also prevents growth of Clostridium botulinum, the bacteria which causes botulism. 
In the European Union it may be used only as a mixture with salt containing at most 0.6% E250 (Sodium nitrite). 
E250 (Sodium nitrite) has the E number E250. Potassium nitrite (E249) is used in the same way.
While E250 (Sodium nitrite) will prevent the growth of bacteria, it is also toxic for mammals. 

Various dangers of using this as a food additive have been suggested and researched by scientists. 
A principal concern is the formation of carcinogenic N-nitrosamines by the reaction of E250 (Sodium nitrite) with amino acids in the presence of heat in an acidic environment.
E250 (Sodium nitrite) is a potent oxidizing agent that impairs oxygen transport and delivery through methemoglobin formation. 

E250 (Sodium nitrite) (NaNO2) is an easily accessible colorless inorganic compound. 
E250 (Sodium nitrite) is used as a preservative, color fixative, and antimicrobial agent, mainly in cheese, meat (such as ham, bacon, and sausages), and fish
Another use is as an industrial chemical and therapeutic antidote agent for cyanide intoxication.
The primary toxicity mechanism of E250 (Sodium nitrite) is the oxidation of ferrous iron (Fe2+) of hemoglobin to methemoglobin (MetHb) containing ferric iron (Fe3+) with consequent methemoglobinemia, in which it loses its ability to bind and transport oxygen.

Recent studies have found a link between high processed meat consumption and colon cancer, possibly due to preservatives such as E250 (Sodium nitrite). publication from wiley.
Recently, E250 (Sodium nitrite) has been found to be an effective means to increase blood flow by dilating blood vessels, acting as a vasodilator. 
Research is ongoing to investigate its applicability towards treatments for sickle cell anemia, cyanide poisoning, heart attacks, brain aneurysms, and pulmonary hypertension in infants.
E250 (Sodium nitrite) is used to convert amines into diazo compounds. 
The synthetic utility of such a reaction is to render the amino group labile for nucleophilic substitution, as the N2 group is a better leaving group.

E250 (Sodium nitrite) has the chemical formula NaNO2. 
E250 (Sodium nitrite) is a white to slight yellowish crystalline powder that is very soluble in water and is hygroscopic.
E250 (Sodium nitrite) is a reagent for conversion of amines into diazo compounds. 
E250 (Sodium nitrite)s are produced from nitrites. 
These are used in the rubber industry.
E250 (Sodium nitrite) may also be used as an electrolyte in electrochemical grinding manufacturing processes, typically diluted to about 10% concentration in water. 
E250 (Sodium nitrite) is used in a variety of metallurgical applications, for phosphatizing and detinning.


E250 (Sodium nitrite) is an effective corrosion inhibitor.
E250 (Sodium nitrite) can be used as part of an intravenous mixture to treat cyanide poisoning. 
However it has now been made obsolete by hydroxocobalamin if this newer medicine is available.
E250 (Sodium nitrite) has been found to inhibit growth of disease-causing microorganisms; give taste and color to the meat; and inhibit lipid oxidation that leads to rancidity. 

In the European Union it may be used only as a mixture with salt containing at most 0.6% E250 (Sodium nitrite). 
E250 (Sodium nitrite) has the E number E250. Potassium nitrite (E249) is used in the same way. 
E250 (Sodium nitrite) is approved for usage in the EU,] USA, Australia and New Zealand.
E250 (Sodium nitrite) is well known for its role in inhibiting the growth of Clostridium botulinum spores in refrigerated meats. 
E250 (Sodium nitrite) is not considered effective for controlling gram-negative enteric pathogens.


APPLICATION:

E250 (Sodium nitrite) is widely used as a weak alkali buffer agent for supplementary feeds, a major raw material for baking powder as food additives and acid  neutralizer agent after chromium tanning in leather manufacturing, as well as dye stuffs and pharmaceutical ingredients.


-Leather & textile:

E250 (Sodium nitrite) is therefore used in tanning as a neutralizer, buffer, pretreating agent and cleaner.

-Specialty chemical manufacture:

E250 (Sodium nitrite) is used in synthesizing, processing and purifying chemicals and polymers, serving as a catalyst, as a neutralizing and buffering agent and a reactant.

-Pollution abatement:
E250 (Sodium nitrite) is a safe, easy-to-use chemical for biological control of waste-water treatment. 
E250 (Sodium nitrite) helps maintain proper pH and alkalinity in waste water 

-Rubber & plastics

E250 (Sodium nitrite) is widely used in the rubber and plastics industry as a blowing agent.

-Deodorizers

E250 (Sodium nitrite) has odour absorbent properties and the deodorizers are used in carpet and room, refrigerator, also garbage containers. 
Highly effective and inexpensive, E250 (Sodium nitrite) absorbs smoke and musty odours.
E250 (Sodium nitrite) has been traditionally used as a buffer to maintain rumen pH, alleviate butterfat depression due to low fibre diets and aid fibre digestibility.


PHYSICAL AND CHEMICAL PROPERTIES:

Chemical formula is NaNO2, in which N has a valency is + III.
E250 (Sodium nitrite) is colorless or yellow crystal, the relative density is 2.168 (0℃), the melting point is 271℃, and it is decomposed when 320℃. 
E250 (Sodium nitrite) is soluble in water, and aqueous solution is alkaline because of nitrate hydrolysis. 
E250 (Sodium nitrite) has the characteristics of reduction and oxidation and is mainly oxidation. 

In acidic solution, the main performance is oxidation. 
In alkaline solution or in case of strong oxidizing agent, its performance is reduction. 
With sulfur, phosphorus, organic matter and other friction or impact can cause combustion or explosion. 
E250 (Sodium nitrite) can be placed in the air with the oxygen reaction, and gradually produce sodium nitrate: NaNO2+1/2O2=NaNO3.

When using strong acidic E250 (Sodium nitrite), it can be nitrited to nitric acid. 
E250 (Sodium nitrite) is very unstable, easily decomposed into nitrogen dioxide, nitric oxide and water. 
The nitrogen atoms and oxygen atoms all have a single pair of electrons, which can be used as ligands, and can be used as ligands to form complexes with many metal ions. 
E250 (Sodium nitrite) is toxic, carcinogenic substances, using it must be attention. 
E250 (Sodium nitrite) is used in printing and dyeing industry and organic synthesis. E250 (Sodium nitrite) is obtained by the reaction of sodium nitrate and lead in a total of hot condtion.


CHEMICAL PROPERTIES:

E250 (Sodium nitrite) is an inorganic compound with the chemical formula NaNO2. 
E250 (Sodium nitrite) is white or yellow patch on the orthorhombic crystal or powder. 
Micro salty and deliquescent. It is soluble in water and liquid ammonia, its aqueous solution is alkaline.

E250 (Sodium nitrite) is also found at low concentrations in most vegetables. 
Spinach and lettuce can have some of the highest concentrations but all vegetables will contain some levels of E250 (Sodium nitrite). 
E250 (Sodium nitrite) has been explored in human and veterinary medicines as a vasodilator, reducing blood pressure, and is also used as an antidote for cyanide poisoning.
E250 (Sodium nitrite), NaN02, is a fire-hazardous, air-sensitive, yellowish white powder that is soluble in water and decomposes at temperatures above 320°C (608 °F). 
E250 (Sodium nitrite) is used as an intermediate for dye stuffs and for pickling of meat, in dyeing of textiles, in rustproofing, in medicine, and as a reagent in organic chemistry.

USES:

E250 (Sodium nitrite) is a commonly used meat preservative, particularly in cured meats such as ham, hot dogs, sausages, and bacon. 
The nitrite ion inhibits the growth of bacteria, particularly Clostridium botulinum, an organism that produces the deadly botulism toxin. 
E250 (Sodium nitrite) is also used to treat packages of red meat, such as beef. 
Blood exposed to the air rapidly produces a brown color, but shoppers much prefer their meat purchases to look bright red.
Thus,the meat is treated with E250 (Sodium nitrite); the nitrite ion is reduced to nitrogen monoxide, which then reacts with the hemoglobin to form a very stable bright red compound.

E250 (Sodium nitrite) is true that the nitrite will prevent bacterial growth in this circumstance as well, but these days, the meat is kept at temperatures low enough to inhibit bacteria.To persuade shoppers to prefer brownish rather than red meat will require a lot of re-education. 
Now that all meats are treated with E250 (Sodium nitrite), there is concern that the cooking process will cause the nitrite ion to react with amines in the meat to produce nitrosamines,compounds containing the -NNO functional group. 
E250 (Sodium nitrite) is used to fix the colors in preserved fish and meats. 
E250 (Sodium nitrite) is also important(along with sodium chloride) in controlling the bacterium Clostridium botulinum, which causes botulism. Lunch meats, hams, sausages, hot dogs, and bacon are usually preserved this way.
In medicines, E250 (Sodium nitrite) is a vasodilator, intestinal relaxant, bronchodilator, and an antidote to cyanide and hydrogen sulfide poisoning.

E250 (Sodium nitrite) is produced in the human body by the action of saliva on sodium nitrate, and is important in controlling bacteria in the stomach, to prevent gastroenteritis. 
The body produces more E250 (Sodium nitrite) than is consumed in food.E250 (Sodium nitrite) can react with proteins in the stomach or during cooking, especially in high heat (such as frying bacon), to form carcinogenic N-nitrosamines.
E250 (Sodium nitrite) is the salt of nitrous acid that functions as an antimicrobial agent and preservative. 
E250 (Sodium nitrite) is a slightly yellow granular powder or nearly white, opaque mass or sticks. 
E250 (Sodium nitrite) is deliquescent in air. 
E250 (Sodium nitrite) has a solubility of 1 g in 1.5 ml of water. 
E250 (Sodium nitrite) is used in meat curing for color fixation and development of flavor. 

TOXICITY:

Due to the oxidizing property of E250 (Sodium nitrite), ingestion of the substance can induce methemoglobinemia as quickly as one hour after ingestion. 
Methemoglobinemia occurs when the iron contained within hemoglobin is oxidized from its ferrous state (HgbFe2+) to its ferric state (HgbFe3+). 
When hemoglobin is in its ferric state, it is called methemoglobin and it is unable to act as a carrier to deliver oxygen to tissues. 
Symptoms of methemoglobinemia can include cyanosis and low SpO2 in the absence of respiratory distress, dizziness, syncope, dyspnea, fatigue, CNS depression, seizures, dysrhythmias, metabolic acidosis, cardiovascular collapse and death. 
Generally symptoms start to occur with methemoglobin levels > 15%. E250 (Sodium nitrite) has a reported elimination half-life between 30-45 minutes when ingested or injected so does not tend to cause prolonged methemoglobinemia like that which is seen with dapsone.

DESCRIPTION:

E250 (Sodium nitrite) is similar in name and use to sodium nitrate. 
Both are preservatives used in processed meats, such as salami, hot dogs, and bacon. 
E250 (Sodium nitrite) has been synthesized by several chemical reactions that involve the reduction of sodium nitrate. 
Industrial production of E250 (Sodium nitrite) is primarily by the absorption of nitrogen oxides into aqueous sodium carbonate or sodium hydroxide. 

Over the years, E250 (Sodium nitrite) has raised some concerns about its safety in foods, but it remains in use and there are indications that it may actually be healthy. 
E250 (Sodium nitrite) was developed during the 1960s. 
The US Department of Agriculture (USDA) considered banning it but the USDA’s final ruling on the additive came out in 1984, allowing its use. 
Studies in the 1990s indicated some adverse effects of E250 (Sodium nitrite), for instance the potential to cause childhood leukemia and brain cancers. 
E250 (Sodium nitrite) is now believed that it can help with organ transplants and leg vascular problems, while preventing heart attacks and sickle cell disease.


PRODUCTION METHOD:

E250 (Sodium nitrite), yellowish-white solid, soluble, formed by reaction of nitric oxide plus nitrogen dioxide and sodium carbonate or hydroxide, and then evaporating, by heating sodium nitrate and lead to a high temperature, and then extracting the soluble portion (lead monoxide insoluble) with H2O and evaporating. Used as an important reagent (diazotizing) in organic chemistry.

DEFINITION:

E250 (Sodium nitrite) is an inorganic sodium salt having nitrite as the counterion. 
E250 (Sodium nitrite) is used as a food preservative and antidote to cyanide poisoning. 
E250 (Sodium nitrite) has a role as an antimicrobial food preservative, an antihypertensive agent, a food antioxidant, a poison and an antidote to cyanide poisoning. 
E250 (Sodium nitrite) is a nitrite salt and an inorganic sodium salt.

GENERAL DESCRIPTION:

A yellowish white crystalline solid. Noncombustible but will accelerate the burning of combustible material. 
If large quantities are involved in a fire or if the combustible material is finely divided, an explosion may result. 
If contaminated by ammonium compounds, spontaneous decomposition can occur and the resulting heat may ignite surrounding combustible material. 
Prolonged exposure heat may result in an explosion.Toxic oxides of nitrogen are produced in fires involving E250 (Sodium nitrite).
Used as a food preservative, and to make other chemicals.

IUPAC NAME:

2,4-dichlorophénoxyacétate de dimethylammonium
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
dusitan sodný
Nitrito di Sodio E250
NITROUS ACID SODIUM SALT
Nitrous acid, sodium salt
Nitrous acid, sodium salt
Nitrous acid, sodium salt (1:1)
Sodium Nitrate
Sodium nitrate
sodium nitrate
E250 (Sodium nitrite)
E250 (Sodium nitrite)
E250 (Sodium nitrite)
E250 (Sodium nitrite)
E250 (Sodium nitrite)
E250 (Sodium nitrite) 
sodium;nitrite
Sofium Nitrite

TRADE NAME:

Natriumnitrit
Nitrous acid sodium salt (1:1)
Nitrous acid, sodium salt (8CI, 9CI
E250 (Sodium nitrite)E250 (Sodium nitrite) (NaNO2)E250 (Sodium nitrite) f.g.E250 (PRD 30216106)
E250 (Sodium nitrite) HQ ff (PRD 30046436)
E250 (Sodium nitrite) Sol.40%
soidium nitrite

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