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EC / List no.: 213-853-0
CAS no.: 1034-01-1
Mol. formula: C15H22O5
Octyl gallate is the ester of 1-octanol and gallic acid.
As a food additive, it is used under the E number E311 as an antioxidant and preservative.
Properties
Octyl gallate is a white powder with a characteristic odor.
Octyl gallate is very slightly soluble in water and soluble in alcohol.
Its solubility in lard is 1.1%.
Octyl gallate darkens in the presence of iron.
Uses:
This antioxidant is used in numerous pharmaceutical, cosmetic, and food products; such as soaps, shampoos, shaving soaps, skin lotions, deodorants, margarine, and peanut butter.
Octyl gallate is a synergistic antioxidant with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA).
Description
Octyl gallate is the ester formed by 1-octanol and gallic acid. Octyl gallate can be used as an antioxidant and preservative to be supplemented with food.
Octyl gallate has been demonstrated to be an effective fungicide being capable of inhibiting the growth of S. cerevisiae and Z. bailii as it can inhibit the fluidity of the cell membrane by acting as a nonionic surface-active agent.
Octyl gallate is also capable of killing both DNA and RNA viruses with relatively moderate cytotoxicity.
For example, it has the potential to treat influenza.
Octyl gallate also has certain bactericidal activity, being capable of treating the infections associated with enterococci.
During the 1940s, propyl gallate and several other alkyl gallates were allowed for use in foods in a number of countries. Since gallic acid contains three phenolic hydroxyl groups, it is a rather potent antioxidant; however, the propyl ester has a significant degree of water solubility.
As a consequence, propyl gallate tends to partition into any water phase which may be present and to complex with iron salts to give bluish-black colors.
Also, its relatively poor resistance to heat degradation makes it ineffective for baking and frying applications.
The higher alkyl gallates (butyl and octyl) are more fat-soluble.
Chemical Properties
White powder
Uses:
Used in the treatment of alcohol dependence.
Octyl gallate is an antioxidant that is used as a preservation agent in a wide variety of foods, oils, and cosmetics.
Octyl gallate is an antioxidant for use in cosmetic and pharmaceutical products and in food products, such as margarine and peanut butter.
Definition
A gallate ester is obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.
General Description
Octyl gallate is an ester of gallic acid which is generally used as an antioxidant in the food and pharmaceutical industries.
Octyl gallate can act against the oxidative damage caused by reactive oxygen species (ROS) in the form of hydroxyl radicals or hydrogen peroxides, and reactive sulfur species (RSS)
Octyl gallate is a gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.
Octyl gallate has a role as a food antioxidant, a plant metabolite, and a hypoglycemic agent.
Where is octyl gallate found?
Octyl gallate is a food additive, preservative, and antioxidant.
Octyl gallate is found primarily in the food and cosmetics industry.
This chemical is used as an antioxidant and can be found in cosmetic and pharmaceutical products as well as in food products such as margarine and peanut butter.
Further research may identify the additional product or industrial usages of this chemical.
What is Octyl gallate?
Octyl gallate is an antioxidant and preservative in food, pharmaceuticals, and cosmetic products, especially those containing oils or fats.
Gallate ester chemicals are used in the food, pharmaceutical, and cosmetic industries as an antioxidant to prevent oils and fats from becoming rancid.
Direct contact with foods or products containing Octyl Gallate may cause symptoms including burning, irritation, and redness.
Direct contact may occur on the skin, lips, or mouth.
Octyl gallate is possible but rare, that ingestion of this substance could cause generalized symptoms such as itching or redness of the skin.
Uses:
Foods
- Broths, instant soups, and gravies
- Instant potato products
- Crisp wheat products
- Marzipan mass and marzipan like products
- Chewing gum
- Flavoring agents, e.g. essential oils
- Margarine
- Peanut butter
- Fats
- Soups
- Sauces
- Cakes
- Pastries
- Dairy blends
Medicines
Skin Care Products / Cosmetics
- Antiperspirants / Deodorants
- Hair sprays, gels, tonics, and lotions
- Make-ups
- Moisturizers
- Shampoos / Conditioners
- Shaving products
- Soaps / Cleansers
- Sunscreens and Self-Tanners
Octyl gallate is an antioxidant (European Community number 311).
Octyl gallate is used as a preservation agent in a wide variety of foods and other non-dietary substances.
Management with an exclusion diet proved effective in both controlling the burning sensation and resolving the erythema of the tongue
Octyl gallate, also known as octyl gallic acid, belongs to the class of organic compounds known as galloyl esters.
These are organic compounds that contain an ester derivative of 3,4,5-trihydroxybenzoic acid.
Based on a literature review a significant number of articles have been published on Octyl gallate.
1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive.
2. Octyl Gallate has antimetastatic activity.
3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug/mL.
4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.
5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM.
6. Octyl gallate has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells.
7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.
Description
Octyl gallate (Progallin O) is widely used as a food additive, with antimicrobial and antioxidant activity.
Octyl gallate (Progallin O) shows selective and sensitive fluorescent property.
Octyl gallate shows a marked antiviral effect against HSV-1, vesicular stomatitis virus (VSV) and poliovirus.
Octyl gallate is a white powder with a characteristic odor.
Octyl gallate is very slightly soluble in water and soluble in alcohol.
Its solubility in lard is 1.1%. Octyl gallate darkens in the presence of iron.
Uses:
This antioxidant is used in numerous pharmaceutical, cosmetic, and food products; such as soaps, shampoos, shaving soaps, skin lotions, deodorants, margarine, and peanut butter.
Octyl gallate is a synergistic antioxidant with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA).
Formula: C15H22O5
Formula Weight: 282.34
Melting point: 96-102°
Storage & Sensitivity: Ambient temperatures.
IUPAC NAMES:
n-Octyl Gallate
Octyl 3,4,5-trihydroxybenzoate
octyl 3,4,5-trihydroxybenzoate
SYNONYMS:
Progallin O
3,4,5-Trihydroxybenzoic acid octyl ester
Gallic acid octyl
Stabilizer GA-8
3,4,5-trihydroxy-benzoicacioctylester
OCTYL 3,4,5-TRIHYDROXYBENZOATE FOR SYNTH
Octyl gallate antioxidant, >=99.0% (HPLC)
n-octylesterof3,4,5-trihydroxybenzoicacid
oktylesterkyselinygallove
N-OCTYL GALLATE
OCTYL 3,4,5-TRIHYDROXYBENZOATE
OCTYL GALLATE
GALLIC ACID OCTYL ESTER
GALLIC ACID N-OCTYL ESTER
Gallic Acid Octyl Eester
Benzoic acid, 3,4,5-trihydroxy-, octyl ester
OCTYL GALLATE(OCTYL 3,4,5-TRIHYDROXYBENZOATE)
OCTYLGALLATE(RG)
n-Octyl gallate, 98+%
Octyl-3,4,5-trihydroxybenzoat
n-OctylGallate>
Octyl gallate CRS
Octyl gallate
Solution in Methanol, 1000μg/mL
Octyl gallate
1034-01-1
Octyl 3,4,5-trihydroxybenzoate
n-Octyl gallate
Progallin O
Stabilizer GA 8
n-Octylgallate
Gallic acid octyl ester
Gallic acid, octyl ester
Gallic acid n-octyl ester
BENZOIC ACID, 3,4,5-TRIHYDROXY-, OCTYL ESTER
Oktylester kyseliny gallove
GA 8 (VAN)
NSC 97419
n-Octyl ester of 3,4,5-trihydroxybenzoic acid
Oktylester kyseliny gallove [Czech]
EINECS 213-853-0
Gallic acid octyl
Stabilizer GA-8
Gallic acid-octyl ester
Gallic acid n-octyl-ester
4-10-00-02005 (Beilstein Handbook Reference
BIDD:ER0271
WLN: QR BQ CQ EVO8
DTXSID4040713
Octyl 3,4,5-trihydroxybenzoate #
CAS-1034-01-1
3,4,5-Trihydroxy-benzoic acid octyl ester
Benzoic acid,4,5-trihydroxy-, octyl ester
Octyl gallate, analytical reference material
n-Octyl ester of 3,5-trihydroxybenzoic acid
octyl 3,4,5-trihydroxybenzoate;Octyl gallate
Octyl gallate, antioxidant, >=99.0% (HPLC)
Octyl gallate, European Pharmacopoeia (EP) Reference Standard
65D
