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GLYOXYLIC ACID

CAS NO.:  298-12-4
EC/LIST NO.:  206-058-5

Glyoxylic acid or oxoacetic acid is an organic compound.
Along with acetic acid, glycolic acid, and oxalic acid, glyoxylic acid is one of the C2 carboxylic acids.
Glyoxylic acid is a colorless solid that occurs naturally and is industrially useful.

Although the structure of glyoxylic acid is described as having an aldehyde functional group, the aldehyde is in some cases only a minor component of the most common form.
Instead, Glyoxylic acid is usually found as a hydrate or a cyclic dimer.
For example, in the presence of water, the carbonyl rapidly converts to a geminal diol (defined as "monohydrate").
The equilibrium constant (K) for the formation of dihydroxyacetic acid at room temperature is 300.

The conjugate base of glyoxylic acid is known as the glyoxylate and is the form in which the compound exists in solution at neutral pH.
Glyoxylic acid is the byproduct of the amidation process in the biosynthesis of several amidated peptides.

Glyoxylic acid or oxoacetic acid is an organic compound that is both an aldehyde and a carboxylic acid.
Glyoxylic acid is a liquid with a melting point of -93°C and a boiling point of 111°C.
Glyoxylic acid is an intermediate in the glyoxylate cycle that enables certain organisms to convert fatty acids to carbohydrates.
The conjugate base of glyoxylic acid is known as glyoxylate (PMID: 16396466).
In humans, glyoxylate is produced in two ways:
via oxidation of glycolate in peroxisomes and catabolism of hydroxyproline in mitochondria.
In peroxisomes, glyoxylate is converted to glycine by glyoxylate aminotransferase (AGT1) or to oxalate by glycolate oxidase.
In the mitochondria, glyoxylate is converted to glycine by the mitochondrial glyoxylate aminotransferase AGT2 or to glycolate by glycolate reductase.
Small amounts of glyoxylate are converted to oxalate by cytoplasmic lactate dehydrogenase.
Glyoxylic acid has been found to be associated with primary hyperoxaluria I, an inborn error of metabolism.
Under certain conditions, the glyoxylate may be a nephrotoxin and a metabotoxin.

Glyoxylic acid (GA) is an important organic acid in the chemical, cosmetic, pharmaceutical and food industries.
Glyoxylic acid is found in plants and is involved in the metabolic cycle of animals.
Glyoxylic acid is produced in several ways:
by nitric acid oxidation of glyoxalin, catalytic oxidation of ethylene or acetaldehyde, and electrochemical reduction of oxalic acid.

For the historical record, glyoxylic acid was prepared electrosynthetically from oxalic acid:
In organic synthesis, lead dioxide cathodes have been applied to prepare glyoxylic acid from oxalic acid in a sulfuric acid electrolyte.

Hot nitric acid can oxidize glyoxal to glyoxylic; however, this reaction is highly exothermic and prone to thermal runaways.
In addition, the main by-product is oxalic acid.

In addition, ozonolysis of maleic acid is also effective.

Glyoxylic acid is an intermediate in the glyoxylate cycle that enables organisms such as bacteria, fungi and plants to convert fatty acids into carbohydrates.
The glyoxylate cycle is also important for stimulating plant defense mechanisms in response to fungi.
The glyoxylate cycle is initiated by isocitrate lyase activity, which converts isocitrate to glyoxylate and succinate.
Research is being done to select the pathway for various uses, such as the biosynthesis of succinate.

Glyoxylic acid is produced in two ways: by oxidation of glycolate in peroxisomes or by catabolism of hydroxyproline in mitochondria.
In peroxisomes, glyoxylate is converted to glycine by AGT1 or to oxalate by glycolate oxidase.
In mitochondria, glyoxylate is converted to glycine by AGT2 or to glycolate by glyoxylate reductase.
Small amounts of glyoxylate are converted to oxalate by cytoplasmic lactate dehydrogenase.

Besides being an intermediate in the glyoxylate pathway, glyoxylate is also an important intermediate in the photorespiration pathway.
Photorespiration is the result of the side reaction of RuBisCO with O2 instead of CO2.
Although initially considered a waste of energy and resources, photorespiration has been shown to be an important method for replenishing carbon and CO2, removing toxic phosphoglycolate and initiating defense mechanisms.
In photorespiration, glyoxylate is converted from glycolate through the activity of glycolate oxidase in the peroxisome.
Glyoxylic acid is then converted to glycine by SGAT and GGAT through parallel actions and then transported to the mitochondria.
Glyoxylic acid has also been reported to play a role in the glycolate and glyoxylate metabolism of the pyruvate dehydrogenase complex.

Glyoxylic acid is a highly reactive chemical intermediate with two functional groups: the aldehyde group and the carboxylic acid group.
Strong organic acid (Ka=4.7x10-4), miscible in water and alcohol, insoluble in organic solvents.
Glyoxylic acid is supplied as a 50% water solution.
Glyoxylic acid is an important C2 building block for many organic molecules of industrial importance used in the production of agrochemicals, flavors, cosmetic ingredients, pharmaceutical intermediates and polymers.

Glyoxylic acid is also called hydroxyacetic acid.
This chemical is the smallest of the Alpha-Hydroxy acids.
Used as AHA used from this phone.

Glyoxylic acid is a value from skin care products in the cosmetic industry and from the pharmaceutical industry.

Glyoxylic acid has collagen and elastin head in the skin.

Glycolic Acid occurs naturally in some plants and vegetables.

This Alpha-Hydroxy Acetic acid production is hydrolyzed with Sodium Hydroxide of monochloroacetic acid.
The temperature of the reaction here is between 90 °C and 130 °C.

After this reaction, 60% concentration of Glycolic Acid and a certain ratio of Sodium Chloride are obtained.
Glyoxylic acid can be carried out by Acid extraction method with acetone to remove salt in solution.

One of the Glycolic Acid Production methods can be accomplished by the electrolytic reduction method of Oxalic Acid.

Glyoxylic acid can be produced by oxidizing the glycol with dilute nitric acid.

Commercially available Alpha-Hydroxyacetic Acid is in the form of a colorless, transparent and clear liquid.
Pure Glycolic Acid exists as a colorless hygroscopic solid.

Glyoxylic acid has no odor.

The boiling point of glyoxylic acids is 100 °C.

The melting point of glyoxylic acids is 79.5 °C.

Solubility in Glyoxylic acid, Acetic Acid, Methyl Alcohol, Ethyl Alcohol, Water and Acetone.

The solubility of glyoxylic acids in water is very good.

Glyoxylic acid finds use in personal care as a neutralizing agent, it is widely used in hair straightening products (shampoos, conditioners, lotions, creams) at 0.5-10% levels.

Dead skin cells accumulate in human skin.
As a result, dry skin, acne formation and wrinkles occur on the skin.
Skin care products containing Glycolic Acid (Glycolic Acid) are produced to prevent dead skin cells from accumulating on the skin.
Chemicals containing 2-Hydroxyacetic Acid are used to increase the moisture level of the skin.
In this way, the water holding capacity of the skin is increased. There is Hyaluronic Acid in the skin.
Glycolic Acid is used to increase the water holding capacity of Hyaluronic Acid.
Age spots form as people age. Formulas containing Glycolic Acid are used in the cosmetic industry to remove these age spots and look younger.
Glyoxylic acid is used for pH control.
Glyoxylic acid is an essential ingredient in the chemical grinding of metals.
Organic acid can be used in formulas as needed.

 

Glyoxylic acid is used in the cosmetic industry with products made to brighten the skin.
Products containing Glycolic Acid, produced in cream form, are formulated with several different compounds.
These include Salicylic Acid, Vitamin E, and Oils.
Glyoxylic acid is used in the manufacture of creams for the treatment of flaky skin skin.
Due to its chemical structure, Glycolic Acid is a chemical compound that can be used to make the hair brighter, healthier and straighter by reacting with the keratin in the hair structure.
Glyoxylic acid is used in the production of chemical peels produced to treat acne on the skin.
Glyoxylic acid is used in cosmetic preparations to fill wrinkles in the skin, prevent moisture loss of the skin and increase hyaluronic acid production.
In this application, xanthan gum is used as a stabilizer.
Glycolic Acid in the Alpha-Hydroxyacid category, which is therapeutically effective, is used to relieve dermatological ailments on the skin.
Formulated in glyoxylic acid, amphoteric compound and polymeric form.

Infrared Spectrum: Authentic
Melting Point: 48.0°C to 52.0°C
Flash Point : >110°C
Packaging : Plastic bottle
Color : White to Yellow
Quantity: 25g
Test Percentage Range: 98%
Linear Formula: HCOCO2H·H2O
Solubility Information Solubility in water: freely soluble.
Formula Weight: 92.06
Physical Form: Crystalline Powder or Particles
Percent Purity: 98%
Class : Pure
Chemical Name or Material : Glyoxylic acid monohydrate, 98%

The review summarizes the approaches known from the literature for the synthesis, isolation and crystallization of glyoxylic acid (GA), an important component in fine organic synthesis and widely used in the pharmaceutical, food and perfume industries.
The review describes research on the synthesis of glyoxylic acid from aqueous solutions of glyoxalin by catalytic, electrochemical and enzymatic methods and ozonolysis of maleic acid in solution.
Alternative methods for the synthesis of glyoxylic acid are contemplated, for example, glycolate oxidase, oxalic acid, glycolic acid in the presence of ethyl alcohol, and various halogenated acetic acid derivatives.
Approaches to the isolation of glyoxylic acid from synthesis products are considered, depending on the starting compound, including extraction with amines or alcohols, use of cation or anion exchange resins at elevated temperatures, and precipitation as insoluble alkaline earth metal salts.
Methods for glyoxylic acid crystallization using various experimental techniques are presented.

Glyoxylic acid, also known as α-ketoacetate or glyoxalate, belongs to the class of organic compounds known as carboxylic acids.
Carboxylic acids are compounds containing a carboxylic acid group with the formula -C(=O)OH.
Glyoxylic acid is an extremely weakly basic (mainly neutral) compound (relative to its pKa).
Glyoxylic acid is found in all living species, from bacteria to humans.
Glyoxylic acid is a potentially toxic compound.

Glyoxylic acid, also known as alpha-ketoacetic acid or glyoxylate, is a member of the class of compounds known as carboxylic acids.
Carboxylic acids are compounds containing a carboxylic acid group with the formula -C(=O)OH.
Glyoxylic acid (water) is a soluble and moderately acidic compound (based on its pKa).
Glyoxylic acid can be found in a number of foodstuffs such as European chestnut, cowpea, wheat and common thyme, making it a potential biomarker for consumption of these food products.
Glyoxylic acid can be found primarily in blood, cerebrospinal fluid (CSF), feces, and urine, as well as in all human tissues.
Glyoxylic acid is found in all living species, from bacteria to humans.

In humans, glyoxylic acid is involved in several metabolic pathways, including alanine metabolism and metabolism of glycine and serine.
Glyoxylic acid is also implicated in a variety of metabolic disorders, some of which include lactic acidemia, pyruvate carboxylase deficiency, 3-phosphoglycerate dehydrogenase deficiency, and non-ketotic hyperglycinemia.
In addition, glyoxylic acid has been found to be associated with transurethral resection of the prostate and primary hyperoxaluria I.
Glyoxylic acid or oxoacetic acid is an organic compound.
Along with acetic acid, glycolic acid, and oxalic acid, glyoxylic acid is one of the C2 carboxylic acids.
Glyoxylic acid is a colorless solid that occurs naturally and is industrially useful.

Determining glyoxylic acid in the electrochemical synthesis reaction mixture is a difficult process because it contains carboxylic acids with convergent acidic dissociation constants and other compounds carrying organic groups that can undergo oxidation or reduction, such as ethylene glycol, glyoxal, and glycolic acid.
Therefore, the quantitative determination of glyoxylic acid using conventional analytical methods such as acid-base or redox titrations, separation or precipitation is expected to be very difficult.

This article provides a simple, reliable and inexpensive spectrophotometric method for the direct determination of glyoxylic acid in such reaction mixtures without the need for separation. The method is based on the formation of a colored chromogen product between glyoxylic acid and tryptophan when they react, according to a reaction discovered by Hopkins and Cole in 1901.
They suggested that one molecule of glyoxylic acid reacts with two molecules of tryptophan, giving it a deep red-violet color that absorbs at 540-545 nm.
This reaction takes place in an anhydrous environment, ideally committed with concentrated sulfuric acid.

A number of reports have been published on the replacement of formaldehyde with glyoxylic acid as a reducing agent.
Not all of them can be discussed here, so only one selection will be presented.
In early 1991, Honma et al.
investigated electroless copper plating using glyoxylic acid as a reducing agent.
However, the authors still used EDTA in their baths.
Bath solution and operating conditions: CuSO4 5H2O 0.03 mol/L, glyoxylic acid 0.20 mol/L, EDTA 0.25 mol/L, 2,2'-bipyridyl 10 mg/L, pH adjusted to 12.5 with sodium hydroxide and temperature 60 °C.
Å indicates the effect of glyoxylic acid concentration, Ç pH value and É bath temperature on the coating speed.
It can be seen that the coating rate increases with glyoxylic acid, glyoxylic acid concentration, pH value and bath temperature, respectively.
Coating rates are significantly faster and bath stability under standard operating conditions is superior to formaldehyde baths.
It was also confirmed that the precipitation homogeneity of the entire wall covering was superior to that of the formaldehyde bath.
Glyoxylic acid is a non-volatile chemical that shows good reducing power in electroless copper plating and therefore can replace formaldehyde and alleviate formaldehyde-related environmental problems.

Glyoxylic acid is a reagent for the synthesis of sulfinilmaleate.
Glyoxylic acid is one of the chemicals used in the Hopkins Cole reaction.
Glyoxylic acid is added to control the presence of tryptophan in proteins.
Glyoxylic acid is condensed with urea and 1,2-diaminobenzene to form heterocycles.
Glyoxylic acid also undergoes Friedel-Crafts and cyclocondensation reactions to form bis(pentamethylphenyl) acetic acid and a beta-carboline, respectively.
Glyoxylic acid is used in the synthesis of a sulfinilmaleate, which serves as an effective dienophil for enantioselective Diels-Alder cycloadditions

Glyoxylic acid (ethanedial) (C2H2O2) is produced from the oxidation of acetaldehyde (ethanal) (C2H4O) with concentrated nitric acid (HNO3).
Glyoxylic acid can also be produced from the catalytic oxidation of ethylene glycol (ethanediol) (CH2OHCH2OH).
Glyoxylic acid is used as crosslinking agent for vinyl acetate/acrylic resins, disinfectant, gelatin curing agent, textile finishing agent (permanent press cotton, rayon fabrics), wet resistant additive (paper coatings).
Glyoxylic acid is produced by nitric acid oxidation of glyoxalin.
Glyoxylic acid is used for the manufacture of synthetic flavors, agrochemicals and pharmaceutical intermediates.

The basic reaction equation for the production of glyoxal from acetaldehyde is:

2C2H4O (Acetaldehyde) + 2HNO3 ^ 2C2H2O2 (Glyoxal) + N2O + H2O

The stoichiometric relationship indicates that the complete reaction will result in 0.543 tons of N2O per tonne of glyoxal.
Under commercial conditions, the N2O yield per ton of glyoxal is about 0.52 tons.

Glyoxylic acid production is a batch process in which nitric acid is reduced to NO and NO, with NO recovered as HNO3 in the process.
N2O is produced through a secondary reaction in which glyoxal is converted to oxalic acid (COOH)2 during the production process.

The putative factors for glyoxal and glyoxylic acid production are shown in Table 3.6.
Emissions can be estimated using the same approach as described for caprolactam above.
To use default destruction factors, inventory compilers must verify that the reduction technology is installed at separate sites and is operating year-round.

Glyoxylic acid, an organic acid, is used in pickling processes by combining the commonly used formic and sulfuric acid.
The effects of glyoxylic acid on chromium adhesion to the skin, reduction of chromium supply in wastewater, and leather quality were investigated.
In the study, two different combinations defined by treatment are applied to Turkish sheepskins made by targeting clothing leather.
The samples taken are subjected to physical tests and chemical analyzes and these test results are considered statistically according to the Possible Blocks Method

Glyoxylic acid, a minor dicarboxylic acid, has been detected in the atmosphere at measurable levels and is suspected of being present in enclosed air environments.
Glyoxylic acid is produced through the ozonolysis of several high-volume production compounds commonly found indoors.
Glyoxylic acid was tested in the combined irritation and local lymph node assay (LLNA). Tested positive with an EC3 value of 5.05% on the LLNA.
Significant increases were observed in the B220+ cell population in the drained lymph nodes. No changes were identified in the IgE+B220+ cell population in drained lymph nodes or in total serum IgE levels; this indicates that glyoxylic acid functions as a T-cell-mediated contact sensitizer.
Exposure to volatile organic compounds (VOCs) similar to glyoxylic acid emitted from building materials, cleaning formulations or other consumer products and/or interior chemistry has been associated with adverse health effects.
These results may provide an explanation for some of the adverse health effects associated with exposure to indoor air.

Low molecular weight dicarboxylic acids, such as glyoxylic acid, have been identified as important components of the organic fraction of atmospheric particulate matter in remote and polluted areas, and their measurable levels have been documented in a rural area of ​​Georgia during the summer months.
Glyoxylic acid, a volatile organic compound (VOC), is produced from the ozonolysis of acrolein, acrylic acid, maleic acid and cinnamic acid.
Acrylic acid and acrolein are classified as some of the most dangerous compounds for human health and ecosystems.
Both are considered high production volume chemicals, with annual production volumes in excess of £1 million.
Acrylic acid is used in the manufacture of carpet resins and floor adhesive resins.
Glyoxylic acid is also an intermediate in the production of acrolein, and other indoor sources include: varnishes, paint coatings, plastics, textiles and paper polishes.
Acrylic acid and acrolein have also been detected in consumer products, building materials or furniture that contribute to indoor air pollution.
Maleic acid is also considered a high production volume chemical, while acrylic acid or acrolein is considered less hazardous.
Glyoxylic acid is used in the manufacture of synthetic resins and rubber adhesives that contribute to indoor air pollution.

Glyoxylic acid has also been observed as an oxidation product of urocanic acid, a UV chromophore found in the skin.
While the specific yields of glyoxylic acid in the gas phase for these reactions are unknown, it is anticipated that the concentrations may be large enough to warrant further studies investigating the health effects associated with exposure to this compound.
Although the presence of glyoxylic acid has been widely documented in the external environment, studies investigating its presence in the indoor environment are lacking.
Since glyoxylic acid is a reaction product of ozone and its main compounds are commonly found in products used indoors, it is anticipated that glyoxylic acid will be found indoors, but this research has not yet been done.

The focus of these studies is to further identify potential adverse effects associated with glyoxylic acid exposure by examining the potential for irritation and sensitization after dermal exposure to glyoxylic acid using a combined mouse LLNA.
Subsequent studies have also been undertaken in an attempt to classify glycosylic as a T-cell-mediated or IgE-mediated sensitizer.

Glyoxylic acid is an important intermediate of organic chemical and can produce dozens of fine chemical products.
Currently, the manufacturing process is mostly in the manufacture of 30 to 50% glyoxylic acid solution.
Due to the availability of large amounts of water, the solution of glyoxylic acid in aqueous solution is difficult to meet the needs of pharmaceuticals, food and other industries that require high-purity crystalline glyoxylic acid products.
Experiments show that the synthesis process is reasonable and feasible, using crystalline glyoxylic acid as raw material in the production of allantoin instead of glyoxylic acid solution.
Compared with other synthetic methods reported in the literature, this method has the advantages of simple technology and high yield.
Solvent inspection results show that solvent polarity has some influence on reaction results.
The polarity is too strong and too weak to be suitable for reaction.
A mixed solution of tetrahydrofuran and ethanol is suitable reaction solvent.

Glyoxylic acid is a carboxylic acid.
The priming hazard had explosive consequences for nitric acid and glyoxal to produce glyoxylic acid.
Carboxylic acids donate hydrogen ions if there is a base to accept them.
They react this way with all bases, both organic (e.g. amines) and inorganic.
Their reaction with bases, called "neutralization", is accompanied by the evolution of a significant amount of heat.
Neutralization between an acid and a base produces water plus a salt.
Carboxylic acids with six or less carbon atoms are freely or moderately soluble in water; Those with more than six carbons are sparingly soluble in water.
The soluble carboxylic acid dissociates to some extent in water to yield hydrogen ions.
Therefore, solutions of carboxylic acids have a pH of less than 7.0.
Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve when neutralization forms a soluble salt.

Glyoxylic acids and liquid or molten carboxylic acids in aqueous solution can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions in principle also occur for solid carboxylic acids, but are slow if the solid acid remains dry.
Even "insoluble" carboxylic acids can absorb enough water from the air and dissolve enough in air to corrode or dissolve iron, steel and aluminum parts and containers.
Glyoxylic acids, like other acids, react with cyanide salts to produce gaseous hydrogen cyanide.
The reaction is slower for dry, solid carboxylic acids.
Insoluble carboxylic acids react with cyanide solutions to cause the release of gaseous hydrogen cyanide.
Flammable and/or toxic gases and heat are produced by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides and sulphides.
Glyoxylic acids also react with sulfides, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2) to produce flammable and/or toxic gases and heat, especially in aqueous solution.
Their reaction with carbonates and bicarbonates produces a harmless gas (carbon dioxide), but still heats it.
Like other organic compounds, carboxylic acids can be oxidized with strong oxidizing agents and reduced with strong reducing agents.
These reactions produce heat.
A wide variety of products are possible.

Glyoxylic acid, also known as xoacetic acid, is one of the C2 carboxylic acids, any of a class of organic compounds in which a carbon (C) atom is bonded to an oxygen (O) atom via a double bond and a hydroxyl. Connect the (-OH) group with a single bond.
Glyoxylic Acid contains an aldehyde functional group and the chemical formula is usually defined as OCHCO2H.
The aldehyde functional group is not observed in solution or as a solid and generally exists mainly as hydrates with electron withdrawing substituents.
Therefore, the chemical formula of Glyoxylic Acid is generally defined as the monohydrate, just like (HO)2CHCO2H.

Scientists at Creative Proteomics use a highly quantitative method with high performance liquid chromatography (HPLC) to determine Glyoxylic Acid levels in a variety of samples, including Plant and more.
High Performance Liquid Chromatography (HPLC) using a differential refractive index detector (RID) to determine Glyoxylic Acid levels in many biological samples.
This Methodology provides accurate, reliable and reproducible results of Glyoxylic Acid measurement enabling analysis of Glyoxylic Acid levels in vitro and in vivo.

When in solution at neutral pH, Glyoxylic Acid exists in the form of glyoxylate, which is the conjugate base of glyoxylic acid.
Glyoxylic acid is an intermediate in the glyoxylate cycle, an anabolic pathway that occurs in plants, bacteria, protists, and fungi, which allows cells to use simple carbon compounds as a carbon source when complex sources such as glucose are not available.
Glyoxylic acid is also the byproduct of the amidation process for the biosynthesis of several amidated peptides.
Glyoxylic Acid can also be used to check for the presence of tryptophan in protein by the Hopkins Cole reaction, also known as the Glyoxylic Acid reaction, and a chemical reaction used to detect the presence of tryptophan in proteins.

The Russian-Polish botanist M. Tswett is generally considered to be the first to establish the principles of chromatography.
In an article he presented in 1906, Tswett described how he filled a glass tube with chalk powder (CaCO3) and separated the chlorophyll into layers of different colors by allowing a solution of ether chlorophyll to flow through the chalk.
He called this technique "chromatography". Basically, chromatography is a technique used to separate components present in a sample.
High Performance Liquid Chromatography (HPLC) is a method that can separate non-volatile, thermally unstable and polar components individually or as a mixture.
HPLC is a type of chromatography that is considered an indispensable analytical technique, especially in the field of organic chemistry, due to its wide application range and quantitative accuracy.
Glyoxylic acid is also widely used as a preparation technique for the isolation and purification of target components in mixtures.

Glyoxylic acid can be used for hair care and treatment.
More precisely, allantoin synthesized from glyoxylic acid can be used as a special additive to hair care products with good results for hair care.

2-oxo monocarboxylic acid, an acetic acid that carries an oxo group at the alpha carbon atom, is glyoxylic acid or oxoacetic acid.
Glyoxylic acid is an organic compound; It is also an industrially useful, naturally occurring colorless solid.
A human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, and a mouse metabolite are involved in glyoxylic acid.
Glyoxylic acid is a 2-oxo monocarboxylic acid, an aldehyde acid and a glyoxylate conjugate acid.
This compound is used in the following products: cosmetics and personal care products.
Other releases of this material are likely to occur from the environment:
indoor use as a processing aid.

Hydrogen ions are donated by carboxylic acids if there is a base to host them.
They react this way with all bases, both organic (e.g. amines) and inorganic.
Their basic reaction, called "neutralization", is followed by the production of large amounts of heat.
Although the structure of glyoxylic acid is described as having a functional aldehyde group, in some cases the aldehyde is only a minor component of the most common type.
Instead, it also occurs as a cyclic dimer or a hydrate.

In an aqueous solution, carboxylic acids and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and metal salts.
In general, such reactions also occur for solid carboxylic acids, but are slow if the solid acid remains dry.
Glyoxal can be oxidized to glyoxylic by hot nitric acid, but this reaction is extremely exothermic and susceptible to thermal runaways.
Also, the primary by-product is oxalic acid; Ozonolysis of maleic acid is also successful.
And "insoluble" carboxylic acids can absorb enough water from the air and dissolve enough in glyoxylic acid to corrode or melt iron, steel and aluminum sections and vessels.

Glyoxylic acid is a glyoxylate cycle intermediate that allows fatty acids to be converted to carbohydrates by animals such as bacteria, fungi and plants.
The glyoxylate cycle is initiated by the isocitrate lyase process, which converts isocitrate to glyoxylate and succinate.
The reaction is slower for dry, strong carboxylic acids. Insoluble carboxylic acids react with cyanide solutions to induce the release of gaseous hydrogen cyanide.
Reactions of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides and sulphides produce flammable and/or toxic gases and heat.

Glyoxylic acid is typically subjected to an electrophilic aromatic substitution reaction with phenols, a versatile step in the synthesis of many other compounds.
Contact may cause severe eye and skin burns; exposure to vapor may cause eye and skin irritation.
As a clear formulation process, the reaction sequence in which glyoxylic acid reacts with the phenolic component, guaiacol, followed by oxidation and decarboxylation provides a pathway for vanillin.
Part of the Hopkins-Cole reaction is glyoxylic acid, which is used to probe the presence of tryptophan in proteins.

Glycolic acid is an attractive raw material used as a dyeing and tanning agent in the textile industry, flavoring and preservative in the food processing industry, and skin care agent in the pharmaceutical industry.
It is also used for the production of glyoxylic acid, polyglycolic acid and other biocompatible copolymers.
Glycolic acid can be isolated from natural sources such as sugar cane, sugar beet, pineapple or melon, but is also chemically synthesized by the newly formed hydrogenation of oxalic acid or the hydrolysis of formaldehyde-derived cyanohydrin.
Ethylene glycol is a relatively inexpensive starting material for the production of glycolic acid by an oxidation reaction.
However, the chemical oxidation reaction of ethylene glycol has some disadvantages, such as the formation of formaldehyde and other compounds as by-products.
One of the preferred methods to overcome such disadvantages of chemical synthesis for glycolic acid production is to use enzymatic production instead of chemical synthesis.
The use of microbial enzymes also has the great advantage of promoting simple and environmentally friendly industrial scale production.
Therefore, we designed a new enzymatic method for the production of glycolic acid from ethylene glycol using two microbial oxidases; The ethylene glycol is first converted to glycolaldehyde by an ethylene glycol oxidizing enzyme, and the resulting glycolaldehyde is then oxidized to glycolic acid by an aldehyde oxidase.

 

IUPAC NAME :

2-oxo acetic acid

2-oxoacetic acid

Acetic acid, 2-oxo-

glyocylic acid

glyoxyl acid

GLYOXYLIC ACID

Glyoxylic acid


SYNONYMS:

206-058-5 
298-12-4 
741891 
Acetic acid, 2-oxo- 
Acide glyoxyl 
Acide glyoxylique 
a-Ketoacetic acid
formylformic acid
Glyoxyl acid 
Glyoxylic acid 
 

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