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CAS NUMBER: 18996-35-5
EC NUMBER: 242-734-6
MOLECULAR FORMULA: C6H7O7Na
Monosodium citrate is an acid salt of citric acid.
Monosodium citrate can be prepared by partial neutralisation of an aqueous solution of sodium bicarbonate or carbonate with citric acid.
Monosodium citrate is highly soluble in water and practically insoluble in ethanol.
Monosodium citrate is used as an anticoagulant in donated blood.
Monosodium citrate is used as an alkalinizing agent.
Monosodium citrate is a monobasic salt of citric acid.
Monosodium citrate is produced by partial neutralisation of citric acid with a high purity sodium source and subsequent crystallization or spray drying.
Monosodium citrate is supplied as anhydrous material.
The properties of this partial neutralised salt are based on its intermediate position between citric acid and the neutral or weakly alkaline trisodium citrate.
Therefore monosodium citrate is used if a buffering effect is required or if citric acid is considered to be too aggressive for the formulation.
Monosodium citrate is also less hygroscopic than citric acid, thus less prone to caking and preferred in critical formulations such as dry blends, instant preparations or tablets.
Monosodium citrate is a white, odourless, fine or crystalline granular powder with slightly acidic taste.
Monosodium citrate is easily soluble in water and practically insoluble in ethanol.
Monosodium citrate is used whenever a buffering effect compared to the pure acid is required (e.g. acid sensitive ingredients are present).
For preparations which are sensitive to water the anhydrous monosodium citrate can replace water containing ingredients.
Due to Monosodium citrates high decomposition temperature (>200°C) and low water content (<0.4%), Monosodium citrate is also the preferred acid source in baking powder or blowing agents in order to prevent premature reaction between acid and alkaline source.
When used as endothermic blowing agent in the plastics industry, Monosodium citrate is the preferred food grade, non-toxic alternative to exothermic blowing agents such as azo compounds (e.g. azodicarbonamide), hydrazine derivatives or semicarbazides.
Monosodium citrate is specifically used in this application due to its approx. 10°C lower decomposition temperature compared to monosodium citrate F3500 and is also recommended for other applications where a quicker dissociation is required.
Furthermore Monosodium citrate can be used to reduce the acrylamide content in heat treated, starch containing food products by up to 80%.
By using monosodium citrate the safety and quality of snacks, cereals, bakery products and potato products such as French Fries can be optimised without influencing the production process.
Monosodium citrate is the monobasic sodium salt of citric acid.
Monosodium citrate has a sour taste similar to citric acid, and is salty as well.
Monosodium citrate is often used as a food preservative, and as a flavoring in the food industry.
In the pharmaceutical industry Monosodium citrate is used to control pH.
Monosodium citrate may be used as an alkalizing agent, buffering agent, emulsifier, or as a strong sequestering agent.
Because Monosodium citrate is less water-loving than citric acid, it may be preferable for dry formulations and tablets.
Monosodium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones.
When Monosodium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load.
The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate.
Monosodium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate.
Monosodium citrate is used as a food additive (E 332) to regulate acidity.
Monosodium Citrate is partially neutralized and occupies an intermediate position between citric acid, and the neutral or weakly alkaline trisodium citrate.
Monosodium Citrate is used if a buffer effect is required or if citric acid is considered to be too aggressive for the formulation.
Monosodium citrate is used in critical formulations such as dry blends, instant preparations or tablets.
Monosodium citrate is an acid salt with two open spots on the citrate anion, Monosodium citrate is used as a relatively strong sequestrant.
Monosodium citrate can perform as a biological buffering agent because Monosodium citrate resists changes in pH.
Monosodium citrate is one of a series of compounds responsible for the physiological oxidation of fats, carbohydrates and proteins to carbon dioxide and water.
Monosodium citrate is also named sodium dihydrogen citrate,monosodium citrate.
Monosodium citrate occurs as white crystalline powder with a slightly acidic taste,the PH value is 3.4-3.8.
Monosodium citrate is freely soluble in water and practically insoluble in ethanol.Monosodium citrate anhydrous should be kept in airtight container in case the product is affected with damp.
Monosodium citrate anhydrous is used for acid regulator in food industry,cleaning agent in detergent industry and filling agent & foaming agent in plastic industry.
Monosodium citrate anhydrous is one foaming agent formulation in similar performance as OBSH.
Monosodium citrates gas released is 110ml/g reacted in 200 centigrade silicon oil but 220-250ml/g for ordinary AC foaming agent.
The gas released for monosodium citrate anhydrous is far less than the ordinary one,so that it can be used in automobile ceiling leather or extrusion molding rubber.
Monosodium citrate, or sodium dihydrogen citrate, is an acid salt with the chemical formula NaH2C6H5O7, or C3H4OH(COOH)2COONa.
Since Monosodium citrate has two remaining open spots on the citrate anion, Monosodium citrate is used as a relatively strong sequestrant.
Monosodium citrate is used to prevent platelet clumping in blood samples.
Monosodium citrate is one of the 3 citric acid salts.
Monosodium citrate acts as a buffering agent and sequestrant.
Monosodium citrate is also employed as a reductant and stabilizer in the preparation of b>Fe3O4 platinum core/shell particles.
Monosodium citrate is used in electrochemical reduction of proton at carbon fiber electrode in the presence and absence of platinum nanoparticles.
Monosodium citrate plays a useful role in characterization of carbon-based electrode materials as cathode in half-cell configuration.
Monosodium citrate has the chemical formula of Na3C6H5O7.
Monosodium citrate is some times referred to simply as sodium citrate, though sodium citrate can refer to any of the three sodium salts of citric acid.
Monosodium citrate possesses a saline, mildly tart flavor. For this reason, citrates of certain alkaline and alkaline earth metals are commonly known as "sour salt" (occasionally citric acid is erroneously termed sour salt).
Monosodium citrate is a buffer and sequestrant that is the trisodium salt of citric acid.
Monosodium citrate is also known as citrate of soda, the white crystals or granular powder was obtained by neutralizing citric acid with sodium carbonate.
Monosodium citrate is soluble in water but less so in alcohol.
Monosodium citrate was used as a preservative in albumen papers.
Monosodium citrate is some times used as an acidity regulator in drinks, and also as an emulsifier for oils when making cheese.
Monosodium citrate allows the cheeses to melt with out becoming greasy.
Monosodium citrate showed that sodium phosphate keeps the water and fat droplets mixed when the cheese is melted.
Monosodium citrate is used Monosodium citrate, which has the same effect and is easier to find.
The resulting texture is as smooth as melted American cheese, but as complex and intense in flavor as any of your favorite cheeses.
Monosodium citrates are used as acidity regulators in food and drinks, and also as emulsifiers for oils.
They enable cheeses to melt without becoming greasy.
Monosodium citrate reduces the acidity of food as well.
Monosodium citrate is used to prevent donated blood from clotting in storage.
Monosodium citrate is also used in a laboratory, before an operation, to determine whether a person's blood is too thick and might cause a blood clot, or if the blood is too thin to safely operate.
Monosodium citrate is used in medical contexts as an alkalinizing agent in place of sodium bicarbonate, to neutralize excess acid in the blood and urine.
Monosodium citrate has applications for the treatment of metabolic acidosis and chronic kidney disease.
Monosodium citrate is a salt of citric acid.
Monosodium citrate is an organic acid that occurs naturally in plants and animals.
Monosodium citrate occurs as colorless crystals or white powder, and is commonly found in citrus fruits, corn, and other foods.
Two ounces of orange juice has about 500 mg, according to the FDA.
Monosodium citrate is an alpha-hydroxy acid and a beta-hydroxy acid.
Monosodium citrate is often used as a pH adjuster and water softener.
Monosodium citrate is common in liquid laundry detergent, though it is also often used in food and medical products.
Monosodium citrate helps control the acidity of ice cream, candy, jelly, and gelatin desserts.
Monosodium citrate is also in dozens of personal care products, such as shampoo, conditioner, sunscreen, facial moisturizer, makeup, baby wipes, soap, and other products.
Monosodium citrate production occurs by neutralizing citric acid with sodium hydroxide.
Monosodium citrate may be produced from fruits or other foods, through yeast fermentation, and by solvent extraction.
Most large-scale production occurs by fermenting molasses or other sugar stocks with Aspergillus niger.
The liquid is separated by filtration, and the citric acid is separated by precipitation.
Monosodium citrate is usually offered commercially as the white, crystalline trisodium citrate dihydrate.
Monosodium citrate is a urine alkalinizing agent.
After absorption Monosodium citrate is metabolized to produce bicarbonate.
Monosodium citrate can be used to treat metabolic acidosis, where the generated bicarbonate buffers excess hydrogen ions in the blood, raising its p H.
Monosodium citrate can also be used to alkalinize urine by promoting urinary excretion of free bicarbonate and therefore hydrogen ions.
Monosodium citrate can be used to prevent development of renal stones that develop in acidic urine Fan et al (2001), and in solution is administered as a bladder irritant during urological surgery.
Monosodium citrate is administered rectally as an osmotic laxative.
Monosodium citrate is widely and particularly used in phosphate-free liquid detergents and cleansers.
As Monosodium citrate is a natural constituent and a ubiquitous metabolite of living organisms it is not surprising that its environmental behavior is very favorable.
In fact, this complexing agent is readily biodegradable and weakly toxic to aquatic organisms.
The acute toxicity is very low with LC50 ≥ 440 mg/l for fish, EC50 ≥ 1500 mg/l for daphniae and EC50≥ 1000 mg/l for algae .
The available long-term ecotoxicity data (algal NOEC = 640 mg/l, daphnia NOEC = 80 mg/l) underline the ecologically favorable characteristics of this cleaning agent.
Monosodium citrate is the sodium salt of citrate with alkalinizing activity.
Upon absorption, Monosodium citrate dissociates into sodium cations and citrate anions; organic citrate ions are metabolized to bicarbonate ions, resulting in an increase in the plasma bicarbonate concentration, the buffering of excess hydrogen ion, the raising of blood pH, and potentially the reversal of acidosis.
In addition, increases in free Monosodium citrate load due to sodium citrate administration may increase intravascular blood volume, facilitating the excretion of bicarbonate compounds and an anti-urolithic effect.
Monosodium citrate is a salt derivative of citric acid.
Monosodium citrate is naturally occurring.
Monosodium citrate is chemically produced by the same process as citric acid .
Commercially, Monosodium citrate is produced microbiologically mostly from the sugar refinery byproduct, molasses.
Monosodium citrate from fermentation is neutralized with sodium hydroxide and crystalized in the production of sodium citrate.
Monosodium citrate can be produced microbiologically, directly from cultures of the yeast Yarrowia lipolytica, since this organism can tolerate a higher pH .
Monosodium citrate is routinely added to blood as Monosodium citrate is removed from animal carcasses during processing.
The addition of Monosodium citrate keeps blood flowing and minimizes extensive cleaning of clotted blood from extraction and collection equipment.
Anticoagulants have been considered incidental to blood meal production and part of the standard identity for blood, since a substantial portion of added sodium citrate is removed during manufacturing.
Furthermore, Monosodium citrate may not be reliably possible for manufacturers to determine if anticoagulants have been added to blood for blood meal production.
Monosodium citrate is routinely used as an anticoagulant for blood collection during slaughtering and processing of livestock.
Monosodium citrate may be applied to the sticking knife, to improve blood flow during bleeding or added to collection or storage tanks to improve stability.
Blood products are separated, cooked and dried into powder at the meat processing plant or further processing plants.
Storage and transfer of blood requires refrigeration.
These differ in clotting or no clotting, drying steps and the separation of red blood cells.
Some examples are batch dried, ring dried and spray dried rendering.
Batch dry rendering is simple cooking of whole blood with indirect high-pressure steam to remove moisture.
Ring dried rendering requires coagulation and separation of the coagulated blood from fluids.
In spray drying, which requires the use of sodium citrate, flowing blood treated with anticoagulant is sprayed into a warm chamber where Monosodium citrate instantly becomes a fine powder.
Drying method affects the characteristics and quality of the final product.
With meat inspection, blood meal can also be used for conventional human and animal nutrition.
In addition to simply drying clotted whole blood, blood may be fractionated during processing to separate red blood cells from plasma or remove specific higher valued products before dried meal is produced
Monosodium citrateis the sodium salt of citric acid.
Monosodium citrate has been produced for many years in high volumes and added to processed food and beverages, used in pharmaceutical preparations and in household cleaners as well as in special technical applications .
Monosodium citrate is a well-known component of carbohydrate metabolism in living organisms, and is found naturally in soil and water.
Monosodium citrate degrades readily when in contact with a variety of microorganisms that are found in soil, natural waters and sewage treatment systems .
Monosodium citrate is of low acute toxicity to freshwater fish, daphnia and algae and a few marine species, e.g. crabs, green algae, diatoms.
Similarly, Monosodium citrate has no obvious toxic potential against protozoans and many species or strains of bacteria including activated sludge micro303 organisms.
Monitoring data has shown that while raw sewage contains up to 10 milligrams citrate/liter, background concentrations in river water range between < 0.04 and maximally 0.2 mg/l, and between 0.025 and 0.145 mg/l in Atlantic coast surface seawater.
However, these water concentrations for citrate do not only arise from manmade citric acid.
Monosodium citrate is extremely widespread in plant and animal tissues and fluids and every single eukaryotic organism produces citric acid and excretes part of it to the environment.
Monosodium citrate is a combination medicine that helps make your urine less acidic.
Sometimes called a urinary alkalizer, Monosodium citrate is used to treat acidosis or to prevent gout or kidney stones.
Monosodium citrate may also be used for purposes not listed in this medication guide.
Monosodium citrate dihydrate is the tribasic salt of citric acids.
Monosodium citrate is produced by tamralization and subsequent crystallization of high purity sourced citric acids.
Monosodium citrate occurs as white, crystals or white crystalline powder.
Monosodium citrate is an odorless substance with a pleasant salty taste.
Monosodium citrate is a moist shear soluble, highly water-soluble and practically non-educational substance in ethanol.
Monosodium citrate is a non-dihydrate, low-activity neutral salt.
Monosodium citrate is as normally stored.
Monosodium citrate is degradable by use and can be used in conjunction with preparing and cooking according to bioavailability.
Monosodium citrate dihydrate is widely used, in soft drinks and various applications, as a sowing buffer, in situ veulsifier, growable agent, and in medicine, it can be used in serum and preparation.
There is an application in Anhydrus that is easier than people.
In combination with improves pH control, complexes trace metal ions, complexes, modifies or enhances their techniques in cheese, gives their cheeses selection, gives uniform properties, stabilizes gelling in applied cream, aids in flavor in cheese, provides flesh color stabilization, on meat surface in the formation of forming phosphates.
Calciumizes, buffers pH, maintains active ingredient stability, acts as astringency-reducing, plaque-inducing and anticoagulating agent, and acts as an alkalizing agent for blood and urine.
The pH buffer breeds methyl parabens.
Monosodium citrate is chiefly used as a food additive, usually for flavor or as a preservative.
Monosodium citrate E number is E331.
Monosodium citrate is employed as a flavoring agent in certain varieties of club soda.
Monosodium citrate is common as an ingredient in bratwurst, and is also used in commercial ready-to-drink beverages and drink mixes, contributing a tart flavor.
Monosodium citrate is found in gelatin mix, ice cream, yogurt, jams, sweets, milk powder, processed cheeses, carbonated beverages, and wine, amongst others.
Monosodium citrate can be used as an emulsifying stabilizer when making cheese.
Monosodium citrate allows the cheese to melt without becoming greasy by stopping the fats from separating.
As a conjugate base of a weak acid, citrate can perform as a buffering agent or acidity regulator, resisting changes in pH.
Monosodium citrate is used to control acidity in some substances, such as gelatin desserts.
Monosodium citrate can be found in the milk minicontainers used with coffee machines.
The compound is the product of antacids when they are dissolved in water.
The pH of a solution of 5 g/100 ml water at 25 °C is 7.5 – 9.0.
Monosodium citrate is used as anticoagulin,chemical reagent,food additive,developer,buffer emulsifying agent, stabilizing agent and used in nonhydrogen electroplation as well as widely in tail gas absorption process of sulfur dioxide for chemical and metallurgy industries.
Monosodium citrate may refer to any of the sodium salts of citric acid (though most commonly the third):
Monosodium citrate is used in ice cream to keep the fat globules from sticking together.
Monosodium citrates have this property.
Monosodium citrate is also an anti-coagulant.
As a buffering agent, Monosodium citrate helps maintain pH levels in soft drinks.
As a sequestering agent, Monosodium citrate attaches to calcium ions in water, keeping them from interfering with detergents and soaps.
Monosodium citrate acts to chelate or remove available calcium required for the fibrinogen to fibrin conversion preventing blood coagulation (clotting).
In chelation, Monosodium citrates to the dentate carboxyl moieties of citrate .
Blood can become recalcified through cell breakdown and bacterial degradation.
When Monosodium citrate is available for fibrinogen to fibrin conversion, clotting resumes.
After bleeding warm blood is only stable for approximately eight hours.
Without refrigeration, fresh whole blood must be processed and dried shortly after bleeding.
Even with the addition of Monosodium citrate, animal byproduct producers reduce whole blood degradation, bacterial contamination and further clotting by chilling stored blood with stirring prior to inspection and further downstream processing.
This is important, if blood must be transported to another facility.
Chilled whole blood held at 2-3 106 oC is stable for approximately 120 hours which facilitates off site processing .
Monosodium citrate is the sodium salt of citric acid.
Monosodium citrate is highly mobile in the environment and partitions to the aquatic compartment.
Monosodium citrate is rapidly degraded microbiologically in sewage works, in surface waters and in soil.
Generally, Monosodium citrate and its salts have not been judged by the EPA or Organization for Economic Cooperation to be substances that present a hazard to the environment
Monosodium citrate is of low acute toxicity to freshwater fish, daphnia, algae and marine species.
Similarly, Monosodium citrate has no obvious toxic potential against protozoans and many species or strains of bacteria including activated sludge micro-organisms
Monosodium citrate is produced biologically by the same submerged fermentation process with starch/sucrose253 based media as citric acid, but is neutralized in the presence of appropriate alkaline solutions (e.g., sodium hydroxide or sodium carbonate) and crystallized.
Several agricultural waste residues and by-products are used as production substrates for Monosodium citrate production including molasses, fruit pomace waste, wheat bran, coffee husk, and cassava bagasse.
Most of the substrates would otherwise be composted, but represent a value-added component in sodium citrate production .
USES:
Monosodium citrate is a buffer and sequestrant obtained from citric acid as sodium citrate anhydrous and as Monosodium citrate dihydrate or sodium citrate hydrous.
The crystalline products are prepared by direct crystallization from aqueous solutions.
Monosodium citrate anhydrous has a solubility in water of 57 g in 100 ml at 25°c, while sodium citrate dihydrate has a solubility of 65 g in 100 ml at 25°c.
Monosodium citrate is used as a buffer in carbonated beverages and to control ph in preserves.
Monosodium citrate improves the whipping properties in cream and pre- vents feathering of cream and nondairy coffee whiteners.
Monosodium citrate provides emulsification and solubilizes protein in processed cheese.
Monosodium citrate prevents precipitation of solids during storage in evaporated milk.
Monosodium citrate improves rehydration which reduces the cooking time.
Monosodium citrate functions as a sequestrant in puddings.
Monosodium citrate functions as a complexing agent for iron, calcium, magnesium, and aluminum.
Monosodium citrates typical usage levels range from 0.10 to 0.25%.
Monosodium citrate is also termed trisodium citrate.
Monosodium citrate has been employed:
-as reductant and stabilizer during the synthesis of Fe3O4 Pt core/shell particles
-in characterization of carbon-based electrode materials as cathode in half-cell configuration
-in electrochemical reduction of proton at carbon fiber electrode in the presence and absence of Pt nanoparticles
APPLICATIONS:
Monosodium citrate is chiefly used as a food additive E331, usually for flavor or as a preservative.
Monosodium citrate is employed as a flavoring agent in certain varieties of club soda.
Monosodium citrate is common as an ingredient in Bratwurst, and is also used in commercial ready to drink beverages and drink mixes, contributing a tart flavour.
As a conjugate base of a weak acid, Monosodium citrate can perform as a buffering agent or acidity regulator, resisting changes in pH.
Monosodium citrate is used to control acidity in some substances, such as gelatin desserts.
Monosodium citrate can be found in the mini milk containers used with coffee machines.
Monosodium citrate is the product of antacids when they are dissolved in water.
Monosodium citrate continues to be used today in blood collection tubes and for the preservation of blood in blood banks.
Monosodium citrate chelates calcium ions in the blood by forming calcium citrate complexes, disrupting the blood clotting mechanism.
Monosodium citrate is used to relieve discomfort in urinary tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative.
Monosodium citrate is a major component of the WHO Oral Rehydration Solution.
CHEMICAL PROPERTIES:
Monosodium citrate is odorless and has a pleasant, acid taste.
Monosodium citrate is anhydrous or contains two molecules of water of crystallization.
TECHNICAL INFORMATIONS:
-Appearance: Crystalline powder
-Physical State: Solid
-Solubility: Soluble in water
-pH: 3.5-4.0 (25° C, 0.25 M in H2O)
-Storage: Store at room temperature
-Melting Point: 208° C
STORAGE:
Store in a well-closed container at a temperature not exceeding 25 C, protected from direct sunlight and Moisture, unless otherwise specified.
SYNONYM:
Sodium dihydrogen citrate
Citric acid monosodium salt
Sodium dihydrogencitrate
sodium 3,4-dicarboxy-3-hydroxybutanoate
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monosodium salt
MFCD00013067
Sodium dihydrogen citrate anhydrous
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:1)
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt
Sodium citrate monobasic
994-36-5
mono sodium citrate
C6H7NaO7
Citric acid 1-sodium salt
SCHEMBL73101
