PRODUCTS

POLYSORBATE 80

CAS NUMBER: 9005-65-6

EC NUMBER: 100.105.529

MOLECULAR FORMULA: C32H60O10

MOLECULAR WEIGHT: 604.8

IUPAC NAME: 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate

Polysorbate 80 is a nonionic surfactant and emulsifier often used in foods and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.

Polysorbate 80's Chemistry:
Polysorbate 80 is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).

The full chemical names for polysorbate 80 are:

*Polyoxyethylene (20) sorbitan monooleate
*(x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)

The critical micelle concentration of polysorbate 80 in pure water is reported as 0.012 mM

Other names:
E number: E433
Brand names:
-Alkest TW 80
-Scattics
-Canarcel
-Poegasorb 80
-Kolliphor PS 80
-Montanox 80
-Tween 80

USES:
*Food:
Polysorbate 80 is used as an emulsifier in foods.

For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding this substance prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.

*Health and beauty:
Polysorbate 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of polysorbate 80 may have more impurities than the food grade.

*Medical:
Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polysorbate 80 is also used as an excipient in some European and Canadian influenza vaccines.

Influenza vaccines contain 2.5 μg of polysorbate 80 per dose.
Polysorbate 80 is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.

Polysorbate 80 is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Polysorbate 80 is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Polysorbate 80 is also used in granulation for stabilization of drugs and excipients when IPA binding.

*Laboratory:
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of polysorbate 80 and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
On RODAC agar plates used in microbiological control, polysorbate 80 counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow

Polysorbate 80 is an amber/golden-colored viscous liquid.
Polysorbate 80 is made from polyethoxylated sorbitan (chemical compounds derived from the dehydration of sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats.
Polysorbate 80 is used as an emulsifier or defoamer in foods, vitamins, medicines, and vaccines.

Why is Polysorbate 80 used in food?
Polysorbate 80 is used as a defoamer for the fermenting process of some wines, and also to bind some ice-creams and other ‘puddings’, to keep their creamy texture without separating.
Polysorbate 80 is also used to bulk foods up and keep sauces smooth.

Why is Polysorbate 80 used in medicine?
Polysorbate 80 is used as an ingredient in some vaccines, as well as in some vitamins and supplements.
Polysorbate 80 is used to improve the consistency of gel capsules and to make pills disperse in the stomach.

What products is Polysorbate 80 used in?
Polysorbate 80 is a versatile and useful ingredient, so it is present in quite a few products.
Here is a short, generalized list of where it is most often found:
• Food shortening
• Chewing Gum
• Ice Cream
• Gelatin
• Vitamins
• Soap
• Shampoo
• Cosmetics
• Skin Creams
• Condiments
• Medicines
• Vaccines

Polysorbate 80 (P80) is a nonionic detergent that is used to solubilize proteins and widely used in injectable medications, including certain vaccines
Polysorbate 80 is an emulsifier that is commonly used in foods.

The full chemical name is polyoxyethylene (20) sorbitan monooleate and is made from the reaction of polyethoxylated sorbitan and oleic acid.
Oleic acid is reacted with sorbitol to make an emulsifier with a maximum acid value of 7.5 which is then reacted with ethylene oxide.

Usage in Foods:
Polysorbate 80 is commonly used in many foods such as ice cream, frozen custard, ice milk sherberts, whipped toppings and other frozen desserts.
Polysorbate 80 should not exceed 0.1% of the finished product.

Polysorbate 80 is commonly used in ice cream and other frozen desserts where it is used at levels up to 0.5% to increase and improve smoothness and handling on automated equipment.
Polysorbate 80 will increase ice cream resistance to melting.

This is accomplished by polysorbate 80 preventing the coating of the milk protein on the fat droplets. This will create chains that act as a net.
This network will hold the air that was incorporated to provide a firmer texture as the ice cream softens or melts.

Polysorbate 80 is a hydrophilic nonionic surfactant.
Polysorbate 80 is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops.

In food or pharmaceutical products, Polysorbate 80 can act as an emulsifier.
Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations

Polysorbates are widely used to protect biological drug products from protein unfolding, aggregation, and precipitation during both shipping and handling.
The polysorbates are amphipathic, nonionic surfactants made of fatty acid esters of polyoxyethylene sorbitan.

Polysorbate 80 is one of the most common surfactants currently used in the formulation of protein-based biopharmaceuticals
Polysorbate 80 is one of the primary components of protein formulations.

Polysorbate 80 is a surfactant and emulsifier used in cleaners and personal care products.
Polysorbate 80 is an amber/golden-colored water-soluble viscous liquid.

Polysorbate 80 is manufactured from polyethoxylated sorbitan (derived from the dehydration of sorbitol, a sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats.
Due to this structure, polysorbate 80 forms an approximate hydrophilic-lipophilic balance of 15.

The final products are free from genetically modified organisms and of vegetable origin.
Polysorbate 80 (or E433) is a non-ionic surfactant and emulsifier find use in foods as emulsifier for salad dressings and chocolates, in cosmetics for preparing skin, facial cleansers and hair care products, and to disperse active ingredients in pharmaceuticals benefiting the pharmacological industry.

Polysorbate 80 is a skincare ingredient used in cosmetics and personal care products to improve the texture of products.
Polysorbate 80 is used as a surfactant, emulsifier, and solubilizer, helping to produce smooth, easy to apply skincare and body care products.

Polysorbate 80 is similar in function to polysorbate 20, and 60 which are used in skincare and cosmetic products as well.
Polysorbate 80 exists as a thick, water-soluble yellow liquid.

Polysorbate 80 improves the texture of products by working as a surfactant, emulsifier and solubilizer.
Polysorbate 80 is also an emulsifier.
As an emulsifier, polysorbate 80 is often used in formulations that contain both water and oil components.

Polysorbate 80 has the ability to function as a solubilizer.
Polysorbate 80 can be used individually, or in combination with a variety of other emulsifiers, to produce many different types of oil-in-water, and water-in-oil emulsion systems.

Is Polysorbate 80 Vegan?
Polysorbate 80 is a vegan ingredient.
Polysorbate 80 is derived from vegetable oils and doesn’t use animal or animal byproducts in its production.

Other Uses:
In addition to its function in cosmetics, polysorbate 80 can be used to prepare a wide variety of products in the food, drug, textile, and metalworking industries.

Polysorbate 80 is used in cosmetics as a non-ionic surfactant (HLB 15) and emulsifier:
Polysorbate 80 helps the oil to mix with water to form emulsions

Polysorbate 80 also allows other ingredients to dissolve better in the skin
Polysorbate 80 is used in multiple cosmetic products

Polysorbate 80's functions:
*Denaturant : Polysorbate 80 Makes cosmetics unpleasant. Mainly added to cosmetics containing ethyl alcohol
*Emulsifying : Polysorbate 80 Promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)
*Surfactant : Polysorbate 80 Reduces the surface tension of cosmetics and contributes to the even distribution of the product when it is used

PHYSICAL PROPERTIES:

-Molecular Weight: 604.8

-XLogP3-AA: 4.8

-Exact Mass: 604.41864811

-Monoisotopic Mass: 604.41864811

-Topological Polar Surface Area: 133 Å²

-Compound Is Canonicalized: Yes

-Appearance: Amber colored liquid

-Density: 1.102 g/mL, oily liquid

-Boiling point: > 100°C

-Solubility in water: 100 mL/L

-Solubility in other solvents: soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene

-Viscosity: 300–500 centistokes

Polysorbate 80 is also used as an excipient in some European and Canadian influenza vaccines.
Polysorbate 80 is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.

Polysorbate 80 is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Polysorbate 80 is also used as an emulsifier in the estrogen-regulating drug Estrasorb.

Polysorbate 80 is also used in granulation for stabilization of drugs and excipients when IPA binding.
Polysorbate 80 is an amber/golden-colored viscous liquid.

Polysorbate 80 is made from polyethoxylated sorbitan (chemical compounds derived from the dehydration of sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats.
Polysorbate 80 is used as an emulsifier or defoamer in foods, vitamins, medicines, and vaccines.

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 3

-Hydrogen Bond Acceptor Count: 10

-Rotatable Bond Count: 31

-Heavy Atom Count: 42

-Formal Charge: 0

-Complexity: 632

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 4

-Defined Bond Stereocenter Count: 1

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

Polysorbate 80 is also used as a defoamer in yeast and cottage cheese, a solubilizing and dispersing agent in pickles (maximum usage of 500ppm), to solubilizing and dispersing of vitamins and vitamin-mineral combinations.
Polysorbate 80 is also commonly used as a dill oil dispersing agent in canned vegetables.
Polysorbate 80 is commonly used in ice cream and other frozen desserts where it is used at levels up to 0.5% to increase and improve smoothness and handling on automated equipment.

Polysorbate 80 will increase ice cream resistance to melting.
Polysorbate 80 is a skincare ingredient used in cosmetics and personal care products to improve the texture of products.
Polysorbate 80 is used as a surfactant, emulsifier, and solubilizer, helping to produce smooth, easy to apply skincare and body care products.

Polysorbate 80 is similar in function to polysorbate 20, and 60 which are used in skincare and cosmetic products as well.
Polysorbate 80 exists as a thick, water-soluble yellow liquid.
Polysorbate 80 improves the texture of products by working as a surfactant, emulsifier and solubilizer.

Polysorbate 80 is also an emulsifier.
As an emulsifier, Polysorbate 80 is often used in formulations that contain both water and oil components.

SYNONYM:

2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate
SCHEMBL19900966
SCHEMBL19900967
Polysorbate 80 (JP17/NF/INN)
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl(e)-octadec-9-enoate
Montanox 80
Alkest TW 80
Tween 80
PS 80
Glycol (polysorbate 80)
Polyethylene oxide sorbitan mono-oleate
Polyoxyethylene (20) sorbitan monooleate
Polyoxyethylene sorbitan monooleate
Polyoxyethylene sorbitan oleate