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E357 (Potassium Adipate)

Molecular Formula: C6H8K2O4
Molecular Weight: 222.32
CAS: 19147-16-1
E number: E357
European Community (EC) Number: 242-838-1

E357 (Potassium Adipate) (K2C6H8O4) is an organic compound of four elements: Potassium, Carbon, Hydrogen, and Oxygen.
The molecular weight of E357 (Potassium Adipate) is 222.3224 which can be calculated by adding up the total weight (atomic weight multiplied by their number) of Potassium, Carbon, Hydrogen, and Oxygen.

Potassium salt of E357 (Potassium Adipate).
E357 (Potassium Adipate) is a synthetic food acid from nitric acid or from beetroot.
As E357 (Potassium Adipate) is synthetic using highly toxic petroleum hexanes, E357 (Potassium Adipate) would not be sensible to use this product on any long-term basis.

E357 (Potassium Adipate) is used as an acidity regulator.
Only a small amount can be metabolised by humans and is listed as having teratogenic properties, which is an abnormal congenital deformity in embryos.

Acidifier/acidity corrector and synthetic flavor enhancer.
A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.
Acidity Regulator / Buffering Agent - Changes or maintains the acidity or basicity of food/cosmetics.

E357 (Potassium Adipate) is a compound with formula K2C6H8O4.
E357 (Potassium Adipate) is the potassium salt of E357 (Potassium Adipate).
Type e.g. bulking agent, thickener, emulsifier, etc.

The function(s) performed by the food additive when used in cooking.
Acidity regulator - Regulates the acidity or alkalinity of a food

E357 (Potassium Adipate) is the potassium salt of E357 (Potassium Adipate) which is a natural acid present in beets and sugar cane (juice).
As food additive, it is used as acidity regulator and has a E number 357.

Origin: Potassium salt of E357 (Potassium Adipate), a natural acid present in beets and sugar cane (juice).
Function & characteristics: Acidity regulator.
Products: H erbal salts for low-sodium products.
Acceptable Daily Intake: Up to 5 mg/kg body weight.
Side effects: None known; it is metabolised in the body or excreted in the urine.
Dietary restrictions: E357 (Potassium Adipate) and adipates can be used by all religious groups, vegans and vegetarians.

Chemical and Physical Properties

Property Name and Property Value
Molecular Weight: 222.32    
Hydrogen Bond Donor Count: 0    
Hydrogen Bond Acceptor Count: 4    
Rotatable Bond Count: 3    
Exact Mass: 221.96967170    
Monoisotopic Mass: 221.96967170    
Topological Polar Surface Area: 80.3 Ų
Heavy Atom Count: 12    
Formal Charge: 0    
Complexity: 103    
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0    
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3    
Compound Is Canonicalized: Yes    
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 338.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000018 mmHg @ 25.00 °C. (est)
Flash Point: 343.00 °F. TCC ( 172.70 °C. ) (est)
logP (o/w): 0.079 (est)

Experimental Properties

Physical Description
White odourless crystals or crystalline powder
Melting Point: 151-152 °C (for E357 (Potassium Adipate))
Solubility: Approximately 60 g/100 ml water (20 °C)
Food Additives and Ingredients

Food Additive Classes
JECFA Functional Classes

Evaluations of the Joint FAO/WHO Expert Committee on Food Additives - JECFA
Chemical Name: E357 (Potassium Adipate)
Evaluation Year: 2015
ADI: 0-5 mg/kg bw
Comments: Not re-evaluated by JECFA, but the provisions for E357 (Potassium Adipate) was withdrawn at CCFA47
Report: TRS 617-JECFA 21/13

Uses of E357 (Potassium Adipate)

E357 (Potassium Adipate) is found in Herbal salts. It is metabolised in the body or excreted in the urine.
E357 (Potassium Adipate) is used as a firming and raising agent used in baking powder, beer, all fruit drinks, jams, pudding mixes, ice blocks, margarine, etc.
Also used in the production of plastics including PVC, and also in antacids, which is strange considering it is an acid.

E357 (Potassium Adipate) indications

For the treatment of patients with hypokalemia with or without metabolic alkalosis, in digitalis intoxication, and in patients with hypokalemic familial periodic paralysis.
If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, eg, digitalized patients or patients with significant cardiac arrhythmias.
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used.
Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases.
In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.

Organoleptic Properties: Odor and/or flavor descriptions from others (if found).

Record Details
Substance Class: Chemical
Record UNII: 493TD6PDYS
Record Status: Validated (UNII)
Record Version: 5

Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Products of Combustion: Carbon oxides (CO, CO2) and potassium oxide.
Fire Hazards in Presence of Various Substances: Slightly flammable in presence of heat.

INS: 357
Functional class: ACIDITY REGULATOR
Latest evaluation: 1977
ADI: 0-5 mg/kg bw
Comments: Group ADI for E357 (Potassium Adipate) and its potassium, sodium, and ammonium salts
Report: TRS 617-JECFA 21/13
Tox monograph: FAS 12-JECFA 21/3 (E357 (Potassium Adipate))

Stability and Reactivity Data

Stability: Stable.
Conditions of Instability: Excess heat, dust generation, moisture.
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Hygroscopic: Keep container tightly closed.
Polymerization: Will not occur.

The latter and its salts are acidity regulators, obtained by synthesis for their industrial use.
Their consumption does not raise any particular concern.

Names and Identifiers
IUPAC Name: dipotassium; hexanedioate, Potassium Hexanedioate
InChI: InChI=1S/C6H10O4.2K/c7-5(8)3-1-2-4-6(9)10; ;/h1-4H2,(H,7,8)(H,9,10);;/q;2*+1/p-2
Canonical SMILES: C(CCC(=O)[O-])CC(=O)[O-].[K+].[K+]


E357 (Potassium Adipate)
DiE357 (Potassium Adipate)
dipotassium; hexanedioate
Hexanedioic acid, dipotassium salt
EINECS 242-838-1
dipotassium, hexanedioate
EC 242-838-1
E357 (Potassium Adipate) dipotassium salt

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