SORBITAN MONOOLEATE

SYNONYM: Sorbitan monooleate; Sorbitan; mono-(9Z)-9-octadecenoate; Arlacel 80; SORBITAN OLEATE; Span 80; Alkamuls SMO; Polyoxyethylene sorbitan monooleate; Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs; Polyoxyethylene sorbitan oleate; Polyethylene oxide sorbitan mono-oleate; Polyoxyethylene (20) sorbitan monooleate; Tween 80; Sorbitan monooleate, ethoxylated; Polyoxyethylene sorbitan monooleate; Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs; Polyoxyethylene sorbitan oleate; Avitears; Rohto; Polyethylene oxide sorbitan mono-oleate; Polyoxyethylene (20) sorbitan monooleate; Tween 80 (TN); Polysorbate 80;2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate; Sorbitan, monooleate polyoxyethylene deriv; 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl(e)-octadec-9-enoate; Sorbitan oleate; Sorbitan (Z)-mono-9-octadecenoate; Polyoxyethylene Sorbitan Monooleate; sorbitan monoleate; monooleate sorbitan; ssorbitol monoleate; sorbiton monoleate; E494; Sorbitan esters; polysorbate 80; Polyoxyethylene (20) sorbitan monooleate; polisorbate 80; (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl); Alkest TW 80; Scattics; Canarcel; Poegasorb 80; Montanox 80; Tween 80; sorbitan oleate; Sorbitan oleate; Sorbitan (Z)-mono-9-octadecenoate; ZTCC® S-20/S-60/S-65/S-80; Sorbitan Esters; Polyoxyethylene (20) Sorbitan Monooleate;     Polyoxyethylene Sorbitan Monooleate; 1,4-Sorbitan; Sorbitan monopalmitate; Sorbitan monostearate; POE (20) sorbitan monooleate; Polyethylene glycol sorbitan monooleate; Polyoxyethylenesorbitan monooleate; Polysorbate 80; TWEEN® 80; Polyethylene glycol sorbitan monolaurate solution; Polyoxyethylenesorbitan monolaurate;  Sorbitane monooleate,sorbitan oleate; Sorbitan Monooleate; armotanmo; sorgen40; o250;  D-Glucitol,1,4-anhydro-,6-(9-octadecenoate),(Z); sorbitan Oleate; sorbitane monooleate; Polyoxyethylene sorbitan monoleate; [2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] (E)-octadec-9-enoate

Polyoxyethylene sorbitan monooleate (CAS number: 9005-65-6) and polyoxyethylene sorbitan trioleate (CAS number: 9005-70-3) are oleate esters of sorbitol. The chemical name polyoxyethylene sorbitan monooleate covers the substances known by the commercial names Polysorbate 80, and Polysorbate 81. Polyoxyethylene sorbitan trioleate covers the substance known by the commercial name Polysorbate 85. The substances are used as excipients (emulsifiers and dispersing agents) in medicinal products. They are also widely used as a emulsifiers in foods products and cosmetics. Sorbitan monooleate is a nonionic surfactant and emulsifier often used in foods and cosmetics. This synthetic compound is a viscous, water-soluble yellow liquid.Polysorbate 80 is derived from polyethoxylated sorbitan and oleic acid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide. In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail. It is a mixture of partial esters of sorbitol and anhydrides and vegetable oleic acid. It may have free fatty acids and sorbitol, isosorbide esters.Product description: Light yellow viscose oily liquid, insoluble in water, soluble in organic solvents, it is water/oil type emulsifier, can be mixed with emulsifier S-60 and emulsifier T-60. HLB: 4.3. Sorbitan esters have widely application areas.  Within food industry, they have variousfunctions such as emulsification, aerating, wetting, texture control, gloss control, crystallization control and so on. Moreover, they are used as dough strengthener, defoamer, dispersant in foodstuffs. By using appropriate sorbitan esters, the quality of food products can be improved and the shelf life can be increased. Non-ionic detergent suited for solubilization of membrane proteins, enzymology, analytical, and diagnostic, work as well as chromatography and electrophoresis. Molecular Biology Grade.Intended for laboratory and manufacturing use only. Not for drug, food, or household use. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.Polysorbate 80 was included in Annex II of Council Regulation (EC) No 2377/90 for all food producing animals under the group “Substances Generally Recognised as Safe” for which no individual assessment was carried out. Polyoxyethylene sorbitan monolaurate (Polysorbate 20), polyoxyethylene sorbitan monopalimitate (Polysorbate 40), polyoxyethylene sorbitan monostearate (Polysorbate 60) and polyoxyethylene sorbitan tristearate (Polysorbate 65) as well as polyoxyethylene sorbitan monooleate (Polysorbate 80) are approved as food additives by Directive 95/2/EC on food additives other than colours and sweeteners, with the E numbers E-432, E-434, E-435, E-436 and E-433, respectively. Therefore, they are included in Annex II of Council Regulation (EC) No 2377/90 by virtue of the entry for substances approved under Directive 95/2/EC as additives in foodstuffs for human consumption with an E-number. The additive is a mixture of the partial esters of sorbitol and its mono- and dianhydrides with edible commercial oleic acidand condensed with approximately 20 moles of ethylene oxide per mole of sorbitol and its anhydrides. It contains a minimum of 65% of oxyethylene groups, equivalent to not less than 96.5% of polyoxyethylene (20) sorbitan monooleate on the anhydrous basis and less than 3% water. Tween 80, (=Polyoxyethylene Sorbitan Monooleate), also known as Polyoxyethylene Sorbitan Monooleate, is a nonionic emulsifier and surfactant and used in cosmetics and foods. Ungraded products supplied by TCI America are generally suitable for common industrial uses or for research purposes but typically are not suitable for human consumption or therapeutic use.Ethoxylated sorbitan monooleate, a non-ionic surfactant belonging to the group of polysorbates. Kotilen-O/1 VL is used as excipient in pharmaceutical applications and as ingredient in cosmetics/personal care products (Ph. Eur. / INCI Declaration: Polysorbate 80). A mainly oil-loving, vegetable raw material based ingredient that helps water and oil to mix together, aka emulsifier. It can also function as a wetting and dispersing agent helping insoluble particles such as color pigments or inorganic sunscreens (zinc/titanium dioxide) to disperse nice and even in liquids.  Chemically speaking, it comes from the attachment of sorbitan (a dehydrated sorbitol (sugar) molecule) with the unsaturated fatty acid Oleic Acid, that creates a partly water (the sorbitan part) and partly oil soluble (oleic part) molecule. Sorbitan oleate is produced by esterification of sorbitan with oleic acid in a solvent-free mixture of fatty acids and molten anhydrous sorbitol with chemical catalysts.Does not contain animal-derived components. Sorbitan Oleate (also claiming sorbitan monooleate or sorbester p17) is a kind of important nonionogenic tenside, is commonly used for the w/o type emulsifying agent.Due to its excellent emulsification, dispersion and the surfactivity such as wetting, and nontoxic, non-stimulated, low volatilization, the characteristics such as micelle-forming concentration is higher and the micella free energy is lower, extensive in sector applications such as oil, food, makeup and medicine. Sorbitan Oleate, a traditional step base catalysis method be with sorbyl alcohol and oleic acid under basic catalyst exists, carry out simultaneously etherificate and esterification in 190 ℃-260 ℃.The production technique of the synthetic Sorbitan Oleate of single stage method is disclosed as patent CN102260228A, it be with sorbyl alcohol and oleic acid under efficient composite catalyst exists, at 190-240 ℃, carry out simultaneously etherificate and esterification 5-8h. Although this method is simple, but because esterification and etherification reaction carry out simultaneously, often occur that esterification carries out better, and etherificate becomes ring not enough, makes the interior etherificate degree in the Sorbitan Oleate molecule low, and the content of the sorbitol ester of straight chain is larger, final result is that the inside regularity of product is poor, the performance of outward appearance is poor fluidity, and muddiness is solidified etc.Simultaneously, sorbyl alcohol can further dewater under higher temperature, long reaction times act on, multiple reaction is carried out under same temperature of reaction, causes that the reaction product color and luster is dark, poor transparency, and by product is many, quality is unstable, and What is more, and coking is serious, and its application prospect is restricted. The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. Toxicity was reported in subchronic and chronic studies at concentrations above that normally used in cosmetics. They are generally mild skin irritants but nonsensitizers in animals. They have the potential to induce cutaneous irritation in humans but not sensitization to normal skin.Carcinogenic studies using Sorbitan Stearate and Laurate were negative. At concentrations of 10 percent or greater, Sorbitan Laurate is a tumor promoter in mouse skin. It is concluded that the latter is not relevant to the use of the Sorbitan esters at low concentrations in cosmetics and that the Sorbitan esters reviewed in the report are safe as cosmetic ingredients under present conditions of concentration and use.Our Span range of sorbitan esters are widely used as W/O emulsifiers and when used in combination with ethoxylated sorbitan esters (the Tween range) they contribute to the overall stability of O/W emulsions. Manipulation of the Span/Tween ratio produces emulsifying systems of various HLB values, allowing the emulsification of a wide range of oils and waxes. Span 80 is a liquid W/O emulsifier and O/W emulsion stabiliser particularly recommended for use with unsaturated lipid components such as oleyl alcohol or vegetable oils. Extensively used as a wetting agent and dispersant for materials such as zinc oxide, calamine and penicillin in lipophilic pharmaceutical bases. Recommended topical usage levels of 0.5-5%. The version of this product manufactured in Brazil (BR) is not intended for pharmaceutical applications. For more information on product availability manufactured in other regions, please contact our sales office. A three-step synthetic route was proposed and tested to obtain a chain-end functional di-sorbitan oleate monomer: First, 1,18-octadec-9-enedioic acid compound was produced by self-metathesis reaction of an oleic acid; then, the 1,18-octadec-9-enoyl dichloride compound was yielded by chlorination of the di-acid with thionyl chloride, and finally, the 1,18-di-sorbitan oleate monomer was yielded by esterification of the dichloride with 1,4-sorbitan. The di-sorbitan oleate monomer was purified and then characterized by FTIR, 1H-NMR, DSC and TGA to establish its structure and properties. A bio-based polyurethane (PU) was synthesized by reacting the obtained 1,18-di-sorbitan oleate monomer and MDI. Rheological analysis showed that a curing reaction occurs as a significant increase of the storage modulus (G’) and the complex viscosity (η*) at 100 °C. The obtained bio-based PU was characterized by FTIR, TGA and DMA, confirming that 1,18-di-sorbitan oleate is a feasible monomer for synthesizing polyurethanes. Sorbitan oleate, also known as arlacel or E494, belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid. Sorbitan oleate is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Sorbitan oleate is a potentially toxic compound. 

APPEARANCE: Cream yellowish bead solid powders and characteristic smell.Non-ionic, vegetable-based, PEG-free liquid emulsifier. Yellow to amber viscous liquid, bland odor. Disperses in water. HLB value 4.3 (gives water-in-oil emulsions).Sorbitan mono oleate is a viscous yellow liquid which is used as an emulsifier for water/oil emulsions. It is a nonionic surfactant with good wetting properties. It is soluble in ethanol, toluene, mineral oil and vegetable oils. It is insoluble in water, acetone and glycols.

SOLUBILITY: It cannot be decomposed in water.Quality Standard:Acid Value (mgKOH/g)≤8 Saponification Value (mgKOH/g)145～160 Hydroxyl Value (mgKOH/g)193～210 Water (%)≤2.0

INTENDED USAGE:It is lipophilic surfactant substance. It is generally used as an emulsifer together with polysorbates. It is used to change crystallization of the oils.As emulsifier, solubilizer, stabilizer, softener, anti-static agent etc. suitable for medicine, cosmetics, textiles, paints etc.Used as W/O emulsion explosive, preparation agent of textile, emulgator of artesian well weighted mud and producing of food and cosmetic, dispersant in beaded paint, stabilizer of itanium dioxide, insecticide, wetting agent and emulgator in pesticide, cosolvent of oil production, antirust of slushing oil, lubricant and softening agent of textile and leather.Vegetable-based emulsifier and co-emulsifier for making stable water-in-oil creams and lotions. Compatible with all kinds of cosmetic oils and active ingredients. Very pleasant application properties. Often used with polysorbates or other high HLB emulsifiers

USAGE AREA: Lotions, creams, ointments, balms.Fine bakery products, Fine bakery products, decoration and coating materials, Baker’s yeasts, Oil emulsions, Milk and cream mixtures, Gel marmelades, Tahini halva varieties, Cocoa based candies, Chocolates, Liquid mixtures of fruits and vegetables, Sweets, Sugar based candies, Food supplements. For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.Polysorbate 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer such as in a mouthwash. The cosmetic grade of polysorbate 80 may have more impurities than the food grade. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the popular antiarrhythmic amiodarone.It is also used as an excipient in some European and Canadian influenza vaccines. Influenza vaccines contain 2.5 μg of polysorbate 80 per dose.Polysorbate 80 is found in many vaccines used in the United States.It is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of polysorbate 80 and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.On RODAC agar plates used in microbiological control, polysorbate 80 counteracts any disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow. 

QUANTITY OF USAGE: It is determined by the practitioner according to intended use and place of use.Can be added to formulas as is, usual concentration 2 - 10%. For external use only.(Method of Sierra, 1957) Prepare a basal medium containing the following (per litre of distilled water): peptone, 10.0 g; NaCl, 5.0 g; CaCl2·2H2O, 0.1 g; and agar, 9.0 g; pH 7.4. Sterilize by autoclaving. Autoclave the desired Tween separately. Cool the basal medium to 45–50°C, add the Tween to give a finalconcentration of 1.0%, shake until the Tween is completely dissolved and pour into plates.Inoculate the cultures as lines on the surface of the agar. Incubate for up to 7 days, inspecting daily. Look for an opaque halo around the growth.Saponification of 100 g of the sample yields not less than 28 g and not more than 32 g of polyols, and not less than 73 g and not more than 77 g of fatty acids. The polyol content shall be not less than 95% of a mixture of sorbitol, 1,4-sorbitan and isosorbide. 

GENERAL NOTES
Take off contaminated clothing. Following inhalation: Provide fresh air. In all cases of doubt, or when symptoms persist, seek medical advice. Following skin contact: Rinse skin with water/shower. In all cases of doubt, or when symptoms persist, seek medical advice.Following eye contact: Rinse cautiously with water for several minutes. In all cases of doubt, or when symptoms persist, seek medical advice.Following ingestion: Rinse mouth. Call a doctor if you feel unwell.