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E460 Micro Crystalline Cellulose (MCC) is also used in vitamin supplements or tablets.
In the pharmaceutical industry, E460 Micro Crystalline Cellulose (MCC) is commonly used as an adsorbent, suspending agent, diluent, disintegrant.
E460 Micro Crystalline Cellulose (MCC) is widely used in pharmaceutical preparations, mainly used as diluents and binders in oral tablets and capsules, not only for wet granulation but also for dry direct compression.
CAS Number: 9004-34-6
EC Number: 232-674-9
MDL number: MFCD00081512
Food additive: E460
Molecular Formula: (C6H10O5)n, “n” represents the number of repeating glucose units.
Molecular Weight: Varies depending on the degree of polymerization, typically ~36,000 to 100,000 g/mol (average range)
SYNONYMS:
Cotton linters, Cellulose crystalline, Cellulose regenerated, Cellulose, powder, Cellulose, powdered, Hydroxycellulose, Powdered cellulose, Pyrocellulose, Rayon, MCC, Avicel, Solka-Floc, α-Cellulose, Cellulose powder, Arbocel, Microcrystalline Cellulose, Cellulose, Microcrystalline, Cellulose Regenerated, OP1R32D61U, Avicel PH, CCRIS 6600, CELLULOSE MICROCRYSTALLINE, CELLULOSE, MICROCRYSTALLINE (EP MONOGRAPH), CELLULOSE, MICROCRYSTALLINE (II), CELLULOSE, MICROPOROUS, CELLULOSE,MICROCRYSTALLINE, CELLULOSUM MICROCRYSTALLINUM, CP-305, Cellulose Powders, Celphere CP-305, Cephere, DISPERSIBLE CELLULOSE, EINECS 232-674-9, Ethispheres250, MICROCRYSTALLINE CELLULOSE (E460), MICROCRYSTALLINE CELLULOSE (MART.), MICROCRYSTALLINE CELLULOSE (USP-RS), MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 102, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 102 SCG, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 103, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 105, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 112, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 200, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 200 LM, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 301, MICROCRYSTALLINE CELLULOSE IN FDA INACTIVE INGREDIENTS INCLUDES MICROCRYSTALLINE CELLULOSE 302, NSC 225105, PHARMACEL, Rayon flock, Sentry aq mardel clout, UNII-5XDI2TS1EZ, UNII-7T9FYH5QMK, UNII-91B875MM4H, UNII-C8DF2GF8L2, UNII-HHJ82DN6MJ, UNII-KO5GYV0DCB, UNII-L5EC3P45R8, UNII-OP1R32D61U, UNII-PNR0YF693Y, UNII-SMD1X3XO9M, UNII-VG6UJI79NF, UNII-W7YXH6D4BD, UNII-X7XJ6RM9Q2, Wood pulp, bleached
E460 Micro Crystalline Cellulose (MCC) (MCC) E460 is a term for refined wood pulp, and it appears as a fine white to off-white powder.
E460 Micro Crystalline Cellulose (MCC) is one of the popular food additives and ingredients in most countries.
E460 Micro Crystalline Cellulose (MCC), the main component is a linear polysaccharide substance bound by β-1,4-glucoside bonds, which is natural cellulose hydrolyzed by dilute acid to the limit degree of polymerization ( LOOP) free-flowing very fine short rod-like or powder-like porous particles, composed of white, odorless, tasteless crystalline powder.
In general plant fibers, E460 Micro Crystalline Cellulose (MCC) accounts for about 70%, and the other 30% is amorphous.
E460 Micro Crystalline Cellulose (MCC), also known as cellulose gel, or its abbreviation MCC.
The color of E460 Micro Crystalline Cellulose (MCC) is white or nearly white.
E460 Micro Crystalline Cellulose (MCC) is odorless, tasteless, particle size is generally 20 ~ 80 Lm, the ultimate degree of polymerization (LODP) in the 15 ~ 375; not fibrous and highly fluid.
E460 Micro Crystalline Cellulose (MCC) is insoluble in water, dilute acid, organic solvents and oils.
E460 Micro Crystalline Cellulose (MCC) partially dissolves and swells in dilute alkali solution.
E460 Micro Crystalline Cellulose (MCC) has high reaction performance in carboxymethylation, acetylation and esterification.
E460 Micro Crystalline Cellulose (MCC) (MCC), also known as cellulose gel or E460, is a naturally occurring substance that is widely used in various industries, including Chemical, food, and cosmetics.
E460 Micro Crystalline Cellulose (MCC) is derived from cellulose, which is the main structural component of plant cell walls.
E460 Micro Crystalline Cellulose (MCC) is a white, odorless, and tasteless powder with excellent binding, bulking, and stabilizing properties.
E460 Micro Crystalline Cellulose (MCC) is a white, odorless powder
E460 Micro Crystalline Cellulose (MCC) is insoluble in water and organic solvents
E460 Micro Crystalline Cellulose (MCC) is a purified, partially depolymerised cellulose prepared by treating alpha-cellulose, obtained as a pulp from strains of fibrous plant material, with mineral acids.
The degree of polymerisation (DP) is typically less than 400.
E460 Micro Crystalline Cellulose (MCC) is known by its chemical name as hydroxypropyl methylcellulose and is the refined form of cellulose, a vital polymer.
E460 Micro Crystalline Cellulose (MCC) is also coded as E460 by some sources and consists of a colloidal crystal portion.
E460 Micro Crystalline Cellulose (MCC) is known for its functions as an emulsifier, thickener, filler in the pharmaceutical, food and cosmetic industries and offers a wide range of applications to improve the texture of products.
Cellulose is a natural substance found in green plant cell walls and is one of the most abundant organic polymers on Earth.
E460 Micro Crystalline Cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production.
The most common form is used in vitamin supplements or tablets.
E460 Micro Crystalline Cellulose (MCC) is a valuable additive in pharmaceutical, food, cosmetic and other industries.
Different properties of E460 Micro Crystalline Cellulose (MCC) are measured to qualify its suitability to such utilization, namely particle size, density, compressibility index, angle of repose, powder porosity, hydration swelling capacity, moisture sorption capacity, moisture content, crystallinity index, crystallite size, and mechanical properties such as hardness and tensile strength.
USES and APPLICATIONS of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
Chemical: E460 Micro Crystalline Cellulose (MCC) is widely used as an excipient in the Chemical industry to improve the compressibility and disintegration properties of tablets and as a suspending agent in liquid formulations.
Food and Beverage Industry: E460 Micro Crystalline Cellulose (MCC) is used as a texturizer, stabilizer, and bulking agent in various food products, including baked goods, dairy products, sauces, dressings, and beverages.
Cosmetics and Personal Care: E460 Micro Crystalline Cellulose (MCC) is utilized in cosmetics and personal care products, such as creams, lotions, and powders, to improve texture, stability, and absorbency.
Other Applications: E460 Micro Crystalline Cellulose (MCC) can also be found in other applications, such as in the production of paper, coatings, paints, and as an anti-caking agent.
E460 Micro Crystalline Cellulose (MCC) is a naturally occurring polymer consisting of glucose units linked by 1-4 beta glycosidic bonds.
In cosmetics, E460 Micro Crystalline Cellulose (MCC) serves multiple purposes including abrasiveness, absorption, anti-caking, viscosity enhancement in aqueous solutions, bulking, stabilization of emulsions, adjustment of slip, and texturizing.
These functionalities make E460 Micro Crystalline Cellulose (MCC) a common ingredient in various hair care, skin care, and makeup products.
E460 Micro Crystalline Cellulose (MCC) is a valuable additive across industries such as pharmaceuticals, food, cosmetics, and others.
E460 Micro Crystalline Cellulose (MCC)'s suitability for different applications is determined by various properties including particle size, density, compressibility index, angle of repose, powder porosity, hydration swelling capacity, moisture sorption capacity, moisture content, crystallinity index, crystallite size, as well as mechanical properties like hardness and tensile strength.
E460 Micro Crystalline Cellulose (MCC) is a white powder derived from the cellulose manufacturing process using high-quality wood pulp.
Registered under CAS number 9004-34-6, E460 Micro Crystalline Cellulose (MCC) exhibits rapid disintegration in water.
Widely employed in medicine and food, E460 Micro Crystalline Cellulose (MCC) functions as an emulsifier, stabilizer, and binding agent in tablet formulations.
E460 Micro Crystalline Cellulose (MCC) E460 is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production.
The most common form OF E460 Micro Crystalline Cellulose (MCC) is used in vitamin supplements or tablets.
E460 Micro Crystalline Cellulose (MCC) is mainly used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in pasteurized cream, fermented milk, cheese, processed fruit, dried vegetables, etc.
E460 Micro Crystalline Cellulose (MCC) is also used in vitamin supplements or tablets.
Due to its special properties such as low degree of polymerization and large specific surface area, E460 Micro Crystalline Cellulose (MCC) is widely used in medicine, food, cosmetics and light chemical industries.
In the pharmaceutical industry, E460 Micro Crystalline Cellulose (MCC) is commonly used as an adsorbent, suspending agent, diluent, disintegrant.
E460 Micro Crystalline Cellulose (MCC) is widely used in pharmaceutical preparations, mainly used as diluents and binders in oral tablets and capsules, not only for wet granulation but also for dry direct compression.
There is also some lubrication and disintegration, very useful in tablet preparation.
In the field of cosmetics, E460 Micro Crystalline Cellulose (MCC) as a material for a variety of cosmetics, skin treatment and care products, and cleaning detergent manufacturing.
E460 Micro Crystalline Cellulose (MCC) is a multi-functional ingredient commonly used as an anticaking agent, binder, thickener or stabilizer.
The European food additive number for E460 Micro Crystalline Cellulose (MCC) is E460(i).
The most common form is used in vitamin supplements or tablets.
Food Industry: E460 Micro Crystalline Cellulose (MCC) is widely used in reduced-fat salad dressings, numerous dairy products including cheese, frozen desserts and whipped toppings, and bakery products.
Pharma Industry uses of E460 Micro Crystalline Cellulose (MCC): E460 Micro Crystalline Cellulose (MCC)can be used as an excipient in most forms of pharmaceutical products such as powders, granules, inhalants, (film) tablets, dragées, ointments, creams, gels or liquids.
E460 Micro Crystalline Cellulose (MCC) is a free-flowing, extremely fine, short rod or powdery porous particle of natural cellulose that is hydrolyzed to the limit polymerization degree (LOOP) by dilute acid.
E460 Micro Crystalline Cellulose (MCC) is widely used in pharmaceutical, cosmetics, food and other industries.
Different particle size and water content have different characteristics and application ranges.
E460 Micro Crystalline Cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production.
The most common form of E460 Micro Crystalline Cellulose (MCC) is used in vitamin supplements or tablets.
E460 Micro Crystalline Cellulose (MCC) is also used in plaque assays for counting viruses, as an alternative to carboxymethylcellulose.
In many ways, cellulose makes the ideal excipient.
A naturally occurring polymer, E460 Micro Crystalline Cellulose (MCC) is composed of glucose units connected by a 1-4 beta glycosidic bond.
These linear cellulose chains are bundled together as microfibril spiralled together in the walls of plant cell.
Each microfibril exhibits a high degree of three-dimensional internal bonding resulting in a crystalline structure that is insoluble in water and resistant to reagents.
There are, however, relatively weak segments of the microfibril with weaker internal bonding.
These are called amorphous regions but are more accurately called dislocations since microfibril containing single-phase structure.
The crystalline region is isolated to produce E460 Micro Crystalline Cellulose (MCC).
E460 Micro Crystalline Cellulose (MCC) is a naturally non-caloric indigestible dietary fiber that is widely used in food, cosmetics and pharmaceutical industries.
E460 Micro Crystalline Cellulose (MCC)'s primary purpose is as an anticaking agent in food and pharmaceutical processing.
Due to the properties of its polymer structure, E460 Micro Crystalline Cellulose (MCC) is often used in applications that provide firm cohesive properties in dough or create a creamy texture.
In the food industry, E460 Micro Crystalline Cellulose (MCC) plays a functional role in the production of a wide variety of products such as ice cream, cream, cheese and soups.
In terms of stability and flammability, E460 Micro Crystalline Cellulose (MCC) is a chemically stable substance and is considered flammable with a certain density.
Under certain conditions, E460 Micro Crystalline Cellulose (MCC) may be incompatible with strong oxidizing agents.
A detailed study of E460 Micro Crystalline Cellulose (MCC)'s chemical structure and areas of use is important in understanding the use of this versatile and functional excipient.
E460 Micro Crystalline Cellulose (MCC), also known as E460, is a polymer isolated from the colloidal crystalline portion of cellulose fibers.
With its small degree of polymerization and high level of crystallinity, E460 Micro Crystalline Cellulose (MCC) is used in a wide range of applications in the cosmetics, food and textile industries.
E460 Micro Crystalline Cellulose (MCC) is used in the cosmetic and pharmaceutical sectors as an active ingredient carrier, as a stabilizer and as an auxiliary agent in the binding of tablets.
In the cosmetic field, E460 Micro Crystalline Cellulose (MCC) is found in fine powder form, especially in skin care products, and its larger particle form is preferred as a gentle scrubbing agent.
In the pharmaceutical industry, E460 Micro Crystalline Cellulose (MCC) acts as a binder and filler in tablet production.
E460 Micro Crystalline Cellulose (MCC) can improve the bioavailability of drugs and facilitate the disintegration and dissolution of compressed tablets.
In the food industry, E460 Micro Crystalline Cellulose (MCC) is listed as food additive E460.
E460 Micro Crystalline Cellulose (MCC) is used as a thickener and anti-caking agent, adding volume and stability to foods.
In milk chocolate production, E460 Micro Crystalline Cellulose (MCC) provides consistency by keeping particles suspended, and acts as a stabilizer in emulsions and foams.
E460 Micro Crystalline Cellulose (MCC) is also used in the textile industry.
In this context, the moisture retention capacity and surface area of E460 Micro Crystalline Cellulose (MCC) allow it to be preferred as a moisturizer and filler in textile production processes.
E460 Micro Crystalline Cellulose (MCC) also plays a role in important functions such as fiber reinforcement and improving the structure of fabrics.
E460 Micro Crystalline Cellulose (MCC) is also used in plaque assays for counting viruses, as an alternative to carboxymethylcellulose.
Approved within the European Union as a thickener, stabilizer or emulsifier, microcrystalline cellulose was granted the E number E460(i) with basic cellulose given the number E460 Micro Crystalline Cellulose (MCC).
E460 Micro Crystalline Cellulose (MCC) has use in cosmetics as an abrasive, absorbent, anti-caking agent, aqueous viscosity increasing agent, binder, bulking agent, emulsion stabilizer, slip modifier, and texturizer, which can be found in various hair and skin care products as well as makeup.
-Food uses of E460 Micro Crystalline Cellulose (MCC):
Food grade E460 Micro Crystalline Cellulose (MCC) is commonly used in combination with CMC, or methylcellulose.
Also, E460 Micro Crystalline Cellulose (MCC) is together with starch to improve thickening.
PROPERTIES OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
*Appearance
E460 Micro Crystalline Cellulose (MCC) is a fine, white or almost white, odourless, free flowing crystalline powder.
*Particle Size
Not less than 5 μm (not more than 10% of particles of less than 5 μm).
*Solubility
E460 Micro Crystalline Cellulose (MCC) is in water
E460 Micro Crystalline Cellulose (MCC) is insoluble in water, but can swell in water, dilute alkali and acids, and in most organic solvents.
E460 Micro Crystalline Cellulose (MCC) is practically insoluble or insoluble in sodium hydroxide solution (concentration: 50 g NaOH/L).
E460 Micro Crystalline Cellulose (MCC) forms colloidal solutions at the concentration below 1%, and generate thixotropic gels at the concentration above 1%.
*In organic Solvents
E460 Micro Crystalline Cellulose (MCC) is insoluble in ethanol, ether and dilute mineral acids.
BENEFITS AND FUNCTIONS OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
Let’s see its benefits and functions in food categories.
*Beverage
E460 Micro Crystalline Cellulose (MCC) stabilizes the liquid, adds viscosity, improves texture, and increases dietary fiber content in beverages, like fruit beverages, soft drinks, nutrition drinks and instant drinks.
*Bakery
E460 Micro Crystalline Cellulose (MCC) retains water longer, reduces oil absorption, and strengthens dough structure while softens the dough structure.
And therefore prolong the shelf-life of donuts, bakery & pastries.
Also, E460 Micro Crystalline Cellulose (MCC) ensures the smoothness of the glaze by creating networks between liquid and sugar in glazings, icings, and fillings.
*Dairy
Generally, E460 Micro Crystalline Cellulose (MCC) stabilizes emulsions and foam, adds creaminess, replaces fats and oils, acts as an anti-caking agent and flavor carrier, improves flowability and prevents ice crystal growth in frozen desserts, whipped toppings, chocolate milk, cheese, ice cream and so on.
*Culinary
E460 Micro Crystalline Cellulose (MCC) provides emulsion stability, forms gels, improves adhesion (icing), enables fat reduction, adds creaminess, modifies texture- thickens with favorable mouth feel in dressing, sauces, dips, soups.
*Fried and Processed Food
E460 Micro Crystalline Cellulose (MCC) can reduce oil intake and fat absorption by adding it to fried food.
In meat, E460 Micro Crystalline Cellulose (MCC) enhances the mouth-feel and texture by providing a fat-like mouthfeel; also, it acts as an emulsifying, stabilizing and binding agent used together with hydrocolloids like sodium alginate and carrageenan.
*Tablets
E460 Micro Crystalline Cellulose (MCC) can be used as a binder in tablet manufacturing to increase tablet hardness & also improves the flow properties, such as in vitamin supplement tablets.
*Cosmetics
Per the “European Commission database for information on cosmetic substances and ingredients”, E460 Micro Crystalline Cellulose (MCC) acts as an absorbent, anticaking, bulking, emulsion stabilising, opacifying, stabilising, and viscosity controlling agent in cosmetics and personal care products.
*Pharmaceuticals
E460 Micro Crystalline Cellulose (MCC) is an excipient in the pharmaceutical industry as an adsorbent, suspending agent, diluent, disintegrating agent or binder in pills, tablets, capsules and etc.
E460 Micro Crystalline Cellulose (MCC) can be used in both wet-granulation and direct-compression processes.
FEATURES OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
*Excellent Binding and Bulking Agent:
E460 Micro Crystalline Cellulose (MCC) has high binding capacity, making it useful as a binder in the formulation of tablets and pellets in the Chemical industry.
E460 Micro Crystalline Cellulose (MCC) also acts as a bulking agent, providing volume and improving the flow properties of powders.
*Stabilizer and Texture Modifier:
E460 Micro Crystalline Cellulose (MCC) functions as a stabilizer and texture modifier in various food and beverage products, enhancing their texture, mouthfeel, and stability.
*Inert and Non-Toxic:
E460 Micro Crystalline Cellulose (MCC) is considered safe for consumption and has no known adverse effects.
E460 Micro Crystalline Cellulose (MCC) passes through the gastrointestinal tract without being absorbed by the body.
*Low Caloric Value:
E460 Micro Crystalline Cellulose (MCC) has a low caloric value and is often used in low-calorie or reduced-fat food products.
*High Absorption Capacity:
E460 Micro Crystalline Cellulose (MCC) has the ability to absorb water and other liquids, making it useful in applications where moisture control is important, such as in Chemical formulations.
STRUCTURE OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
A naturally occurring polymer, it is composed of glucose units connected by a 1-4 beta glycosidic bond.
These linear cellulose chains are bundled together as microfibril spiralled together in plant cell walls.
Each microfibril exhibits a high degree of three-dimensional internal bonding resulting in a crystalline structure that is insoluble in water and resistant to reagents.
There are, however, relatively weak segments of the microfibril with weaker internal bonding.
These are called amorphous regions; some[citation needed] argue that they are more accurately called dislocations, because of the single-phase structure of microfibrils.
The crystalline region is isolated to produce microcrystalline cellulose.
SYNTHESIS OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
E460 Micro Crystalline Cellulose (MCC) is pure partially depolymerized cellulose synthesized from α-cellulose precursor.
E460 Micro Crystalline Cellulose (MCC) can be synthesized by different processes such as reactive extrusion, enzyme mediated, mechanical grinding, ultrasonication, steam explosion and acid hydrolysis.
The latter process can be done using mineral acids such as H2SO4, HCl and HBr as well as ionic liquids.
The role of these reagents is to destroy the amorphous regions leaving the crystalline domains.
The degree of polymerization is typically less than 400.
E460 Micro Crystalline Cellulose (MCC) particles with size lower than 5 μm must not be more than 10%.
Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) or differential scanning calorimetry (DSC) are also important to predict the thermal behavior of the E460 Micro Crystalline Cellulose (MCC) upon heat stresses.
WHAT IS IT MADE OF?
E460 Micro Crystalline Cellulose (MCC) is a linear polymer composed of repeating beta-D-glucopyranosyl units linked via (1,4) glycosidic bonds.
H0W IS IT MADE?
Generally, E460 Micro Crystalline Cellulose (MCC) is produced by the controlled hydrolysis of highly purified alpha-cellulose made from naturally occurring wood cellulose.
The following are the simple manufacturing process:
*Step 1: Alpha-cellulose production
Alpha cellulose is the highest degree of polymerization and is the most stable among the three classes of cellulose: alpha, beta and gamma.
It is the major component of wood and paper pulp.
Three types of cellulose all have the same chemical structure but differ in DP: alpha-cellulose DP > 200; beta-cellulose DP 30-200; gamma-cellulose DP 10-30.
Alpha type can be separated from the other components by treating with 17.5% solution of sodium hydroxide as beta and gamma types are soluble while alpha is not.
*Step 2: Hydrolysis
In plant fibers, E460 Micro Crystalline Cellulose (MCC) accounts for about 70% (acid-insoluble), and the rest 30% is amorphous regions of cellulose (acid-soluble fraction).
When treated alpha-cellulose with a dilute mineral acid, e.g. hydrochloric acid to reduce the degree of polymerization, the acid-soluble fraction can be completely hydrolyzed and subsequently obtain the tiny, acid-resistant E460 Micro Crystalline Cellulose (MCC).
PHYSICAL AND CHEMICAL PROPERTIES OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
E460 Micro Crystalline Cellulose (MCC) is an opaque white powder, has the ability to disperse in water and has a unique structure with both crystalline and amorphous regions.
E460 Micro Crystalline Cellulose (MCC) is chemically stable and particle size is also an important physical property.
*Crystalline and Amorphous Regions
The structure of E460 Micro Crystalline Cellulose (MCC) contains both crystalline and amorphous regions.
The crystalline structure of E460 Micro Crystalline Cellulose (MCC) results from the spatial arrangement of cellulose chains in a regular and repeating pattern and exhibits a high degree of order.
Amorphous regions are less orderly than crystalline regions and may increase the solubility of the material.
*Particle Size and Distribution
The particle size of E460 Micro Crystalline Cellulose (MCC) is generally between 20-80 μm.
The small size and distribution of the particles contribute to the creation of homogeneous mixtures and stable dispersions by providing high surface area.
The crystal particle size of E460 Micro Crystalline Cellulose (MCC) with a colloidal grade is smaller and is in the range of approximately 0.2-2 μm.
These sizes have a direct impact on the applications of the material and can manage opacity.
*Mechanical Properties
E460 Micro Crystalline Cellulose (MCC) (MCC) is a preferred filler in many application areas, from dental composites to packaging materials.
This section examines the basic mechanical properties of MKC, such as hardness and density, tensile strength, and microhardness.
*Hardness and Density
E460 Micro Crystalline Cellulose (MCC) is a material with a generally high level of hardness, which makes it an ideal filler material to meet various mechanical demands.
E460 Micro Crystalline Cellulose (MCC)'s density is typically around 1.5 g/cm³ , which indicates the strength of the material.
*Tensile Strength
Composites containing E460 Micro Crystalline Cellulose (MCC) can, in some cases, show increased resistance to tensile stresses.
In particular, when integrated into polymer matrices, E460 Micro Crystalline Cellulose (MCC) contributes significantly to the mechanical properties of the matrix, allowing high tensile strength to be achieved.
*Microhardness
The microhardness values of MKS indicate how resistant the material is at the micro level.
E460 Micro Crystalline Cellulose (MCC) is known that when used in dental resin formulations, microhardness properties are improved, which increases the overall performance of the material and allows for the production of more durable composites.
E460 Micro Crystalline Cellulose (MCC), also known as cellulose gel, or its abbreviation MCC.
E460 Micro Crystalline Cellulose (MCC) is a multi-functional ingredient commonly used as an anticaking agent, binder, thickener or stabilizer.
The European food additive number for E460 Micro Crystalline Cellulose (MCC) is E460(i).
POSSIBLE SIDE EFFECTS OF E460 MICRO CRYSTALLINE CELLULOSE (MCC):
Although E460 Micro Crystalline Cellulose (MCC) E460 generally regarded as a very safe and effective supplement, there can be some minor side effects.
The side effects may:
E460 Micro Crystalline Cellulose (MCC) may cause mild side effects in certain individuals.
You may find that you have to frequent the bathroom more often due to an increase in stool production.
You may also experience gas and bloating.
IS E460 MICRO CRYSTALLINE CELLULOSE (MCC) SAFE TO EAT?
Yes, E460 Micro Crystalline Cellulose (MCC)'s safety when used as a food additive has been approved by the U.S. Food and Drug Administration (FDA), European Food Safety Authority (EFSA), Joint FAO/WHO Expert Committee on Food Additives (JECFA), as well as other authorities.
FDA
The FDA has claimed that E460 Micro Crystalline Cellulose (MCC) can be used for anticaking agent or free-flow agent, drying agent, flavor enhancer, flavoring agent or adjuvant, formulation aid, humectant, stabilizer or thickener in food.
However, E460 Micro Crystalline Cellulose (MCC) is not listed in 21CFR as GRAS (Generally Recognized as Safe).
EFSA
E460 Micro Crystalline Cellulose (MCC) is listed in Commission Regulation (EU) No 231/2012 as an authorised food additive and categorized as “additives other than colours and sweeteners”.
PHYSICAL and CHEMICAL PROPERTIES of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
Appearance: A fine white or almost white odorless powder
Particle size: 98% pass 120 mesh
Assay (as α- cellulose, dry basis): ≥97%
Water-soluble matter: ≤ 0.24%
Sulphated ash: ≤ 0.5%
pH (10% solution): 5.0- 7.5
Molecular Formula: (C12H20O10)n
EINECS: 232-674-9
Appearance:
White Powder
CAS No.: 9004-34-6
Appearance: A fine white or almost white odorless powder
Particle size: 98% pass 120 mesh
Assay (as α- cellulose, dry basis): ≥97%
Water-soluble matter: ≤ 0.24%
Sulphated ash: ≤ 0.5%
pH (10% solution): 5.0- 7.5
Molecular Formula: (C6H10O5)n, “n” represents the number of repeating glucose units.
Molecular Weight: Varies depending on the degree of polymerization,
typically ~36,000 to 100,000 g/mol (average range)
FIRST AID MEASURES of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of E460 MICRO CRYSTALLINE CELLULOSE (MCC):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
