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Polysorbate 80 (E433) is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements.
Polysorbate 80 (E433) is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach.
Polysorbate 80 (E433) is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating.
CAS Number: 9005-65-6
Molecular Formula: C24H44O6
Molecular Weight: 428.600006103516
EINECS Number: 500-019-9
9005-65-6, 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl octadec-9-enoate, DTXSID10864155, HDTIFOGXOGLRCB-UHFFFAOYSA-N, MFCD00082107, 2-{2-[3,4-Bis(2-hydroxyethoxy)tetrahydro-2-furanyl]-2-(2-hydroxyethoxy)ethoxy}ethyl 9-octadecenoate
Polysorbate 80 (E433) is a nonionic surfactant and emulsifier often used in foods and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.
Tween 80, commonly known as Polysorbate 80 (E433), is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics.
Besides, Polysorbate 80 (E433) commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive.
In laboratory, Polysorbate 80 (E433) is occasionally used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.
Polysorbate 80 (E433) is a polyethylene sorbitol ester, with a calculated molecular weight of 1,310 daltons, assuming 20 ethylene oxide units, sorbitol, and 1 oleic acid as the primary fatty acid.
Polysorbate 80 (E433)s are a series of nonionic surfactants derived from sorbitan esters.
They are soluble or dispersible in water but differ widely in organic and oil solubilities.
Polysorbate 80 (E433) has been widely used in biochemical applications including: solubilizing proteins, isolating nuclei from cells in culture,5 growing of tubercule bacilli,6 and emulsifying and dispersing substances in medicinal and food products.
Polysorbate 80 (E433) has little or no activity as an anti-bacterial agent1 except it has been shown to have an adverse effect on the antibacterial effect of methyl paraben and related compounds.
Polysorbates have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid. They may reduce the activity of many preservatives.
Polysorbate 80 (E433), also known as Tween 80 or E433, is a nonionic surfactant commonly used as an emulsifier, stabilizer, and solubilizing agent in various pharmaceuticals, cosmetics, and food products.
Polysorbate 80 (E433) is derived from polyethoxylated sorbitan and oleic acid.
Polysorbate 80 (E433) is amphiphilic, meaning it has both hydrophilic (water-loving) and lipophilic (fat-loving) properties, which allows it to interact with both water and oil phases, facilitating the formation and stabilization of emulsions.
Polysorbate 80 (E433) has a faint, characteristic odor and a warm, somewhat bitter taste.
Polysorbate 80 (E433) is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
Polysorbate 80 (E433), commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid.
Polysorbate 80 (E433) is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v).
A number of anticancer drugs can be formulated by Polysorbate 80 (E433).
Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
Polysorbate 80 (E433) is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.
Polysorbate 80 (E433), also known as PEG 80 and Polyoxyethylene Sorbitan Monooleate, is a polyoxyethylene derivative of sorbitan and olive oil in the form of oleic acid.
Polysorbate 80 (E433) is an emulsifier derived from animal fatty acids, and natural oils and used as synthetic flavourings, surfactants, de foaming agents and dough conditioners.
Polysorbate 80 (E433) may increase the absorption of fat-soluble substances.
Polysorbate 80 (E433) is a synthetic surfactant composed of fatty acid esters of polyoxyethylene sorbitan.
Polysorbate 80 (E433) is usually available as a chemically diverse mixture of different fatty acid esters, with the oleic acid comprising?>?58% of the mix.
However, the main component of Polysorbate 80 (E433) is polyoxyethylene-20-sorbitan monooleate, which is structurally similar to polyethylene glycols.
Polysorbate 80 (E433) has a molecular weight of 1309.7 Da and a 1.064 g/ml density.
Polysorbate 80 (E433) is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.
In pharmaceuticals, Polysorbate 80 (E433) is often used in formulations to improve the solubility and bioavailability of poorly soluble drugs.
Polysorbate 80 (E433) can also serve as a dispersing agent in oral and topical medications, helping to ensure uniform distribution of active ingredients.
Polysorbate 80 (E433) is commonly found in skincare products such as creams, lotions, and serums.
Polysorbate 80 (E433) functions as an emulsifier, helping to blend water-based and oil-based ingredients together to create stable formulations with smooth textures.
Polysorbate 80 (E433) is used as an emulsifier in a variety of products, including ice cream, salad dressings, and baked goods.
Polysorbate 80 (E433) helps prevent the separation of ingredients, improves texture and mouthfeel, and enhances the overall stability of food products.
Polysorbate 80 (E433) is rapidly removed from systemic circulation.
Polysorbate 80 (E433) plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (polysorbate 80 1.75 g) showed a Polysorbate 80 (E433) peak concentration of 304 μg/ml.
The AUC for Polysorbate 80 (E433) was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h.
The distribution of polysorbate 80 at steady state was similar to the total blood volume (4.16 l), suggesting that polysorbate 80 circulates as large micelles and does not significantly distribute outside the central compartment.
In vitro studies suggest that Polysorbate 80 (E433) is metabolized by rapid carboxylesterase-mediated hydrolysis.
Polysorbate 80 (E433) is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in Polysorbate 80 (E433) are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
Polysorbate 80 (E433) sorbitan monooleate (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) The critical micelle concentration of Polysorbate 80 (E433) in pure water is reported as 0.012 mM.
Polysorbate 80 (E433)s are derived from ethoxylated sorbitan (a derivative of sorbitol) esterified with fatty acids and exist as oily liquids.
These Polysorbates belong to the class of emulsifiers used in pharmaceuticals and food preparations (salad dressing, ice cream, chocolates, baked goods and confectionery).
They are used in cosmetics to solubilize essential oils into water-based products, pharmaceuticals, detergents, paints, and plastic applications.
These Polysorbates surfactants consist primarily of oleic, stearic or lauric fatty acid esters with sorbitol-derived cyclic ethers (sorbitans and sorbides) and further polymerized with approximately 20 molecules of oxirane per molecule of Polysorbates.
The number following the 'polysorbates' part reflects the type of fatty acid connected with the polyoxyethylene sorbitan part of the molecule.
Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
The number 20 following the 'polyoxyethylene' part refers to the total number of oxyethylene -(CH2CH2O)- groups found in the molecule.
Polysorbate 80 (E433) is an amber/golden-colored water-soluble viscous liquid.
Polysorbate 80 (E433) is manufactured from polyethoxylated sorbitan (derived from the dehydration of sorbitol, a sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats.
Due to this structure, Polysorbate 80 (E433) forms an approximate hydrophilic-lipophilic balance of 15.
The final products are free from genetically modified organisms and of vegetable origin.
Polysorbate 80 (E433) is a non-ionic surfactant and emulsifier find use in foods as emulsifier for salad dressings and chocolates, in cosmetics for preparing skin, facial cleansers and hair care products, and to disperse active ingredients in pharmaceuticals benefiting the pharmacological industry.
The solubility of Polysorbate 80 (E433) allows it to assist in dissolving ingredients that would remain solid under normal circumstances.
In foods like ice cream, Polysorbate 80 is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Vitamins, tablets, and supplements also contain Polysorbate 80 (E433) because of its preservative nature.
Polysorbate 80 (E433) being a nonionic surfactant is used in soaps and cosmetics (including eyedrops), or as solubilizer in mouthwashes.
Polysorbate 80 (E433), or Tween 80, is the abbreviation of “polyoxyethylene (20) sorbitan monooleate”, is a nonionic surfactant and emulsifier commonly used in food (with the European food additive number E433) and cosmetics mainly due to its ability to mix water-based and oil-based ingredients well (with a high approximate HLB value 15).
Polysorbate 80 (E433) is an amber viscous liquid that is easily soluble in water, methanol, and ethanol, but insoluble in mineral oil.
The hydroxyl value is between 65 and 82, the saponification value is between 43 and 55, the acid value is less than or equal to 2, the moisture is less than or equal to 3, and the hydrophilic-lipophilic balance value is 15.
Polysorbate 80 (E433) is the most popular product in the polysorbate series.
Polysorbate 80 (E433) can be applied to various industries such as medicine, cosmetics, food, paint and pigment, textiles, and pesticides.
Polysorbate 80 (E433) is regarded as an emulsifier, dispersant, wetting agent, solubilizer and stabilizer.
Polysorbate 80 (E433) is a nonionic surfactant and emulsifier often used in foods and cosmetics.
Polysorbate 80 (E433) is a viscous, water-soluble yellow liquid.
Polysorbate 80 (E433) commercially also known as Tween 80.
Polysorbate 80 (E433) is the ethoxylated sorbitan esters which are manufactured by the reaction among sorbitol, a specific fatty acid, and ethylene oxide (an average of 20 polymerized ethylene oxide per molecule of polysorbate 80).
Polysorbate 80 (E433) is a liquid substance, oily and slightly viscous.
The color of Polysorbate 80 (E433) can be from light yellow to bright amber.
The smell is not strong, characteristic.
The main quality of Polysorbate 80 (E433) is water solubility and solubility in vegetable and animal oils.
Polysorbate 80 (E433), one using area widely food emulsifier, named TW80 as well, yellow liquid, cas no. Is :9005-65-6, E code is E433, Slightly bitter, soluble in water, ethanol, ethyl acetate and toluene, insoluble in mineral oils and vegetable oils.
Polysorbate 80 (E433) also dissolves well in isopropyl and ethyl alcohol, benzene.
Polysorbate 80 (E433) does not dissolve in mineral oils.
Polysorbate 80 (E433) has emulsifying, wetting and foaming properties.
Polysorbate 80 (E433) is also a viscosity agent with the viscosity 300–500 centistokes (@25°C).
Polysorbate 80 (E433), one using area widely food emulsifier, named TW80 as well, yellow liquid, E code is E433, Slightly bitter, soluble in water, ethanol, ethyl acetate and toluene.
Soluble in water due to the long polyoxyethylene chains.
Soluble in most solvents, such as ethanol, methanol, ethyl acetate and toluene.
The critical micelle concentration of Polysorbate 80 (E433) in pure water is reported as 0.012 mM.
The fatty acid used for the production of E433 - Polyoxyethylene sorbitan monooleate is oleic acid.
Polysorbate 80 (E433) is a sugar alcohol produced by the reduction reaction (or hydrogenation) of glucose which is obtained from maize or tapioca starch.
According to the FDA, there are generally two steps in the manufacturing process of Polysorbate 80 (E433): Esterification between oleic acid and sorbitol to obtain sorbitan esters.
Condensation sorbitan esters with ethylene oxide.
Polysorbate 80 (E433) is highly effective as an emulsifier, meaning it helps to disperse and stabilize immiscible liquids, such as oil and water, in various formulations.
This property is particularly valuable in the production of creams, lotions, and other cosmetic and pharmaceutical products where uniform dispersion of ingredients is essential.
In addition to its emulsifying properties, Polysorbate 80 (E433) acts as a stabilizer, helping to prevent the separation of ingredients over time.
This contributes to the shelf stability of products and ensures that they maintain their desired consistency and texture throughout their intended shelf life.
Polysorbate 80 (E433) is also used as a solubilizing agent, especially in pharmaceutical formulations.
Polysorbate 80 (E433) can improve the solubility of hydrophobic (water-insoluble) compounds in aqueous solutions, making it easier to formulate drugs and enhancing their bioavailability.
In cosmetics, Polysorbate 80 (E433) is valued for its ability to create smooth and creamy textures in products like moisturizers, sunscreens, and makeup.
Polysorbate 80 (E433) is emulsifying and stabilizing properties contribute to the overall sensory experience of these products, making them easier to apply and more pleasant to use.
Polysorbate 80 (E433) is approved for use as a food additive by regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA).
Polysorbate 80 (E433) is commonly used in the production of processed foods, including baked goods, sauces, and salad dressings, where it helps to improve texture, consistency, and mouthfeel.
While Polysorbate 80 (E433) is generally regarded as safe for use in cosmetics and food products, some studies have raised concerns about its potential health effects in high concentrations or with prolonged exposure.
These concerns include possible irritation, allergic reactions, and effects on the gastrointestinal tract.
However, such effects are typically associated with high doses or specific individual sensitivities.
Polysorbate 80 (E433) is regulated as a food additive and cosmetic ingredient by regulatory agencies worldwide.
Polysorbate 80 (E433) must meet stringent safety and quality standards to be used in consumer products, and its concentrations are limited based on its intended application.
Melting point: -25 °C
Boiling point: >100°C
Density: 1.08 g/mL at 20 °C
vapor pressure: <1 mm Hg ( 20 °C)
refractive index: n20/D 1.473
FEMA: 2917 | POLYSORBATE 80
Flash point: >230 °F
storage temp.: -20°C
solubility: DMSO (Soluble), Methanol (Slightly)
form: viscous liquid
color: Amber
Specific Gravity: 1.080 (25/4℃)
PH Range: 6
Odor: mild alcoholic
PH: 5-7 (50g/l, H2O, 20℃)
Odor Type: alcoholic
Water Solubility: 5-10 g/100 mL at 23 ºC
Merck: 14,7582
Hydrophilic-Lipophilic Balance (HLB): 10
LogP: 4.392 (est)
Substances Added to Food (formerly EAFUS): POLYSORBATE 80
EWG's Food Scores: 3-8
Polysorbate 80 (E433) is derived from sorbitol, a natural sugar alcohol and forms a polysorbate-type nonionic surfactant by the ethoxylation of sorbitan (derived from the dehydration of sorbitol) before the addition of lauric acid.
Polysorbate 80 (E433) is relatively nontoxic and stable therefore can be used as a emulsifier and detergent in a number of domestic, scientific, and pharmacological applications.
Polysorbate 80 (E433) functions as a good wetting agent having food application in flavoured mouth drops, providing a spreading feeling to other added flavour ingredients.
In biochemical applications, Polysorbate 80 (E433) finds use as washing agent in immunoassays, solubilizing agent for membrane proteins, and lysis solutions for mammalian cells.
While in the pharma sector, Polysorbate 80 (E433) functions as an excipient helping to stabilize emulsions and suspensions.
The Cosmetics Ingredient Review (CIR) Expert Panel evaluated the scientific data and concluded that Polysorbate 80 (E433) is safe for use in cosmetic formulations.
As a high HLB emulsifier, its food grade can be blended with a low HLB emulsifier (e.g. sorbitan stearate, mono and diglycerides) to provide a suitable HLB value for the various food uses, either oil in water, or water in oil emulsion.
Its general purpose in cosmetics is to mix water and oil together.
Polysorbate 80 (E433) functions as a surfactant, emulsifier, solubilizer and dispersing agent.
Some of its applications as follows: Help wash away body dirt by lowering the surface tension on the skin when used in shampoos and body washes.
Polysorbate 80 (E433) heps distribute essential oils, fragrances and colorants evenly in water for Lotions, Creams, Hair products, Skin care products and Makeup products.
Polysorbate 80 (E433) is safe to consume and has been approved as a safe ingredient by the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA), as well as the Joint FAO/WHO Expert Committee on Food Additives (JECFA).
Polysorbate 80 (E433) powder is a functional ingredient that is commonly used as an emulsifier in baked goods, dairy products, salad dressings, and other processed foods.
Polysorbate 80 (E433) works by breaking the water tension of the surface to allow the lifting of dirt and oil.
Polysorbate 80 (E433) acts as an emulsifier to improve the consistency of any product.
Polysorbate 80 (E433) acts as a solubilizer that blends all the ingredients.
Polysorbate 80 (E433) is a nonionic surfactant and emulsifier often used in foods and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.
Polysorbate 80 (E433) is used to enable medications to pass through the blood brain barrier.
There some that question Polysorbate 80 (E433)'s use as a food additive as when it is consumed in food it may allow toxic chemicals in the body to pass through the blood brain barrier.
Polysorbate 80 (E433) also known as Polysorbate 80, is a type of nonionic surfactant.
Polysorbate 80 (E433) functions as an emulsifier, a dispersant, a wetting agent, a solubilizer, and a stabilizer in food, pharmaceutical, cosmetics, pigments, textiles, agrichemicals etc.
Like other polysorbates, Polysorbate 80 (E433) can be used alone or used in combination with sorbitan ester 60, 65 or 80.
Polysorbate 80 (E433) can also be produced by reacting sorbitol and ethylene oxide first then esterified with oleic acid;
Obtaining the mixture of sorbitol and sorbitan by partially dehydrating sorbitol.
Adding ethylene oxide to the mixture to obtain sorbitan polyethylene ether.
Polysorbate 80 (E433) is a surfactant which can also reduce bacterial attachment and inhibit biofilm formation.
Polysorbate 80 (E433)s are stable to electrolyes and weak acids and bases; gradual saponification occurs with strong acids and bases.
Polysorbate 80 (E433)s are hygroscopic and should be examined for water content prior to use and dried if necessary.
Also, in common with other polyoxyethylene surfactants, prolonged storage can lead to the formation of peroxides.
E433 - Polyoxyethylene sorbitan monooleate, also known as PEG 80 and Polyoxyethylene Sorbitan Monooleate, is a polyoxyethylene derivative of sorbitan and olive oil in the form of oleic acid.
Polysorbate 80 (E433), (=Tween 80), also known as Polyoxyethylene Sorbitan Monooleate, is a nonionic emulsifier and surfactant and used in cosmetics and foods.
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of Polysorbate 80 (E433) and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
Micelles combine with substances that needs to be solubilized, thereby enhance the solubilities of the substances such as active pharmaceutical ingredients.
To optimize solubilization, researchers have suggested to first combine Polysorbate 80 (E433) with lipidsoluble pharmaceutical ingredients, then add water to further solubilize the mixture.
Synthetic food additive with emulsifying and flavoring role.
Polysorbate 80 (E433) is also used as a solvent for other food additives.
Polysorbate 80 (E433) is used in fine bakery products, sauces, desserts, confectioneries, fat emulsions for pastry, instant soups, ice, dietetic foods for body weight control.
Polysorbate 80 (E433) is not recommended for vegetarians, because it can come from animal fats.
Polysorbate 80 (E433) is a viscous, water-soluble yellow liquid.
The hydrophilic groups in Polysorbate 80 (E433) are polyethers also known as polyoxyethylene groups which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case the oleic acid (see polysorbate for more detail).
Polysorbate 80 (E433), or Tween 80, is the abbreviation of “polyoxyethylene (20) sorbitan monooleate”, is a nonionic surfactant and emulsifier commonly used in food (with the European food additive number E433) and cosmetics mainly due to Polysorbate 80 (E433)'s ability to mix water-based and oil-based ingredients well (with a high approximate HLB value 15).
Polysorbates are derived from ethoxylated sorbitan (a derivative of sorbitol) esterified with fatty acids and exist as oily liquids.
These Polysorbates surfactants consist primarily of oleic, stearic or lauric fatty acid esters with sorbitol-derived cyclic ethers (sorbitans and sorbides) and further polymerized with approximately 20 molecules of oxirane per molecule of Polysorbates.
These Polysorbates belong to the class of emulsifiers used in pharmaceuticals and food preparations (salad dressing, ice cream, chocolates, baked goods and confectionery).
The number following the 'polysorbates' part reflects the type of fatty acid connected with the polyoxyethylene sorbitan part of the molecule.
Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
The number 20 following the 'polyoxyethylene' part refers to the total number of oxyethylene -(CH2CH2O)- groups found in the molecule.
Polysorbate 80 (E433) is an amber/golden-colored water-soluble viscous liquid.
Polysorbate 80 (E433) is manufactured from polyethoxylated sorbitan (derived from the dehydration of sorbitol, a sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats.
Due to this structure, Polysorbate 80 (E433) forms an approximate hydrophilic-lipophilic balance of 15.
The final products are free from genetically modified organisms and of vegetable origin.
Taking into account the distinctive properties of the food stabilizer E433 - Polyoxyethylene sorbitan monooleate, Polysorbate 80 (E433) belongs to the group of emulsifiers and stabilizers.
Polysorbate 80 (E433), also known as Polysorbate 80, consists of sorbitol, ethylene oxide, and oleic acid.
Polysorbate 80 (E433) has a molecular formula of C64H124O26.
At room temperature, E433 - Polyoxyethylene sorbitan monooleate is in the form of pale-yellow to amber oily liquid.
Polysorbate 80 (E433) is an O/W emulsifier with a polysorbate 80 HLB value of 15.0.
Polysorbate 80 (E433) is soluble in water, ethanol, toluene etc.
Polysorbate 80 (E433) - polysorbate, monooleate, nonionic surfactant.
Polysorbate 80 (E433) is obtained from sorbitol and fatty acids olive oil chemically.
Polysorbate 80 (E433) is an ethoxylated monoester of fatty acid anhydrohexavites.
Polysorbate 80 (E433) refers to the type of fatty acid attached to the polyoxyethylene sorbitan part of the molecule, here E433 - Polyoxyethylene sorbitan monooleate is monooleate or oleic acid.
Oleic acid is a monounsaturated fatty acid naturally found in animal fats & oils and vegetable oils.
Commercial food grade oleic acid is not pure and is a mixture of several fatty acids.
Uses Of Polysorbate 80 (E433):
Polysorbate 80 (E433) is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
Polysorbate 80 (E433) is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations.
Polysorbate 80 (E433) is the trade name of a detergent that can be useful in identifying mycobacteria that possess a lipase that splits the compound into oleic acid and polyoxyethylated sorbitol.
Polysorbate 80 (E433) is used as an additive for cell culture media.
Polysorbate 80 (E433) has numerous effects, e.g. increasing the transformation frequency of Brevibacterium lactofermentum or enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Polysorbate 80 (E433) is used as an emulsifier in foods, though research suggests it may "profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states."
For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding Polysorbate 80 (E433) prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Polysorbate 80 (E433) is a synthetic multi-ingredient that can be used as a surfactant, emulsifier, solubilizer, stabilizer in food, cosmetics and personal care products.
Polysorbate 80 (E433) helps water-based and oil-based ingredients blend easily and prevent their separation in food.
Polysorbate 80 (E433) are mostly used in food among the category of Polysorbates, but the latter is used more than polysorbate 60 in food.
Polysorbate 80 (E433) are the most commonly used in bakery food production.
They help to extend shelf life, improve the strength and increase volume of baked goods and frozen desserts.
Polysorbate 80 (E433) is commonly used in cosmetics and personal care products such as lotions, creams, shampoos, and conditioners.
Polysorbate 80 (E433) acts as an emulsifier, helping to blend oil and water-based ingredients to create stable formulations with smooth textures.
Additionally, Polysorbate 80 (E433) can improve the solubility of certain ingredients and enhance the spreadability of products on the skin or hair.
In the pharmaceutical industry, Polysorbate 80 (E433) serves multiple purposes.
Polysorbate 80 (E433) is used as an emulsifier and solubilizing agent in oral and injectable medications to improve the bioavailability of poorly soluble drugs.
Polysorbate 80 (E433) can also stabilize protein-based drugs and vaccines, helping to maintain their potency and efficacy during storage and administration.
Polysorbate 80 (E433) is approved as a food additive by regulatory agencies such as the FDA and EFSA.
Polysorbate 80 (E433) is used in various food and beverage products, including ice cream, salad dressings, sauces, and baked goods.
As an emulsifier, Polysorbate 80 (E433) helps to create smooth textures, prevent ingredient separation, and enhance the stability of these products.
Polysorbate 80 (E433) finds applications in biomedical research, particularly in cell culture and laboratory diagnostics.
Polysorbate 80 (E433) is used in cell culture media to facilitate the solubility and uptake of hydrophobic compounds by cells.
Polysorbate 80 (E433) can also serve as a dispersing agent in diagnostic assays and techniques.
Polysorbate 80 (E433) has industrial applications in various sectors.
Polysorbate 80 (E433) is used in the manufacturing of plastics, textiles, and lubricants, where its surfactant properties aid in processing and performance.
Polysorbate 80 (E433) can also be found in household cleaning products, where it helps disperse oils and greases for effective cleaning.
Polysorbate 80 (E433) is used in veterinary medicine for similar purposes as in human pharmaceuticals and cosmetics.
Polysorbate 80 (E433) can be found in topical treatments, oral medications, and vaccines for animals to improve solubility, stability, and efficacy.
Polysorbate 80 (E433) is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of polysorbate 80 may have more impurities than the food grade.
Polysorbate 80 (E433) is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Polysorbate 80 (E433) is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polysorbate 80 (E433) is also used as an excipient in some European and Canadian influenza vaccines.
Influenza vaccines contain 2.5 μg of Polysorbate 80 (E433) per dose.
Polysorbate 80 (E433) is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
Polysorbate 80 (E433) is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Polysorbate 80 (E433) is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Polysorbate 80 (E433) is also used in granulation for stabilization of drugs and excipients when IPA binding.
Polysorbate 80 (E433) used as emulsifier, stabiliser in a large range of foods including chewing gum, ice cream, soft drinks.
Also used in a wide range of detergents, pharmaceuticals and beauty and skin products.
Polysorbate 80 (E433) is the reason behind the creaminess of your products.
Polysorbate 80 (E433) boosts rinse off and adds extra strength to other surfactants.
Seldom Polysorbate 80 (E433) is used as a food additive in wines and ice-creams.
Polysorbate 80 (E433) is used in sauces to keep their texture smooth.
Polysorbate 80 (E433) is also used to improve the consistency of gel capsules and to make the pills disperse in the stomach.
Polysorbate 80 (E433) is used as an emulsifier in foods.
For example, in ice cream, polysorbate is added up to 0.5 % (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding Polysorbate 80 (E433) prevents milk proteins from completely coating the fat droplets.
This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Polysorbate 80 (E433) is utilized in various topical formulations such as creams, ointments, and gels.
Polysorbate 80 (E433) helps to evenly distribute active ingredients throughout the formulation, ensuring consistent application and absorption into the skin.
Polysorbate 80 (E433) can also improve the texture and feel of topical products, making them more pleasant to use.
Polysorbate 80 (E433) plays a critical role in the production of certain vaccines.
Polysorbate 80 (E433) is used as a stabilizer to maintain the integrity of vaccine formulations during manufacturing, storage, and transportation.
Polysorbate 80 (E433) helps prevent the aggregation of vaccine components and preserves their potency, ensuring that vaccines remain effective.
Polysorbate 80 (E433) is included in some formulations of parenteral nutrition solutions, which are administered intravenously to patients who cannot consume nutrients orally.
As an emulsifier, Polysorbate 80 (E433) helps to disperse lipid components in these solutions, allowing for the delivery of essential fats and nutrients to patients.
Polysorbate 80 (E433) is sometimes used in the production of medical devices such as catheters and surgical instruments.
Polysorbate 80 (E433) can be incorporated into lubricants and coatings to reduce friction and improve the performance of these devices during use.
Polysorbate 80 (E433)'s compatibility with various materials makes it a suitable additive for medical applications.
Similar to its use in human medicine, Polysorbate 80 (E433) is employed in veterinary pharmaceuticals to enhance the solubility, stability, and bioavailability of active ingredients.
Polysorbate 80 (E433) may be included in oral medications, topical treatments, and injectable formulations for animals, contributing to the effectiveness of veterinary therapies.
Polysorbate 80 (E433) is commonly used in research laboratories and academic institutions for experimental purposes.
Polysorbate 80 (E433) may be incorporated into experimental formulations to assess its effects on solubility, stability, and delivery of active compounds.
Researchers may also investigate novel applications of Polysorbate 80 in drug delivery systems and biomedical technologies.
In manufacturing processes across various industries, Polysorbate 80 (E433) may be subject to stringent quality control measures to ensure its purity, stability, and consistency.
Quality control tests may include assessments of chemical composition, physical properties, and performance characteristics to meet regulatory standards and product specifications.
Safety Profile Of Polysorbate 80 (E433):
Moderately toxic by intravenous route.
Mildly toxic by ingestion.
Experimental reproductive effects.
Questionable carcinogen with experimental tumorigenic data.
Human mutation data reported. An eye irritant.
When heated to decomposition it emits acrid smoke and irritating fumes.
In some individuals, Polysorbate 80 (E433) may cause skin irritation or allergic reactions, particularly in those with sensitive skin or allergies to related compounds.
Symptoms of skin irritation may include redness, itching, or rash.
If irritation occurs, discontinuing use and seeking medical advice is recommended.
Contact with Polysorbate 80 (E433) may cause irritation to the eyes.
If the substance comes into contact with the eyes, it should be flushed with water for several minutes while gently holding the eyelids open.
If irritation persists, medical attention may be necessary.
