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DESCRIPTION
Sodium ascorbate is an organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion.
Sodium ascorbate has a role as a food antioxidant, a flour treatment agent, a coenzyme, a plant metabolite, a human metabolite, a Daphnia magna metabolite and a reducing agent.
Sodium ascorbate is an organic sodium salt and a vitamin C.
Sodium ascorbate contains a L-ascorbate.
CAS Number 134-03-2
SYNONYMS OF SODIUM ASCORBATE
SODIUM ASCORBATE,134-03-2,L-Ascorbic acid sodium salt,Sodium L-ascorbate,Vitamin C sodium,Monosodium L-ascorbate,Ascorbicin,Ascorbic acid sodium salt,Natrii ascorbas,Iskia-C,Natri-C,Ascorbate de sodium,Sodascorbate,L-Ascorbic acid, monosodium salt,Vitamin C Sodium Salt,Vitamin C, sodium salt,(+)-Sodium L-ascorbate,ascorbate,Ascorbin,Cevalin,MFCD00082340,3-Oxo-L-gulofuranolactone sodium,INS NO.301,L(+)-Ascorbic acid sodium salt,INS-301,S033EH8359,L-Ascorbic acid (sodium salt),DTXSID0020105,E-301,CHEBI:113451,l-Ascorbate, sodium,Sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate,Cebitate,Aminofenitrooxon,sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate,sodium (L)-ascorbate,sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate,SODIUM ASCORBATE (II),SODIUM ASCORBATE [II],SODIUM ASCORBATE (MART.),SODIUM ASCORBATE [MART.],sodiumascorbate,SODIUM ASCORBATE (USP-RS),SODIUM ASCORBATE [USP-RS],sodico,Ascorbato sodico [DCIT],sodium;(2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate,SODIUM ASCORBATE (EP MONOGRAPH),SODIUM ASCORBATE [EP MONOGRAPH],SODIUM ASCORBATE (USP MONOGRAPH),SODIUM ASCORBATE [USP MONOGRAPH],Monosodium Ascorbate,Natrii ascorbas [INN-Latin],Ascorbic acid sodium derivative,CCRIS 3291,HSDB 694,HBL 508,L-Ascorbic acid sodium,Ascorbate de sodium [INN-French],EINECS 205-126-1,Sodium ascorbate [USP:INN],UNII-S033EH8359,Sodium derivative of 3-oxo-L-gulofuranolactone,Ascorbate, Sodium,sodium (2R)-2-((1S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate,Sodium ascorbate; Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate,(+)-Sodium L-ascorbate;Vitamin C sodium salt;Sodium L-ascorbate,E301,sodium L-ascorbate salt,VITA-JEC C,EC 205-126-1,SCHEMBL3745,ASK-P 10KR,DTXCID60105,L(+)Ascorbic acid sodium salt,SODIUM ASCORBATE [FCC],SODIUM ASCORBATE [INN],CHEMBL591665,SODIUM ASCORBATE [HSDB],SODIUM ASCORBATE [VANDF],HY-B0166A,SODIUM ASCORBATE [WHO-DD],L-Ascorbic Acid Sodium Salt,(S),Tox21_300556,AKOS015895058,L-Ascorbic acid, sodium salt (1:1),SODIUM ASCORBATE [ORANGE BOOK],ASCORBIC ACID SODIUM SALT [MI],CS-6063,DB14482,3-Keto-L-gulofuranlactone sodium enolate,NCGC00254355-01,BP-30077,CAS-134-03-2,DA-77918,A0539,E80761,EN300-221566,A806721,Q424551,J-006471,2,3-Didehydro-L-theo-hexono-1,4-lactone sodium enolate,Z1255486556,sodium (2R)-2-[(1S)-1,2-bis(oxidanyl)ethyl]-4-oxidanyl-5-oxidanylidene-2H-furan-3-olate,Sodium(R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
A brief summary of the chemical, biological, and health-related aspects of sodium ascorbate, emphasizing its significance as a supplement and its applications in various fields.
Sodium ascorbate, a salt form of vitamin C, has gained significant attention due to its antioxidant properties and role in immune system support.
This article explores its chemical and biological characteristics, health benefits, safety profile, and applications in medicine, food, and industry. Emphasis is placed on scientific findings that highlight its therapeutic potential and ongoing research into its role in chronic disease prevention.
Overview of Vitamin C and its importance in human health.
Differentiation between ascorbic acid and its salts, particularly sodium ascorbate.
Vitamin C, or ascorbic acid, is an essential nutrient vital for various physiological functions.
Among its derivatives, sodium ascorbate stands out due to its bioavailability and reduced acidity, making it a preferred alternative for individuals with gastrointestinal sensitivities to ascorbic acid.
Recognized for its antioxidant, anti-inflammatory, and immune-boosting properties, sodium ascorbate has been extensively studied for its therapeutic and preventive roles in health.
Sodium ascorbate, chemically known as C6H7NaO6, is the sodium salt of ascorbic acid.
CHEMICAL PROPERTIES OF SODIUM ASCORBATE:
Sodium ascorbate is a white to slightly yellow crystalline powder with the following notable properties:
Molecular Weight:
198.11 g/mol.
Solubility:
Highly soluble in water, which facilitates its use in liquid formulations.
pH Level:
Sodium ascorbate solutions have a pH closer to neutral (6.5–7.0), unlike ascorbic acid (pH ~2–3), making it gentler on the stomach.
Stability: While more stable than ascorbic acid in neutral and alkaline environments, it is still sensitive to heat, light, and oxygen, requiring careful storage.
Sodium ascorbate's reduced acidity and enhanced stability in specific formulations make it an advantageous choice for both dietary supplements and intravenous applications.
PRODUCTION METHODS
Sodium ascorbate is synthesized through the following key steps:
Fermentation of Glucose or Sorbitol:
Microbial fermentation processes are used to produce L-sorbose, a precursor to ascorbic acid.
Conversion to Ascorbic Acid:
L-sorbose undergoes a series of chemical reactions to form ascorbic acid.
Neutralization with Sodium Hydroxide:
Ascorbic acid is then neutralized with sodium hydroxide to produce sodium ascorbate.
Modern production methods often employ environmentally friendly processes, minimizing waste and ensuring high-purity end products suitable for pharmaceutical and food-grade applications.
Biological Function and Mechanism:
Role in collagen synthesis and antioxidant defense.
Mechanism of action in neutralizing free radicals.
Involvement in immune modulation and neurotransmitter biosynthesis.
Sodium ascorbate shares the same biological activity as vitamin C due to its ability to release ascorbate ions.
Key functions include:
Collagen Synthesis:
Essential for the hydroxylation of proline and lysine residues, sodium ascorbate supports collagen stability, critical for connective tissue health.
Antioxidant Activity:
Sodium ascorbate donates electrons to neutralize reactive oxygen species (ROS), preventing cellular damage caused by oxidative stress.
Immune System Support:
It enhances the proliferation and activity of lymphocytes, increases interferon production, and modulates inflammation.
Iron Absorption:
Sodium ascorbate enhances non-heme iron absorption in the gut by reducing ferric ions (Fe³⁺) to the more absorbable ferrous form (Fe²⁺).
Through these mechanisms, sodium ascorbate contributes to maintaining cellular health and preventing disease.
HEALTH BENEFITS OF SODIUM ASCORBATE
Immunity Boosting Properties:
Enhancement of innate and adaptive immunity.
Studies on cold and flu prevention.
Antioxidant Effects:
Prevention of oxidative stress-related diseases.
Cardiovascular Health:
Impact on cholesterol and blood pressure.
Protection against atherosclerosis.
Cancer:
Potential adjuvant role in cancer therapy.
Other Benefits
Skin health, wound healing, and improved iron absorption.
Safety and Dosage:
Recommended daily intake.
Toxicity and side effects at high doses.
Interaction with medications and conditions like kidney stones.
APPLICATIONS OF SODIUM ASCORBATE:
Medical and Pharmaceutical Use
Role in intravenous therapy.
Use in tablets, capsules, and powder forms.
Food Industry:
Antioxidant and preservative in processed foods.
Veterinary Applications
Supplementation in animal diets.
Research and Innovations:
Recent studies on high-dose sodium ascorbate therapy.
Emerging roles in anti-aging and chronic disease prevention.
Future prospects and clinical trials.
Controversies and Misconceptions
Misuse in alternative medicine.
Myths about sodium ascorbate vs. ascorbic acid.
SAFETY INFORMATION ABOUT SODIUM ASCORBATE
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
